4.5 Article

Bis-Carbaborane-Bridged Bis-Glycophosphonates as Boron-Rich Delivery Agents for BNCT

Journal

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2010, Issue 16, Pages 3129-3139

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201000213

Keywords

Boron; Antitumor agents; Medicinal chemistry; Phosphorus; Cluster compounds

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The synthesis and properties of boron-rich bis(meta-carbaborane) derivatives containing glycophosphonate and glycophosphonothioate moieties are reported. All compounds are water-soluble; however, the tetragalactosylated compounds show lower solubility than their disodium salts.

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