Microwave-Assisted Synthesis of a Nitro-m-xylylenedioxycalix[6]arene Building Block Functionalized at the Upper Rim

Microwave-assisted synthesis represents a new methodology to obtain calix[6]arene building blocks. The synthesis of compounds 1 and 2 is described. These compounds are A, D-m-xylylenedioxy-bridged calix[6]arenes in cone conformation, functionalized with potential amino groups in the lower rim spacer (5-position) and amino groups or their precursors in A,D-para positions at the upper rim. A conformational study has been performed for all newly synthesized compounds.