Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2009, Issue 10, Pages 1598-1605Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.200801285
Keywords
Bioorganic chemistry; Inhibitors; Glycoconjugates; Enzymes; Chelation
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Funding
- Japanese Ministry of Education, Culture, Sports, Science and Technology [19655056]
- Grants-in-Aid for Scientific Research [19655056] Funding Source: KAKEN
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Conjugates of 2,4-diamino sugars and uridine have been synthesized as galactosyltransferase inhibitors. The relationship between inhibitory activity and the chelation abilility of the hinge-like diamino sugar towards a metal ion was studied by NMR spectroscopy. One of the conjugates exhibited a moderate inhibition that ranks between those of UDP and UMP probably through the chelation of the hinge-like diamino sugar to Mn-II. ((C) Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)
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