Article
Chemistry, Multidisciplinary
Pragati Shukla, Madan D. Ambhore, Venkataramanarao G. Anand
Summary: The electronic properties of a hexaphyrin were fine-tuned by core-modification, resulting in a Huckel aromatic 30 pi hexaphyrin with two pyrrole and four furan rings in the pi-conjugated pathway. This Huckel aromatic hexaphyrin changed its conformation upon two-electron ring oxidation with triflic acid or Meerwein salt [Et3O](+)[SbCl6](-), forming 28 pi Mobius aromatic dication species. The reversible aromatic transition was confirmed through spectroscopic techniques and quantum chemical calculations.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Marija Baranac-Stojanovic, Milovan Stojanovic, Jovana Aleksic
Summary: By employing density functional theory calculations, this study investigates the effect of silicon substitution on the aromaticity of polycyclic aromatic hydrocarbons. The results show that the placement of silicon atoms can tune the singlet-triplet energy gaps and regulate the extent of global, semiglobal, and local aromaticity. This work extends the importance of Huckel aromaticity to excited triplet states.
CHEMISTRY-AN ASIAN JOURNAL
(2022)
Article
Chemistry, Multidisciplinary
Friedrich Wossidlo, Daniel S. Frost, Jinxiong Lin, Nathan T. Coles, Katrin Klimov, Manuela Weber, Tobias Boettcher, Christian Mueller
Summary: In this study, a novel phosphinine selenide was successfully synthesized and isolated for the first time, showing enhanced basicity and nucleophilicity compared to unsubstituted phosphinine. This compound exhibits distinct reactivity towards various reagents, paving the way for new perspectives in low coordination phosphorus chemistry.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Tobias Brueckner, Felipe Fantuzzi, Tom E. Stennett, Ivo Krummenacher, Rian D. Dewhurst, Bernd Engels, Holger Braunschweig
Summary: The study found that NHC-stabilised diboryne can undergo a high-yielding reaction with tetraethyldiphosphine at room temperature to form a B2P2 heterocycle, which can be oxidised to different ionic forms. With each oxidation step, the structure of the heterocycle changes, showing different forms.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Peter Coburger, Clara Schweinzer, Zhongshu Li, Hansjoerg Gruetzmacher
Summary: The reaction of IDP with trityl phosphaalkyne leads to the formation of a mixture containing molecules 1a and 1b with a C3P3 core carrying a two-fold negative charge. In order to avoid the formation of an antiaromatic 8 pi electron system, 1a adopts a bicyclic [3.1.0] structure and 1b a tricyclic [2.2.0.0] structure, which are in dynamic equilibrium. 1a and 1b can be reversibly oxidized to [5](2+), a triphosphinine dication with a flat aromatic C3P3 ring, through a two-electron redox reaction mediated by the 7 pi-radical cation [4](center dot+).
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Chemistry, Multidisciplinary
Junki Kashida, Yoshiaki Shoji, Hideo Taka, Takanori Fukushima
Summary: In this study, a new synthesis method for h-CBNs with a B4N4-heteropentalene core and polycyclic aromatic hydrocarbon wings was developed. By using 1,2-azaborinine derivatives as building blocks, a stepwise synthesis protocol was established to form B4N4 rings, resulting in the synthesis of three triblock molecules with B4N4 core and naphthalene, anthracene, or phenanthrene wings. Among them, 1(Phen) showed the highest triplet-state energy and served as a host material for phosphorescent OLED devices with a maximum external quantum efficiency of 13.7%. These findings may lead to the synthesis of various h-CBNs with new properties arising from the synergy of two different pi-electronic systems.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Multidisciplinary
Silvia Escayola, Claire Tonnele, Eduard Matito, Albert Poater, Henrik Ottosson, Miquel Sola, David Casanova
Summary: Pro-aromatic molecules have distinct diradicaloid and T-1 states with potential Baird aromaticity, which can be designed using strategies involving electron-donating substituents on small conjugated rings, electron withdrawing substituents on small exocyclic groups, or electron-deficient conjugated rings with exocyclic electron-donor substitution.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Organic
Kazuki Urakawa, Yurie Yatsuoka, Yuta Kawabata, Hyuma Masu, Masaki Matsuda, Hayato Ishikawa
Summary: Borocyclic radicals with highly conjugated aromatics were generated from orthoquinone-containing polycyclic aromatic compounds by trapping the photoinduced triplet state. The stable picene-based borocyclic radical exhibited a unique crystal structure and higher electrical conductivity.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Johannes Nebauer, Christian Neiss, Marcel Krug, Alexander Vogel, Dominik Fehn, Shuhei Ozaki, Frank Rominger, Karsten Meyer, Kenji Kamada, Dirk M. Guldi, Andreas Goerling, Milan Kivala
Summary: This article describes a new type of nitrogen-centered polycyclic scaffold synthesized through intramolecular oxidative cyclodehydrogenation of tri(1-naphthyl)amine, which is the first example of a direct 3-fold cyclization of a triarylamine under oxidative conditions. Experimental and theoretical studies reveal the impact of cyclization on the electronic and photophysical properties, and mechanistic studies suggest the cyclization occurs under kinetic control via a dicationic mechanism.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Article
Chemistry, Applied
Siqi Zhu, Fang Li, Claire Empel, Sripati Jana, Chao Pei, Rene M. Koenigs
Summary: Here, we report a photocatalytic reaction of acceptor/acceptor diazoalkanes with terminal alkynes, leading to the formation of furan heterocycles. Experimental and computational studies reveal the involvement of a key triplet carbene intermediate, which undergoes addition reaction followed by cyclization. This reaction provides a mild and efficient method for the synthesis of furans using a broad range of substrates.
ADVANCED SYNTHESIS & CATALYSIS
(2022)
Article
Chemistry, Multidisciplinary
Longbin Ren, Yi Han, Xudong Hou, Yong Ni, Jishan Wu
Summary: Researchers reported a globally aromatic cage, showing a transition from localized aromaticity to global aromaticity through chemical oxidation. The 2D macrocycles in the cage skeleton exhibit aromaticity and follow the Hiickel rule.
Article
Chemistry, Physical
Sladana Dordevic, Slavko Radenkovic
Summary: In this work, we demonstrate that both neutral BeB8 and MgB8 exhibit a singlet ground state umbrella-like form. The stability, electronic structure, and aromaticity of these target molecules are compared. The magnetically induced current densities show that both BeB8 and MgB8 are double aromatic systems with different spatial distribution of current density patterns.
Article
Chemistry, Multidisciplinary
Peng-Fei Zhang, Jing-Cai Zeng, Fang-Dong Zhuang, Ke-Xiang Zhao, Ze-Hao Sun, Ze-Fan Yao, Yang Lu, Xiao-Ye Wang, Jie-Yu Wang, Jian Pei
Summary: Introducing BN units into polycyclic aromatic hydrocarbons expands the chemical space of conjugated materials with novel properties. The study shows that the orientation of BN has significant effects on the structure, (anti)aromaticity, crystal packing, and photophysical properties. These findings provide guidance for the synthesis of BN-PAHs with specific stacking structures.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Physical
Sheng-Jie Lu
Summary: In this study, a global-search for B8C10 anion and neutral was conducted using the CALYPSO genetic algorithm and DFT calculations. The structural and bonding properties of these compounds were investigated using quantum chemical calculations. The results showed that the B8C10- anion has a cross-bridged three-ringed structure, while the B8C10 neutral adopts a C-2v symmetric planar polycyclic structure cross-bridged by the central C-C bond. Interestingly, B8C10 neutral exhibits some aromaticity.
CHEMICAL PHYSICS LETTERS
(2022)
Article
Chemistry, Multidisciplinary
Quentin Dherbassy, Srimanta Manna, Chunling Shi, Watcharapon Prasitwatcharakorn, Giacomo E. M. Crisenza, Gregory J. P. Perry, David J. Procter
Summary: In this study, an enantioselective copper-catalyzed borylative cyclization was reported for the assembly of privileged pyrroloquinazolinone motifs. The reaction demonstrated high enantio- and diastereocontrol, yielding products with quaternary stereocenters. The utility of the products was further demonstrated through additional manipulations.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Benedikt W. Grau, Maximilian Dill, Frank Hampel, Axel Kahnt, Norbert Jux, Svetlana B. Tsogoeva
Summary: A generally applicable synthetic strategy has been developed to access asymmetrical hexaarylbenzenes via a high-yielding domino reaction using easily available starting materials. This method avoids statistical steps and results in the creation of diverse and still unexplored aromatic benzene scaffolds.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Multidisciplinary
Michael Mauksch, Svetlana B. Tsogoeva
Summary: The text discusses Zimmerman aromaticity and its application in cyclic compounds, as well as the discovery of the oldest Mobius aromatic system. The exploration of global paramagnetic ring currents and antiaromaticity expands traditional magnetic criteria. Through the study of PAH with nontrivial topology, a new type of aromaticity that evades the Huckel rule was discovered.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Medicinal
Aysun capci, Lars Herrmann, Halmuthur M. Sampath Kumar, Tony Froehlich, Svetlana B. Tsogoeva
Summary: Considerable progress has been made in the development of new effective antimalarial, anticancer, and antiviral agents using the recently developed dimer approach. The activity of artemisinin-based dimers has significantly improved compared to monomers, with no toxicity to normal cells and fewer side effects. This high potential concept has led to the discovery of many new artemisinin-derived dimer compounds with promising biological activities.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Chemistry, Multidisciplinary
Lars Herrmann, Friedrich Hahn, Christina Wangen, Manfred Marschall, Svetlana B. Tsogoeva
Summary: The synthesis of new bioactive quinoline-morpholine hybrid compounds shows pronounced inhibitory effects against SARS-CoV-2 in cell culture, suggesting potential for specific drug development.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Editorial Material
Chemistry, Multidisciplinary
Lars Herrmann, Friedrich Hahn, Christina Wangen, Manfred Marschall, Svetlana B. Tsogoeva
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Medicinal
Lars Herrmann, Ivan A. Yaremenko, Aysun Capci, Julia Struwe, Dhanir Tailor, Arpit Dheeraj, Jan Hodek, Yulia Yu Belyakova, Peter S. Radulov, Jan Weber, Sanjay Malhotra, Alexander O. Terent'ev, Lutz Ackermann, Svetlana B. Tsogoeva
Summary: In this study, new artesunic acid and synthetic peroxide-based hybrids were synthesized and analyzed for their inhibitory activity against SARS-CoV-2 and leukemia cell lines. The results showed that several artesunic acid-derived hybrids exhibited potent inhibition against both K562 leukemia cells and SARS-CoV-2. These findings provide valuable insights for the design of artemisinin-derived hybrids to treat cancer and SARS-CoV-2 infections.
Article
Biochemistry & Molecular Biology
Friedrich Hahn, Stuart T. Hamilton, Christina Wangen, Markus Wild, Jintawee Kicuntod, Nadine Brueckner, Jasmine E. L. Follett, Lars Herrmann, Ahmed Kheimar, Benedikt B. Kaufer, William D. Rawlinson, Svetlana B. Tsogoeva, Manfred Marschall
Summary: The study shows that a PROtac based on a cyclin-dependent kinase inhibitor has strong anti-HCMV activity and potential for broader antiviral applications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Editorial Material
Medicine, General & Internal
Svetlana B. Tsogoeva
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Multidisciplinary Sciences
Annemarie Ackermann, Aysun Capci, Michael Buchfelder, Svetlana B. Tsogoeva, Nicolai Savaskan
Summary: A newly synthesized hybrid drug, AC254, combining sulfasalazine (SAS) and dihydroartemisinin (DHA), has shown promising anti-tumor effects on glioma cells by potentiating the individual anti-tumor properties of SAS and DHA. Chemical hybridization of clinically established compounds like SAS and DHA presents a potential avenue for the development of new effective chemotherapeutic agents.
SCIENTIFIC REPORTS
(2021)
Review
Chemistry, Medicinal
Ivan A. Yaremenko, Peter S. Radulov, Yulia Yu. Belyakova, Dmitriy I. Fomenkov, Svetlana B. Tsogoeva, Alexander O. Terent'ev
Summary: This article summarizes the main achievements in the synthesis of organic peroxides using Lewis acids and heteropoly acids for the first time. It is divided into three parts: (1) the application of metal-based Lewis acids in the synthesis of organic peroxides; (2) the synthesis of organic peroxides promoted by non-metal-based Lewis acids; and (3) the application of heteropoly acids in the synthesis of organic peroxides. The information covered in this review will be useful for specialists in organic synthesis, reactions and processes of oxygen-containing compounds, catalysis, pharmaceuticals, and materials engineering.
Article
Chemistry, Physical
Lena Kersting, Leah Kuhn, Maksim Anokhin, Florian Schuster, Cecile Haeberli, Shainy Sambyal, Halmuthur M. Sampath Kumar, Jennifer Keiser, Igor Alabugin, Svetlana B. Tsogoeva
Summary: An efficient metal-free visible-light-driven two-step domino reaction method was developed for the synthesis of new bioactive compounds. The combination of fluorescein and thiourea was found to be the most effective way to promote the reaction, achieving high yields with a broad substrate scope. Experimental and computational evidence supported the crucial role of singlet oxygen in the reaction, while thiourea acted as an electron-transfer mediator and/or scavenger of reactive oxygen species. Furthermore, the synthesized compounds showed high antischistosomal and anti-cancer activities.
Review
Chemistry, Multidisciplinary
Benedikt W. Grau, Alexander Neuhauser, Sadig Aghazada, Karsten Meyer, Svetlana B. Tsogoeva
Summary: Metathesis reaction is an important tool in synthetic chemistry that transforms hydrocarbon molecules through exchange of molecular fragments. There have been many modifications and improvements, including the use of iron as a catalyst.
CHEMISTRY-A EUROPEAN JOURNAL
(2022)
Article
Chemistry, Organic
Anton Guryev, Florian Schuster, Lars Herrmann, Friedrich Hahn, Christina Wangen, Jan Hodek, Jan Weber, Manfred Marschall, Svetlana B. Tsogoeva
Summary: We have developed a metal-free synthetic strategy for the efficient construction of functionalized phthalazines, which shows strong antiviral activity against major human pathogens.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Editorial Material
Chemistry, Physical
Lena Kersting, Leah Kuhn, Maksim Anokhin, Florian Schuster, Cecile Haberli, Shainy Sambyal, Halmuthur M. Sampath Kumar, Jennifer Keiser, Igor Alabugin, Svetlana B. Tsogoeva
Summary: An efficient metal-free visible-light-driven two-step domino reaction has been developed for synthesizing new bioactive compounds. The combination of fluorescein and thiourea proved to be the most effective promoter, with yields up to 97% and a broad substrate scope. Experimental and computational evidence supported the role of singlet oxygen in the reaction, and thiourea acted as an electron-transfer mediator and/or scavenger of reactive oxygen species. Furthermore, in vitro studies showed high antischistosomal and anti-cancer activities of the tetrahydroisoquinoline-butenolide hybrid compounds.
Article
Pharmacology & Pharmacy
Friedrich Hahn, Christina Wangen, Sigrun Haege, Lars Herrmann, Alexandra Herrmann, Svetlana B. Tsogoeva, Manfred Marschall
Summary: Since 2019, the development of medical countermeasures for the spread of SARS-CoV-2 and the pandemic of COVID-19 has been a major focus. Vaccines have reduced severe cases, but the emergence of the omicron variant shows the challenges in keeping up with viral evolution. The approved antiviral drugs remdesivir, molnupiravir, and Paxlovid have broad effectiveness, but none are recommended for prophylactic use, highlighting the need for new small molecules and antiviral strategies.