Article
Rheumatology
Hubert de Boysson, Clivia Barakat, Anael Dumont, Jonathan Boutemy, Nicolas Martin Silva, Gwenola Maigne, Alexandre Nguyen, Amandine Lavergne, Paul Castan, Sophie Gallou, Audrey Sultan, Samuel Deshayes, Achille Aouba
Summary: This study assessed the tolerance of glucocorticoids in patients with giant cell arteritis and their related adverse events. The results showed that a high percentage of patients experienced various adverse events including cognitive and psychological changes, cutaneous changes, muscle loss, and metabolic issues. The study suggests careful monitoring of glucocorticoid-related adverse events and consideration of glucocorticoid-sparing strategies in some patients.
Article
Clinical Neurology
Anna Castaldo, Mariangela Farinotti, Mario Fichera, Lorenzo Nanetti, Filippo Fortuna, Caterina Mariotti, Alessandra Solari
Summary: This study translated and culturally adapted the PROM-Ataxia questionnaire into Italian and conducted cognitive interviews. Italian patients found the questionnaire to be complete, but identified some redundant or ambiguous items. The translation and cultural adaptation are necessary for the subsequent psychometric validation of the scale.
NEUROLOGICAL SCIENCES
(2023)
Article
Toxicology
Rita Farah, Ziad Kazzi, Jeffrey Brent, Keith Burkhart, Paul Wax, Kim Aldy
Summary: This study describes the adverse events associated with the use of ivermectin for the prevention or treatment of COVID-19. The findings suggest that there are potential adverse health effects, particularly related to neurological function, when ivermectin is self-treated or used in formulations intended for non-human use.
CLINICAL TOXICOLOGY
(2022)
Review
Environmental Sciences
Renly Lim, Lisa Kalisch Ellett, Elizabeth E. Roughead, Phaik Yeong Cheah, Nashwa Masnoon
Summary: This study summarized available patient-reported questionnaires for detecting adverse drug reactions and highlighted the need for more robust validity and reliability testing.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2021)
Article
Otorhinolaryngology
Laila A. Gharzai, Michelle L. Mierzwa, John Devin Peipert, Kedar Kirtane, Keith Casper, Poonam Yadav, Nan Rothrock, David Cella, Sara Shaunfield
Summary: To quantify the common adverse effects (AEs) of radiation therapy (RT) for head and neck squamous cell carcinoma (HNSCC), a brief patient-reported outcome (PRO) measure was developed. Through literature review, patient interviews, and physician surveys, an 8-item AE-focused measure was developed. Cognitive interviews demonstrated strong face validity for this measure.
JAMA OTOLARYNGOLOGY-HEAD & NECK SURGERY
(2023)
Article
Surgery
Johan Clausen, Victor Boesen, Ismail Gogenur, Torquil Watt
Summary: This study aimed to conceptualize a novel patient-reported outcome instrument for detecting early adverse events within two weeks of discharge after major emergency abdominal surgery and colorectal cancer surgery. An exhaustive health concept pool was generated through systematic content analysis of existing measures and interviews with readmitted patients and health professionals. The relevant health concepts for detecting adverse events after discharge were selected based on ratings by colorectal cancer surgeons and emergency general surgeons.
WORLD JOURNAL OF SURGERY
(2023)
Article
Oncology
Yanyan Zhu, Milenka Jean-Baptiste, William R. R. Lenderking, Jill A. A. Bell, Dennis A. A. Revicki, Huamao M. M. Lin, Rachael Brake, Bryce B. B. Reeve
Summary: This study aimed to identify the most relevant patient-reported symptomatic adverse events in patients with EGFR exon 20 mutation NSCLC. Through patient and clinician interviews, 12 symptomatic AEs were identified and adapted into a 25-item PRO-CTCAE form for future clinical trials.
Article
Medicine, Research & Experimental
Lechoslaw Pawel Chmielik, Grazyna Mielnik-Niedzielska, Anna Kasprzyk, Tomasz Stankiewicz, Artur Niedzielski
Summary: This study used the 50-item Child Health Questionnaire (CHQ-PF50) to evaluate parental responses regarding the health-related quality of life (HRQL) of Polish children and adolescents. The study found that family cohesion, parental emotional, and general health perceptions were the domains with the lowest HRQL scores.
MEDICAL SCIENCE MONITOR
(2022)
Article
Oncology
Reshma Mahtani, Alexander Niyazov, Bhakti Arondekar, Katie Lewis, Alex Rider, Lucy Massey, Michael Patrick Lux
Summary: This study provides real-world data on treatment patterns and patient outcomes in gBRCA1/2-mutated HER2-ABC patients, supporting the use of PARPi in this population.
Review
Gastroenterology & Hepatology
Jane Fletcher, Sheldon C. Cooper, Amelia Swift
Summary: Evaluating healthcare or research interventions in inflammatory bowel disease (IBD) relies on the measurement of outcomes. Patient-reported outcome measures (PROMs) play a central role in this evaluation in patient-centred care. This review provides an overview of validated, adult disease-specific PROMs developed for use in IBD, aiming to assist clinicians and researchers in selecting PROMs for outcome measurement in their patient cohort. Despite the identification of 21 PROMs and their shortened versions, it appears that there is no single PROM that is entirely suitable for both research and clinical practice.
GASTROENTEROLOGY INSIGHTS
(2021)
Article
Psychology, Developmental
Bruna Costa, Paul White, James D. Kiff, Amy Davies, Nicola M. Stock
Summary: This study assessed parent-reported socioemotional and cognitive development in children born with CL/P at 18 months of age, finding that the majority of children were developing as expected, but a minority had developmental concerns. Risk factors included physical development issues in children, maternal anxiety and depression, and marital status. The study suggests the need for routine screening for potential risk factors and the potential usefulness of ASQs in early identification of developmental concerns in children with CL/P.
CHILD CARE HEALTH AND DEVELOPMENT
(2021)
Article
Health Care Sciences & Services
Yi Zhang, Jennifer L. Clegg, Shannon Keith, Shehan McFadden, Tara Symonds, Rajesh Kumar, Asif H. Khan, Siddhesh Kamat, Jingdong Chao
Summary: This study aimed to evaluate the content validity of the Pediatric Asthma Questionnaire (PAQ), a newly developed 6-item observer-reported outcome measure for caregivers of children aged 2-5 years diagnosed with asthma. Qualitative data analysis revealed that most participants found the PAQ easy to complete, relevant to their child's experience with asthma, and appropriate in terms of instructions, response scales, and recall period. Based on feedback, the PAQ underwent some modifications to improve clarity and consistency.
JOURNAL OF PATIENT-REPORTED OUTCOMES
(2022)
Article
Computer Science, Interdisciplinary Applications
Anne Dirkson, Suzan Verberne, Gerard van Oortmerssen, Hans Gelderblom, Wessel Kraaij
Summary: Patients share coping strategies for illnesses in online support groups. Automatic extraction of these strategies from patient discussion groups has not been attempted before. This study introduces a new task that faces challenges such as complex entities, numerous labels, and relations between documents. The authors present an initial ontology for coping strategies and compare two computational solutions for this task. The evaluation results show limited performance, with multi-label classification outperforming named entity recognition with entity linking.
JOURNAL OF BIOMEDICAL INFORMATICS
(2023)
Letter
Pharmacology & Pharmacy
Mirjam de With, Jonathan Knikman, Jan H. M. Schellens, Hans Gelderblom, Annemieke Cats, Henk-Jan Guchelaar, Ron H. J. Mathijssen, Jesse J. Swen, Didier Meulendijks
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Oncology
Astrid Lipplaa, Debora Meijer, Michiel A. J. van de Sande, Hans Gelderblom, Judith V. M. G. Bovee, Hailiang Mei, Karoly Szuhai
Summary: This article describes a newly identified gene fusion in diffuse TSGCT, which potentially plays a vital role in the pathogenesis of the disease.
GENES CHROMOSOMES & CANCER
(2023)
Article
Oncology
Geert Spierenburg, Floortje G. M. Verspoor, Jay S. Wunder, Anthony M. Griffin, Peter C. Ferguson, Matthew T. Houdek, David M. King, Richard Boyle, Robert Lor Randall, Steven W. Thorpe, Jacob I. Priester, Erik J. Geiger, Lizz van der Heijden, Nicholas M. Bernthal, Bart H. W. B. Schreuder, Hans Gelderblom, Michiel A. J. van de Sande
Summary: This study compared the short-term postoperative outcomes of one-stage and two-stage surgeries on both sides for diffuse-type tenosynovial giant cell tumors (D-TGCTs) of the knee. The results showed that one-stage surgery did not impair rehabilitation, and patients had a shorter hospital stay and no more complications.
Article
Oncology
Emanuela Palmerini, John H. Healey, Nicholas M. Bernthal, Sebastian Bauer, Hendrik Schreuder, Andreas Leithner, Javier Martin-Broto, Francois Gouin, Julio Lopez-Bastida, Hans Gelderblom, Eric L. Staals, Florence Mercier, Petra Laeis, Xin Ye, Michiel van de Sande
Summary: This article describes the impact of Tenosynovial giant cell tumor (D-TGCT) on patient-reported outcomes (PROs) based on the Tenosynovial giant cell tumor Observational Platform Project (TOPP) registry. The study found that patients without active treatment strategy had lower pain levels and better quality of life at 1-year and 2-year follow-ups. On the other hand, patients receiving systemic treatment had higher pain levels when they changed treatment strategies. These findings highlight the significant impact of treatment strategies on patient quality of life.
Article
Oncology
Rieneke T. Lugtenberg, Stefanie de Groot, Danny Houtsma, Vincent O. Dezentje, Annelie J. E. Vulink, Maarten J. Fischer, Johanneke E. A. Portielje, Jacobus J. M. van der Hoeven, Hans Gelderblom, Hanno Pijl, Judith R. Kroep
Summary: Docetaxel, an anti-cancer agent, can cause hypersensitivity reactions and fluid retention. High-dose corticosteroids, such as dexamethasone, have been used to reduce these adverse effects, but there is little evidence to support this practice and high doses of corticosteroids can have undesirable effects. This study aimed to evaluate the impact of reducing the dose of dexamethasone on the incidence of hypersensitivity reactions and fluid retention in patients with breast or prostate cancer.
Article
Oncology
Hans Gelderblom, Robin L. Jones, Jean-Yves Blay, Suzanne George, Margaret von Mehren, John R. Zalcberg, Yoon-Koo Kang, Albiruni Abdul Razak, Jonathan Trent, Steven Attia, Axel Le Cesne, Brittany L. Siontis, David Goldstein, Kjetil Boye, Cesar Sanchez, Neeltje Steeghs, Piotr Rutkowski, Mihaela Druta, Cesar Serrano, Neeta Somaiah, Ping Chi, Brooke Harrow, Claus Becker, William Reichmann, Matthew L. Sherman, Rodrigo Ruiz-Soto, Michael C. Heinrich, INTRIGUE Investigators
Summary: In the INTRIGUE trial, there was no significant difference in progression-free survival between ripretinib and sunitinib for advanced gastrointestinal stromal tumour (GIST) patients. The study compared the impact of these treatments on health-related quality of life (HRQoL) and found that patients receiving ripretinib had better HRQoL during the dosing period compared to patients receiving sunitinib.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
Philip Heesen, Andreas Ranft, Vivek Bhadri, Benedicte Brichard, Stephane Collaud, Sona Cyprova, Hans Eich, Torben Ek, Hans Gelderblom, Jendrik Hardes, Lianne Haveman, Susanne Jabar, Wolfgang Hartmann, Dimosthenis Andreou, Peter Hauser, Josephine Kersting, Heribert Juergens, Jukka Kanerva, Thomas Kuehne, Anna Raciborska, Jelena Rascon, Arne Streitbuerger, Beate Timmermann, Yasmin Uhlenbruch, Uta Dirksen
Summary: This study analyzed the association between local therapy and event-free survival (EFS), overall survival (OS), and local recurrence (LR) in patients with Ewing sarcoma. The results showed that in certain situations, combination therapy with radiotherapy and surgery can improve the prognosis of patients. This provides important evidence for the personalized treatment of Ewing sarcoma.
EUROPEAN JOURNAL OF CANCER
(2023)
Article
Oncology
William D. Tap, Maitreyi G. Sharma, Marc Vallee, Bryan D. Smith, Matthew L. Sherman, Rodrigo Ruiz-Soto, Michiel van de Sande, R. Lor Randall, Nicholas M. Bernthal, Hans Gelderblom
Summary: TGCT is a rare neoplasm caused by upregulation of the CSF1 gene. Vimseltinib, an oral tyrosine kinase inhibitor, is being tested in the Phase III MOTION trial for its efficacy and safety in TGCT patients who are not suitable for surgery. Participants will receive vimseltinib or placebo in Part 1, followed by open-label vimseltinib treatment in Part 2.
Article
Medicine, General & Internal
Adrian Sacher, Patricia LoRusso, Manish R. Patel, Wilson H. Miller, Elena Garralda, Martin D. Forster, Armando Santoro, Alejandro Falcon, Tae Won Kim, Luis Paz-Ares, Samantha Bowyer, Maria de Miguel, Sae-Won Han, Matthew G. Krebs, Jong-Seok Lee, Michael L. Cheng, Kathryn Arbour, Erminia Massarelli, Yoonha Choi, Zhen Shi, Sandhya Mandlekar, Mark T. Lin, Stephanie Royer-Joo, Julie Chang, Neekesh V. Dharia, Jennifer L. Schutzman, Jayesh Desai
Summary: Divarasib, a KRAS G12C inhibitor, has shown promising therapeutic effects with minimal adverse events in patients with tumors harboring the KRAS G12C mutation.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Oncology
Astrid Lipplaa, Willem H. Schreuder, Sarina E. C. Pichardo, Hans Gelderblom
Summary: This study aimed to determine the efficacy of denosumab in patients with giant cell rich tumors of bone (GCRTB) that have recurred or require morbid surgery. Due to low patient accrual, the study was prematurely stopped and the results did not support the use of denosumab for this indication.
Editorial Material
Pharmacology & Pharmacy
Sofia L. J. Peeters, Maarten J. Deenen, Anna M. J. Thijs, Emma C. Hulshof, Ron H. J. Mathijssen, Hans Gelderblom, Henk-Jan Guchelaar, Jesse J. Swen
Article
Orthopedics
Gijsbert M. M. Kalisvaart, Thomas Van Den Berghe, Willem Grootjans, Maryse Lejoly, Wouter C. J. Huysse, Judith V. M. G. Bovee, David Creytens, Hans Gelderblom, Frank M. M. Speetjens, Lore Lapeire, Michiel A. J. van de Sande, Gwen Sys, Lioe-Fee de Geus-Oei, Koenraad L. L. Verstraete, Johan L. L. Bloem
Summary: This study aimed to identify the best DCE-MRI features that can predict histological response to neoadjuvant chemotherapy in osteosarcoma patients. The results showed that using the whole slab segmentation method and setting a threshold of relative wash-in rate <2.3 provided the most accurate prediction. The findings were externally validated in a separate test cohort.
SKELETAL RADIOLOGY
(2023)
Review
Oncology
J. -y. Blay, M. von Mehren, R. L. Jones, J. Martin-Broto, S. Stacchiotti, S. Bauer, H. Gelderblom, D. Orbach, N. Hindi, A. Dei Tos, M. Nathenson
Summary: Synovial sarcoma is a rare and aggressive disease, accounting for 5%-10% of all soft tissue sarcomas. Diagnosis is often challenging, but referral to a specialist center is crucial for optimal outcomes. Treatment strategies for localized disease include surgery, radiotherapy, and chemotherapy, while advanced disease has a poor prognosis and requires novel management strategies such as targeted agents and immunotherapies.
Article
Oncology
Emanuela Palmerini, John H. Healey, Nicholas M. Bernthal, Sebastian Bauer, Hendrik Schreuder, Andreas Leithner, Javier Martin-Broto, Francois Gouin, Julio Lopez-Bastida, Hans Gelderblom, Eric L. Staals, Florence Mercier, Petra Laeis, Xin Ye, Michiel van de Sande
Summary: This study investigated the impact of diffuse-type Tenosynovial giant cell tumor (D-TGCT) on treatment strategies and quality of life for patients. The results showed that patients who switched to an active treatment strategy had higher scores for pain and interference, while patients who remained off-treatment had lower scores at the 2-year follow-up. These findings are important for guiding the treatment and management of D-TGCT.
Article
Oncology
Diomidis Antoniadis, Alexander Giakoustidis, Vasileios Papadopoulos, Konstantinos N. Fountoulakis, Maggie Watson
Summary: The purpose of this study was to investigate the relationships between distress, psychological adjustment, and quality of life in patients with colon cancer. The results showed that quality of life was positively correlated with fighting spirit, cognitive avoidance, and fatalism, and negatively correlated with helplessness and hopelessness, and anxious preoccupation.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2024)
Article
Oncology
Irem Gul, Ismail Toygar, Oznur Usta Yesilbalkan
Summary: This study investigated the support needs of carers of cancer patients and how the patient's age and cancer type affect their needs. The study found that carers of older adults and patients with hematological malignancies require more support in various aspects of caregiving.
EUROPEAN JOURNAL OF ONCOLOGY NURSING
(2024)
