Review
Nutrition & Dietetics
Jose Luis Mansur, Beatriz Oliveri, Evangelina Giacoia, David Fusaro, Pablo Rene Costanzo
Summary: Vitamin D deficiency in pregnancy and infants may lead to health issues such as rickets, preeclampsia, and fetal growth restriction; supplementation with Vitamin D can reduce the risk of complications for pregnant women, fetuses, and newborns.
Article
Nutrition & Dietetics
Jinhua Wu, Bule Shao, Xing Xin, Wenliang Luo, Minjia Mo, Wen Jiang, Shuting Si, Shuojia Wang, Yu Shen, Yunxian Yu
Summary: This study explored the associations of vitamin D metabolic pathway gene polymorphisms with gestational 25(OH)D levels in pregnant women, and found that the associations varied by season and VD supplements. Additionally, the Gc isoform had a significant impact on gestational 25(OH)D levels.
CLINICAL NUTRITION
(2021)
Review
Biochemistry & Molecular Biology
Khaled M. Abdelrahman, Kevin V. Hackshaw
Summary: Neuropathic pain affects a significant portion of the population and is often treated ineffectively, leading patients to turn to nonpharmacologic treatments such as nutritional supplements. While patients commonly use vitamins, minerals, and herbal remedies for pain relief, there is limited evidence on the efficacy and mechanisms of these supplements in neuropathic pain, necessitating further exploration through large randomized controlled trials.
Article
Biochemistry & Molecular Biology
Cristian Sandoval, Jorge Farias, Mauricio Zamorano, Christian Herrera
Summary: The present review examined the relationship between vitamin deficiency and chronic liver disease. It was found that alcohol patients have low blood vitamin levels and that antioxidant mechanisms can prevent alcohol-induced liver damage. However, the effectiveness of antioxidants remains uncertain. Deficiencies in nutritional vitamins can rapidly develop during chronic liver disease.
Article
Pediatrics
Zahra Jamali, Fereshteh Ghorbani, Mohammad Shafie'ei, Fatemeh Tolooefar, Elham Maleki
Summary: This study aimed to evaluate the vitamin D levels in preterm neonates and investigate its association with influential factors. The results showed that maternal vitamin D levels were strongly correlated with neonatal vitamin D levels. Therefore, it is recommended to provide vitamin D supplementation during pregnancy to improve the health of both the mother and newborn.
Article
Nutrition & Dietetics
Malgorzata Starek, Pawel Gumulka, Monika Dabrowska
Summary: Nowadays, the quality of dietary supplements is of utmost importance due to reports of insufficient content or absence of ingredients. This study developed optimal conditions for analyzing the content of vitamins D-2, D-3, and K-2 in various dietary supplements. The results showed that the methodology developed was reliable and met analytical requirements. The amount of vitamin D-3 in the analyzed products matched the manufacturer's declaration, while the content of vitamin K-2 varied.
Article
Medical Laboratory Technology
Ashley S. P. Boggs, Lisa E. Kilpatrick, Carolyn Q. Burdette, Denise S. Tevis, Zachary A. Fultz, Michael A. Nelson, Jeffery M. Jarrett, Jennifer Kemp, Ravinder J. Singh, Stefan K. G. Grebe, Stephen A. Wise, Brittany L. Kassim, Stephen E. Long
Summary: This study developed Standard Reference Material 1949 for measuring hormone and nutrient concentrations during pregnancy. Significant differences were found in serum concentrations across different trimesters, especially in TSH and Tg measurements. The results indicate the material functions well by providing a relevant matrix-matched reference material.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Nutrition & Dietetics
Lisa Daneels, Dries S. Martens, Soumia Arredouani, Jaak Billen, Gudrun Koppen, Roland Devlieger, Tim S. Nawrot, Manosij Ghosh, Lode Godderis, Sara Pauwels
Summary: The study found a positive association between maternal vitamin D intake (diet + supplements) and newborn TL, particularly during the first trimester. However, there was no significant association between mean maternal serum 25-OHD concentrations during pregnancy and newborn TL.
Review
Nutrition & Dietetics
Andreea Bianca Stoica, Claudiu Marginean
Summary: This article reviews the impact of vitamin D deficiency on the health of infants, emphasizing its global significance and the need for further research and strategies. While conflicting results exist regarding the effects of vitamin D, it is clear that deficiency has significant implications, particularly for infants.
Article
Nutrition & Dietetics
Spyridon N. Karras, Erdinc Dursun, Merve Alaylioglu, Duygu Gezen-Ak, Stefan Pilz, Cedric Annweiler, Fatme Al Anouti
Summary: This study aimed to evaluate the combined effect of maternal and neonatal VDBP polymorphism heterogeneity in conjunction with different maternal and neonatal 25(OH)D cutoffs on neonatal anthropometric profile at birth. The findings suggest a potential role for neonatal VDBP genotypes rs2298850 and rs4588, in conjunction with specific neonatal 25(OH)D cutoffs, in affecting neonatal growth and development. However, no significant effects were observed for maternal VDBP polymorphisms or maternal 25(OH)D concentrations at birth on neonatal anthropometry.
Article
Public, Environmental & Occupational Health
Su H. Chu, Mengna Huang, Rachel S. Kelly, Priyadarshini Kachroo, Augusto A. Litonjua, Scott T. Weiss, Jessica Lasky-Su
Summary: This study found that higher levels of maternal vitamin D in the third trimester are associated with a lower risk of ADHD in offspring, with a stronger effect observed in male offspring.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Claire Stenhouse, Emma Hurst, Richard J. Mellanby, Cheryl J. Ashworth
Summary: Recent evidence suggests that vitamin D plays a crucial role in pregnancy, fetal growth, and development in various mammalian species. However, little is known about the changes in maternal vitamin D levels during pregnancy in pigs and its relationship with litter characteristics. This study examined the levels of 25(OH)D in maternal plasma at different gestational days and found a significant increase between days 18 and 30. The study also investigated the association between maternal vitamin D levels and various litter characteristics, such as gilt weight, ovulation rate, mean litter weight, number of live fetuses, prenatal survival rate, and sex ratio of the litter. The results showed that maternal 25(OH)D levels were positively associated with prenatal survival rate on day 60 and inversely associated with gilt weight on day 90. Maternal plasma 25(OH)D levels were also inversely associated with the percentage of male fetuses in the litter on day 90. This study provides valuable insights into the temporal changes in maternal vitamin D levels during pregnancy and its impact on economically important litter characteristics. Understanding the role of vitamin D in fetal growth during key developmental stages is vital for improving reproductive success in livestock species.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Philip R. Fischer, Neamat Almasri
Summary: Nutritional rickets can be caused by either vitamin D deficiency or insufficient dietary intake of calcium, and the combined deficiencies of calcium and vitamin D interact. Other factors also play a role in the pathogenesis of nutritional rickets.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2022)
Article
Nutrition & Dietetics
Spyridon N. Karras, Erdinc Dursun, Merve Alaylioglu, Duygu Gezen-Ak, Fatme Al Anouti, Stefan Pilz, Pawel Pludowski, Edward Jude, Kalliopi Kotsa
Summary: Dysregulation of vitamin D-binding protein has been associated with various pregnancy complications. The effects of VDBP polymorphisms on adipokine profiles in mothers and neonates have not been fully investigated. This study found that VDBP polymorphisms had minimal impact on adiponectin, irisin, and VDBP concentrations at birth under different vitamin D status cut-offs.
Review
Nutrition & Dietetics
Chrysoula Kosmeri, Vasileios Giapros, Dimitrios Rallis, Foteini Balomenou, Anastasios Serbis, Maria Baltogianni
Summary: Data on the nutritional management of preterm SGA infants are limited. The recommended energy intake for very preterm infants has increased, but may not be suitable for all preterm infants. Differentiating between FGR and constitutional SGA infants, as well as preterm SGA and preterm AGA infants, is important due to potential differences in nutritional needs.
Article
Nanoscience & Nanotechnology
Tamilselvan Mohan, Urban Ajdnik, Chandran Nagaraj, Florian Lackner, Andreja Dobaj Stiglic, Thirvengadam Palani, Lunjakorn Amornkitbamrung, Lidija Gradisnik, Uros Maver, Rupert Kargl, Karin Stana Kleinschek
Summary: This study developed a facile method for the fabrication of hollow cellulose beads that can release drugs in response to external pH stimuli. These hollow cellulose structures exhibit pH-responsive fluid uptake properties and high drug encapsulation efficiency, and their drug release can be fine-tuned by adjusting the pH of the release medium. The modified beads show excellent characteristics for drug delivery and are biocompatible, making them a promising platform for the development of sustainable and effective drug delivery systems.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Cell Biology
Kristijan Skok, Lidija Gradisnik, Helena Celesnik, Marko Milojevic, Uros Potocnik, Gregor Jezernik, Mario Gorenjak, Monika Sobocan, Iztok Takac, Rajko Kavalar, Uros Maver
Summary: In this study, a patient-derived triple-negative breast cancer cell line MFUM-BrTNBC-1 was isolated and characterized, and a comprehensive comparison was made with three commercial cell lines. MFUM-BrTNBC-1 maintained the primary triple-negative receptor status, expressed EMT transition markers, and showed changes in several cancer-related pathways. The cell line had good growth characteristics and genetic stability, making it a valuable model for studying triple-negative breast cancer.
Article
Chemistry, Analytical
Tanja Zidaric, David Majer, Tina Maver, Matjaz Finsgar, Uros Maver
Summary: An electrochemical sensor based on molecularly imprinted polymers (MIP) was developed for the detection of insulin in a single drop. The MIP receptors were assembled on a screen-printed carbon electrode (SPCE) through electropolymerization, creating imprinting cavities for insulin detection. The sensor showed a linear concentration range, a low detection limit, and good accuracy and precision.
Article
Materials Science, Multidisciplinary
Jernej Vajda, Luka Banovic, Mihael Misko, Igor Drstvensek, Marko Milojevic, Uros Maver, Bostjan Vihar
Summary: Accuracy and precision are crucial in extrusion-based material handling, such as 3D bioprinting. To address the issue of discrepancies between piston motion and material extrusion, we propose an algorithmic approach that optimizes piston movements based on extrusion analysis. This approach improves the accuracy and precision of complex extrusion-based bioprinting systems.
MATERIALS & DESIGN
(2023)
Article
Chemistry, Physical
Tanja Zidaric, Kristijan Skok, Kristjan Orthaber, Matevz Pristovnik, Lidija Gradisnik, Tina Maver, Uros Maver
Summary: This study presents an innovative wound dressing system that combines diclofenac and a biocompatible matrix for targeted pain relief. The multilayer structure of the dressing, achieved through layer-by-layer coating technique and inclusion of superparamagnetic iron platinum nanoparticles, allows for sustained drug release and precise application. The dressings were characterized for their physicochemical, structural, and morphological properties and found to be biocompatible with human skin fibroblasts. The findings suggest that this wound dressing system can contribute to tailored therapeutic strategies for local pain relief.
Review
Chemistry, Physical
Tina Lovrec-Krstic, Kristjan Orthaber, Uros Maver, Tomislav Sarenac
Summary: The field of ophthalmology is rapidly expanding with the increasing incidence of eye-related diseases. Due to an aging population and climate change, the number of ophthalmic patients will continue to rise, leading to potential under-treatment. Drug-loaded contact lenses provide a promising alternative to eye drops for ocular therapy, potentially transforming clinical practice. This review focuses on current roles, materials, drug binding, and future developments of contact lenses in ocular drug delivery.
Article
Polymer Science
Mojca Skerget, Maja Colnik, Lidija Fras Zemljic, Lidija Gradisnik, Tanja Zivkovic Semren, Blanka Tariba Lovakovic, Uros Maver
Summary: The isolation of keratin from poultry feathers using subcritical water was studied. The optimal operating parameters for obtaining a high molecular weight protein hydrolysate from poultry feathers were determined. The obtained hydrolysate showed a positive influence on skin fibroblast viability, making it potentially useful for biomedical applications.
Article
Materials Science, Multidisciplinary
Jernej Vajda, Bostjan Vihar, Laura Cinc Curic, Uros Maver, Matej Vesenjak, Polona Dobnik Dubrovski, Marko Milojevic
Summary: In this study, the effects of CaCl2 and SrCl2 as ionic crosslinkers on alginate- and cellulose-based materials were compared. Results showed that Sr2 crosslinked scaffolds had higher compressive strength, faster swelling, slower degradation, and rougher surface. Both crosslinking agents were non-toxic to cells and allowed stable culture for 30 days, but Sr2 crosslinked scaffolds exhibited higher metabolic activity. Overall, Sr2 is a viable alternative to Ca2 for crosslinking.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Article
Materials Science, Multidisciplinary
Katja Andrina Kravanja, Luka Suhadolnik, Marjan Bele, Uros Maver, Jan Rozanc, Zeljko Knez, Masa Knez Marevci, Matjaz Finsgar
Summary: This study synthesized titania and titanium oxynitride (Ti-O-N) nanotubular arrays on TiAl6V4 substrates using an anodic oxidation process followed by annealing in air or additional nitridation in NH3 atmosphere, and investigated their morphology, structure, and biocompatibility. Surface analysis techniques such as FE-SEM, AFM, XRD, XPS, and ToF-SIMS were performed. Cell testing with adipose-derived mesenchymal stem cells and human fetal osteoblasts demonstrated the favorable effects of Ti-O-N nanotubes on cell viability, proliferation, and morphology.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2023)
Review
Pharmacology & Pharmacy
Sabina Fijan, Nina Kolc, Metka Hrasovec, Gro Jamtvedt, Maja Sikic Pogacar, Dusanka Micetic Turk, Uros Maver
Summary: This study evaluated the effect of single-strain probiotic lactobacilli on treating children's atopic dermatitis. The results showed that certain strains were more effective in reducing the severity of atopic dermatitis, and treatment time and patient age also played a role.
Review
Materials Science, Biomaterials
Beste Elveren, Manja Kurecic, Tina Maver, Uros Maver
Summary: Functional tissue engineering is an important field in regenerative medicine and drug discovery, with electrospinning being a widely used method. This review discusses the process and materials of cell electrospinning (C-ES) and highlights recent advances in its applications for tissue engineering.
Article
Green & Sustainable Science & Technology
Tina Rocnik Kozmelj, Matej Zula, Janvit Terzan, Blaz Likozar, Uros Maver, Laura Cinc Curicc, Edita Jasiukaityte-Grojzdeka, Miha Grilc
Summary: The mechanisms, activity, and selectivity of the acid-supported transition metal rate catalyst (NiMo/Al2O3) for the hydrogenation, hydrodeoxygenation (HDO), and defunctionalization of lignin model compounds were investigated. The commercially available NiMo/Al2O3 intermediates showed strong acidity, which did not promote complete bond saturation but instead favored the formation of higher molecular weight compositions. The study provides insights for understanding and optimizing efficient valorization processes.
JOURNAL OF CLEANER PRODUCTION
(2023)
Review
Urology & Nephrology
Tadej Petreski, Luka Varda, Lidija Gradisnik, Uros Maver, Sebastjan Bevc
Summary: The kidneys are the primary excretion organ with various functions, and the nephron is their central structural unit. The treatment of acute kidney injury or chronic kidney disease is complex due to limited regeneration potential. The development of in vitro cell models based on patient-derived renal cells provides an opportunity to address issues related to drug-drug interactions and complications.
Review
Engineering, Biomedical
Jakob Naranda, Matej Bracic, Matjaz Vogrin, Uros Maver, Teodor Trojner
Summary: This review focuses on the use of Quartz Crystal Microbalance (QCM) in the tissue engineering of cartilage. QCM is an accurate technique that can monitor key parameters in developing cellular scaffolds, such as interactions with extracellular matrix components, adsorption of proteins onto biomaterials, and biomaterial-cell interactions. The review highlights the importance of material selection and proposes the use of QCM as a screening tool to improve the process. The future trends of QCM application in 3D printing of cellular scaffolds are also discussed.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Lidija Gradisnik, Uros Maver, Boris Gole, Gorazd Bunc, Matjaz Vorsic, Janez Ravnik, Tomaz Smigoc, Roman Bosnjak, Tomaz Velnar
Summary: This study established a quick and simple method for isolating human chondrocytes, which showed high viability and proliferative capacity. The cell model created in this study can be used to study the cellular properties, biochemical aspects, and potential therapeutic candidates for disc degeneration, as well as toxicology studies.
BIOENGINEERING-BASEL
(2022)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)