Article
Oncology
Meng-Nan Yang, Rong Huang, Tao Zheng, Yu Dong, Wen-Juan Wang, Ya-Jie Xu, Vrati Mehra, Guang-Di Zhou, Xin Liu, Hua He, Fang Fang, Fei Li, Jian-Gao Fan, Jun Zhang, Fengxiu Ouyang, Laurent Briollais, Jiong Li, Zhong-Cheng Luo, Shanghai Birth Cohort
Summary: This study found that fetal overgrowth may be associated with a large number of altered placental gene methylations. The placental genes VSX1 and CDH13 were found to be hypermethylated in cases of fetal overgrowth. Methylation of the placental ADIPOQ gene was correlated with adiponectin levels in cord blood, suggesting the contribution of placenta-originated adiponectin to fetal adiponectin.
CLINICAL EPIGENETICS
(2022)
Article
Psychiatry
Yuying Qiu, Meijuan Li, Yonghui Zhang, Ying Liu, Yongping Zhao, Jing Zhang, Qiong Jia, Jie Li
Summary: Berberine could reduce weight gain in schizophrenia patients, with significant weight loss observed in the berberine group compared to placebo. The effect may be related to the regulation of leptin levels.
ASIAN JOURNAL OF PSYCHIATRY
(2022)
Article
Multidisciplinary Sciences
Olukayode O. Akinmola, Babasola O. Okusanya, Gbenga Olorunfemi, Henry C. Okpara, Elaine C. Azinge
Summary: The study found that there is a relationship between fetal insulin, insulin-like Growth factor-1(IGF-1), and macrosomia in a resource-limited setting.
Article
Immunology
Florenzo Iannone, Emanuela Praino, Cinzia Rotondo, Dorotea Natuzzi, Rita Bizzoca, Nunzia Lacarpia, Marco Fornaro, Fabio Cacciapaglia
Summary: The study found that levels of certain adipokines and cytokines were correlated with BMI and specific disease features in systemic sclerosis (SSc) patients. For example, SSc patients with obesity had the highest levels of IL-17A, IL-2, IL-10, leptin, and visfatin, while underweight patients showed the highest levels of TNF-alpha.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Shanu Jain, Sai P. Pydi, Young-Hwan Jung, Mirko Scortichini, Efrat L. Kesner, Tadeusz P. Karcz, Donald N. Cook, Oksana Gavrilova, Jurgen Wess, Kenneth A. Jacobson
Summary: Obesity is a major factor in the global epidemic of type 2 diabetes, with elevated plasma free fatty acids contributing to insulin resistance; adipocyte P2Y(14)Rs play a crucial role in regulating lipid and glucose homeostasis, with their absence enhancing lipolysis, reducing body weight, and improving glucose tolerance; P2Y(14)R antagonists may hold therapeutic potential for obesity and T2D by inhibiting lipolysis.
Article
Oncology
Agnes Bocian-Jastrzebska, Anna Malczewska-Herman, Violetta Rosiek, Beata Kos-Kudla
Summary: This study investigated the potential relationship between leptin, adiponectin, and the leptin-adiponectin ratio with the grade, stage, and metastases of PanNENs. It was found that adiponectin concentration was significantly higher in the control group compared to the study group, and both leptin and adiponectin levels were higher in females than males. An increased leptin-adiponectin ratio was observed in well-differentiated PanNENs and PanNENs with low Ki-67. Additionally, lower leptin levels and a decreased leptin-adiponectin ratio were found in PanNENs with distal disease. These findings suggest that leptin, adiponectin, and their ratio may serve as potential biomarkers for the diagnosis, prognosis, and prediction of PanNENs.
Article
Multidisciplinary Sciences
Xixi Chen, Kaiwen Wang, Tao Lu, Jiajia Wang, Ting Zhou, Juan Tian, Bin Zhou, Li Long, Qiao Zhou
Summary: This study investigated the relationship between serum adiponectin level and disease activity in treatment-naive Han Chinese RA patients, finding a negative correlation with DAS28(ESR) and the Sharp score. These results suggest that adiponectin may be useful for assessing disease activity and radiographic progression of RA.
SCIENTIFIC REPORTS
(2022)
Article
Nutrition & Dietetics
Sara Becerril, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Amaia Mentxaka, Gabriela Neira, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: Biological sex and aging play a role in obesity development and type 2 diabetes, affecting the secretion of leptin and adiponectin. The Adpn/Lep ratio is proposed as a reliable biomarker for adipose tissue dysfunction. The study found that female mice were more metabolically protected from obesity and its comorbidities than males, with an increased Adpn/Lep ratio in aged females negatively correlated with body weight gain and insulin resistance.
Article
Endocrinology & Metabolism
Jessie Nallely Zurita-Cruz, Miguel Angel Villasis-Keever, Leticia Manuel-Apolinar, Leticia Damasio-Santana, Eulalia Garrido-Magana, Aleida de Jesus Rivera-Hernandez
Summary: In girls with central precocious puberty (CPP) undergoing GnRH analogs treatment, leptin levels and higher leptin/adiponectin ratio (LAR) are associated with greater weight gain. This association is particularly evident in girls with BMI < 94th percentile.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, General & Internal
Chia-Wen Lu, Kuen-Cheh Yang, Yu-Chiao Chi, Tsan-Yu Wu, Chien-Hsieh Chiang, Hao-Hsiang Chang, Kuo-Chin Huang, Wei-Shiung Yang
Summary: Lean non-alcoholic fatty liver disease (NAFLD) is similar to overweight NAFLD and should be detected early. The adiponectin-leptin ratio (AL ratio) may serve as a reliable marker for early detection of lean NAFLD independent of insulin resistance.
ANNALS OF MEDICINE
(2023)
Article
Medicine, Research & Experimental
Erica P. Homan, Bruna B. Brandao, Samir Softic, Abdelfattah El Ouaamari, Brian T. O'Neill, Rohit N. Kulkarni, Jason K. Kim, Ronald Kahn
Summary: The research found that FOXO transcription factors play different roles in the action of insulin/IGF-1 in different adipose tissue, with the most significant effect in BAT. While the loss of FOXOs in fat can partially rescue subcutaneous WAT and hepatosteatosis, it cannot rescue systemic insulin resistance and may lead to more severe hyperinsulinemia.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Medicine, Research & Experimental
Laurian Stoica, Ramona Gadea, Dan-Bogdan Navolan, Fulger Lazar, Ciprian Duta, Dana Stoian, Cristi Tarta, Flavius Olaru, Alexandru Isaic, Amadeus Dobrescu
Summary: The study showed a significant decrease in body weight and fasting glucose levels, as well as an increase in adiponectin levels, after SG and GP surgeries in obese rats with T2DM. This suggests hormonal factors may contribute to weight loss.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Article
Multidisciplinary Sciences
Liyan Fan, Alexander F. Lesser, David R. Sweet, Komal S. Keerthy, Yuan Lu, Ernest R. Chan, Vinesh Vinayachandran, Olga Ilkayeva, Tapatee Das, Christopher B. Newgard, Mukesh K. Jain
Summary: Brown adipose tissue (BAT) is crucial for maintaining metabolic health and survival by regulating and utilizing nutrient resources. The transcription factor KLF15 plays a critical role in the metabolic flexibility of BAT.
Article
Medicine, General & Internal
Sylwia Sluczanowska-Glabowska, Marzena Staniszewska, Mariola Marchlewicz, Ewa Duchnik, Karolina Luczkowska, Krzysztof Safranow, Boguslaw Machalinski, Andrzej Pawlik
Summary: Psoriasis is a common chronic skin disease characterized by hyperproliferation of keratinocytes, parakeratosis, and T-cell infiltration. Adipose tissue produces adipokines, including leptin, resistin, and adiponectin, which may play a role in the pathogenesis of psoriasis. This study examined the plasma levels of adiponectin, leptin, and resistin in psoriasis patients and their correlation with disease activity parameters and clinical parameters.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Ahmed Abdel-Razik, Nasser Mousa, Walaa Shabana, Ahmed H. Yassen, Mostafa Abdelsalam, Mohamed M. Wahba, Eman Mohamed Helmy, Ahmed M. Tawfik, Khaled Zalata, Ahmad S. Hasan, Rania Elhelaly, Rasha Elzehery, Aya Ahmed Fathy, Niveen El-Wakeel, Waleed Eldars
Summary: This study found that increased central obesity and leptin/adiponectin ratio (LAR) were independently associated with the development of PVT in non-cirrhotic NAFLD patients, suggesting that they may be considered as risk factors in the multifactorial pathogenesis of PVT.
FRONTIERS IN MEDICINE
(2021)
Article
Pediatrics
Linda Lindstrom, Anna-Karin Wikstrom, Eva Bergman, Ajlana Mulic-Lutvica, Ulf Hogberg, Fredrik Ahlsson, Maria Lundgren
PEDIATRIC RESEARCH
(2019)
Review
Pediatrics
Dirk Wackernagel, Anna Gustafsson, Anna-Karin Edstedt Bonamy, Annika Reims, Fredrik Ahlsson, Maria Elfving, Magnus Domellof, Ingrid Hansen Pupp
Article
Cardiac & Cardiovascular Systems
Loren Skudder-Hill, Fredrik Ahlsson, Maria Lundgren, Wayne S. Cutfield, Jose G. B. Derraik
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2019)
Article
Pediatrics
Inger Wahlstrom Johnsson, Fredrik Ahlsson, Jan Gustafsson
Article
Endocrinology & Metabolism
Solveig Serapio, Fredrik Ahlsson, Anders Larsson, Theodora Kunovac Kallak
HORMONE RESEARCH IN PAEDIATRICS
(2020)
Article
Multidisciplinary Sciences
Linda Lindstrom, Fredrik Ahlsson, Maria Lundgren, Eva Bergman, Erik Lampa, Anna-Karin Wikstrom
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Jose G. B. Derraik, Sarah E. Maessen, John D. Gibbins, Wayne S. Cutfield, Maria Lundgren, Fredrik Ahlsson
SCIENTIFIC REPORTS
(2020)
Article
Nutrition & Dietetics
Barbro Diderholm, Erik Normann, Fredrik Ahlsson, Richard Sindelar, Johan Agren
Summary: In extremely preterm infants, a more liberal compared to a restricted fluid allowance during the first week did not have a clinically significant impact on early changes in body weight, sodium homeostasis, or hospital morbidities.
Article
Medicine, General & Internal
Georg Bach Jensen, Fredrik Ahlsson, Magnus Domellof, Anders Elfvin, Lars Naver, Thomas Abrahamsson
Summary: The mortality rate of ELGA infants is high, requiring more attention and care.
Article
Pediatrics
Cornelia Spath, Elisabeth Stoltz Sjostrom, Johan Agren, Fredrik Ahlsson, Magnus Domellof
Summary: This study aimed to investigate the associations between sodium supply, fluid volume, sodium imbalances, and severe intraventricular haemorrhage (IVH) in extremely preterm infants. The study found that total sodium supply and fluid volume were higher in infants with severe IVH compared to controls, primarily due to sodium and fluid from transfused blood products. High plasma sodium concentrations or large sodium fluctuations were not associated with severe IVH.
Article
Pediatrics
Nima Naseh, Nuno Canto Moreira, Tania F. Vaz, Karla Gonzalez Tamez, Hugo Ferreira, Ylva Fredriksson Kaul, Martin Johansson, Barbro Diderholm, Fredrik Ahlsson, Johan agren, Lena Hellstroem-Westas
Summary: This study found that hyperglycemia in very preterm infants is associated with white matter injury and poorer neurodevelopment.
Article
Obstetrics & Gynecology
Jennifer Curtiss, Pamela Griffiths, Kevin G. Stephenson, Teresa D. Puthoff, Fredrik Ahlsson, Roopali Bapat, Britany Lendrum-Gatten, Kristen Lindamood, Leah Lumbaca, Margaret Mehling, Lauren H. Peck, Barbara S. Stonestreet, Kelly Susey, Molly Susi, Huayan Zhang, Susan Lynch
Summary: This study developed a scoring tool for evaluating clinical improvement in infants with severe bronchopulmonary dysplasia (sBPD) and found that the scores were significantly correlated with linear growth.
JOURNAL OF PERINATOLOGY
(2023)
Article
Nutrition & Dietetics
Jenny Ericson, Fredrik Ahlsson, Dirk Wackernagel, Emilija Wilson
Summary: There were no significant differences in neurological outcomes, growth, or health at six years of age between moderately preterm infants who received exclusive breast milk and those who received fortified breast milk and/or formula during neonatal hospitalization. Further research is needed to assess the potential effects on health and developmental outcomes in larger populations.
Article
Health Care Sciences & Services
K. C. Ashish, So Yeon Joyce Kong, Omkar Basnet, Solveig Haukas Haaland, Pratiksha Bhattarai, Oystein Gomo, Rejina Gurung, Fredrik Ahlsson, Oyvind Meinich-Bache, Anna Axelin, Honey Malla, Yuba Nidhi Basula, Om Krishna Pathak, Sunil Mani Pokharel, Hira Subedi, Helge Myklebust
Summary: This study assessed the usability, feasibility, and acceptability of a novel technology that provides real-time visual guidance and records audio and video during resuscitation, aiming to improve the quality of care.
BMJ HEALTH & CARE INFORMATICS
(2022)
Article
Multidisciplinary Sciences
Sarah E. Maessen, Fredrik Ahlsson, Maria Lundgren, Wayne S. Cutfield, Jose G. B. Derraik
SCIENTIFIC REPORTS
(2019)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)