Article
Virology
Puja Bagri, Ramtin Ghasemi, Joshua J. C. McGrath, Danya Thayaparan, Emma Yu, Andrew G. Brooks, Martin R. Staempfli, Charu Kaushic
Summary: This study reveals a new role for E2 in enhancing CD4(+) memory T cells postintranasal immunization with HSV-2. Under the influence of E2 treatment, there is an enhanced establishment of antiviral memory T cell responses in the upper respiratory tract and female reproductive tract, with greater T(h)17 memory cells preceding enhanced T(h)1 memory responses. The findings suggest potential strategies for generating optimal immunity during vaccination.
JOURNAL OF VIROLOGY
(2021)
Review
Immunology
Christine Johnston
Summary: This article discusses the management of genital herpes infection and provides recommendations based on a systematic literature review, serving as a basis for updating the treatment guidelines.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Dermatology
Mauro Cunha Ramos, Maria Rita Castilhos Nicola, Natalia Tenorio Cavalcante Bezerra, Jose Carlos Gomes Sardinha, Julia Sampaio de Souza Morais, Antonio Pedro Schettini
Summary: Genital ulcers can be caused by neoplastic and inflammatory processes, with sexually transmitted infections being a common reason for seeking medical help. It is important to pay attention to the characteristics of ulcers and changes in the regional lymph nodes when diagnosing. Molecular tests are considered reference exams, while rapid immunochromatographic tests represent a significant advance.
ANAIS BRASILEIROS DE DERMATOLOGIA
(2022)
Review
Medical Laboratory Technology
Sita Awasthi, Harvey M. Friedman
Summary: The rapid development of two nucleoside-modified mRNA vaccines has revolutionized the field of COVID-19 vaccines with their safety and high effectiveness. The mRNA technology offers advantages such as accelerated immunogen discovery, robust immune response induction, and rapid manufacturing scale-up. Developing a genital herpes vaccine has been a longstanding public health priority, and the advent of mRNA technology holds promise in changing the narrative. The development of nucleoside-modified mRNA-lipid nanoparticle vaccines for genital herpes shows great potential in inducing higher levels of neutralizing antibodies and more durable immune responses compared to protein-adjuvanted vaccines.
TRANSLATIONAL RESEARCH
(2022)
Review
Virology
Hemant Borase, Deepak Shukla
Summary: This review summarizes the pathogenesis of HSV-2 and its cellular interactions, explores new strategies and challenges in regulating HSV-2 replication and influencing the cell cycle through host cellular components, and presents a fresh perspective on the treatment of HSV-2 by targeting cellular proteins and pathways.
Article
Infectious Diseases
Samuel T. Eppink, Sagar Kumar, Kathryn Miele, Harrell W. Chesson
Summary: This study estimated the lifetime direct medical costs per incident case of genital herpes in the United States, providing valuable information for cost-effectiveness analysis of interventions and quantifying the cost burden of sexually transmitted infections in the country. Initial diagnosis and subsequent clinical visits and medications related to genital herpes accounted for a significant portion of the lifetime costs, highlighting the importance of addressing this issue.
SEXUALLY TRANSMITTED DISEASES
(2021)
Article
Medicine, Research & Experimental
Sita Awasthi, James J. Knox, Angela Desmond, Mohamad-Gabriel Alameh, Brian T. Gaudette, John M. Lubinski, Alexis Naughton, Lauren M. Hook, Kevin P. Egan, Ying K. Tam, Norbert Pardi, David Allman, Eline T. Luning Prak, Michael P. Cancro, Drew Weissman, Gary H. Cohen, Harvey M. Friedman
Summary: Nucleoside-modified mRNA vaccines show more durable protection in animal models compared to protein vaccines, with higher neutralizing antibody titers and robust B cell immune memory. The correlation between high neutralizing titers and B cell immune memory likely explains the more lasting protection provided by the mRNA vaccine.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Review
Virology
Ehsan Ghasemian, Emma Harding-Esch, David Mabey, Martin J. Holland
Summary: The global incidence of sexually transmitted infections (STIs) remains high, with co-infections of multiple pathogens being prevalent. Chlamydia trachomatis (CT) is the most reported bacterial STI worldwide, co-infecting with viral and other bacterial STIs. This review provides an overview of the epidemiology of these co-infections and specifically focuses on the underlying mechanisms by which CT influences the transmission and infection dynamics of HIV and HSV. It also explores the complex relationship between CT and HPV infection.
Article
Infectious Diseases
Mikele Macho-Aizpurua, Manuel Imaz-Perez, Jose Angel Alava-Menica, Leonora Hernandez-Ragpa, Maria-Josefina Lopez-de-Munain-Lopez, Mari-Mar Camara-Perez, Amaia Bilbao-Gonzalez, Jose-Luis Diaz-de-Tuesta-Del Arco, Josefa Munoz-Sanchez, Miren Basaras-Ibarzabal, Ramon Cisterna-Cancer
Summary: This study analyzed the epidemiological characteristics of patients with genital herpes infection and found that HSV-2 was the most common causative agent, but there was an increasing proportion of HSV-1 infections. The study also revealed that antecedent of STD and sexual risk behaviors were more frequent in patients with genital HSV-2 infection.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2021)
Article
Public, Environmental & Occupational Health
Mariana Martel, Eduardo Gotuzzo
Summary: HTLV-1 is a retrovirus that causes various diseases, significantly impacting the quality of life and mortality rate of its infected population. It is neglected despite its global distribution and endemicity in many countries. The virus spreads through vertical, sexual, and parenteral transmission, and prevention measures are crucial due to the lack of effective treatments. This article presents evidence on the magnitude, risk factors, and prevention of sexual transmission, aiming to raise awareness among healthcare workers for eradicating the infection.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Pathology
Melissa Krystel-Whittemore, May P. Chan, Sara C. Shalin, Kenan J. Sauder, Amy Hudson, Ruth K. Foreman, Mai P. Hoang, Jeoffry B. Brennick, Shaofeng Yan, Rosalynn M. Nazarian
Summary: This study presents the first known report of herpes virus infecting deep stromal cells of the dermis, highlighting the importance of considering cutaneous stromal herpes in patients with atypical clinical lesions, especially when immunocompromised. Establishing the correct diagnosis is crucial for initiating therapy.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Medicine, General & Internal
Magda Orzechowska, Mateusz Cybulski, Elzbieta Krajewska-Kulak, Marek Sobolewski, Agnieszka Gniadek, Wiaczeslaw Niczyporuk
Summary: This study conducted a comparative analysis of sexually transmitted viral infections in Poland from 2010 to 2015, taking into account the country's administrative division. It found a declining trend in the incidence of genital herpes, with genital warts being the most frequent infection. The incidence of newly detected HIV infections appeared to be stable. The study also observed a correlation between the incidence rates and urbanization.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Health Care Sciences & Services
Angela Devine, Xiuqin Xiong, Sami Lynne Gottlieb, Maeve Britto de Mello, Christopher K. Fairley, Jason J. Ong
Summary: This study aimed to assess the impact of genital herpes on quality of life and found that the existing literature is limited and needs updating. Future research should be conducted in diverse settings and use condition-specific or generic tools to inform economic modeling.
HEALTH AND QUALITY OF LIFE OUTCOMES
(2022)
Article
Dermatology
Deepthi Konda, Laxmisha Chandrashekar, Rahul Dhodapkar, Rajesh Nachiappa Ganesh, Devinder Mohan Thappa
Summary: This study characterized the clinical markers of herpes simplex virus (HSV) infection among patients with pemphigus vulgaris. It was found that male sex, presence of fissures, hemorrhagic crusts, erosions with angulated margins, linear erosions, and raised erythrocyte sedimentation rate were significantly associated with HSV infection. Hemorrhagic crusts and linear erosions were identified as independent predictors of HSV infection.
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY
(2023)
Article
Virology
Tajanna Stinn, Steve Kuntz, Dana Varon, Meei-Li Huang, Stacy Selke, Samuel Njikan, Emily S. Ford, Joan Dragavon, Robert W. Coombs, Christine Johnston, Marta E. Bull
Summary: This study suggests that subclinical HSV shedding in HIV/HSV-coinfected women during ART may sustain HIV tissue reservoirs through antigen exposure or HIV replication. Frequent subclinical HSV DNA shedding was associated with increased HIV DNA tissue concentrations and increased divergence from ancestral sequences, indicating a potential role of immune responses to common coinfections in sustaining HIV tissue reservoirs during suppressive ART.
JOURNAL OF VIROLOGY
(2021)
Article
Infectious Diseases
Gustavo Henrique O. Cavalcante, Joselio M. G. de Araujo, Jose Verissimo Fernandes, Daniel C. F. Lanza
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
(2018)
Article
Parasitology
Allan R. D. Nunes, Brenda Elen B. Alves, Hannaly W. B. Pereira, Yasmin M. Nascimento, Ingryd C. Morais, Jose Verissimo Fernandes, Joselio M. G. Araujo, Daniel C. F. Lanza
MEMORIAS DO INSTITUTO OSWALDO CRUZ
(2018)
Article
Multidisciplinary Sciences
Arlinete S. Medeiros, Diego M. P. Costa, Mario S. D. Branco, Daise M. C. Sousa, Joelma D. Monteiro, Silvio P. M. Galvao, Paulo Roberto M. Azevedo, Jose A. V. Fernandes, Selma M. B. Jeronimo, Joselio M. G. Araujo
Review
Oncology
Jayra Juliana Paiva Alves, Thales Allyrio Araujo De Medeiros Fernandes, Joselio Maria Galvao De Araujo, Ricardo Ney Oliveira Cobucci, Daniel Carlos Ferreira Lanza, Fabiana Lima Bezerra, Vania Sousa Andrade, Jose Verissimo Fernandes
Article
Immunology
Marcelo Henrique Matias da Silva, Raiza Nara Cunha Moises, Brenda Elen Bizerra Alves, Hannaly Wana Bezerra Pereira, Anne Aline Pereira de Paiva, Ingryd Camara Morais, Yasmim Mesquita Nascimento, Joelma Dantas Monteiro, Janeusa Trindade de Souto, Manuela Sales Lima Nascimento, Joselio Maria Galvao de Araujo, Paulo Marcos Matta da Guedes, Jose Verissimo Fernandes
MEDICAL MICROBIOLOGY AND IMMUNOLOGY
(2019)
Article
Multidisciplinary Sciences
Mariana Kikuti, Jaqueline S. Cruz, Moreno S. Rodrigues, Aline S. Tavares, Igor A. D. Paploski, Monaise M. O. Silva, Perla M. Santana, Laura B. Tauro, Greice A. O. F. Silva, Gubio S. Campos, Josello M. G. Araujo, Uriel Kitron, Mitermayer G. Reis, Guilherme S. Ribeiro
Article
Integrative & Complementary Medicine
Emanuelly Bernardes-Oliveira, Kleber Juvenal Silva Farias, Dayanne Lopes Gomes, Joselio Maria Galvao de Araujo, Wilmar Dias da Silva, Hugo Alexandre Oliveira Rocha, Eduardo Antonio Donadi, Matheus de Freitas Fernandes-Pedrosa, Janaina Cristiana de Oliveira Crispim
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2019)
Article
Parasitology
Izabel Cristina dos Reis, Gerusa Gibson, Tania Ayllon, Alessandre de Medeiros Tavares, Joselio Maria Galvao de Araujo, Elias da Silva Monteiro, Amanda Rodrigues Aguiar, Josinaldo Vital de Oliveira, Anne Aline Pereira de Paiva, Hannaly Wana Bezerra Pereira, Joelma Dantas Monteiro, Marilia Sa Carvalho, Paulo Chagastelles Sabroza, Nildimar Alves Honorio, Alexandre San Pedro Siqueira, Aline de Araujo Nobre, Andrea Sobral de Almeida, Bianca Borges da Silva, Daniel Cardoso Portela Camara, Diego Ricardo Xavier Silva, Elaine Barroso, Heitor Levy Ferreira Praca, Hermano Gomes Albuquerque, Jefferson Pereira Caldas dos Santos, Leandro Henrique Vouga Pereira, Mariane Branco Alves, Manoel Caetano Mayrink, Paulo Roberto de Abreu Bruno, Rafael Santos Erbisti, Taynana Cesar Simoes, Vanderlei Pascoal de Matos, Veerle Vanlerberghe
Article
Immunology
Valeria Duarte de Almeida, Eduardo B. L. da Camara, Marcelo Augusto A. Castro, Suyane Maria P. Pimenta, Bruna Luiza T. Hernandes, Dayane Carla C. Paiva, Cleber M. Andrade, Ellany G. C. do Nascimento, Thales Allyrio A. M. Fernandes, Micassio F. Andrade
Summary: Chronic Chagas disease (CD) patients with cardiac clinical form release less NETs compared to non-infected individuals, potentially increasing the risk of death in CD patients with cardiac events. The release of DNA and elastase by neutrophils from CD patients was measured to investigate their role in the disease.
PARASITE IMMUNOLOGY
(2021)
Article
Infectious Diseases
Rebeca Costa Castelo Branco, Patricia Brasil, Joselio Maria Galvao Araujo, Flavia Oliveira Cardoso, Zulmira Silva Batista, Valeria Maria Souza Leitao, Marcos Antonio Custodio Neto da Silva, Lailson Oliveira de Castro, Joanna Gardel Valverde, Selma Maria Bezerra Jeronimo, Joselia Alencar Lima, Raimunda Ribeiro da Silva, Maria do Carmo Lacerda Barbosa, Luciane Maria Oliveira Brito, Marcelo Antonio Pascoal Xavier, Maria Do Desterro Soares Brandao Nascimento
Summary: This study investigated the prevalence of Zika infection in asymptomatic pregnant women attending two public maternities in MaranhAo state, Northeast Brazil. The findings show that ZIKV infection was common in umbilical cord and placental samples, but did not result in morphological or psychomotor abnormalities in newborns at birth. These results highlight the importance of awareness of the risk of ZIKV infection during pregnancy and the need for improved healthcare and strategic planning for obstetric and neonatal care.
PLOS NEGLECTED TROPICAL DISEASES
(2021)
Review
Medicine, Research & Experimental
Martha Laysla Ramos Da Silva, Beatriz Helena Dantas Rodrigues De Albuquerque, Thales Allyrio Araujo De Medeiros Fernandes, Valeria Duarte De Almeida, Ricardo Ney De Oliveira Cobucci, Fabiana Lima Bezerra, Vania Sousa Andrade, Daniel Carlos Ferreira Lanza, Jenner Christian Verissimo De Azevedo, Joselio Maria Galvao De Araujo, Jose Verissimo Fernandes
Summary: Cervical cancer, caused by high-risk HPV infection, remains the second most common cancer type in women in developing regions. Epigenetic modifications are stable changes in DNA that affect gene expression and genomic stability, playing a key role in various biological processes. These modifications have been identified in both viral DNA and infected cell genomes, contributing to the development of cervical cancer.
BIOMEDICAL REPORTS
(2021)
Review
Pediatrics
Jenner Chrystian Verissimo de Azevedo, Thales Allyrio Araujo de Medeiros Fernandes, Gilson Aquino Cavalcante, Iluska Almeida Carneiro Martins de Medeiros, Daniel Carlos Ferreira Lanza, Joselio Maria Galvao de Araujo, Fabiana Lima Bezerra, Jose Verissimo Fernandes
Summary: Type 1 diabetes mellitus is caused by an autoimmune response that leads to inadequate insulin production due to the progressive loss of pancreatic islet beta-cells. Genetic, epigenetic, and environmental factors contribute to the deregulation of the immune system responsible for this condition. In addition to immune cell infiltration and inflammation of the islets, other factors, such as HLA and other immune-related genes, polymorphisms, epigenetic modifications, and the microbiome, play important roles in the etiology and pathogenesis of this metabolic disorder. Dysregulation of regulatory T cells, influenced by gene expression and epigenetic modifications, is crucial in the development of the disease.
CURRENT PEDIATRIC REVIEWS
(2023)
Review
Oncology
Alan Lopes de Oliveira, Valeria Duarte de Almeida, Taue Posada Pereira, Amanda Estevam Carvalho, Victor Sena Nogueira Wojcieszyn, Micassio F. Andrade, Ellany G. C. do Nascimento, Wogelsanger Oliveira Pereira, Jose Verissimo Fernandes, Thales Allyrio A. M. Fernandes
Summary: This study investigated the biological significance of changes in long non-coding RNA (lncRNA) expression induced by HPV oncoproteins in the development of cervical cancer. The results showed that alterations in lncRNA expression were associated with higher staging and worse prognosis in cervical cancer. These changes can affect target gene regulation by competing for miRNAs, and play roles in various biological processes such as chromatin modification, transcription, translation, splicing, and epigenetic regulation.
EURASIAN JOURNAL OF MEDICINE AND ONCOLOGY
(2022)
Article
Infectious Diseases
Jose Garcia de Brito-Neto, Micassio Fernandes de Andrade, Valeria Duarte de Almeida, Dayane Carla Costa Paiva, Nickson Melo de Morais, Christiane Medeiros Bezerra, Jose Verissimo Fernandes, Ellany Gurgel Cosme do Nascimento, Ivana Alice Teixeira Fonseca, Thales Allyrio Araujo de Medeiros Fernandes
INFECTIOUS DISEASE REPORTS
(2019)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
