Journal
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Volume 156, Issue 2, Pages 149-152Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejogrb.2011.01.021
Keywords
Autopsy; Fetal malformations; Fetopathological investigation; Post mortem examination; Positive predictive value of sonography; Ultrasonography
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Objective: To analyse the positive predictive value of ultrasonography based on the results of postmortem investigations in respect of the most common malformations. Study design: We processed the details of 683 cases affecting the nervous, cardiovascular, urinary and skeletal systems, and the abdominal/thoracic walls. Results: In four of the investigated groups of malformations, the proportion of sonographic diagnoses completely coinciding with the post mortem results was found to be approximately 70%, but it was found to be much lower (32%) in urinary malformations. The cumulative proportion of coinciding sonographic and post mortem diagnoses was 63%, while completely incorrect ultrasonographic diagnoses amounted to 17%. Conclusions: Sonography is an essential method for the diagnosis of the majority of fetal malformations, but post-mortem examinations yield an indispensable quality control as well as additional information to ultrasound examinations. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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