Review
Immunology
Jason Cheung, Beata Zahorowska, Michael Suranyi, Jeffrey K. W. Wong, Jason Diep, Stephen T. T. Spicer, Nirupama D. D. Verma, Suzanne J. Hodgkinson, Bruce M. M. Hall
Summary: The immune response to an allograft can activate lymphocytes that cause rejection. The activation of T regulatory cells can reduce allograft rejection and induce immune tolerance. Activated T regulatory cells can be distinguished by various markers. A more detailed characterization of these cells may help reduce non-specific immunosuppression.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Agnese Fiori, Stefanie Uhlig, Harald Kluter, Karen Bieback
Summary: Mesenchymal stromal cells (MSC) have immunomodulatory effects on various immune cells. In this study, human adipose tissue-derived MSC (ASC) were found to inhibit CD4 + T cell proliferation, induce Treg cells, and modulate cytokine secretion, suggesting a potential role in immune regulation. These findings highlight the complex interplay between ASC and CD4 + T cells.
Article
Immunology
Sanja Loeb, Niklas Amann, Christina Kuhn, Elisa Schmoeckel, Achim Woeckel, Alaleh Zati Zehni, Till Kaltofen, Simon Keckstein, Jan-Niclas Mumm, Sarah Meister, Thomas Kolben, Sven Mahner, Udo Jeschke, Theresa Vilsmaier
Summary: The study found a significant upregulation of IL-1 beta in the decidua of recurrent miscarriage specimens, as well as in the decidua of spontaneous abortion cases, suggesting its potential role in early pregnancy loss. Double-immunofluorescence revealed that decidual stroma cells are the major IL-1 beta expressing cells at the fetomaternal interface.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Immunology
Jingnan Liao, Yuan Li, Xiaofeng Li, Xian Su, Jing Peng, Na Xiao, Xiangxiu Fan, Huijun Chen, Guangxiu Lu, Ge Lin, Lamei Cheng, Fei Gong
Summary: The study found that pre-pregnancy blood Treg levels were significantly lower in URPL patients than in controls, and that Treg levels predicted subsequent miscarriages. There were no significant differences among other blood cell types between the two groups.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Xiao-Hui Wang, Sha Xu, Xiang-Yu Zhou, Rui Zhao, Yan Lin, Jing Cao, Wei-Dong Zang, Hui Tao, Wei Xu, Ming-Qing Li, Shi-Min Zhao, Li-Ping Jin, Jian-Yuan Zhao
Summary: Abnormal metabolite levels in the villous tissues inhibit extravillous trophoblast function, leading to an increased risk of recurrent spontaneous abortion (RSA). Modulating succinate levels may serve as a potential intervention strategy for RSA.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Bruce M. Hall, Rachael M. Hall, Giang T. Tran, Catherine M. Robinson, Paul L. Wilcox, Prateek K. Rakesh, Chuanmin Wang, Alexandra F. Sharland, Nirupama D. Verma, Suzanne J. Hodgkinson
Summary: The CD4(+)CD25(+)Foxp3(+)T cell population is heterogeneous, consisting of three major subgroups with different functions and characteristics. Treatment with rIL-5 can prevent rejection of transplants by activating Ts2 cells and Th2-like Treg. This therapeutic approach significantly improves survival rates and reduces rejection reactions.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiuhua Yang, Yingying Tian, Linlin Zheng, Thanh Luu, Joanne Kwak-Kim
Summary: Recurrent pregnancy losses (RPL) is a common reproductive disorder with various underlying etiologies. Recent research has shown that the immune response, particularly the imbalance of cytokines in the maternal-fetal interface, plays a crucial role in RPL. The increased NK1/NK2 ratio in decidual NK (dNK) cells of RPL patients contributes to a pro-inflammatory cytokine milieu and increased NK cell cytotoxicity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Li Ye Zhu, Mian Ping Chen
Summary: The study revealed that the polymorphisms of interleukin-18 gene at rs1946519 and rs360717 loci are closely related to the risk of recurrent spontaneous abortion, and these genotypes have a certain impact on serum hormone levels, increasing the risk of recurrent spontaneous abortion in pregnant women.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Immunology
Sanja Loeb, Beate Ochmann, Zhi Ma, Theresa Vilsmaier, Christina Kuhn, Elisa Schmoeckel, Saskia-Laureen Herbert, Thomas Kolben, Achim Woeckel, Sven Mahner, Udo Jeschke
Summary: The research indicates that IL-18 expression may be necessary in early gestation but requires tight regulation for a successful pregnancy. The significant upregulation of IL-18 in the decidua only in patients with recurrent miscarriage suggests it may be a potential diagnostic marker. Further studies are needed to evaluate the exact pathophysiological mechanisms.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Nirupama D. Verma, Andrew D. Lam, Christopher Chiu, Giang T. Tran, Bruce M. Hall, Suzanne J. Hodgkinson
Summary: The study found significant shifts in CD4(+) T cell subpopulations in multiple sclerosis (MS) patients, with reduced resting Treg, increased activated Treg, and increased effector CD4(+) cells. Additionally, some MS patients showed reduced CCR6(+)Th17-like Treg, which may contribute to the activity of MS.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Bowen Liu, Jun Liu, Yang Qiu, Jiao Chen, Jing Yang
Summary: This study revealed that MITA is highly expressed in decidual macrophages of recurrent miscarriage patients and can promote apoptosis and proinflammatory polarization of THP-1-derived macrophages. Additionally, a circRNA (circKIAA0391) overexpressed in decidual macrophages of patients with recurrent miscarriage was identified, which functions through the miR-512-5p/MITA axis to promote apoptosis and proinflammatory polarization of TDM cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Shafat Ali, Sabhiya Majid, Md. Niamat Ali, Mujeeb Zafar Banday, Shahnaz Taing, Saima Wani, Mansour Almuqbil, Sultan Alshehri, Kashif Shamim, Muneeb U. Rehman
Summary: IL17A gene polymorphism may play a potential role in recurrent miscarriage, but it does not significantly affect IL17A gene expression. Different genotypes may have different effects on pregnancy risk.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Dongeon Kim, Mingyo Kim, Tae Woo Kim, Yong-ho Choe, Hae Sook Noh, Hyun Min Jeon, HyunSeok Kim, Youngeun Lee, Gayeong Hur, Kyung-Mi Lee, Kihyuk Shin, Sang-il Lee, Seung-Hyo Lee
Summary: LN-TRCs trans-present IL-2 to naive CD4(+) T cells through CD25, regulating CD4(+) T cell differentiation and immune responses. Reduced CD25 expression on LN-TRCs exacerbates autoimmune phenotypes by enhancing Th17 cell differentiation.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Review
Obstetrics & Gynecology
Kilian Vomstein, Anna Aulitzky, Laura Strobel, Michael Bohlmann, Katharina Feil, Sabine Rudnik-Schoeneborn, Johannes Zschocke, Bettina Toth
Summary: The risk factors for spontaneous miscarriage include various factors such as endocrine, infection, genetic, etc., making diagnosis and treatment more complicated. While there may be differing opinions among international specialist societies, most agree that anatomical malformations, antiphospholipid syndrome, and thyroid dysfunction should be excluded.
GEBURTSHILFE UND FRAUENHEILKUNDE
(2021)
Article
Biochemistry & Molecular Biology
Yun-Yun Li, Yi-Kong Lin, Yue Li, Xin-Hua Liu, Da-Jin Li, Xiao-Lin Wang, Li Wang, Yi-Zhun Zhu, Min Yu, Mei-rong Du
Summary: This study found that Tregs were increased in the peritoneal fluid of EMS patients, accompanied by overactivation of estrogen-ER alpha. SCM-198 could reverse the expansion of Tregs induced by estrogen-ER alpha and reduce their invasion and viability effects on eESCs. In vivo experiments confirmed that SCM-198 significantly retarded the growth of ectopic lesions.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Obstetrics & Gynecology
Tal Margaliot Kalifa, Hen Y. Sela, Jordanna Joseph, Sorina Grisaru-Granovsky, Fayez Khatib, Misgav Rottenstreich
Summary: Pregnancies following a second trimester uterine evacuation do not have an increased risk of preterm delivery or other adverse perinatal outcomes compared to pregnancies following a first trimester uterine evacuation.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Dominique A. Badr, Mieke M. Cannie, Caroline Kadji, Xin Kang, Andrew Carlin, Jacques C. Jani
Summary: The objective of this study was to assess the influence of the test-to-delivery interval on the performance of ultrasound and MRI in predicting birthweight. The results showed that MRI performed best in predicting birthweight greater than gestational age if delivery occurred within two weeks of the examination, with a slight decrease thereafter, while ultrasound performance decreased drastically over time.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Corina N. Schoen, Sami Backley, Lauren Orr, Amrita Roy, Tiffany Corlin, Alexander B. Knee
Summary: This retrospective cohort study aimed to evaluate whether induction of labor is associated with a lower risk of cesarean section in patients with isolated polyhydramnios. The study found that planned induction was associated with a lower rate of cesarean delivery compared to expectant management, but the difference was not statistically significant. Additionally, no differences were observed in maternal or fetal secondary outcomes.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Article
Obstetrics & Gynecology
Ohad Houri, Asaf Romano, Yossi Geron, Gil Zeevi, Eran Hadar, Shiri Barbash-Hazan, Shir Danieli-Gruber
Summary: Women with prior uterine rupture have good maternal and neonatal outcomes in subsequent pregnancies when managed at a tertiary medical center, with planned elective term cesarean delivery, or even earlier, at the onset of spontaneous preterm labor.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Correction
Obstetrics & Gynecology
Laura E. Janssen, Marjon A. de Boer, Eline C. E. von Konigslow, Elisa Dal, Martijn A. Oudijk, Danielle Robbers-Visser, Christianne J. M. de Groot
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)
Review
Obstetrics & Gynecology
Natalia Rzewuska, Jacek Kunicki, Katarzyna Pieniak, Paulina Laskus, Bernadeta Zabielska, Roman Smolarczyk, Michal Kunicki
Summary: This systematic review examined the comorbidity of idiopathic intracranial hypertension (IIH) and polycystic ovarian syndrome (PCOS) and their impact on metabolism, hormone levels, and reproduction. The findings showed a high prevalence of comorbidity between the two conditions, which may have significant clinical implications for patient management.
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
(2024)