Journal
EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY
Volume 144, Issue -, Pages S170-S178Publisher
ELSEVIER
DOI: 10.1016/j.ejogrb.2009.02.041
Keywords
Estrogen; Progesterone; Uterine vascular resistance; Circumferential elastic modulus
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Funding
- NHLBI NIH HHS [HL086939, HL49210, R01 HL086939, R01 HL086939-02, R01 HL087144, R01 HL049210, HL087144] Funding Source: Medline
- NICHD NIH HHS [P01 HD038843, HD38843] Funding Source: Medline
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Objectives: Uterine vascular resistance (UVR) is the ratio of systemic mean arterial pressure to mean uterine blood flow and is sensitive to changes in small arteries and arterioles. However, it provides little or no insight into changes in large, conduit arteries. Fluctuations in estrogen (E2) and progesterone (P4) levels during the ovarian cycle are thought to cause uterine resistance artery vasodilation; the effects on large arteries are unknown. Herein, our objective was to use the uterine vascular impedance, which is sensitive to changes in small and large arteries, to determine the effects of the ovarian cycle and pregnancy on the entire uterine vasculature. Study design: Uterine vascular perfusion pressure and flow rate were recorded simultaneously in anesthetized sheep in the nonpregnant (NP) luteal (NP-L, n = 6) and follicular (NP-F, n = 7) phases and in late pregnancy (CP, n = 10). Impedance and metrics of impedance (input impedance Z(0), index of wave reflection R-W, characteristic impedance Z(C)) were calculated. E2 and P4 levels were measured from jugular vein blood samples. Finally, from pressure-diameter tests post-mortem, large uterine artery circumferential elastic modulus (E-Circ) was measured. Significant differences were evaluated by two-way ANOVA or Student's t-test. Results: As expected, E2:P4 was higher in the NP-F group compared to the NP-L group (p < 0.05). Also as expected, UVR and Z(0) decreased in the follicular phase compared to the luteal (p < 0.05), but R-W, Z(C), and E-Circ were unaltered. Pregnancy not only substantially decreased UVR (and Z(0)) (p < 0.00001) but also decreased Z(C) (p < 0.001), Rw (p < 0.0001), E-Circ (p < 0.01), and pulse wave velocity (p < 0.0001). Conclusions: The E2:P4 ratio mediates resistance artery vasodilatation in nonpregnant states, but has no effect on conduit artery size or stiffness. In contrast, pregnancy causes dramatic vasodilation and remodeling, including Substantial reductions in conduit artery stiffness and increases in conduit artery size, which affect pulsatile uterine hemodynamics. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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