Journal
EUROPEAN JOURNAL OF NUTRITION
Volume 58, Issue 6, Pages 2535-2543Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00394-018-1806-y
Keywords
Vitamin D; Chronic heart failure; Mortality
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Funding
- British Heart Foundation [PG/08/020/24617]
- Leeds Charitable Foundation Fellowship
- Wellcome Trust Sir Henry Wellcome Fellowship
- MRC [MR/J00281X/1] Funding Source: UKRI
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Purpose Low 25-hydroxyvitamin D (25[OH]D) concentrations have been associated with adverse outcomes in selected populations with established chronic heart failure (CHF). However, it remains unclear whether 25[OH]D deficiency is associated with mortality and hospitalisation in unselected patients receiving contemporary medical and device therapy for CHF. Methods We prospectively examined the prevalence and correlates of 25[OH]D deficiency in 1802 ambulatory patients with CHF due to left ventricular systolic dysfunction (left ventricular ejection fraction <= 45%) attending heart failure clinics in the north of England. Results 73% of patients were deficient in 25[OH]D (< 50 nmol/L). 25[OH]D deficiency was associated with male sex, diabetes, lower serum sodium, higher heart rate, and greater diuretic requirement. During a mean follow-up period of 4 years, each 2.72-fold increment in 25[OH]D concentration (for example from 32 to 87 nmol/L) is associated with 14% lower all-cause mortality (95% confidence interval (CI) 1, 26%; p = 0.04), after accounting for potential confounding factors. Conclusions Low 25-hydroxyvitamin D deficiency is associated with increased mortality in patients with chronic heart failure due to left ventricular systolic dysfunction. Whether vitamin D supplementation will improve outcomes is, as yet, unproven.
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