Article
Biochemistry & Molecular Biology
Kayleigh Griffiths, Tomoaki Ida, Masanobu Morita, Reece J. Lamb, Jordan J. Lee, Michael P. Frenneaux, Jon M. Fukuto, Takaaki Akaike, Martin Feelisch, Melanie Madhani
Summary: Earlier studies have shown that CysSSH, a sulfur-containing compound, has antioxidant and oxidant properties and can mitigate oxidative stress. However, its role in myocardial IRI was not understood. This study investigated the production and consumption of CysSSH in the heart under normoxic and hypoxic conditions and found that exogenous administration of Cys-SSS-Cys can rescue the heart from injury and improve cardiac function.
Article
Medicine, Research & Experimental
Abolfazl Badripour, Mohamad Behzadi, Amin Hassanipour, Pasha Reza Shams Azar, Alireza Rahbar, Zhaleh Abbaslou, Elnaz Ehghaghi, Ashkan Piranviseh, Mohammad Mahdi Khavandi, Seyed Mohsen Ahmadi-Tafti, Mohammad Ashouri, Zahra Ebrahim Soltani, Ahmadreza Dehpour
Summary: This study aimed to evaluate the effects of Albendazole pretreatment on mesenteric ischemia reperfusion (MIR) injury. The findings demonstrated that Albendazole could ameliorate the inflammatory response and enhance the ischemia threshold following MIR injury.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Lei-Lei Ma, Zhi-Wen Ding, Pei-Pei Yin, Jian Wu, Kai Hu, Ai-Jun Sun, Yun-Zeng Zou, Jun-Bo Ge
Summary: The study shows that preconditioning with hypertrophic stress protects the heart from I/R injury by improving mitochondrial metabolism, reducing oxidative/nitrative stress and inhibiting apoptosis. ALDH2 is obligatorily required for the development of cardiac hypertrophic preconditioning and acts as the mediator of this process.
Article
Multidisciplinary Sciences
Iheanyichukwu Wopara, Olusegun G. Adebayo, Elizabeth B. Umoren, Wadioni Aduema, Adaku Iwueke, O. E. Etim, Egelege Aziemeola Pius, Woha Boobondah James, Joel Wodo
Summary: The study found that exposure to tartrazine and erythrosine led to decreased neurobehavioral function, increased oxido-nitrosative stress and pro-inflammatory responses, decreased antioxidants, and increased acetylcholinesterase activity in rats.
Article
Immunology
Miyuki Takashima, Christian Lalonde, Laura Ashley Olszanski, Feng-Qi Zhao
Summary: The study identified strong inflammatory responses and oxidative stress in mammary glands following endotoxin challenge, along with decreased metabolic processes. Various cytokines showed increased levels post-LPS treatment, providing potential markers for prevention and treatment of gram-negative bacteria-induced mastitis.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Rachid Akki, Rosalba Siracusa, Marika Cordaro, Alessia Remigante, Rossana Morabito, Mohammed Errami, Angela Marino
Summary: Studies have shown that cells and tissues may enhance their resistance to more severe ischaemic injuries by undergoing ischemic preconditioning under low oxidative stress conditions. This review summarizes the latest knowledge on adaptive mechanisms, signaling transduction pathways, antioxidant systems, and in vivo adaptation strategies in response to ischemia/reperfusion and brain trauma events.
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Sunshan Lu, Xingtong Chen, Qian Chen, Zhen Cahilog, Lili Hu, Yan Chen, Jian Cao, Jiaolin Ning, Bin Yi, Kaizhi Lu, Jianteng Gu
Summary: Intraoperative administration of dexmedetomidine in elderly patients undergoing iatrogenic lower limb ischemia-reperfusion injury can mitigate respiratory function deterioration and suppress oxidative stress response.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Cell Biology
Wenyan Liu, Yang Fan, Hongfan Ding, Dan Han, Yang Yan, Rongqian Wu, Yi Lv, Xinglong Zheng
Summary: NMP attenuates IRI of DCD liver by inhibiting CIRP-mediated oxidative stress and mitochondrial fission.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cell Biology
Ruikang Feng, Yufeng Xiong, Yourong Lei, Qin Huang, Hao Liu, Xiaojie Zhao, Zhiyuan Chen, Hui Chen, Xiuheng Liu, Lei Wang, Xiaodong Weng
Summary: AKI is mainly caused by renal IRI, and LSD1 has been shown to be positively related to renal IRI. Inhibition of LSD1 can alleviate tissue damage, ferroptosis, and oxidative stress caused by IRI through the TLR4/NOX4 pathway. LSD1 may be a potential therapeutic target for renal IRI.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Katarzyna Dziabowska-Grabias, Malgorzata Sztanke, Przemyslaw Zajac, Michal Celejewski, Katarzyna Kurek, Stanislaw Szkutnicki, Patryk Korga, Wlodzimierz Bulikowski, Krzysztof Sztanke
Summary: Inflammatory bowel diseases (IBD) are chronic, incurable diseases of the digestive tract with unclear etiology, resulting in significant impact on patients' quality of life. The incidence and prevalence of IBD are continuously increasing worldwide, becoming a significant public health burden. Current pharmaceutical management options often have side effects and may not provide sufficient disease control, leading to research on antioxidant and anti-inflammatory substances as potential treatment options.
Article
Andrology
Recep B. Degirmentepe, Fatih Altunrende, Muammer Bozkurt, Erkan Merder, Alper Otunctemur, Kivilcim Sonmez, Funda Yildirim, Saniye Ada, Ferruh K. Isman, Mustafa B. Cekmen
Summary: In this study, the effect of liraglutide on experimental testicular ischaemia reperfusion in rats was evaluated in terms of biochemistry, histopathology, and immunohistochemistry. The results showed that liraglutide treatment has a moderate preventive effect against I/R injury in testicular torsion by demonstrating anti-inflammatory, antioxidant, and antiapoptotic properties.
Article
Cardiac & Cardiovascular Systems
Muding Li, Yingyun Hu, Hao Zhou, Yundai Chen
Summary: Mitochondrial fusion is inhibited in myocardial IR, and the upstream mechanism is unclear. NR4A1 aggravates myocardial IR and increases oxidative stress, affecting mitochondrial function and morphology. Inhibiting NR4A1 improves oxidative stress levels and mitochondrial function, reducing IR.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Jose Antonio Garcia-Partida, Sonia Torres-Sanchez, Karina MacDowell, Maria Teresa Fernandez-Ponce, Lourdes Casas, Casimiro Mantell, Maria Luisa Soto-Montenegro, Diego Romero-Miguel, Nicolas Lamanna-Rama, Juan Carlos Leza, Manuel Desco, Esther Berrocoso
Summary: Mango leaf extract may serve as an alternative therapeutic or preventive add-on strategy for schizophrenia, improving clinical expression and modifying the course of the disease at earlier stages.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Andrology
Oladele Afolabi, Babatunde Alabi, Temidayo Omobowale, Olufemi Oluranti, Olugbenga Iwalewa
Summary: The study found that cysteamine plays an antioxidant, anti-inflammatory, and anti-apoptotic role in testicular torsion/detorsion reperfusion injury. Cysteamine reversed the oxidative stress, inflammation markers, and reduced sperm motility seen in IRI rats. Additionally, cysteamine inhibited apoptosis in the testicular tissue, providing protection against reperfusion injury.
Article
Cell Biology
Mel S. Lee, Hon-Kan Yip, Chih-Chao Yang, John Y. Chiang, Tien-Hung Huang, Yi-Chen Li, Kuan-Hung Chen, Pei-Hsun Sung
Summary: This study showed that therapy with double overexpression of miR-19a-3p and miR-20a-5p to human inducible pluripotent stem cell-derived mesenchymal stem cells was more effective than using mesenchymal stem cells alone for preserving renal function in rats with pre-existing chronic kidney disease and subsequent ischaemia-reperfusion injury. The in vitro study demonstrated that the double overexpression of miR-19a-3p reversed the increased oxidative stress, inflammatory signaling, and cell apoptosis/death signaling induced by p-Cresol in NRK-52E cells. Additionally, animal experiments indicated that the double overexpression of miR-19a-3p and miR-20a-5p was superior to mesenchymal stem cells alone in preserving residual kidney function and architecture in chronic kidney disease with ischaemia-reperfusion injury rat models.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Gabor Bari, Daniel Erces, Gabriella Varga, Szilard Szucs, Zoltan Varga, Gabor Bogats, Mihaly Boros
EUROPEAN JOURNAL OF CARDIO-THORACIC SURGERY
(2019)
Article
Critical Care Medicine
Szilard Szucs, Gabor Bari, Melinda Ugocsai, Reza Ali Lashkarivand, Norbert Lajko, Arpad Mohacsi, Anna Szabo, Jozsef Kaszaki, Mihaly Boros, Daniel Erces, Gabriella Varga
CRITICAL CARE MEDICINE
(2019)
Article
Cell Biology
Eszter Tuboly, Renata Gaspar, Miguel Olias Ibor, Kamilla Gomori, Bernadett Kiss, Gerda Strifler, Petra Hartmann, Peter Ferdinandy, Monika Bartekova, Mihaly Boros, Aniko Gorbe
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2019)
Article
Critical Care Medicine
Attila Rutai, Roland Fejes, Laszlo Juhasz, Szabolcs Peter Tallosy, Marietta Zita Poles, Imre Foldesi, Andras T. Meszaros, Andrea Szabo, Mihaly Boros, Jozsef Kaszaki
Article
Medicine, Research & Experimental
Dimitri Barski, Holger Gerullis, Thorsten Ecke, Mihaly Boros, Jan Brune, Ulrich Beutner, Igor Tsaur, Albert Ramon, Thomas Otto
ADVANCES IN THERAPY
(2020)
Article
Surgery
Sandor Varga, Laszlo Juhasz, Peter Gal, Gabor Bogats, Mihaly Boros, Zsolt Palasthy, Andrea Szabo, Jozsef Kaszaki
JOURNAL OF SURGICAL RESEARCH
(2019)
Article
Multidisciplinary Sciences
Anna Naszai, Emil Terhes, Jozsef Kaszaki, Mihaly Boros, Laszlo Juhasz
SCIENTIFIC REPORTS
(2019)
Article
Multidisciplinary Sciences
Petra Varga, Noemi Vida, Petra Hartmann, Anna Szabo, Arpad Mohacsi, Gabor Szabo, Mihaly Boros, Eszter Tuboly
Article
Medicine, General & Internal
Anett Barsony, Noemi Vida, Amos Gajda, Attila Rutai, Arpad Mohacsi, Anna Szabo, Mihaly Boros, Gabriella Varga, Daniel Erces
FRONTIERS IN MEDICINE
(2020)
Article
Medicine, General & Internal
Laszlo Juhasz, Attila Rutai, Roland Fejes, Szabolcs P. Tallosy, Marietta Z. Poles, Andrea Szabo, Istvan Szatmari, Ferenc Fulop, Laszlo Vecsei, Mihaly Boros, Jozsef Kaszaki
FRONTIERS IN MEDICINE
(2020)
Article
Cardiac & Cardiovascular Systems
Kalman Benke, David Kurszan Jasz, Agnes Lilla Szilagyi, Balint Barath, Eszter Tuboly, Anett Roxana Marton, Petra Varga, Arpad Mohacsi, Anna Szabo, Zsofia Szell, Mihaly Ruppert, Tamas Radovits, Gabor Szabo, Bela Merkely, Petra Hartmann, Mihaly Boros
Summary: Adding methane during cold storage of organs for transplantation has been shown to improve early graft function, reduce mitochondrial dysfunction and inflammation, as well as lower myocardial damage and proapoptotic signaling caused by heart transplantation.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Article
Cell Biology
David Kurszan Jasz, Agnes Lilla Szilagyi, Eszter Tuboly, Balint Barath, Anett Roxana Marton, Petra Varga, Gabriella Varga, Daniel Erces, Arpad Mohacsi, Anna Szabo, Renata Bozo, Kamilla Gomori, Aniko Gorbe, Mihaly Boros, Petra Hartmann
Summary: The study showed that methane can reduce mitochondrial ROS production under anoxic-reoxygenation conditions, leading to decreased mitochondrial dysfunction and cardiomyocyte injury.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2021)
Article
Immunology
Marietta Z. Poles, Anna Naszai, Levente Gulacsi, Balint L. Czako, Krisztian G. Gal, Romy J. Glenz, Dishana Dookhun, Attila Rutai, Szabolcs P. Tallosy, Andrea Szabo, Balint Lorinczi, Istvan Szatmari, Ferenc Fulop, Laszlo Vecsei, Mihaly Boros, Laszlo Juhasz, Jozsef Kaszaki
Summary: KYNA and its synthetic analogues have been found to be potential neuroprotective agents in sepsis by reducing peripheral formation of NETs, lowering BBB permeability changes, and alleviating mitochondrial dysfunction in the CNS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Multidisciplinary Sciences
Szabolcs Peter Tallosy, Marietta Zita Poles, Attila Rutai, Roland Fejes, Laszlo Juhasz, Katalin Burian, Jozsef Soki, Andrea Szabo, Mihaly Boros, Jozsef Kaszaki
Summary: This study investigated the impact of the composition of sepsis-inducing bacterial flora on the course of fecal peritonitis in rodents. It was found that similar bacterial loads with mono- or polymicrobial dominance could lead to varying degrees of sepsis severity and outcomes. Initial and intraperitoneal microbiological testing should be considered to enhance translational research success.
SCIENTIFIC REPORTS
(2021)
Review
Critical Care Medicine
Marietta Zita Poles, Laszlo Juhasz, Mihaly Boros
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2019)