Article
Medicine, Research & Experimental
Shuxue Pang, Min Jia, Jianxin Gao, Xiaoyu Liu, Wenhui Guo, Hongyan Zhang
Summary: The study found that the combination treatment of dietary phytochemicals and different diet types has inhibitory effects on breast cancer metastasis, with enhanced effects when combined. The in vivo CTC capture method allows dynamic monitoring of cancer metastasis over time, providing a useful approach for real-time evaluation of treatment effects.
Review
Nutrition & Dietetics
Hsueh-Han Tsai, Jyh-Cherng Yu, Huan-Ming Hsu, Chi-Hong Chu, Tzu-Ming Chang, Zhi-Jie Hong, An-Chieh Feng, Chun-Yu Fu, Kuo-Feng Hsu, Ming-Shen Dai, Guo-Shiou Liao
Summary: Breast cancer is a global public health problem and there is increasing interest in prevention strategies as its incidence rises. A healthy dietary pattern, such as the Mediterranean diet, with high levels of fiber, phytochemicals, antioxidants, and advantageous fatty acids, is considered a promising approach to reduce breast cancer risk. This review summarizes the important active compounds in preventing breast cancer, including polyunsaturated fatty acids, fiber, phytochemicals, and alcohol. While the exact mechanism is not well understood, the combination of these elements in a healthy diet plays a role in reducing breast cancer risk.
Article
Nutrition & Dietetics
Edda Cava, Paolo Marzullo, Deborah Farinelli, Alessandra Gennari, Chiara Saggia, Sergio Riso, Flavia Prodam
Summary: Breast cancer survivors often experience weight gain and fat accumulation after diagnosis, which decreases survival rate and increases the risk of recurrence. Multiple interventions, including healthy dietary patterns, have been studied to reduce the risk of second primary cancer or breast cancer recurrence and mortality.
Article
Oncology
Beata Stasiewicz, Lidia Wadolowska, Maciej Biernacki, Malgorzata Anna Slowinska, Ewa Stachowska
Summary: This study found that higher dietary fat intake (>32%) may increase the risk of peri- and postmenopausal breast cancer in women. Unhealthy dietary patterns characterized by the consumption of highly processed, high in sugar foods and animal fat foods were positively associated with fat intake, while a pro-healthy diet rich in low-processed plant foods, fish, and moderate consumption of low-fat dairy was inversely associated with fat intake.
Article
Public, Environmental & Occupational Health
Peilu Wang, Mingyang Song, A. Heather Eliassen, Molin Wang, Edward L. Giovannucci
Summary: This study compared the associations between different dietary patterns and the risk of colorectal cancer. The results suggest that DASH, Western dietary pattern, EDIH, and EDIP may be the most relevant diets for preventing colorectal cancer.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2022)
Article
Nutrition & Dietetics
Ijeamaka C. Anyene, Isaac J. Ergas, Marilyn L. Kwan, Janise M. Roh, Christine B. Ambrosone, Lawrence H. Kushi, Elizabeth M. Cespedes Feliciano
Summary: This study found that adhering to a healthful plant-based diet was associated with a reduced risk of all-cause and non-breast-cancer mortality, while adherence to an unhealthful plant-based diet was associated with increased mortality risks. No associations were observed with recurrence or breast-cancer-specific mortality.
Review
Nutrition & Dietetics
Elisa Pastore, Saverio Caini, Benedetta Bendinelli, Domenico Palli, Ilaria Ermini, Nora de Bonfioli Cavalcabo', Melania Assedi, Daniela Ambrogetti, Miriam Fontana, Giovanna Masala
Summary: In this study, we conducted a systematic review and found suggestive evidence that the adoption of a healthy diet is associated with lower mammographic breast density (MBD).
Article
Immunology
Wenchang Lv, Yufang Tan, Xiaomei Zhou, Qi Zhang, Jun Zhang, Yiping Wu
Summary: This study establishes a predictive signature based on glycosyltransferase-related lncRNAs (GT-lncRNAs) in breast cancer prognosis and response to immune checkpoint inhibitors (ICIs) treatment. The risk score calculated from the coefficients of 8 GT-lncRNAs can divide breast cancer patients into high- and low-risk groups, with the high-risk group showing shorter survival and the risk score being an independent predictor of breast cancer prognosis. The risk score can also stratify patients with distinct immune infiltration and patients in the high-risk group might benefit more from ICIs treatment. The well-constructed prognostic signature with GT-lncRNAs provides reliable tools for predicting breast cancer outcomes and making rational follow-up strategies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Food Science & Technology
Xiuxiu Wang, Xiaoyu Liu, Zhenzhen Jia, Yilun Zhang, Shuo Wang, Hongyan Zhang
Summary: The study found that high-salt, high-sugar, and high-fat diets significantly promoted the increase in CTC numbers, while ketogenic, low-fat, low-protein, diet restriction, and Mediterranean diets delayed the increase. Through in-depth study of the effects of different dietary patterns on tumor growth and metastasis, a new horizon in future cancer treatments may be expanded.
Article
Nutrition & Dietetics
Inarie Jacobs, Christine Taljaard-Krugell, Mariaan Wicks, Herbert Cubasch, Maureen Joffe, Ria Laubscher, Isabelle Romieu, Carine Biessy, Sabina Rinaldi, Inge Huybrechts
Summary: The study found that in the South African population, traditional dietary pattern and cereal-dairy breakfast dietary pattern may reduce the risk of developing breast cancer.
Article
Cell Biology
Yajas Shah, Akanksha Verma, Andrew R. Marderstein, Jessica White, Bhavneet Bhinder, J. Sebastian Garcia Medina, Olivier Elemento
Summary: Older age is a strong risk factor for various diseases, including cancer. There are molecular differences between tumors in younger and older patients, with tumors in younger individuals showing a dysregulated molecular aging phenotype. These tumors may have unique characteristics that could be used for therapy.
Article
Oncology
Sarah R. Kaslow, Leena Hani, Greg D. Sacks, Ann Y. Lee, Russell S. Berman, Camilo Correa-Gallego
Summary: Hospital-level adherence to guidelines for gastric cancer varies significantly by region and is associated with longer overall survival.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Review
Nutrition & Dietetics
Yuan Bu, Junchao Qu, Siqi Ji, Jingxin Zhou, Mengxin Xue, Jiling Qu, Huiping Sun, Yongbing Liu
Summary: The morbidity of breast cancer is increasing globally, surpassing that of lung cancer for the first time. The effects of dietary patterns on breast cancer risk, prognosis, and quality of life in survivors have attracted increasing attention. Numerous studies have examined different dietary patterns in relation to breast cancer, but caution is needed in interpreting the findings.
FRONTIERS IN NUTRITION
(2023)
Article
Public, Environmental & Occupational Health
Michela Dalmartello, Jeroen Vermunt, Diego Serraino, Werner Garavello, Eva Negri, Fabio Levi, Carlo La Vecchia
Summary: The study identified three dietary patterns among ESCC patients, including the 'Prudent' pattern rich in fruits and vegetables, the 'Western' pattern with low consumption of these food groups and higher sugar intake, and the 'Lower consumers-combination' pattern with a diet poor in nutrients. Italy and Switzerland showed differences in pattern sizes and specific food preferences, with the 'Western' and 'Lower consumers-combination' patterns associated with an increased risk of ESCC compared to the 'Prudent' pattern.
JOURNAL OF EPIDEMIOLOGY AND COMMUNITY HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Patrick Mullie, Gilles Guillot, Cecile Pizot, Philippe Autier, Peter Boyle
Summary: Based on the largest prospective studies in the USA and Europe, researchers found that to prevent one case of female breast cancer, European women need to increase fruit and vegetable intake, while US women need to increase fruit intake. To prevent one case of colorectal cancer, both European and US subjects need to decrease red meat and processed meat intake.
EUROPEAN JOURNAL OF PUBLIC HEALTH
(2021)
Article
Public, Environmental & Occupational Health
Natalia Tumas, Santiago Rodriguez Lopez, Usama Bilal, Ana F. Ortigoza, Ana V. Diez Roux
Summary: This study examined the associations between education level and non-communicable disease risk factors among Argentinian adults. The results showed that the effects of individual-level education varied by gender and were modified by city education. In addition, there were contextual effects of neighborhood and city education on some risk factors. This study highlights the importance of context and gender sensitivity in tackling non-communicable disease risk factors in urban areas of Argentina.
Article
Public, Environmental & Occupational Health
Sonia Alejandra Pou, Maria Del Pilar Diaz, Guillermo Angel Velazquez, Laura Rosana Aballay
Summary: The study found that socio-environmental determinants of obesity operate differently according to sex and age in Argentina, highlighting the need to address the obesity epidemic considering gender inequalities and the socio-environmental context at each stage of life.
PUBLIC HEALTH NUTRITION
(2022)
Article
Endocrinology & Metabolism
A. Caretto, S. Pintus, M. L. Petroni, A. R. Osella, C. Bonfiglio, S. Morabito, P. Zuliani, A. Sturda, M. Castronuovo, V Lagattolla, A. Maghetti, E. Lapini, A. M. Bianco, M. Cisternino, N. Cerutti, C. A. Mulas, O. Hassan, N. Cardamone, M. Parillo, L. Sonni
Summary: This study investigated the impact of the COVID-19 lockdown on the weight and mental health of Italian patients with obesity. The results showed that 48.8% of participants gained weight, 27.1% lost weight, and 37% experienced increased emotional difficulties. Additionally, 61% reduced their physical activity and 55% experienced changes in sleep quality and quantity. Lack of online communication with obesity centers was strongly correlated with weight gain.
INTERNATIONAL JOURNAL OF OBESITY
(2022)
Article
Nutrition & Dietetics
Sonia E. Munoz, Maria del Pilar Diaz, Gabriela A. Reartes, Laura R. Aballay, Camila Niclis, Maria D. Roman, Julia Becaria Coquet, Mariana N. del V. Carrillo, Marcela G. Canale
Summary: The study constructed a diet model and identified four main dietary patterns among two Argentinian populations, showing associations with different components of metabolic syndrome.
Article
Nutrition & Dietetics
Eugenia Haluszka, Camila Niclis, Maria del Pilar Diaz, Alberto R. Osella, Laura R. Aballay
Summary: This study found a positive association between the intake of high glycemic index foods and the occurrence of breast cancer. Additionally, the intake of high glycemic index foods and insulin load were also associated with breast cancer occurrence.
NUTRITION RESEARCH
(2022)
Article
Nutrition & Dietetics
Maria Principia Scavo, Nicoletta Depalo, Federica Rizzi, Livianna Carrieri, Grazia Serino, Isabella Franco, Caterina Bonfiglio, Pasqua Letizia Pesole, Raffaele Cozzolongo, Vito Gianuzzi, Maria Lucia Curri, Alberto Ruben Osella, Gianluigi Giannelli
Summary: Non-alcoholic fatty liver disease (NAFLD) is a complex disease characterized by increased triglyceride levels and fat accumulation in the liver. The progression of NAFLD is associated with changes in the Wnt/Frizzled (FZD) signaling pathway. This study found that the expression levels of FZD7 in exosomes derived from the plasma of NAFLD patients were significantly higher compared to healthy individuals, but these levels normalized after 90 days of specific lifestyle interventions.
Review
Biochemistry & Molecular Biology
Livianna Carrieri, Alberto Ruben Osella, Fausto Ciccacci, Gianluigi Giannelli, Maria Principia Scavo
Summary: Non-alcoholic fatty liver disease (NAFLD) is a complex condition that affects 25% of the global population. There are geographical and gender differences, but they decrease with age. Factors such as hormonal imbalance, microbiome dysregulation, insulin resistance, early menarche, breastfeeding duration, and polycystic ovarian syndrome contribute to the development of NAFLD in premenopausal women. Future clinical management and research should focus on personalized monitoring and treatment, particularly for women who had early metabolic symptoms considered insignificant at the time.
Article
Medicine, General & Internal
Santiago Rodriguez Lopez, Natalia Tumas, Usama Bilal, Kari A. Moore, Binod Acharya, Harrison Quick, D. Alex Quistberg, Gabriel E. Acevedo, Ana V. Diez Roux
Summary: This study evaluated the variability in life expectancy at birth in small areas of Cordoba, Argentina, and described the spatial pattern of life expectancy. The study found positive associations between small-area socioeconomic characteristics and life expectancy, indicating that inequities in life expectancy are not limited to large cities or high-income countries.
Article
Nutrition & Dietetics
Antonella Bianco, Isabella Franco, Ritanna Curci, Caterina Bonfiglio, Angelo Campanella, Antonella Mirizzi, Fabio Fucilli, Giuseppe Di Giovanni, Nicola Giampaolo, Pasqua Letizia Pesole, Alberto Ruben Osella
Summary: This study aimed to estimate the effect of the Low Glycemic Index Mediterranean Diet (LGIMD) and exercise on the longitudinal trajectories of glucose metabolism pathways. The results showed that the proposed program significantly improved glucose metabolism parameters, especially HbA1c.
Article
Nutrition & Dietetics
Francesco Maria Calabrese, Giuseppe Celano, Caterina Bonfiglio, Angelo Campanella, Isabella Franco, Alessandro Annunziato, Gianluigi Giannelli, Alberto Ruben Osella, Maria De Angelis
Summary: Calorie-restrictive dietary interventions and physical activity regimens can reduce the progression of NAFLD, and there is a close relationship between liver function and gut microbiota.
Article
Genetics & Heredity
Julieta Don, Dante G. Secchi, Maria Fernanda Galindez, Laura R. Aballay, Maria Eugenia Pasqualini, Mabel Brunotto
Summary: This study found that high-fat dietary intake and the presence of mutant alleles of TP53 and micro34b/c were associated with a high risk of oral squamous cell carcinoma (OSCC) and potentially malignant oral lesions (PPOL).
Article
Public, Environmental & Occupational Health
Laura Rosana Aballay, Julia Becaria Coquet, Graciela Fabiana Scruzzi, Eugenia Haluszka, German Franchini, Paula Carreno, Elias Raboy, Maria Dolores Roman, Camila Niclis, Marcos Balangero, Natalia Altamirano, Maria Gabriela Barbas, Laura Lopez
Summary: Seroepidemiological studies help identify the distribution of diseases, and this study found that the seroprevalence of SARS-CoV-2 antibodies in Cordoba, Argentina was 16.68%. Factors such as age (2-18 years), living in neighborhoods with low socioeconomic status, and obesity increase the likelihood of seropositivity.
CADERNOS DE SAUDE PUBLICA
(2022)
Article
Nutrition & Dietetics
Francesco Maria Calabrese, Vittoria Disciglio, Isabella Franco, Paolo Sorino, Caterina Bonfiglio, Antonella Bianco, Angelo Campanella, Tamara Lippolis, Pasqua Letizia Pesole, Maurizio Polignano, Mirco Vacca, Giusy Rita Caponio, Gianluigi Giannelli, Maria De Angelis, Alberto Ruben Osella
Summary: This study investigates the impact of different lifestyle interventions on the gut microbiota composition in NAFLD patients and demonstrates the synergistic effect of lifestyle interventions (diet and/or physical activity programs) on the gut microbiota composition in NAFLD patients.