Article
Endocrinology & Metabolism
Edward Czerwinski, Jose Cardona, Rafal Plebanski, Chris Recknor, Tamara Vokes, Kenneth G. Saag, Neil Binkley, E. Michael Lewiecki, Jonathan Adachi, Dorota Knychas, David Kendler, Eric Orwoll, Yinzhong Chen, Leny Pearman, Y. Heather Li, Bruce Mitlak
Summary: The study shows that Abaloparatide significantly increases bone mineral density in men with osteoporosis and has a safety profile consistent with previous studies. These results suggest that Abaloparatide can be considered as an effective anabolic treatment option for male patients with osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Briana M. Nosal, Junichi R. Sakaki, Zachary Macdonald, Kyle Mahoney, Kijoon Kim, Matthew Madore, Staci Thornton, Thi Dong Binh Tran, George Weinstock, Elaine Choung-Hee Lee, Ock K. Chun
Summary: This study aimed to examine the dose-dependent effects of blackcurrant supplementation on preventing bone loss in adult women. The results showed that blackcurrant supplementation decreased the loss of whole-body bone mineral density and increased the marker of bone formation, P1NP. Further studies with larger samples and different skeletal conditions are needed to confirm these findings.
Article
Medicine, Research & Experimental
Francesco Squadrito, Egidio Imbalzano, Michelangelo Rottura, Vincenzo Arcoraci, Giovanni Pallio, Antonino Catalano, Marco Atteritano, Natasha Irrera, Federica Mannino, Giovanni Squadrito, Mario Vaccaro, Pierangela Irrera, Igor Pirrotta, Alessandra Bitto
Summary: This study examined the effects of genistein on bone loss in postmenopausal women with glucocorticoid-induced osteoporosis (GIO). The results showed that genistein can increase bone mineral density and may serve as an additional therapeutic option for patients with GIO.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Endocrinology & Metabolism
Ratchanon Inpan, Mingkwan Na Takuathung, Wannachai Sakuludomkan, Nahathai Dukaew, Supanimit Teekachunhatean, Nut Koonrungsesomboon
Summary: This systematic review and meta-analysis evaluated the efficacy of isoflavone interventions on bone mineral density (BMD) in postmenopausal women. The results suggest that isoflavone interventions can effectively enhance BMD, especially those containing genistein of at least 50 mg/day and when the intervention duration is ≥ 12 months.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Katherine N. Haseltine, Tariq Chukir, Pinar J. Smith, Justin T. Jacob, John P. Bilezikian, Azeez Farooki
Summary: Bone mineral density measurement and FRAX assessment tools can help evaluate fracture risk and guide decisions for osteoporosis pharmacologic treatment. Specific populations like postmenopausal women and men over 50 should receive pharmacologic treatment according to guidelines. Monitoring BMD regularly and considering secondary causes or non-compliance is important during treatment.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Graziamaria Corbi, Vincenzo Nobile, Valeria Conti, Alessandro Cannavo, Vincenzo Sorrenti, Alessandro Medoro, Giovanni Scapagnini, Sergio Davinelli
Summary: This study aimed to evaluate the effects of equol and resveratrol on bone turnover biomarkers in postmenopausal women. The results showed that the combination of equol and resveratrol significantly improved bone turnover biomarkers and increased bone mineral density, suggesting a potential approach to prevent age-related bone loss in postmenopausal women.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
N. Binkley, E. Orwoll, R. Chapurlat, B. L. Langdahl, B. B. Scott, H. Giezek, A. C. Santora
Summary: Odanacatib showed significant efficacy in improving bone mineral density and reducing bone resorption in men with osteoporosis. However, its development was discontinued due to an increased risk of stroke in another study.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Se-Won Lee, Younghyun Yoon, Junhyuk Kwon, Jun-Young Heu, Jihyo Hwang
Summary: The clinical significance of BMD discordance between the hip and spine for hip fractures was evaluated in this study. The results showed that the rates of BMD discordance and low hip discordance were significantly higher in the hip fracture group than in the non-fracture group, indicating a higher risk of hip fractures.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
William D. Leslie, Heenam Goel, Neil Binkley, Eugene McCloskey, Didier Hans
Summary: Lumbar spine trabecular bone score (TBS) is a bone mineral density (BMD)-independent risk factor for fracture, but its sensitivity to technical factors and oral antiresorptive therapies is limited. This study analyzed TBS changes over time and in response to osteoporosis treatment, and found that TBS is strongly affected by technical factors and has little effect on monitoring response to antiresorptive treatment. Therefore, the current version of the TBS algorithm has limited usefulness in untreated individuals or routine clinical practice.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hussein Sakr, Zenat Khired, Marzieh Moghadas
Summary: This study examined the effect of a wheat grain diet on bone turnover markers in rats. The results showed that rats fed whole or refined grains had lower bone density and mineral content compared to the control group. Additionally, levels of bone turnover indicators in the blood were altered, indicating a decrease in bone turnover and mass with a grain diet.
Review
Pharmacology & Pharmacy
Yi Chen, Jun Zhu, Yiqin Zhou, Jinhui Peng, Bo Wang
Summary: Denosumab is a promising antiresorptive agent in postmenopausal women with osteoporosis or low bone mineral density, showing greater increase in bone mineral density and reduced fracture risk compared to placebo, without excess risks of adverse events.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Nutrition & Dietetics
Nasser M. Al-Daghri, Syed Danish Hussain, Abdullah M. Alnaami, Naji Aljohani, Shaun Sabico
Summary: Osteoporosis is a significant public health concern in Saudi Arabia, particularly among the aging population. This study examined the association between dietary calcium intake and osteoporosis risk in Saudi adults. Results showed that the overall mean calcium intake was very low and that certain dietary factors, such as tea intake and consumption of fish and eggs, were associated with a lower risk of osteoporosis.
Article
Medicine, General & Internal
Masashi Uehara, Yukio Nakamura, Takako Suzuki, Masaki Nakano, Jun Takahashi
Summary: This study compared the efficacy and safety of ibandronate and zoledronic acid in Japanese postmenopausal osteoporotic patients, finding that both drugs significantly and safely improved bone turnover markers and BMD during 30 months of treatment. The ZOL group tended to exhibit greater gains in BMD compared to the IBN group, warranting further investigation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Ewa Jowko, Barbara Dlugolecka, Igor Cieslinski, Jadwiga Kotowska
Summary: The aim of this study was to identify relevant factors that affect bone mineral content (BMC) and bone mineral density (BMD) in young, healthy men reaching peak bone mass. The results showed that age, BMI, engaging in combat and team sports at a competitive level, and certain genetic polymorphisms were significant predictors of BMD/BMC at different skeletal sites. Specifically, the SOD2 AG genotype was associated with lower BMC values, while the VDR FokI GG genotype was associated with lower BMD. However, the CALCR AG genotype was linked to higher arm BMD. These findings suggest that sports training may mitigate the negative impact of genetic factors on bone tissue and reduce the risk of osteoporosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Masaki Nakano, Yukio Nakamura, Akiko Miyazaki, Jun Takahashi
Summary: This study investigated the efficacy and safety of zinc pharmacotherapy in Japanese elderly patients with osteoporosis. The results showed that zinc treatment successfully elevated serum zinc levels, significantly increased bone mineral density, and had a positive association with BMD changes. Zinc supplementation also significantly raised bone formation markers, potentially contributing to fracture prevention in elderly osteoporotic patients.