Review
Biochemistry & Molecular Biology
Hye Young Kim, Young Hyun Yoo
Summary: Nonalcoholic fatty liver disease (NAFLD) is a major health issue with no approved treatment options. The six transmembrane protein of prostate 2 (STAMP2) plays a critical role in the development of NAFLD and targeting its involvement in iron metabolism dysregulation could be a new therapeutic strategy.
Review
Neurosciences
Daejin Lim, Jae-ho Jeong, Juhyun Song
Summary: Dementia accompanied by memory loss is a common neurodegenerative disease with increasing prevalence worldwide. Recent evidence suggests that lipocalin 2 (LCN2) plays a regulatory role in dementia and may be a promising therapeutic target to address the neuropathology of dementia.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Genetics & Heredity
Edoardo Monfrini, Sara Pelucchi, Maija Hollmen, Miro Viitala, Raffaella Mariani, Francesca Bertola, Silvia Majore, Alessio Di Fonzo, Alberto Piperno
Summary: This study identified bi-allelic STAB1 mutations associated with hyperferritinemia, suggesting another genetic cause of hyperferritinemia without iron overload and revealing an unexpected function of stabilin-1 in ferritin metabolism.
AMERICAN JOURNAL OF HUMAN GENETICS
(2023)
Article
Biochemistry & Molecular Biology
Marta Gaburjakova, Jana Gaburjakova, Eva Krejciova, Daniel Kosnac, Helena Kosnacova, Stefan Nagy, Stefan Polak, Michal Sabo, Michal Trnka, Martin Kopani
Summary: Iron, essential for most living organisms, is involved in various physiological processes. Disruption in iron homeostasis can lead to pathologies, especially in the heart and brain. Research shows that ferritin can block the RYR2 channel through a direct electrostatic interaction.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2021)
Review
Medicine, General & Internal
Miriam Sandnes, Rune J. Ulvik, Marta Vorland, Hakon Reikvam
Summary: This review focuses on the importance of ferritin as a laboratory test, as well as the diagnosis and management of hyperferritinemia. Low ferritin is highly specific for iron deficiency, while hyperferritinemia is a non-specific finding that may or may not indicate iron overload.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hyeong Seok An, Jung-Wan Yoo, Jong Hwan Jeong, Manbong Heo, Si Hwan Hwang, Hye Min Jang, Eun Ae Jeong, Jaewoong Lee, Hyun Joo Shin, Kyung Eun Kim, Meong Cheol Shin, Gu Seob Roh
Summary: Lipocalin-2 (LCN2) is an acute-phase protein that regulates inflammatory responses to bacteria or lipopolysaccharide (LPS). This study found that LCN2 plays a key role in inflammation and oxidative stress following acute lung injury and may be a potential therapeutic target for pneumonia or acute lung injury.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Eun Bee Choi, Jae Hun Jeong, Hye Min Jang, Yu Jeong Ahn, Kyu Hyeon Kim, Hyeong Seok An, Jong Youl Lee, Eun Ae Jeong, Jaewoong Lee, Hyun Joo Shin, Kyung Eun Kim, Gu Seob Roh
Summary: The study revealed that elevated levels of LCN2 in skeletal muscle of obese individuals are associated with inflammation and oxidative stress related to muscle atrophy.
Review
Endocrinology & Metabolism
Lulu Liu, Feng Yan, Hongyuan Yan, Zhiqiang Wang
Summary: Gestational diabetes mellitus (GDM) is a common complication of pregnancy, affecting 14% of pregnancies worldwide. The potential risk of iron supplementation in GDM needs to be clarified. In this review, we comprehensively assess the role of iron in pregnancy, including the necessity of iron supplementation and the mechanisms of excess iron contributing to the pathogenesis of GDM.
DIABETES OBESITY & METABOLISM
(2023)
Article
Medicine, General & Internal
Christopher Seifen, Johannes Pordzik, Tilman Huppertz, Berit Hackenberg, Cornelia Schupp, Christoph Matthias, Perikles Simon, Haralampos Gouveris
Summary: Obstructive sleep apnea (OSA) is associated with inflammatory diseases and serum ferritin. However, little is known about the relationship between OSA severity and serum ferritin levels in healthy individuals. This retrospective study analyzed polysomnographic recordings and serum ferritin levels in 90 healthy individuals with suspected OSA. Results showed a positive correlation between serum ferritin levels and apnea-hypopnea index (AHI). Patients with severe OSA had higher serum ferritin levels compared to those without or with mild OSA, while serum C-reactive protein and hemoglobin levels did not differ significantly. Age and body-mass index (BMI) were also higher with increasing OSA severity.
Article
Nutrition & Dietetics
Sixtus Aguree, Manju B. Reddy
Summary: Limited evidence suggests dysregulation of serum iron and hepcidin concentrations in obesity and inflammation. This study compared inflammatory markers, serum lipids, and iron status between obese and normal-weight women. Obese women showed higher levels of inflammation, triglycerides, and hepcidin, but lower HDL and serum iron/hepcidin ratio compared to normal-weight women. BMI correlated positively with inflammatory markers, triglycerides, and total cholesterol/HDL ratio, and negatively with HDL and serum iron/hepcidin ratio.
Article
Nutrition & Dietetics
Hyung Seok Lee, Hye-Mi Noh, Jung Nam An, Young Rim Song, Sung Gyun Kim, Jwa-Kyung Kim
Summary: Obesity is common in PD patients, leading to high serum ferritin levels. Increased adiposity is associated with higher ferritin levels and mortality in PD patients.
Article
Gastroenterology & Hepatology
Andrew M. Shearer, Yanling Wang, Elizabeth K. Fletcher, Rajashree Rana, Emily S. Michael, Nga Nguyen, Manal F. Abdelmalek, Lidija Covic, Athan Kuliopulos
Summary: PAR2 expression increases in diabetes and NAFLD/NASH, suppressing glucose internalization and insulin signaling through a G(q)-dependent mechanism, making it a potential target for treating diabetes and NASH.
Review
Biology
Jianlin Zhang, Xuehui Chen, Juanji Hong, Aifa Tang, Yang Liu, Ni Xie, Guohui Nie, Xiyun Yan, Minmin Liang
Summary: Ferritin, a vital iron-storage protein, plays a key role in regulating cellular iron metabolism and oxidative stress. It forms a unique spherical cage structure to safely store iron and prevent oxidative damage. The expression of ferritin is regulated by iron status and oxidative stress, and it functions by catalyzing oxidation and mediating iron recycling within cells.
SCIENCE CHINA-LIFE SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Huynh Tan Hop, Tran Xuan Ngoc Huy, Hu Jang Lee, Suk Kim
Summary: Bacteria of the genus Brucella can cause brucellosis, a common zoonotic disease. The DNA-binding protein Dps from Brucella is secreted within the macrophage cytosol, modulating host iron homeostasis and mediating intracellular growth of Brucella.
Article
Biochemistry & Molecular Biology
Cole A. Guggisberg, Juyoung Kim, Jaekwon Lee, Xiaoli Chen, Moon-Suhn Ryu
Summary: Macrophages recycle iron from erythrocytes and NCOA4 regulates ferritinophagy and iron release. NCOA4 has functional association with immune response.
Review
Biochemistry & Molecular Biology
Carlota Tuero, Sara Becerril, Silvia Ezquerro, Gabriela Neira, Gema Fruhbeck, Amaia Rodriguez
Summary: The development of nonalcoholic fatty liver disease (NAFLD) is complex and multifactorial, with ghrelin playing a significant role. Ghrelin, a gut hormone, regulates appetite and adiposity. It targets the liver and regulates pathways related to lipid metabolism, inflammation, and fibrosis. Altered ghrelin levels are observed in patients with metabolic diseases, which are known risk factors for NAFLD. This review highlights the mechanisms by which ghrelin protects the liver, including reducing hepatocyte lipotoxicity, promoting autophagy and fatty acid β-oxidation, improving mitochondrial dysfunction, decreasing inflammation, and inactivating hepatic stellate cells. The regulation of metabolic and inflammatory pathways in the liver suggests that ghrelin could be a potential therapeutic target for preventing NAFLD in patients with metabolic disorders.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Correction
Immunology
Gema Fruhbeck, Javier Gomez-Ambrosi, Beatriz Ramirez, Amaia Mentxaka, Amaia Rodriguez, Sara Becerril, Gabriel Reina, Victor Valenti, Rafael Moncada, Camilo Silva, Victoria Catalan
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Endocrinology & Metabolism
Laura Salmon-Gomez, Victoria Catalan, Gema Fruhbeck, Javier Gomez-Ambrosi
Summary: Obesity is a common metabolic disorder worldwide, increasing the risk of developing cardiometabolic disorders. Body mass index (BMI) is widely used but doesn't accurately reflect body fat. This document reviews different classification systems for phenotyping obesity and suggests incorporating advances in body composition techniques and understanding of cardiometabolic risk factors into clinical practice for better diagnosis and treatment.
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2023)
Article
Oncology
Amaia Mentxaka, Javier Gomez-Ambrosi, Gabriela Neira, Beatriz Ramirez, Sara Becerril, Amaia Rodriguez, Victor Valenti, Rafael Moncada, Jorge Baixauli, Maria A. Burrell, Camilo Silva, Vasco Claro, Albert Ferro, Victoria Catalan, Gema Fruhbeck
Summary: This study found that excess visceral adipose tissue in patients with obesity and colon cancer is associated with increased expression levels of NTN-1 and its main receptors, leading to the development of an inflammatory microenvironment that favors colon cancer progression.
Editorial Material
Cell Biology
Javier Gomez-Ambrosi
Correction
Immunology
G. Fruhbeck, A. Mentxaka, P. Ahechu
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Gema Fruhbeck, Leire Mendez-Gimenez, Sara Becerril, Beatriz Ramirez, Ana Wenting Hernandez-Pardos, Javier A. Cienfuegos, Victor Valenti, Rafael Moncada, Victoria Catalan, Javier Gomez-Ambrosi, Ines V. da Silva, Graca Soveral, Amaia Rodriguez
Summary: We investigated the role of AQP7 in the process of BAT whitening and found that its expression is upregulated in diet-induced obesity (DIO). Interestingly, the expression of AQP7 is downregulated after cold exposure or bariatric surgery, which is associated with the improvement of BAT whitening. Furthermore, AQP7 expression is regulated by specific lipogenic signals and correlated with the expression of lipogenic genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Sara Becerril, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Amaia Mentxaka, Gabriela Neira, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: Biological sex and aging play a role in obesity development and type 2 diabetes, affecting the secretion of leptin and adiponectin. The Adpn/Lep ratio is proposed as a reliable biomarker for adipose tissue dysfunction. The study found that female mice were more metabolically protected from obesity and its comorbidities than males, with an increased Adpn/Lep ratio in aged females negatively correlated with body weight gain and insulin resistance.
Article
Biochemistry & Molecular Biology
Sara Becerril, Javier A. Cienfuegos, Amaia Rodriguez, Victoria Catalan, Beatriz Ramirez, Victor Valenti, Rafael Moncada, Xabier Unamuno, Javier Gomez-Ambrosi, Gema Fruhbeck
Summary: SADI-S is more effective than SG or caloric restriction in improving glycemic control and metabolic profile, with a higher remission of insulin resistance as well as long-term weight loss.
JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY
(2023)
Article
Surgery
Jasper P. Sijberden, Federica Cipriani, Jacopo Lanari, Nadia Russolillo, Andrea Benedetti Cacciaguerra, Daniel Osei-Bordom, Simone Conci, Burak Gorgec, John N. Primrose, Bjorn Edwin, Santi Lopez-Ben, Mathieu D'Hondt, Fernando Rotellar, Marc G. Besselink, Ibrahim Dagher, Felice Giuliante, David Fuks, Renzo Rozzini, Andrea Ruzzenente, Robert P. Sutcliffe, Marco Vivarelli, Alessandro Ferrero, Umberto Cillo, Luca A. Aldrighetti, Mohammad Abu Hilal
BRITISH JOURNAL OF SURGERY
(2023)