Article
Radiology, Nuclear Medicine & Medical Imaging
Edouard Reizine, Julia Chalaye, Sebastien Mule, Helene Regnault, Clara Perrin, Julien Calderaro, Alexis Laurent, Giuliana Amaddeo, Hicham Kobeiter, Vania Tacher, Emmanuel Itti, Alain Luciani
Summary: The purpose of this study is to evaluate the utility of early post-treatment evaluation by PET/CT using FDG or F-18-FCH to predict 6-month treatment response and survival after TARE in patients with HCC.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Gustavo Costa, Benjamin Spencer, Negar Omidvari, Cameron Foster, Michael Rusnak, Heather Hunt, Denise T. Caudle, Rex T. Pillai, Catherine Tram Vu, Emilie Roncali
Summary: This study aimed to evaluate the suitability of using total-body Y-90 PET with the uEXPLORER scanner for liver dosimetry and investigate possible improvements in TARE Y-90 PET-based dosimetry. The results showed good agreement between the uEXPLORER and mCT in terms of total liver-absorbed dose, with the uEXPLORER demonstrating higher signal-to-noise ratio and lower image noise, which is expected to improve dose quantification and tumor dosimetry.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Benedikt M. Schaarschmidt, Moritz Wildgruber, Roman Kloeckner, James Nie, Verena Steinle, Arthur J. A. T. Braat, Fabian Lohoefer, Hyun S. Kim, Harald Lahner, Manuel Weber, Jens Theysohn
Summary: Y-90 radioembolization (Y-90 RE) could be an important alternative treatment option for neuroendocrine neoplasms (NENs) patients with hepatic metastases, but more clinical evidence is needed.
JOURNAL OF NUCLEAR MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Frank Kolligs, Dirk Arnold, Rita Golfieri, Maciej Pech, Bora Peynircioglu, Thomas Pfammatter, Maxime Ronot, Bruno Sangro, Niklaus Schaefer, Geert Maleux, Graham Munneke, Helena Pereira, Bleranda Zeka, Niels de Jong, Thomas Helmberger, R. Gol, Maciej Pech, Bora Peynircioglu, Thomas Pfammatter, Maxime Ronot, Bruno Sangro, Niklaus Schaefer, Geert Maleux, Graham Munneke, Helena Pereira, Bleranda Zeka, Thomas Helmberger
Summary: This prospective observational study aimed to evaluate the effectiveness, safety, and prognostic factors of transarterial radioembolization (TARE) for hepatocellular carcinoma (HCC). The use of partition model dosimetry was associated with improved overall survival outcomes compared to body surface area calculations. Factors such as patient health, ascites, and liver function predicted outcomes after TARE.
Article
Radiology, Nuclear Medicine & Medical Imaging
Joey Roosen, Lovisa E. L. Westlund Gotby, Mark J. Arntz, Jurgen J. Futterer, Marcel J. R. Janssen, Mark W. Konijnenberg, Meike W. M. van Wijk, Christiaan G. Overduin, J. Frank W. Nijsen
Summary: This study investigated the feasibility and safety of performing Ho-166 TARE within an MRI scanner and explored the potential of intraprocedural MRI-based dosimetry. The results showed that Ho-166 microspheres could be administered within the MRI scanner in 82% of injection positions, and intraprocedural MRI allowed for tumor dosimetry in 95% of treated tumors. In addition, post-procedure analysis of dose distribution using MRI provides valuable information for optimizing treatment efficacy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Immunology
Aranka Brockmueller, Constanze Buhrmann, Parviz Shayan, Mehdi Shakibaei
Summary: This study demonstrates a negative reciprocal crosstalk between p53 and Sirt-1, and high concentrations of resveratrol can induce apoptosis in colorectal cancer cells by modulating the expression of these two proteins.
FRONTIERS IN IMMUNOLOGY
(2023)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Sreedharan Thankarajan ArunRaj, Arunav Kumar, Haresh KP, Nikhil Mohan, Subhash Gupta, Madhavi Tripathi, Chandrasekhar Bal
Summary: F-18-FDG and Ga-68-DOTANOC PET imaging proved useful in assessing treatment response in a case of metastatic medulloblastoma, with the patient showing excellent response to systemic chemotherapy.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Oncology
Vijay Mistry, Justin R. R. Scott, Tzu-Yang Wang, Peter Mollee, Kenneth A. A. Miles, W. Phillip Law, Greg Hapgood
Summary: This study compared the diagnostic performance of FDG PET/MRI and FDG PET/CT in adult patients with newly diagnosed Hodgkin and Non-Hodgkin lymphoma. The results showed high concordance in disease site identification, staging, and response assessment between PET/MRI and PET/CT. PET/MR has the potential to be an alternative to PET/CT in lymphoma, minimizing radiation exposure.
Review
Biology
Francesco Dondi, Achille Lazzarato, Joana Gorica, Priscilla Guglielmo, Francesca Borgia, Rossella Filice, Antonio Vento, Sara Pacella, Riccardo Camedda, Matteo Caracciolo, Maria Silvia De Feo, Paolo Mammucci, Viviana Frantellizzi, Naima Ortolan, Elisa Fiasconaro, Luca Urso, Laura Evangelista, Riccardo Laudicella, Giulia Santo
Summary: This review explores PET criteria developed for interpretation and treatment response assessment in non-FDG PET imaging in oncology, highlighting their potential role in predicting prognosis and their need for clinical trials to evaluate their impact on patient management.
Article
Medicine, General & Internal
Matthew D. Walker, Jonathan I. Gear, Allison J. Craig, Daniel R. McGowan
Summary: Respiratory motion can degrade the quantification accuracy of PET imaging, particularly in dosimetric measures. However, using device-driven quiescent period respiratory motion correction can improve accuracy.
Article
Medicine, General & Internal
Poul F. Hoilund-Carlsen, Mona-Elisabeth Revheim, Tommaso Costa, Kasper P. Kepp, Rudolph J. Castellani, George Perry, Abass Alavi, Jorge R. Barrio
Summary: In June 2021, the FDA accelerated approved aducanumab and in January 2023 also lecanemab, based on perceived drug-induced removal of cerebral amyloid-beta as assessed by amyloid-PET and, in the case of lecanemab, limited clinical efficacy assumption. Approval for donanemab is pending further data. However, published trial data indicate minimal and uncertain clinical benefits, similar to conventional medication. Additionally, amyloid-PET signal decrease may reflect increased cell damage instead of amyloid removal, as supported by increased amyloid-related imaging abnormalities and brain volume loss in treated patients compared to placebo. We also question the current AD diagnostic criteria based on amyloid-PET imaging biomarkers and recommend future anti-AD therapy trials to incorporate (1) diagnosis based on cognitive decline and decreased cerebral metabolism assessed by FDA-approved FDG-PET, (2) therapy efficacy determined by cognitive ability, cerebral metabolism by FDG-PET, and brain volumes by MRI, and (3) neuropathologic examination of all deaths occurring in these trials.
Article
Surgery
Robert Drescher, Philipp Seifert, Falk Guehne, Rene Aschenbach, Christian Kuehnel, Martin Freesmeyer
Summary: This study aimed to evaluate the outflow dynamics and residual Ho-166 activity during and after transarterial radioembolization procedures. Results showed that residual activities could be significantly decreased by using different injection methods and the main predilection sites of residual microspheres were identified. During treatment procedures, the majority of microspheres were transferred to the patient during the initial injection cycles, with a small estimated residual waste included in the treatment activity calculation.
JOURNAL OF ENDOVASCULAR THERAPY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sang Hyun Hwang, Hye-Suk Hong, Dongwoo Kim, Gyoung Min Kim, Hye Won Lee, Misu Lee, Do Young Kim, Mi-Ae Park, Mijin Yun
Summary: This study evaluated the prognostic value of metabolic parameters on F-18-FDG PET/CT and tumor dose (TD) on post-treatment Y-90 PET/CT in HCC patients undergoing Y-90 transarterial radioembolization (TARE). The results showed that TLG is a better prognostic factor for OS than TD in these patients.
CLINICAL NUCLEAR MEDICINE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Martijn V. Verhagen, Leon J. Menezes, Deena Neriman, Tom A. Watson, Shonit Punwani, Stuart A. Taylor, Ananth Shankar, Stephen Daw, Paul D. Humphries
Summary: This study demonstrates that F-18-FDG PET/MRI has high diagnostic accuracy in pediatric HL patients, particularly in staging and treatment response assessment. It shows high sensitivity and specificity compared to F-18-FDG PET/CT, and is a promising alternative for staging and response assessment in children with HL.
JOURNAL OF NUCLEAR MEDICINE
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Amy R. Deipolyi, C. Bryce Johnson, Christopher C. Riedl, Henry Kunin, Stephen B. Solomon, Rahmi Oklu, Meier Hsu, Chaya S. Moskowitz, Faruk E. Kombak, Umesh Bhanot, Joseph P. Erinjeri
Summary: This study aimed to determine whether the response to transarterial radioembolization (TARE) at PET/CT in breast cancer liver metastasis (BCLM) participants is associated with specific immune markers. The results showed that complete response was associated with lower cytokine, monocyte, and myeloid-derived suppressor cell levels, and higher programmed cell death protein 1-positive tumor-infiltrating lymphocyte levels.
Article
Radiology, Nuclear Medicine & Medical Imaging
Claus Christian Pieper, Alois Martin Sprinkart, Guido Mattias Kukuk, Petra Muertz
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2019)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Martin Ries, Fadi Khreish, Christian Veith, Joachim von den Hoff, Samer Ezziddin
CLINICAL NUCLEAR MEDICINE
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Claus Christian Pieper, Saebeom Hur, Christof-Matthias Sommer, Gregory Nadolski, Geert Maleux, Jinoo Kim, Maxim Itkin
INVESTIGATIVE RADIOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Claus C. Pieper, Andreas Feisst, Hans H. Schild
Letter
Cardiac & Cardiovascular Systems
M. Vach, U. I. Attenberger, C. C. Pieper
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Alexander Isaak, Michael Praktiknjo, Christian Jansen, Anton Faron, Alois M. Sprinkart, Claus C. Pieper, Johannes Chang, Rolf Fimmers, Carsten Meyer, Darius Dabir, Daniel Thomas, Jonel Trebicka, Ulrike Attenberger, Daniel Kuetting, Julian A. Luetkens
Article
Cardiac & Cardiovascular Systems
Julia Wagenpfeil, Ulrike Attenberger, Claus Christian Pieper
Summary: Complex oncological treatment may lead to lymphatic vascular injury with high morbidity. In this case, a 59-year-old woman with an unusual lympho-veno-cutaneous fistula was diagnosed and treated using minimally invasive methods. This highlights the importance of lymphatic imaging and interventional techniques in managing lymphatic vascular injuries.
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christoph H. Endler, Daniel Ginzburg, Alexander Isaak, Anton Faron, Narine Mesropyan, Daniel Kuetting, Claus C. Pieper, Patrick A. Kupczyk, Ulrike Attenberger, Julian A. Luetkens
Summary: Among trauma patients evaluated with cervical spine CT, 146 out of 1553 patients (9%) had asymmetric LADI. Subsequent MRI may only provide diagnostic benefit for symptomatic patients with LADI asymmetry, while showing no diagnostic benefit and potential overtreatment in asymptomatic patients without confirmed cervical injuries.
Article
Radiology, Nuclear Medicine & Medical Imaging
Dmitrij Kravchenko, Alexander Isaak, Sebastian Zimmer, Narine Mesropyan, Matthaus Reinert, Anton Faron, Claus C. Pieper, Annkristin Heine, Markus Velten, Jacob Nattermann, Daniel Kuetting, Georg D. Duerr, Ulrike Attenberger, Julian A. Luetkens
Summary: This study explored the relationship between chronic COVID-19 syndrome (CCS) and myocardial injury and inflammation in previously healthy individuals. The results showed that individuals with CCS who did not require hospitalization for COVID-19 did not demonstrate signs of active myocardial injury or inflammation at cardiac MRI.
Article
Radiology, Nuclear Medicine & Medical Imaging
Anton Faron, Alexander Isaak, Narine Mesropyan, Matthaeus Reinert, Katjana Schwab, Judith Sirokay, Alois M. Sprinkart, Franz-Georg Bauernfeind, Darius Dabir, Claus C. Pieper, Annkristin Heine, Daniel Kuetting, Ulrike Attenberger, Jennifer Landsberg, Julian A. Luetkens
Summary: This study investigated the extent of cardiac injury and inflammation related to ICI therapy in cancer patients using cardiac MRI. The results showed that during follow-up, participants displayed significant signs of myocardial edema and inflammation, as well as a decrease in cardiac function compared to baseline.
Article
Medicine, General & Internal
Anton Faron, Nikola S. Opheys, Sebastian Nowak, Alois M. Sprinkart, Alexander Isaak, Maike Theis, Narine Mesropyan, Christoph Endler, Judith Sirokay, Claus C. Pieper, Daniel Kuetting, Ulrike Attenberger, Jennifer Landsberg, Julian A. A. Luetkens
Summary: Analyzing body composition of patients with melanoma undergoing immune checkpoint inhibitor therapy using deep learning showed that lower skeletal muscle index was associated with worse outcomes. This indicates the prognostic value of CT-based body composition assessment.
Article
Biochemistry & Molecular Biology
Daniel Kuetting, Patrick Kupczyk, Tatjana Dell, Julian A. Luetkens, Carsten Meyer, Ulrike Attenberger, Claus C. Pieper
Summary: The embolic properties of different acrylic adhesive/iodized oil mixtures for lymphatic interventions are influenced by the triglyceride concentration and flow rate in the lymphatic fluid. The polymerization time of acrylic glue is positively correlated with the iodized oil concentration, triglyceride concentration, and volume of glucose flush.
Article
Otorhinolaryngology
Marius Vach, Julia Wagenpfeil, Andreas Henkel, Sebastian Strieth, Julian Alexander Luetkens, Yon-Dschun Ko, Hans Heinz Schild, Ulrike Irmgard Attenberger, Claus Christian Pieper
Summary: Idiopathic recurrent cervical swelling may be caused by lymphatic abnormalities. MR-lymphangiography displays the characteristics of lymphatic abnormalities and aids in treatment planning.
LARYNGOSCOPE INVESTIGATIVE OTOLARYNGOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lea C. Kaminski, Julia Wagenpfeil, Jens Buermann, Philipp L. Lutz, Julian A. Luetkens, Ulrike I. Attenberger, Christian P. Strassburg, Jorg C. Kalff, Hans H. Schild, Claus C. Pieper
Summary: The aim of this study was to retrospectively evaluate the long-term results of lymphatic interventions in adults with abdomino-thoracic lymphatic pathologies. The study found that lymph-vessel embolization (LVE) has a high clinical success rate for treating abdomino-thoracic chylous effusions and can significantly prolong patient survival.
Article
Radiology, Nuclear Medicine & Medical Imaging
Thomas M. Vollbrecht, Christopher Hart, Shuo Zhang, Christoph Katemann, Alexander Isaak, Claus C. Pieper, Daniel Kuetting, Bettina Faridi, Brigitte Strizek, Ulrike Attenberger, Florian Kipfmueller, Ulrike Herberg, Annegret Geipel, Julian A. Luetkens
Summary: The purpose of this study was to investigate the diagnostic performance of DUS-gated fetal cardiac cine MRI compared with fetal echocardiography in complex congenital heart disease. The results showed that the performance of fetal cardiac MRI was comparable to that of fetal echocardiography in diagnosing complex fetal CHD.
RADIOLOGY-CARDIOTHORACIC IMAGING
(2023)