Article
Radiology, Nuclear Medicine & Medical Imaging
Georgios Krokos, Lucy C. Pike, Gary J. R. Cook, Paul K. Marsden
Summary: This study aimed to assess the applicability of Fluorine-18 performance specifications defined by EANM Research Ltd (EARL) in Gallium-68 multi-centre PET-CT trials using conventional and advanced iterative reconstructions, and found it possible to standardise the advanced reconstruction methods while requiring Gallium-68 specific recovery coefficient limits.
Article
Radiology, Nuclear Medicine & Medical Imaging
Laura Harper, Curtis Simmons, Mark Nathan, Gita Thanarajasingam, Hidong Kim, Jason Young
Summary: The study established normal testicular SUV ranges among adult men in North America, showing significant differences in SUV values across age groups and a negative correlation between blood glucose level and testicular SUVmean.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Multidisciplinary Sciences
Paulina Cegla, Frank Hofheinz, Ewa Burchardt, Rafal Czepczynski, Anna Kubiak, Joerg van den Hoff, Pavel Nikulin, Agnieszka Bos-Liedke, Andrzej Roszak, Witold Cholewinski
Summary: The study aimed to assess the prognostic value of asphericity (ASP) and standardized uptake ratio (SUR) in cervical cancer patients. A retrospective analysis was conducted on 508 previously untreated cervical cancer patients. The study showed that ASP and metabolic tumor volume (MTV) were prognostic factors for all investigated endpoints, while SUR and maximum standardized uptake value (SUVmax) were not. The alternative parameter ASP has the potential to improve the prognostic value of [F-18]FDG PET/CT for event-free survival and locoregional control in radically treated cervical cancer patients.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Akira Watanabe, Norifumi Harimoto, Kenichiro Araki, Norio Kubo, Takamichi Igarashi, Mariko Tsukagoshi, Norihiro Ishii, Keitaro Hirai, Hiroshi Tanaka, Yasushi Mochida, Norimichi Kogure, Tetsuya Higuchi, Ken Shirabe
Summary: This study found that FDG-PET has value in predicting tumor invasion in ampullary cancer, with SUVmax showing significant correlation with tumor invasion and lymph node metastasis. This suggests that FDG-PET can be a useful tool in preoperative staging and treatment strategy.
JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Annan Zhang, Xiangxi Meng, Yuan Yao, Xin Zhou, Yan Zhang, Nan Li
Summary: This study compared the application of [Ga-68]Ga-DOTA-FAPI-04 and [F-18]FDG PET/CT in fibro-blastic tumors. The results showed that [Ga-68]Ga-DOTA-FAPI-04 outperformed [F-18]FDG PET/CT in displaying the primary, recurrent and metastatic lesions.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Haiqun Xing, Haiyan Ding, Bo Hou, Zhixin Hao, Ya Hu, Wenjia Zhu, Sayuan Liang, Feng Feng, Fang Li, Yupei Zhao, Li Huo
Summary: This study compared the performance of F-18-FDG PET/MRI and PET/CT in the clinical evaluation of pancreatic neoplasms. The results showed that both PET/MRI and PET/CT had comparable overall performance in identifying pancreatic neoplasms. However, PET/MRI showed better performance for patients with suspected pancreatic neoplasms but no visible FDG uptake on PET/CT.
MOLECULAR IMAGING AND BIOLOGY
(2022)
Article
Oncology
Kjersti Skipar, Tord Hompland, Kjersti Vassmo Lund, Ayca Londalen, Eirik Malinen, Gunnar B. Kristensen, Kristina Lindemann, Esten S. Nakken, Kjersti Bruheim, Heidi Lyng
Summary: This study investigated the potential of a multimodal combination of imaging parameters for classifying patients with locally advanced cervical cancer (LACC). The results showed that the multimodal combination of MR and FDG-PET/CT images improved the classification of LACC patients compared to single modality images and clinical factors. The hypoxic fraction (HF) was identified as an important multimodal biomarker that increased the accuracy of identifying high-risk patients.
RADIOTHERAPY AND ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Kylie Keijzer, Anne G. H. Niezink, Janneke W. de Boer, Jaap A. van Doesum, Walter Noordzij, Tom van Meerten, Lisanne V. van Dijk
Summary: Multiple therapeutic options are available for the treatment of Non-Hodgkin lymphoma (NHL). This study aimed to review literature on different segmentation methods used for NHL and evaluate selected methods using a software tool. The study demonstrated a large and significant variation in metabolic active tumor volume (MATV) based on different segmentation methods. Identifying the most optimal segmentation method for NHL patients is essential to improve treatment outcomes.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Filiz Celebi, Aysegul Gormez, Ahmet Serkan Ilgun, Yaman Tokat, Numan Cem Balci
Summary: The study found that SUVmax was an independent risk factor for predicting HCC MVI, and 18F-FDG PET/MRI is a useful noninvasive imaging tool.
EUROPEAN JOURNAL OF RADIOLOGY
(2022)
Article
Biology
Ruben Hack, Anton S. Becker, Beata Bode-Lesniewska, G. Ulrich Exner, Daniel A. Mueller, Daniela A. Ferraro, Geoffrey Warnock, Irene A. Burger, Christian Britschgi
Summary: This study aimed to investigate whether volume-based PET metrics (tumor volume and total lesions glycolysis) are superior to SUVmax and other metrics in predicting survival of patients with soft tissue and bone sarcomas. The results showed that different sarcoma types were associated with different PET/CT metrics, with SUVmax remaining the best prognostic factor in soft tissue sarcomas, while tumor volume may be more suitable for evaluating bone sarcomas.
Article
Radiology, Nuclear Medicine & Medical Imaging
Kim Ben Tikva Kagan, Dmitri Guz, Shira Buchrits, Ronit Gurion, Iuliana Vaxman, Miriam Priss, David Groshar, Onofrio A. Catalano, Adi Sherban, Pia Raanani, Anat Gafter-Gvili, Hanna Bernstine
Summary: In this retrospective cohort study, prediction models for FDG uptake and SUVmax in MZL patients were presented, aiming to help clinicians choose suitable patients for FDG-PET/CT staging and monitoring of the disease.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yao Liu, Mei-jia Gao, Jie Zhou, Fan Du, Liang Chen, Zhong-ke Huang, Ji-bo Hu, Cen Lou
Summary: The BPL reconstruction algorithm significantly increased SUVmax, SUVmean, and SBR while decreasing MTV of tumor lesions, especially in small or relatively hypometabolic lesions. The differences between BPL and OSEM + TOF were higher compared to those between BPL and OSEM + TOF + PSF. Significant correlations were found between parameter variations and the size and degree of [F-18]FDG uptake in the lesions.
BMC MEDICAL IMAGING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Bingxin Gu, Xin Liu, Shuoer Wang, Xiaoping Xu, Xiaosheng Liu, Silong Hu, Wangjun Yan, Zhiguo Luo, Shaoli Song
Summary: This study evaluated the diagnostic value of [(68)Ga]Ga-DOTA-FAPI-04 PET/CT for recurrent soft tissue sarcoma (STS) and compared it with [F-18]FDG PET/CT. The results showed that [(68)Ga]Ga-DOTA-FAPI-04 PET/CT was more accurate than [F-18]FDG PET/CT in detecting recurrent lesions of liposarcoma, MSFT, and IDCS.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Christos Sachpekidis, Leyun Pan, Annette Kopp-Schneider, Vivienn Weru, Jessica C. C. Hassel, Antonia Dimitrakopoulou-Strauss
Summary: The study aims to determine an appropriate acquisition time range for the new long axial field of view Biograph Vision Quadra PET/CT scanner in melanoma patients. The results show that low-dose LAFOV PET/CT imaging is feasible and can provide comparable diagnostic data to standard lengths of acquisition in a shorter scanning time, which is significant for the diagnostic work-up of melanoma patients.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Engineering, Biomedical
Xueqi Chen, Sulei Zhang, Jianhua Zhang, Lixin Chen, Rongfu Wang, Yun Zhou
Summary: The study evaluates an optimization approach based on Patlak plot with reduced blood samples for noninvasive quantification of dynamic F-18-FDG PET imaging. The results show that the method is reliable and can potentially be extended to further translational human studies.
PHYSICS IN MEDICINE AND BIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Wyanne A. Noortman, Jacob M. Mostert, Jan Booij, Catherine B. Brouwer, Bart de Keizer, John M. H. de Klerk, Wim J. G. Oyen, Floris H. P. van Velden, Lioe-Fee De Geus-Oei, Dennis Vriens
Summary: The study aimed to evaluate whether quantitative [F-18]FDG-PET/CT assessment and radiomic analysis of [F-18]FDG-positive thyroid nodules could improve the preoperative differentiation of indeterminate thyroid nodules. The results showed that applying distinct SUV cut-offs for non-Hurthle cell and Hurthle cell nodules can optimize the ability to rule out malignancy, while radiomic analysis did not provide additional differentiation for [F-18]FDG-positive nodules.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Lioe-Fee de Geus-Oei, Adrienne H. Brouwers, Eveline W. C. M. van Dam, Lioe-Ting Dijkhorst-Oei, Adriana C. H. van Engen-van Grunsven, Wilbert B. van den Hout, Tamira K. Klooker, Romana T. Netea-Maier, Marieke Snel, Wim J. G. Oyen, Dennis Vriens
Summary: The study aimed to assess the impact of an [F-18]FDG-PET/CT-driven diagnostic workup on patients with indeterminate thyroid nodules. The results showed that this workup accurately reduced futile surgeries by 40% and should be limited to non-Hurthle cell nodules.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Rheumatology
Chantal A. M. Bouman, Noortje van Herwaarden, Annelies B. Blanken, Conny J. Van der Laken, Martin Gotthardt, Wim J. G. Oyen, Alfons A. den Broeder, Aatke van der Maas, Cornelia H. van den Ende
Summary: FDG-PET arthritis scoring in RA patients with low disease activity is reliable and has some construct validity, but no predictive values were found for FDG-PET parameters for successful tapering and/or discontinuation of TNFi.
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Dennis Vriens, Maarten O. van Aken, Lioe-Ting Dijkhorst-Oei, Wim J. G. Oyen, Robin P. Peeters, Abbey Schepers, Lioe-Fee De Geus-Oei, Wilbert B. van den Hout
Summary: This study evaluates the cost-effectiveness of an [F-18]FDG-PET/CT-driven diagnostic workup compared to diagnostic surgery for thyroid nodules with Bethesda III/IV cytology. The results show that [F-18]FDG-PET/CT avoids unnecessary diagnostic surgeries and reduces costs while maintaining quality of life.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Fijs W. B. van Leeuwen, Margret Schottelius, Felix M. Mottaghy, Fabien Hyafil, Mark Lubberink, Gabriela Kramer-Marek, Wim J. G. Oyen
Review
Oncology
Wietske I. Luining, Matthijs C. F. Cysouw, Dennie Meijer, N. Harry Hendrikse, Ronald Boellaard, Andre N. Vis, Daniela E. Oprea-Lager
Summary: Imaging plays a crucial role in the accurate staging of prostate cancer, and targeting the prostate-specific membrane antigen (PSMA) protein has become of great clinical value. PSMA-based imaging techniques have shown superior detection rates compared to previous methods, and PSMA has also become a target for delivering radionuclide therapy. This review summarizes recent developments in nuclear medicine related to PSMA in prostate cancer diagnostics and targeted radionuclide therapy, highlighting the potential benefits of PSMA-positron emission tomography (PET) imaging and PSMA-based radioligand therapy in the treatment of metastatic castration-resistant prostate cancer (mCRPC).
Article
Oncology
Maarten J. van der Doelen, Irma M. Oving, Dirk N. J. Wyndaele, Jean-Paul van Basten, Frederiek Terheggen, Addy C. M. van de Luijtgaarden, Wim J. G. Oyen, W. Dick van Schelven, Franchette van den Berkmortel, Niven Mehra, Marcel J. R. Janssen, Judith B. Prins, Winald R. Gerritsen, Jose A. E. Custers, Inge M. van Oort
Summary: This study evaluated the health-related quality of life, psychological distress, and fatigue in patients with metastatic castration-resistant prostate cancer (mCRPC) treated with radium-223. The study found that patients who discontinued radium-223 therapy had worse HR-QoL, psychological distress, and fatigue at baseline and more frequent deterioration over time compared to patients who completed therapy.
PROSTATE CANCER AND PROSTATIC DISEASES
(2023)
Article
Endocrinology & Metabolism
Elizabeth J. de Koster, Olga Husson, Eveline W. C. M. van Dam, G. Sophie Mijnhout, Romana T. Netea-Maier, Wim J. G. Oyen, Marieke Snel, Lioe-Fee de Geus-Oei, Dennis Vriens
Summary: The study examined HRQoL in patients undergoing FDG-PET/CT for an indeterminate thyroid nodule, finding that active surveillance following a negative FDG result resulted in stable HRQoL scores over a year. Patients with benign histopathology who underwent diagnostic surgery had more cognitive impairment and physical problems, but improved goitre symptoms and anxiety. Anxiety also decreased in patients with malignant histopathology.
ENDOCRINE CONNECTIONS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elizabeth J. de Koster, Adriana C. H. van Engen-van Grunsven, Johan Bussink, Cathelijne Frielink, Lioe-Fee de Geus-Oei, Benno Kusters, Hans Peters, Wim J. G. Oyen, Dennis Vriens
Summary: This study explored the association between [F-18]FDG uptake and the quantitative expression of immunohistochemical markers related to glucose metabolism, hypoxia, and cell proliferation in benign and malignant thyroid nodules of indeterminate cytology. The results showed that the expression of GLUT1, HK2, and MCT4 increased in [F-18]FDG-positive benign nodules and thyroid carcinomas as compared to [F-18]FDG-negative benign nodules, and VEGF expression was higher in thyroid carcinomas.
MOLECULAR IMAGING AND BIOLOGY
(2023)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Dennis Vriens, Elizabeth J. de Koster, Lioe-Fee de Geus-Oei, Wim J. G. Oyen, EfFECTS trial consortium
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Medicine, General & Internal
Lidija Antunovic, Alessia Artesani, Michael Coniglio, Wim J. G. Oyen, Michele Ciccarelli, Carlo Selmi, Arturo Chiti, Martina Sollini
Summary: This study evaluated the diagnostic accuracy of [F-18]-fluorodeoxyglucose ([F-18]FDG) PET/CT in large vessel vasculitis (LVV) and found that an experienced reader had higher accuracy compared to a less experienced one. The expert reader performed better in patients with normal BMI, normal glycemia, younger age, and no ongoing therapy. The use of semi-quantitative parameters did not improve the diagnostic performance of the readers.
Article
Radiology, Nuclear Medicine & Medical Imaging
H. Adams, E. M. W. van de Garde, D. J. Vugts, J. C. Grutters, Wim. J. G. Oyen, R. G. Keijsers
Summary: This study investigates the use of imaging CD20-positive cells in predicting the response to anti-CD20 treatment for immune-mediated interstitial lung disease. PET/CT imaging was performed on 21 patients, and it was found that the uptake of [89Zr]-rituximab in the lungs correlated with changes in pulmonary function test results and treatment outcomes. Patients with a higher uptake of [89Zr]-rituximab had better response to treatment. Therefore, [89Zr]-rituximab PET imaging may serve as a potential predictive biomarker for anti-CD20 therapy.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Oncology
Elizabeth J. de Koster, Willem E. Corver, Lioe-Fee de Geus-Oei, Wim J. G. Oyen, Dina Ruano, Abbey Schepers, Marieke Snel, Tom van Wezel, Dennis Vriens, Hans Morreau
Summary: This study described the patterns of copy number alterations (CNA) in benign and malignant oncocytic cell thyroid neoplasms (OCN) using a next-generation sequencing (NGS) panel. The study found that the CNA patterns differed between benign and malignant cases, and suggested the application of CNA-LOH analysis using the NGS panel in the molecular diagnostics of OCN.
ENDOCRINE-RELATED CANCER
(2023)
Article
Oncology
Stefano Fanti, Alberto Briganti, Louise Emmett, Karim Fizazi, Silke Gillessen, Karolien Goffin, Boris A. Hadaschik, Ken Herrmann, Jolanta Kunikowska, Tobias Maurer, Steven MacLennan, Nicolas Mottet, Declan G. Murphy, Daniela E. Oprea-Lager, Joe M. O'Sullivan, Wim J. G. Oyen, Olivier Rouviere, Oliver Sartor, Arnulf Stenzl, Hendrik Van Poppel, Jochen Walz, Wim Witjes, Anders Bjartell
Summary: The use and potential of PSMA PET/CT in prostate cancer treatment and management were assessed and achieved consensus among a panel of experts, particularly in utilizing PSMA PET/CT for patient selection and guiding [177Lu]Lu-PSMA therapy.
EUROPEAN UROLOGY ONCOLOGY
(2022)
Review
Oncology
Miriam N. Mikhail Lette, Diana Paez, Lawrence N. Shulman, Mathias Guckenberger, Jean-Yves Douillard, Wim J. G. Oyen, Francesco Giammarile, Venkatesh Rangarajan, Michelle Ginsberg, Olivier Pellet, Zhongxing Liao, May Abdel Wahab
Summary: This paper emphasizes the importance of improving medical imaging and nuclear medicine infrastructure globally to achieve better outcomes for lung cancer patients. It highlights the significant role of imaging findings in treatment selection and patient outcomes, and discusses the current gaps in diagnostics and therapies. The paper also emphasizes the high burden of lung cancer in low- and middle-income countries and the need for strategic planning to improve population-based outcomes.
JCO GLOBAL ONCOLOGY
(2022)