Article
Psychology, Biological
Sara Peck, Gregory J. Madden
Summary: Research has focused on reducing impulsive choice by increasing options of larger, more-delayed rewards. Providing rats with extended exposure to high-effort training temporarily reduced effort-based impulsive choice, but the effect was short-term.
BEHAVIOURAL PROCESSES
(2021)
Article
Behavioral Sciences
Macarena Moreno, Victor Azocar, Alvaro Verges, Jose Antonio Fuentealba
Summary: The study found that increased dopamine release in the dorsolateral striatum of high impulsive rats may contribute to impulsive choice, indicating a hyper-activated nigro-striatal pathway. However, differences in DA uptake and DA extracellular concentration were not significant.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Behavioral Sciences
C. Renee Renda, Jillian M. Rung, Sara Peck, Gregory J. Madden
Summary: Research shows that reducing impulsive choice through delay-exposure training can help ameliorate maladaptive behaviors. In rat experiments, it was found that 60 sessions of delay-exposure training significantly decreased impulsive choice, with this effect remaining prominent at the follow-up assessment.
Article
Behavioral Sciences
Lidia Belles, Chloe Arrondeau, Ginna Uruena-Mendez, Nathalie Ginovart
Summary: Impulsivity is a complex concept with multiple dimensions, and its underlying dopaminergic mechanisms in the general population are not well understood. This study investigated the relationships between impulsivity constructs and their dopaminergic basis using a rat model. The results showed that risky decision-making and delay discounting were positively correlated, while impulsive action was only correlated with risky decision-making. There were innate differences in impulsivity between the high-avoidance and low-avoidance rats. The effects of dopaminergic drugs varied across different impulsivity constructs, with D2/3R agonism showing baseline-dependent effects on impulsive action and impulsive choice.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Behavioral Sciences
Magdalen G. Schluter, David C. Hodgins
Summary: The study suggests a potential maintaining role of probabilistic discounting in gambling disorder, but does not support a maintaining role for delay discounting.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Guy A. Higgins, Matt Brown, Cam MacMillan, Leo B. Silenieks, Sandy Thevarkunnel
Summary: In this study, the effects of AMP and ATX were compared in different tasks, with ATX showing a reducing effect on impulsive behavior but no significant impact on impulsive choice and risky decision making, while AMP affecting choice preference and discounting, but in a nuanced manner.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2021)
Article
Psychology, Biological
Tyler S. Garman, Barry Setlow, Caitlin A. Orsini
Summary: Chronic exposure to a high-fat diet does not significantly affect impulsive choice, but it may increase motivation for a sucrose reward. Amphetamine has a similar effect on impulsive choice in both diet groups.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Psychology, Biological
Szymon Mizak, Pawel Ostaszewski, Przemyslaw Marcowski, Wojciech Bialaszek
Summary: Research suggests that loss aversion causes people to place greater importance on losses than on equivalent gains. When it comes to intertemporal choices, losses are discounted more slowly than gains, but only for smaller amounts- with no asymmetrical evaluation for larger amounts.
BEHAVIOURAL PROCESSES
(2021)
Article
Nutrition & Dietetics
Joseph S. Bellitti, Tera L. Fazzino
Summary: The study found no significant associations between discounting of money and hyper-palatable foods (HPF) and food addiction (FA) symptoms among a general population sample. This suggests that discounting HPF may not be a key behavioral feature among individuals who endorse FA symptoms.
Article
Psychology, Biological
Sara Peck, Emma Preston, Kelsey B. Smith, Gregory J. Madden
Summary: This study examined the effects of delay exposure training on impulsive choice in rats of different genders. The findings showed that delay-exposure training reduced impulsive choice in male rats, but only had a temporary effect in female rats.
BEHAVIOURAL PROCESSES
(2022)
Article
Behavioral Sciences
Fernanda Gonzalez-Barriga, Vladimir Orduna
Summary: Both positive and aversive delayed consequences play a crucial role in decision making. While there is extensive research on temporal discounting of positive consequences, the study of aversive consequences is limited. This study evaluated impulsive behavior in spontaneously hypertensive rats (SHR), an animal model of ADHD, and found that choice impulsivity was similar between strains for both positive and aversive consequences. However, SHR exhibited a higher level of impulsive action compared to the control strain.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Multidisciplinary Sciences
David A. O'Connor, Remi Janet, Valentin Guigon, Anael Belle, Benjamin T. Vincent, Uli Bromberg, Jan Peters, Brice Corgnet, Jean-Claude Dreher
Summary: The study used virtual reality technology to investigate the impact of spatial proximity on impulsive behavior, finding that participants were significantly less able to stop motor actions when rewarding cues were near compared with when they were far. This suggests that proximity plays a distinctive role in driving impulsive actions for rewards.
Article
Nutrition & Dietetics
Nikola Ljusic, Asle Fagerstrom, Valdimar Sigurdsson, Erik Arntzen
Summary: This study investigates the impact of technology-enabled healthy food labels on food choice in an online grocery store setting. The results show that self-monitoring, pre-commitment, and social comparison-based labels have varying levels of impact on food choice, with self-monitoring and pre-commitment labels being more effective for impulsive participants.
FRONTIERS IN NUTRITION
(2023)
Article
Psychology, Experimental
Daniel M. Bartels, Ye Li, Soaham Bharti
Summary: A comprehensive examination was conducted to assess the relationship between laboratory-derived estimates of time preference and self-reported behaviors in a large sample. Time preference was found to be significantly associated with about half of the behaviors, even after controlling for other demographic variables and psychological scales. The predictive validity of time preference falls in the middle of the 16 possible predictors. Time preference researchers tend to overestimate its predictive power. The implications of using time preference as a predictor or determinant of behaviors with delayed consequences are discussed.
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
(2023)
Article
Psychology, Mathematical
S. Tobias Johnson, Steven B. Most
Summary: Effort discounting refers to the devaluation of rewards that require effort to obtain. This study finds that the discounting of cognitive effort depends on the temporal distance to the effort, and it may be influenced by an individual's need for cognition. The results also suggest that both the amount of effort required and the immediacy of the effort contribute to the discounting of rewards. Individuals with low need for cognition exhibit more effort discounting overall, and the discounting increases linearly as the effort becomes imminent. In contrast, individuals with high need for cognition engage in less effort discounting, and the temporal distance to the effort does not influence their discounting behavior.
PSYCHONOMIC BULLETIN & REVIEW
(2023)
Article
Geriatrics & Gerontology
Abbi R. Hernandez, Jessica M. Hoffman, Caesar M. Hernandez, Constanza J. Cortes, Patricia Jumbo-Lucioni, Mark G. Baxter, Karyn A. Esser, Andrew C. Liu, Lori L. McMahon, Jennifer L. Bizon, Sara N. Burke, Thomas W. Buford, Christy S. Carter
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Geriatrics & Gerontology
Jessica M. Hoffman, Caesar M. Hernandez, Abbi R. Hernandez, Jennifer L. Bizon, Sara N. Burke, Christy S. Carter, Thomas W. Buford
Summary: Neurodegenerative diseases are commonly diagnosed in older individuals, but there is often a lack of collaboration between gerontologists and neuroscientists. Enhanced cooperation between the two fields could lead to more efficient research with translational potential.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Geriatrics & Gerontology
Caesar M. Hernandez, Abigail R. Hernandez, Jessica M. Hoffman, Peter H. King, Lori L. McMahon, Thomas W. Buford, Christy Carter, Jennifer L. Bizon, Sara N. Burke
Summary: The article discusses the history of neuroscience research on the neurobiology of aging and introduces gerontologists to the methodological approaches used by neuroscientists. The goal is to enhance collaboration between neuroscientists and gerontologists in order to strengthen the field of cognitive aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Samantha M. Smith, Sabrina Zequeira, Meena Ravi, Sarah A. Johnson, Andriena M. Hampton, Aleyna M. Ross, Wonn Pyon, Andrew P. Maurer, Jennifer L. Bizon, Sara N. Burke
Summary: This study examined cognition in aged rats using a cross-species touchscreen-based platform known as paired-associates learning (PAL) and trial-by-trial behavioral analysis approach. The results revealed age-related deficits in PAL task acquisition in male rats, which appeared to be caused by vulnerability to accumulating, proactive interference. This detailed behavioral analysis provides new insights into the etiology of age-associated cognitive deficits.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Caesar M. Hernandez, Joseph A. McQuail, Tyler W. Ten Eyck, Alexa-Rae Wheeler, Chase C. Labiste, Barry Setlow, Jennifer L. Bizon
Summary: The ability to choose between immediate and delayed gratification is crucial for well-being. This study investigates the neural mechanisms underlying age differences in intertemporal choice using a rat model. The findings suggest that GABA(B) receptors in the prelimbic cortex and basolateral amygdala contribute to these age differences, and the expression of GABA(B)R subunits differs in these brain regions among aged rats.
Article
Behavioral Sciences
Shelby L. Blaes, Kristy G. Shimp, Sara M. Betzhold, Barry Setlow, Caitlin A. Orsini
Summary: Individuals who use cocaine tend to overvalue rewards and underestimate potential risks. This study found that chronic cocaine self-administration in young adult male rats leads to long-term increases in risk taking. However, the route of cocaine administration and gender did not significantly affect cocaine's impact on risk taking.
BEHAVIORAL NEUROSCIENCE
(2022)
Article
Psychiatry
Nicole D. Fitzgerald, Yiyang Liu, Anna Wang, Catherine W. Striley, Barry Setlow, Lori Knackstedt, Linda B. Cottler
Summary: This study developed a new assessment tool (PSU-TPS) to detect detailed temporal patterns of polysubstance use. The PSU-TPS showed good reliability in measuring the frequency, quantity, and duration of polysubstance use in the past 30 days.
INTERNATIONAL JOURNAL OF METHODS IN PSYCHIATRIC RESEARCH
(2022)
Article
Clinical Neurology
Brianna Costales, Scott M. Vouri, Joshua D. Brown, Barry Setlow, Amie J. Goodin
Summary: This study examines the pharmacotherapy treatment patterns for early-onset idiopathic RLS and finds that ropinirole, pramipexole, and gabapentin are the most commonly initiated treatments. However, persistence is low and the use of FDA-approved drugs for RLS is less frequent.
Editorial Material
Behavioral Sciences
Barry Setlow, Jennifer L. Bizon
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Geriatrics & Gerontology
Karienn A. Souza, Andrew Powell, Gregg C. Allen, David J. Earnest
Summary: Preclinical quantitative models of cognitive performance are necessary for translation from basic research to clinical studies. To address the limitations of existing models in rodents, researchers developed a cognitive index based on mice's strategies in escaping the Barnes maze. The cognitive index was positively correlated with the memory portion of the task in all age groups. The study also found age-related alterations in circadian entrainment of the activity rhythm, which preceded learning and memory deficits in aged mice. The results suggest that circadian rhythm disturbances may serve as an early predictor of age-related cognitive decline.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Caitlin A. Orsini, Wonn S. Pyon, Richard J. Dragone, Mojdeh Faraji, Alexa-Rae Wheeler, Marjory Pompilus, Marcelo Febo, Jennifer L. Bizon, Barry Setlow
Summary: Altered decision making at advanced ages can impact quality of life and personal independence. Rodent models have been useful in understanding age-related changes in decision making, but have focused mostly on rewards and timing, neglecting the potential risk of adverse consequences. This study used a rat model to examine age-related changes in decision making and identified potential cognitive and neurobiological mechanisms, finding that aged rats displayed greater risk aversion and changes in brain connectivity.
Article
Neurosciences
Leah M. Truckenbrod, Sara M. Betzhold, Alexa-Rae Wheeler, John Shallcross, Sarthak Singhal, Scott Harden, Marek Schwendt, Charles J. Frazier, Jennifer L. Bizon, Barry Setlow, Caitlin A. Orsini
Summary: Decision making is a complex cognitive process that involves brain regions such as BLA and NAcSh. Recent research suggests that communication between these structures and activity of D2R-expressing cells in NAcSh are necessary for decision making. However, their contributions during decision making under risk of punishment are still unknown.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Diana P. P. Guerra, Wei Wang, Karienn A. A. Souza, Justin M. M. Moscarello
Summary: The bed nucleus of the stria terminalis (BNST) plays a role in aversive responses to uncertain threat. This study investigates the contribution of BNST to a task where subjects learn to prevent an aversive outcome. Chemogenetic inhibition of BNST reduces the avoidance response in male rats, while inactivation of the neighboring medial septum has no effect, suggesting that BNST specifically mediates avoidance behavior. Activation of BNST extends the tone-evoked shuttling period, suggesting a sex-specific role of the systems underlying proactive defensive behavior.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Brianna Costales, Scott M. Vouri, Joshua D. Brown, Barry Setlow, Amie J. Goodin
Summary: Limited long-term safety information exists for gabapentinoid treatment of idiopathic restless legs syndrome. This study found higher incidence rates of mental health-related emergency department visits and hospitalizations among early-onset idiopathic RLS patients treated with gabapentinoids compared to dopamine agonists. However, no statistically significant risk of mental health diagnoses was detected.
PSYCHIATRY RESEARCH
(2023)