Cerebrovascular contributions to Alzheimer's disease pathophysiology and potential therapeutic interventions in mouse models

Alzheimer's Disease, Cerebrovascular Disease, and the β-amyloid Cascade

(2014) Kie Honjo et al.   CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES

Cerebrospinal Fluid Levels ofβ-Amyloid 1-42, but Not of Tau, Are Fully Changed Already 5 to 10 Years Before the Onset of Alzheimer Dementia

(2012) Peder Buchhave   ARCHIVES OF GENERAL PSYCHIATRY

Impact of Angiotensin Receptor Blockers on Alzheimer Disease Neuropathology in a Large Brain Autopsy Series

(2012) Ihab Hajjar et al.   ARCHIVES OF NEUROLOGY

Amyloid-β-dependent compromise of microvascular structure and function in a model of Alzheimer’s disease

(2012) Adrienne Dorr et al.   BRAIN

The early contribution of cerebrovascular factors to the pathogenesis of Alzheimer’s disease

(2012) Pedro M. Pimentel-Coelho et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Contrast-Enhanced Magnetic Resonance Microangiography Reveals Remodeling of the Cerebral Microvasculature in Transgenic ArcA  Mice

(2012) J. Klohs et al.   JOURNAL OF NEUROSCIENCE

Apolipoprotein E, Not Fibrillar  -Amyloid, Reduces Cerebral Glucose Metabolism in Normal Aging

(2012) W. J. Jagust et al.   JOURNAL OF NEUROSCIENCE

Age-Dependent Rescue by Simvastatin of Alzheimer's Disease Cerebrovascular and Memory Deficits

(2012) X.-K. Tong et al.   JOURNAL OF NEUROSCIENCE

Florbetapir PET analysis of amyloid-β deposition in the presenilin 1 E280A autosomal dominant Alzheimer's disease kindred: a cross-sectional study

(2012) Adam S Fleisher et al.   LANCET NEUROLOGY

Brain imaging and fluid biomarker analysis in young adults at genetic risk for autosomal dominant Alzheimer's disease in the presenilin 1 E280A kindred: a case-control study

(2012) Eric M Reiman et al.   LANCET NEUROLOGY

Alzheimer’s drugs take a new tack

(2012) Ewen Callaway   NATURE

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Morphological and Pathological Evolution of the Brain Microcirculation in Aging and Alzheimer’s Disease

(2012) Jesse M. Hunter et al.   PLoS One

ApoE-Directed Therapeutics Rapidly Clear  -Amyloid and Reverse Deficits in AD Mouse Models

(2012) P. E. Cramer et al.   SCIENCE

Cerebrovascular Disease and Mechanisms of Cognitive Impairment

(2012) Raj N. Kalaria   STROKE

Vascular β-amyloid and early astrocyte alterations impair cerebrovascular function and cerebral metabolism in transgenic arcAβ mice

(2011) Mario Merlini et al.   ACTA NEUROPATHOLOGICA

Perivascular drainage of solutes is impaired in the ageing mouse brain and in the presence of cerebral amyloid angiopathy

(2011) Cheryl A. Hawkes et al.   ACTA NEUROPATHOLOGICA

Toward defining the preclinical stages of Alzheimer’s disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease

(2011) Reisa A. Sperling et al.   Alzheimers & Dementia

Effects of Age and Amyloid Deposition on Aβ Dynamics in the Human Central Nervous System

(2011) Yafei Huang   ARCHIVES OF NEUROLOGY

Brain microbleeds and Alzheimer’s disease: innocent observation or key player?

(2011) Charlotte Cordonnier et al.   BRAIN

Detection of Cerebral Microbleeds with Quantitative Susceptibility Mapping in the Arcabeta Mouse Model of Cerebral Amyloidosis

(2011) Jan Klohs et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Therapeutic Modulation of Cerebral Microhemorrhage in a Mouse Model of Cerebral Amyloid Angiopathy

(2011) Mark Fisher et al.   STROKE

Vascular Contributions to Cognitive Impairment and Dementia

(2011) Philip B. Gorelick et al.   STROKE

Object recognition memory and BDNF expression are reduced in young TgCRND8 mice

(2010) Beverly M. Francis et al.   NEUROBIOLOGY OF AGING

Vascular response to acetazolamide decreases as a function of age in the arcAβ mouse model of cerebral amyloidosis

(2010) Felicitas L. Princz-Kranz et al.   NEUROBIOLOGY OF DISEASE

Protective Effects of Intranasal Losartan in the APP/PS1 Transgenic Mouse Model of Alzheimer Disease

(2010) Lusine Danielyan et al.   REJUVENATION RESEARCH

Simultaneous Measurement of Arterial Transit Time, Arterial Blood Volume, and Cerebral Blood Flow Using Arterial Spin-Labeling in Patients with Alzheimer Disease

(2009) T. Yoshiura et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Alzheimer Disease–Associated Peptide, Amyloid β40, Inhibits Vascular Regeneration With Induction of Endothelial Autophagy

(2009) Shin-ichiro Hayashi et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade

(2009) Clifford R Jack et al.   LANCET NEUROLOGY

Selective targeting of perivascular macrophages for clearance of  -amyloid in cerebral amyloid angiopathy

(2009) C. A. Hawkes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracerebroventricular amyloid-  antibodies reduce cerebral amyloid angiopathy and associated micro-hemorrhages in aged Tg2576 mice

(2009) D. R. Thakker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mild Cognitive Impairment and Alzheimer Disease: Patterns of Altered Cerebral Blood Flow at MR Imaging

(2009) Weiying Dai et al.   RADIOLOGY

Cerebrovascular Dysfunction in Amyloid Precursor Protein Transgenic Mice: Contribution of Soluble and Insoluble Amyloid-  Peptide, Partial Restoration via  -Secretase Inhibition

(2008) B. H. Han et al.   JOURNAL OF NEUROSCIENCE

Capillary cerebral amyloid angiopathy is associated with vessel occlusion and cerebral blood flow disturbances

(2008) Dietmar Rudolf Thal et al.   NEUROBIOLOGY OF AGING

Nox2-derived radicals contribute to neurovascular and behavioral dysfunction in mice overexpressing the amyloid precursor protein

(2008) L. Park et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spatial Distribution of White-Matter Hyperintensities in Alzheimer Disease, Cerebral Amyloid Angiopathy, and Healthy Aging

(2008) Christopher M. Holland et al.   STROKE