Review
Biology
Mitsuhiro Fukuda, Alexander J. Poplawsky, Seong-Gi Kim
Summary: High-resolution functional magnetic resonance imaging (fMRI) is gaining popularity due to the availability of ultra-high magnetic fields, but the accuracy of detecting the true location of neuronal activity using increased spatial resolutions remains debatable.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jeffrey M. Dendy, Sean G. Hughes, Jonathan H. Soslow, Daniel E. Clark, Cynthia B. Paschal, John C. Gore
Summary: We propose a method for quantitatively measuring drug-induced microvascular volume changes and blood oxygenation using calibrated blood oxygen level-dependent MRI. Through the examination of healthy rats, we demonstrate the potential of this method to examine microvascular disease in different disease states without the use of radiopharmaceuticals or gadolinium-based contrast agents.
INVESTIGATIVE RADIOLOGY
(2022)
Article
Neurosciences
Chun-Qiang Lu, Chu-Hui Zeng, Ying Cui, Xiang-Pan Meng, Ying Luan, Xiao-Min Xu, Shenghong Ju
Summary: This study investigated the task-fMRI and rs-fMRI results on SD and Wistar rats under different anesthetic regimens, and found differences in brain activation and functional connectivity patterns between the two rat strains.
BRAIN CONNECTIVITY
(2022)
Article
Anatomy & Morphology
Siyang Li, Yali Chen, Peng Ren, Zhipeng Li, Jun Zhang, Xia Liang
Summary: Spontaneous brain activity exhibits modular organization that may be constrained by economy. Research found that during unconsciousness, modular variability increased and became more dependent on basal metabolism. This suggests that unconsciousness may lead to brain modular reorganization.
BRAIN STRUCTURE & FUNCTION
(2023)
Article
Biophysics
Viivi Hypponen, Petteri Stenroos, Riikka Nivajarvi, Jan Henrik Ardenkjaer-Larsen, Olli Grohn, Jaakko Paasonen, Mikko I. Kettunen
Summary: The use of hyperpolarised C-13 pyruvate in non-oncological neurological applications is not widespread, with studies showing differences in brain metabolism between awake and anaesthetized rats.
NMR IN BIOMEDICINE
(2022)
Article
Biology
Paul Shin, Qi Pian, Hidehiro Ishikawa, Gen Hamanaka, Emiri T. Mandeville, Shuzhen Guo, Buyin Fu, Mohammed Alfadhel, Srinivasa Rao Allu, Ikbal Sencan-Egilmez, Baoqiang Li, Chongzhao Ran, Sergei A. Vinogradov, Cenk Ayata, Eng Lo, Ken Arai, Anna Devor, Sava Sakadzic, Daniel Henrion
Summary: Aging is a risk factor for cognitive impairment. Aerobic exercise benefits brain function and may promote cognitive health in older adults. This study found that aerobic exercise can improve cerebral microcirculation and cognitive function in aging individuals.
Article
Multidisciplinary Sciences
Michael Iorga, James Higgins, David Caplan, Richard Zinbarg, Swathi Kiran, Cynthia K. Thompson, Brenda Rapp, Todd B. Parrish
Summary: Predicting language outcomes after speech and language therapy in post-stroke aphasia is challenging. This study found that behavioral language measures showed strong performance in predicting outcomes for naming impairment, while fALFF predictors performed well for agrammatism and dysgraphia. This suggests that rsfMRI may have prognostic value for aphasia therapy outcomes.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Zhenyi Zhao, Wenqing Gao, Yun Chang, Yue Yang, Hechen Shen, Tong Li, Song Zhao
Summary: A novel triple-functional membrane with Janus architecture is proposed for blood oxygenation, consisting of hydrophobic polydimethylsiloxane (PDMS), ultrathin polyamide (PAD), and hydrophilic poly(sulfobetaine methacrylate) (PSBMA) layers. The membrane exhibits excellent oxygenation performance in terms of adequate gas transfer rate and resistances to thrombus formation and plasma leakage, thereby demonstrating novel concepts for the advancement of oxygenation membranes.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Neurosciences
Jie Zhang, Zhen Zhou, Lingling Li, Jing Ye, Desheng Shang, Shuchang Zhong, Bo Yao, Cong Xu, Yamei Yu, Fangping He, Xiangming Ye, Benyan Luo
Summary: This study found increased right-hemispheric subcortical connectivity in stroke patients, which exhibited significantly negative correlations with total naming score. Perfusion changes in the right thalamic subregions affect naming performance through thalamo-cortical circuits in the non-dominant hemisphere.
HUMAN BRAIN MAPPING
(2022)
Article
Multidisciplinary Sciences
Gergely Somogyi, David Hlatky, Tamas Spisak, Zsofia Spisak, Gabriella Nyitrai, Andras Czurko
Summary: This study investigated the effects of scopolamine on brain activity using functional MRI in rats under different drug administration and anesthesia conditions. The results suggest that scopolamine may affect brain activation through central pathways, and its peripheral vascular actions depend on the type of anesthesia or dose.
SCIENTIFIC REPORTS
(2021)
Article
Food Science & Technology
Cristina Rezende, Gustavo Vieira de Oliveira, Monica Volino-Souza, Patricia Castro, Juan Manuel Murias, Thiago Silveira Alvares
Summary: The study showed that turmeric supplementation could improve cerebral oxygenation and blood volume during dynamic handgrip exercise in older males and females. Changes in heart rate and blood pressure were not significant. The findings suggest the potential of curcumin as an intervention for improving cerebral oxygenation and blood volume in older individuals.
INTERNATIONAL JOURNAL OF FOOD SCIENCES AND NUTRITION
(2022)
Article
Neurosciences
Atena Akbari, Saskia Bollmann, Tonima S. Ali, Markus Barth
Summary: Functional magnetic resonance imaging (fMRI) using blood-oxygenation-level-dependent (BOLD) contrast is a widely used noninvasive method for studying human brain function. However, spatial signal specificity in depth-dependent fMRI can be degraded due to signal leakage. VAscular-Space-Occupancy (VASO) contrast, which measures cerebral blood volume, has shown higher spatial specificity compared to BOLD. In this study, a cortical vascular model was used to predict layer-specific BOLD and VASO responses in the human primary visual cortex, and the model's predictions were compared with experimental results. The results confirmed that VASO is less affected by large vessel effects compared to BOLD.
HUMAN BRAIN MAPPING
(2023)
Article
Neurosciences
Hidemasa Miyata, Ryouji Tani, Shigeaki Toratani, Tetsuji Okamoto
Summary: Tongue pressure measurement is an indicator of oral function, but its association with cerebral activation is unclear. Using near-infrared spectroscopy, researchers found that tongue pressure stimulation caused changes in cerebral blood flow, with activation and deactivation observed in specific areas. The study suggests that tongue pressure stimulation activates the somatosensory motor area and deactivates the anterior prefrontal cortex.
Article
Toxicology
Kevin Lee, Sara Bohnert, Cory Vair, John Mikler, Jeff F. Dunn
Summary: Exposure to nerve agents can lead to debilitating neurological damage, especially without direct neuroprotection. Seizures induced by nerve agents may be the main contributor to neuropathology, highlighting the importance of addressing metabolic impairment and reduced blood supply in treatment.
TOXICOLOGY LETTERS
(2021)
Article
Physiology
Christopher Lopez, Tanja Taivassalo, Maria G. Berru, Andres Saavedra, Hannah C. Rasmussen, Abhinandan Batra, Harneet Arora, Alex M. Roetzheim, Glenn A. Walter, Krista Vandenborne, Sean C. Forbes
Summary: The study found that the postcontractile blood oxygen level-dependent (BOLD) response is impaired in boys with Duchenne muscular dystrophy (DMD) after brief muscle contractions, and this impairment is correlated to disease severity. This measure may be valuable for evaluating treatments targeting microvascular function in DMD.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Lingjue Li, Samuel M. Poloyac, Simon C. Watkins, Claudette M. St Croix, Henry Alexander, Gregory A. Gibson, Patricia A. Loughran, Levent Kirisci, Robert S. B. Clark, Patrick M. Kochanek, Alberto L. Vazquez, Mioara D. Manole
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2019)
Article
Engineering, Biomedical
James R. Eles, Alberto L. Vazquez, Takashi D. Y. Kozai, X. Tracy Cui
Article
Endocrinology & Metabolism
Bistra Iordanova, Alberto Vazquez, Takashi D. Y. Kozai, Mitsuhiro Fukuda, Seong-Gi Kim
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2018)
Article
Engineering, Biomedical
Nicholas J. Michelson, Alberto L. Vazquez, James R. Eles, Joseph W. Salatino, Erin K. Purcell, Jordan J. Williams, X. Tracy Cui, Takashi D. Y. Kozai
JOURNAL OF NEURAL ENGINEERING
(2018)
Article
Neurosciences
Matthew C. Murphy, Kevin C. Chan, Seong-Gi Kim, Alberto L. Vazquez
Article
Neurosciences
Alberto L. Vazquez, Mitsuhiro Fukuda, Seong-Gi Kim
Article
Neurosciences
Nicholas J. Michelson, James R. Eles, Alberto L. Vazquez, Kip A. Ludwig, Takashi D. Y. Kozai
JOURNAL OF NEUROSCIENCE RESEARCH
(2019)
Article
Multidisciplinary Sciences
Sergei V. Baranov, Oxana V. Baranova, Svitlana Yablonska, Yalikun Suofu, Alberto L. Vazquez, Takashi D. Y. Kozai, X. Tracy Cui, Lisa M. Ferrando, Timothy M. Larkin, Yulia Y. Tyurina, Valerian E. Kagan, Diane L. Carlisle, Bruce S. Kristal, Robert M. Friedlander
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Engineering, Biomedical
J. R. Eles, A. L. Vazquez, T. D. Y. Kozai, X. T. Cui
Article
Engineering, Biomedical
Kaylene C. Stocking, Alberto L. Vazquez, Takashi D. Y. Kozai
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2019)
Article
Endocrinology & Metabolism
Michael B. Krawchuk, Catherine F. Ruff, Xiaoling Yang, Sarah E. Ross, Alberto L. Vazquez
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2020)
Article
Neurosciences
Jordan J. Williams, Alan M. Watson, Alberto L. Vazquez, Andrew B. Schwartz
FRONTIERS IN NEUROSCIENCE
(2019)
Article
Neurosciences
Alexander John Poplawsky, Bistra Iordanova, Alberto L. Vazquez, Seong-Gi Kim, Mitsuhiro Fukuda
Summary: Functional MRI responses are primarily driven by the postsynaptic activities of synaptically-evoked inhibitory neurons, possibly through NMDA receptor-dependent calcium signaling that is not wholly dependent on nitric oxide.
Article
Engineering, Biomedical
Qianru Yang, Alberto L. Vazquez, Xinyan Tracy Cui
Summary: Advancements in in vivo imaging technologies, such as two-photon microscopy, have improved our understanding of biomaterials in the brain, but chronic studies show limitations in high-resolution imaging due to inflammatory responses caused by craniotomy and foreign biomaterial insertion. Microprisms offer a unique vertical view breaking through this imaging depth limitation, but responses to microprism implants in vivo remain unclear. Analysis of microglial/macrophage activation and morphology after microprism implantation revealed changes in cell density and processes, indicating eventual inactive phenotypes. Long-term observations using microprisms showed sustained microglial/macrophage responses to injuries, suggesting feasibility for inflammatory response characterizations at deeper depths than traditional methods.
Article
Multidisciplinary Sciences
Xin Sally Zheng, Qianru Yang, Alberto Vazquez, Xinyan Tracy Cui
Summary: This study is important for understanding the challenges of chronic microstimulation in terms of stability and safety. Silicon arrays coated with PEDOT/CNT or PC and IrOx were implanted into the cortex of GCaMP6s mice and electrical stimulation was applied for up to 12 weeks. The neuronal responses to stimulation were quantified using two-photon imaging and mesoscale fluorescence microscopy, and the performance of the electrodes over time was characterized. The results showed dynamic changes in stimulation stability over time and revealed the advantage of PC coated electrodes in terms of energy efficiency compared to IrOx coated electrodes. Abnormal cortical responses were also observed in some mice, suggesting the need for further investigation of potential neuronal damage and redefining the safety limit of stimulation.