Article
Nutrition & Dietetics
Aurelie De Valliere, Ana Catarina Lopes, Andrea Addorisio, Noah Gilliand, Monique Nenniger Tosato, Dean Wood, Julien Brechbuehl, Marie-Christine Broillet
Summary: Food preference is a conserved trait across different organisms, including humans. The ability to discriminate odors and make food choices is influenced by the olfactory marker protein (OMP) in mice. Mice lacking OMP display compensatory behaviors in odor discrimination and social contexts, leading to a compromised ability to differentiate olfactory messages, such as those involved in the social transmission of food preference.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Maria Roa Oyaga, Ines Serra, Devika Kurup, Sebastiaan K. E. Koekkoek, Aleksandra Badura
Summary: This study investigated the effect of sex, strain, and locomotion on delay eyeblink conditioning using male and female mice of C57BL/6J (B6) and B6CBAF1 strains. The results showed that females of both strains outperformed males in the initial stages of learning, but this sex difference disappeared as learning progressed. There was a strong positive correlation between learning scores and voluntary locomotion, regardless of training duration. The c-Fos immunostaining results revealed positive correlations between c-Fos expression and learning scores in the cerebellar cortex and brainstem, as well as previously unreported areas, after the short paradigm. However, after the long paradigm, c-Fos expression was significantly elevated only in the brainstem.
Article
Clinical Neurology
Milica Potrebic, Zeljko Pavkovic, Natasa Loncarevic-Vasiljkovic, Selma Kanazir, Vesna Pesic
Summary: This study used a peripubertal rat model to investigate the effects of early social isolation, revealing a range of behavioral and physiological changes in peripubertal rats, including anxiety, risk-taking behavior, reduced response to rewards, etc. These features deepen over time as a stable marker of the outcomes of reduced direct social contact during adolescence.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Endocrinology & Metabolism
Guolin Miao, Xi Zhao, Siu-Lung Chan, Lijun Zhang, Yaohua Li, Yuke Zhang, Lijun Zhang, Beibei Wang
Summary: The study demonstrates the critical role of the mtROS/c-Fos/LOX-1 signaling pathway in promoting oxLDL uptake and VSMC-derived foam cell formation during atherosclerosis, suggesting c-Fos as a potential therapeutic target for clinical translation in the future.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2022)
Article
Medicine, Research & Experimental
Eun-Taex Oh, Ha Gyeong Kim, Chul Hoon Kim, Jeonghun Lee, Chulhee Kim, Jae-Seon Lee, Yunmi Cho, Heon Joo Park
Summary: The overexpression of NQO1 is linked to tumor cell proliferation and growth in various human cancers. The molecular mechanisms underlying the role of NQO1 in cell cycle progression, specifically at the G2/M phase, are unclear. This study reveals a novel function of NQO1 in modulating CKS1, a cell cycle regulator, through its effect on the stability of c-Fos.
Article
Neurosciences
Nunzia Papotto, Sara Reithofer, Kaya Baumert, Richard Carr, Frank Mohrlen, Stephan Frings
Summary: This study showed that olfactory co-stimulation can alleviate aversive responses to noxious stimuli in mice and reduce neural activity in the SpVc, indicating a significant analgesic potential of odor stimulation in the trigeminal system.
Article
Anatomy & Morphology
Cecilia Pardo-Bellver, Manuel E. Vila-Martin, Sergio Martinez-Bellver, Maria Villafranca-Faus, Anna Teruel-Sanchis, Camila A. Savarelli-Balsamo, Sylwia M. Drabik, Joana Martinez-Ricos, Ana Cervera-Ferri, Fernando Martinez-Garcia, Enrique Lanuza, Vicent Teruel-Marti
Summary: This study investigates the integration of chemosensory information in rodents, specifically the olfactory and vomeronasal systems. The results suggest that the amygdala plays a crucial role in controlling the activity of the olfactory bulbs, highlighting its active involvement in the integration of chemosensory information.
FRONTIERS IN NEUROANATOMY
(2022)
Editorial Material
Oncology
Oliver H. Kraemer, Gunter Schneider
Summary: In this commentary, we summarize and discuss recent evidence on the regulation and relevance of the transcription factor c-FOS in diffuse large B cell lymphoma cells treated with epigenetic erasers of the histone deacetylase inhibitor family.
CLINICAL AND TRANSLATIONAL MEDICINE
(2022)
Review
Developmental Biology
Judith E. Mank, Elizabeth J. Rideout
Summary: Male-female differences exist in various developmental mechanisms, impacting organ formation, function, and whole-body physiology. Even traits that do not show obvious male-female differences are affected by sex-specific processes. Including both sexes is crucial for a comprehensive understanding of animal development.
Article
Biochemistry & Molecular Biology
Daniela Peruzzu, Maria Luisa Dupuis, Marina Pierdominici, Katia Fecchi, Maria Cristina Gagliardi, Elena Ortona, Maria Teresa Pagano
Summary: This study investigated the different effects of calcitriol in modulating T cell immunity of age-matched male and female healthy donors. The results showed that calcitriol increased vitamin D receptor expression levels and reduced pro-inflammatory cytokine expression levels in T lymphocytes of both sexes. Furthermore, calcitriol only increased the expression level of the anti-inflammatory cytokine IL-10 in T lymphocytes from female healthy donors. These findings provide new insights into the sex-specific anti-inflammatory role of calcitriol in T cell immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Chin-Hee Song, Nayoung Kim, Ryoung Hee Nam, Soo In Choi, Jae Young Jang, Jin Won Kim, Hee Young Na, Ha-Na Lee
Summary: 17 beta-estradiol has a protective effect in colorectal cancer and combination therapy with anti-PD-L1 antibodies can inhibit tumor growth and reduce PD-L1 expression in MC38 colon tumor model. These effects are influenced by sex and estrogen levels.
Article
Biochemistry & Molecular Biology
Yan Lin, Fengkang Lin, Zhuoran Zhang, Lijia Peng, Wenli Yang, Mao Yang, Bo Luo, Ting Wu, Dabing Li, Xuesen Li, Bing Ran, Songyot Anuchapreeda, Rujirek Chaiwongsa, Pinyaphat Khamphikham, Suwit Duangmano, Jianming Xu, Tao He, Sakorn Pornprasert
Summary: FGFR1 is a receptor tyrosine kinase that is deregulated in certain breast cancers with poor prognosis. However, the key genes regulated by FGFR1 in breast cancer are largely unknown. In this study, we found that activation of FGFR1 upregulated FOXQ1 expression and that FOXQ1 is essential for FGFR1-stimulated cell proliferation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Endocrinology & Metabolism
Shuai Lu, Xi Chen, Maoqi Gong, Shuo Chen, Jianyu Zhang, Xigong Zhang, Chengai Wu, Aimin Cui, Xieyuan Jiang
Summary: This study explored the differences in parathyroid tissue-derived cells between male and female patients with primary hyperparathyroidism (PHPT). The results showed that there was no substantial difference in cell population, function, or communication between the two sexes. However, in female patients, pathways and cellular interactions were up-regulated in fibroblast cells, endothelial cells, parathyroid cells, and myeloid cells. Subcluster analysis of parathyroid cells identified different subpopulations in males and females. Cellular functions were also elevated in females compared to males. The findings suggest that sex differences in PHPT may be caused by differentially expressed genes and activated pathways in different cell types in the parathyroid tissue.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Public, Environmental & Occupational Health
Hoang T. Phan, Seana Gall, Christopher L. Blizzard, Natasha A. Lannin, Amanda G. Thrift, Craig S. Anderson, Joosup Kim, Rohan Grimley, Helen C. Castley, Monique F. Kilkenny, Dominique A. Cadilhac
Summary: This study found sex differences in cause of death and cause-specific mortality after first-ever stroke. Women had higher mortality rates associated with stroke and other cardiovascular diseases, which were mainly explained by age and stroke severity. Greater implementation of secondary stroke prevention is important for both sexes.
JOURNAL OF WOMENS HEALTH
(2021)
Article
Immunology
Veronika A. Myasoedova, Ilaria Massaiu, Donato Moschetta, Mattia Chiesa, Paola Songia, Vincenza Valerio, Valentina Alfieri, Romain Capoulade, Daniela Trabattoni, Daniele Andreini, Elvira Mass, Valentina Parisi, Paolo Poggio
Summary: The study found that aortic valve fibrosis in severe AS patients is sex-specific, with women exhibiting higher fibrotic tissue composition and lower aortic valve calcium content compared to men. Gene expression analysis showed that pro-fibrotic processes are predominant in women, while pro-inflammatory processes linked to the immune response system are enhanced in men. Cell type enrichment analysis revealed that mesenchymal cells are over-represented in stenotic aortic valves of women, while signatures for monocytes, macrophages, T and B cells are enriched in men.
FRONTIERS IN IMMUNOLOGY
(2022)
Editorial Material
Veterinary Sciences
C. M. Moody, G. J. Mason, C. E. Dewey, L. Niel
Article
Agriculture, Dairy & Animal Science
Victoria L. Shouldice, A. Michelle Edwards, James A. Serpell, Lee Niel, J. Andrew B. Robinson
Review
Agriculture, Dairy & Animal Science
Sarah M. L. Tan, Anastasia C. Stellato, Lee Niel
Article
Veterinary Sciences
Carly M. Moody, Cate E. Dewey, Lee Niel
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2020)
Article
Veterinary Sciences
Alisha R. Matte, Deep K. Khosa, Jason B. Coe, Michael Meehan, Lee Niel
Article
Multidisciplinary Sciences
Eve Robinson, James R. Templeman, Emma Thornton, Candace C. Croney, Lee Niel, Anna Kate Shoveller
Article
Veterinary Sciences
Alisha R. Matte, Deep K. Khosa, Jason B. Coe, Michael Meehan, Lee Niel
Article
Agriculture, Dairy & Animal Science
Eve Robinson, Emma Thornton, James R. Templeman, Candace C. Croney, Lee Niel, Anna K. Shoveller
Summary: Sled dogs gradually decrease their voluntary activity during training but show a recovery of this activity during consecutive rest days. These findings can be used to optimize conditioning programs and enhance the overall well-being of sled dogs.
Article
Agriculture, Dairy & Animal Science
Kristina A. O'Hanley, David L. Pearl, Lee Niel
Summary: This study examined the influence of early and adult management factors on aggressive behavior in cats, finding that female cats were more likely to show aggression towards their owners, while households with three or more cats and owners using positive reinforcement had lower odds of aggression. Additionally, aggression towards novel people, objects, and situations was more prevalent when owners used positive punishment.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2021)
Review
Endocrinology & Metabolism
Phoebe D. Edwards, Sophia G. Lavergne, Laura K. McCaw, Sanoji Wijenayake, Rudy Boonstra, Patrick O. McGowan, Melissa M. Holmes
Summary: This review discusses the impact of five major maternal cues on offspring phenotype during the perinatal period: maternal androgen levels, photoperiod, microbiome, immune regulation, and milk composition. The mechanisms of action for each of these cues in mammals are explored, along with their interactions with each other and with maternal diet and stress. The review also highlights the importance of considering these effects in non-model species and natural ecological systems.
FRONTIERS IN NEUROENDOCRINOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Andrea Polanco, Brenda McCowan, Lee Niel, David L. Pearl, Georgia Mason
Summary: Monkeys in captivity often display abnormal behaviors, which are poorly categorized by current subcategories. Therefore, researchers have investigated and identified new valid subcategories to accurately assess animal welfare.
Article
Veterinary Sciences
Madalyn Couture, Anastasia C. Stellato, Carly M. Moody, Lee Niel
Summary: This study used an online survey to assess cat owners' attitudes towards different cat handling techniques during veterinary appointments. The results showed that participants generally disagreed with higher restraint techniques and agreed with lower restraint methods. Logistic regression models found that pet attachment, nationality, and age were factors that influenced participants' attitudes towards specific handling techniques.
JOURNAL OF APPLIED ANIMAL WELFARE SCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Alissa Cisneros, Dorothy Litwin, Lee Niel, Anastasia C. Stellato
Summary: This study explored the influence of owner management strategies, owner characteristics, and cat characteristics on unwanted scratching behavior in cats. The results suggest that providing appropriate scratching surfaces, enrichment items, outdoor access, and positive reinforcement training can reduce reports of unwanted scratching. Older cats and restricting access to items not to be scratched were also associated with fewer reports of unwanted scratching.
Article
Veterinary Sciences
Maggie Henry, Terri L. O'Sullivan, Anna Kate Shoveller, Lee Niel, Robert M. Friendship
Summary: This case study describes a severe tail-biting event on a multi-site swine operation in Ontario and the management strategies implemented to control the problem. Factors such as environmental conditions, management practices, and animal health were considered in understanding the occurrence of the tail-biting event. Changes in feeding schedule, enrichment devices, and increased surveillance were implemented to address the tail-biting issue. The subsequent batch of pigs showed a lower incidence of tail-biting compared to the previous group.
CANADIAN VETERINARY JOURNAL-REVUE VETERINAIRE CANADIENNE
(2022)
Article
Veterinary Sciences
Anastasia C. Stellato, Cate E. Dewey, Tina M. Widowski, Lee Niel
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION
(2020)