Article
Neurosciences
Ruth Fabian-Fine, Anna M. Aiken, Julia R. Aug, Jason D. Boucher, Danielle C. Butler, Liam J. Clancy, Shaun A. Clem, Samantha C. Crotty, Abigail M. Dalpe, Elizabeth J. Donzello-Jewett, Taylor M. Galgay, Bonnie K. Gillis, Brigid W. Heinrich, Kai R. Hines, Jordan E. Kimmel, Joseph M. McGrath, Marissa M. Miles, Jordyn A. Morey, Isaiah A. Ortiz, Kevin Q. Pham, Liam C. Quinn, Colin J. Radican, Nolan T. Speidel, Bailey J. Thomas, Angela R. Troisi, Joshua L. Weiss, Kayne V. Wentzheimer, Adam L. Weaver
Summary: Neurodegenerative diseases are a major cause of death in the United States, but the cellular mechanisms behind neurodegeneration are not well understood. To investigate these mechanisms, researchers used a spider model organism and found that neuron degeneration may be triggered by dissociation of microtubules and weakening of desmosomal junctions. They also discovered that glial cells may play a role in clearing neuronal debris, similar to the glymphatic system in mammals. This model system could be valuable for studying neurodegeneration in both invertebrates and mammals.
JOURNAL OF COMPARATIVE NEUROLOGY
(2023)
Review
Biochemistry & Molecular Biology
Scotland Farley, Carsten Schultz, Jeremy M. Baskin, Jeremy M. Baskin
Summary: This study introduces strategies to manipulate lipid levels in live cells by light, focusing on photoremovable protecting groups for subcellular restricted localization and activation, along with alternative techniques and organelle targeting development. Recent advances in chromatic orthogonality of caging groups for future applications are also discussed.
CURRENT OPINION IN CHEMICAL BIOLOGY
(2021)
Article
Chemistry, Analytical
Jin-Ye Lu, Jia-Xin Wang, Yang Li, Qiu-Yun Chen, Ling-Ling Qu, Su-Ci Meng, Ming-Qi Wang
Summary: Phthalates esters (PAEs) have been detected using a BODIPY fluorescent dye, forming nano fluorescent dyes upon binding, and the binding ratio with DBP affects the detection sensitivity of PAEs. This study suggests that attenuating the isomerization of water caged BODIPY dyes could be a potential strategy for the development of turn-on fluorescence sensors.
SENSORS AND ACTUATORS B-CHEMICAL
(2021)
Article
Engineering, Biomedical
Artem K. Efremov, Mingxi Yao, Yuze Sun, Yee Han Tee, Michael P. Sheetz, Alexander D. Bershadsky, Boris Martinac, Jie Yan
Summary: This study verifies the mechanosensitivity of L-type Ca2+ channels in Filopodia and reveals the interplay between mechanical forces and Ca2+ signaling in Filopodia, providing novel mechanistic insights into the guidance function of Filopodia in cell migration.
Review
Physiology
Balazs Horvath, Norbert Szentandrassy, Csaba Dienes, Zsigmond M. Kovacs, Peter P. Nanasi, Ye Chen-Izu, Leighton T. Izu, Tamas Banyasz
Summary: The patch clamp technique has undergone continuous advancement in cardiac electrophysiology, allowing for the recording of multiple currents under various command pulses. Its potential applications in integrative physiology are highlighted in this review.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Nanoscience & Nanotechnology
Jiaru Fang, Xinwei Wei, Hongbo Li, Ning Hu, Xingxing Liu, Dongxin Xu, Tao Zhang, Hao Wan, Ping Wang, Xi Xie
Summary: Cardiovascular diseases pose a significant threat to human health, but drug development is time-consuming and costly. Researchers have developed a drug assessment platform based on an electrical-mechanical synchronized biosensing system, which allows for high-throughput and time-dependent assessment. The system can record and analyze dynamic responses of cardiomyocytes to drugs, enabling rapid and effective drug screening.
MICROSYSTEMS & NANOENGINEERING
(2021)
Article
Biochemistry & Molecular Biology
Lea Rethore, Joohee Park, Jerome Montnach, Sebastien Nicolas, Joseph Khoury, Elodie Le Seac'h, Kamel Mabrouk, Harold De Pomyers, Helene Tricoire-Leignel, Cesar Mattei, Daniel Henrion, Ziad Fajloun, Michel De Waard, Claire Legendre, Christian Legros
Summary: This study investigates the interaction between Na+ and Ca2+ channels in GH3b6 cells, revealing a crosstalk between Na-V and LTCC and providing new insights into the mode of action of neurotoxins.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Tai-Qun Yang, Xiao-Dan Hu, Bing-Qian Shan, Bo Peng, Jia-Feng Zhou, Kun Zhang
Summary: The research found that structurally bound water molecules exhibit strong tunable photoluminescence, ultra-long lifetimes, and characteristics dependent on H-bond interactions in confined nanocavities. This emission behavior is due to topological excitations resulting from many-body quantum electron correlations in confined nanocavities, differing from local excitation of organic chromophores.
Article
Multidisciplinary Sciences
Hironori Takahashi, Mako Kamiya, Minoru Kawatani, Keitaro Umezawa, Yoshiaki Ukita, Shinsuke Niwa, Toshiyuki Oda, Yasuteru Urano
Summary: By developing BODIPY-derived caged compounds that release bioactive phenol derivatives upon illumination in the yellow wavelength range, optical control of neural activity in Caenorhabditis elegans can be achieved without inducing a photophobic response or crosstalk between uncaging and simultaneous fluorescence monitoring.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Chemistry, Analytical
Ryo Nishihara, Ryoji Kurita
Summary: The study developed a luciferase-independent copper detection platform using a novel luminogenic caged coelenterazine analogue (TPA-H1) to detect free copper ions in serum with high specificity and sensitivity. This new method can be a simple mix-and-read approach for quantitatively analyzing copper ions.
Article
Biochemistry & Molecular Biology
George Papageorgiou, John E. T. Corrie
Summary: Neuroactive amino acids derivatised with a photolabile nitroindolinyl group at their carboxylate groups are effective for sub-micromolar release of neuroactive amino acids in physiological solutions. However, this does not apply to calcium ion chelators. In this study, nitroindolinyl-caged BAPTA is found to be completely photostable, while nitroindolinyl-caged EDTA photolyses only in the presence of saturated calcium ions.
Article
Multidisciplinary Sciences
Jerome Montnach, Maxime Lorenzini, Adrien Lesage, Isabelle Simon, Sebastien Nicolas, Eleonore Moreau, Celine Marionneau, Isabelle Baro, Michel De Waard, Gildas Loussouarn
Summary: The whole-cell voltage-clamp technique requires consideration of the impact of current amplitude on data accuracy, especially in high throughput patch-clamp applications to prevent inaccuracies. Mathematical kinetic models can predict how large current amplitudes and series resistance artifacts affect voltage-dependent activation and inactivation processes, providing simple guidelines for practice.
SCIENTIFIC REPORTS
(2021)
Article
Neurosciences
Minh-Son To, Suraj Honnuraiah, Greg J. Stuart
Summary: This study investigates the impact of voltage clamp errors on synaptic conductance estimates during concurrent excitation and inhibition onto dendrites. The results show that dendritically located conductances are consistently underestimated, especially inhibitory conductances. The study also reveals correlations and distortions in the estimated conductance time course.
Article
Multidisciplinary Sciences
Takushi Shimomura, Kiichi Hirazawa, Yoshihiro Kubo
Summary: This study reveals that different conformations of DII-S4 determine the gating modes in Two-pore channels (TPCs), with the intermediate state representing the PIP2-gating mode. TPC3 is primarily voltage-dependent, while TPC2 is PIP2-gated and nonvoltage-dependent. Furthermore, the antidepressant desipramine induces voltage dependence in TPC2, and the flavonoid naringenin biases the mode preference from PIP2-gating to desipramine-induced voltage gating.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Physiology
Ettore Tiraboschi, Luana Leonardelli, Gianluca Segata, Albrecht Haase
Summary: Insects, particularly bees, have been found to have a significant neuronal response to mechanical stimuli in addition to odors. This study using fast two-photon calcium imaging in honey bees revealed that clean air pulses generate a complex pattern of glomerular activation, providing a code for stimulus intensity and dynamics. The discovery of a dual function in the insect olfactory system gives hope for a better understanding of sensory mechanisms in animals.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Computer Science, Cybernetics
Andrew S. French, Keram Pfeiffer
BIOLOGICAL CYBERNETICS
(2018)
Article
Neurosciences
Irina I. Ignatova, Andrew S. French, Roman Frolov
JOURNAL OF NEUROPHYSIOLOGY
(2018)
Article
Physiology
Vaishnavi Sukumar, Hongxia Liu, Shannon Meisner, Andrew S. French, Paivi H. Torkkeli
FRONTIERS IN PHYSIOLOGY
(2018)
Article
Behavioral Sciences
Paulus Saari, Esa-Ville Immonen, Joni Kemppainen, Kyosti Heimonen, Marianna Zhukovskaya, Ekaterina Novikova, Andrew S. French, Paivi H. Torkkeli, Hongxia Liu, Roman V. Frolov
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2018)
Article
Biology
Paulus Saari, Esa-Ville Immonen, Andrew S. French, Paivi H. Torkkeli, Hongxia Liu, Kyosti Heimonen, Roman Frolov
JOURNAL OF EXPERIMENTAL BIOLOGY
(2018)
Article
Physiology
Roman Frolov, Esa-Ville Immonen, Paulus Saari, Paivi H. Torkkeli, Hongxia Liu, Andrew S. French
JOURNAL OF GENERAL PHYSIOLOGY
(2018)
Article
Neurosciences
Anneka Hennenfent, Hongxia Liu, Paivi H. Torkkeli, Andrew S. French
INVERTEBRATE NEUROSCIENCE
(2020)
Article
Neurosciences
Ben Warren, Georgina E. Fenton, Elizabeth Klenschi, James F. C. Windmill, Andrew S. French
JOURNAL OF NEUROSCIENCE
(2020)
Article
Behavioral Sciences
Irina I. Ignatova, Andrew S. French, Paivi H. Torkkeli, Hongxia Liu, Roman V. Frolov
JOURNAL OF COMPARATIVE PHYSIOLOGY A-NEUROETHOLOGY SENSORY NEURAL AND BEHAVIORAL PHYSIOLOGY
(2020)
Article
Neurosciences
Andrew S. French, Ben Warren
Summary: In this study, transcript abundances in locust ears exposed to noise were measured and compared with control ears, revealing an increase in genes responsible for cuticular construction and a decrease in genes involved in lipid and protein metabolism. The findings suggest remodeling of the ear tympanum and a significant reduction in metabolic activity in response to overstimulation.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jessica A. G. Johnson, Hongxia Liu, Ulli Hoger, Samantha M. Rogers, Kajanan Sivapalan, Andrew S. French, Paivi H. Torkkeli
Summary: Mechanosensory neurons in spiders predominantly express the Piezo protein as the MET channel, with no significant detection of other MET channel families. The Piezo protein is widely expressed in the spider nervous system, potentially contributing to mechanosensory transduction in mechanosensilla and serving other functions in peripheral and central neurons. Blocking MET channels did not affect mechanically activated currents in VS-3 neurons, but reduced action potential firing under electrical stimulation.
SCIENTIFIC REPORTS
(2021)