Review
Neurosciences
Jessica A. L. Tucker, Derek P. D. Bornath, Seth F. F. McCarthy, Tom J. J. Hazell
Summary: Leptin is an important hormone for appetite regulation and energy balance. It interacts with various appetite-regulating hormones such as ghrelin, cholecystokinin, and GLP-1. The relationships between leptin and other neuropeptides are not well understood yet.
NUTRITIONAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Paola Sousa Santos, Caio Cesar Ruy, Cintia Rabelo Paiva Caria, Alessandra Gambero
Summary: The study found that sucralose consumption can reduce weight gain in high-fat diet-fed mice, but has no effect on weight gain in mice fed with a normal diet. In high-fat diet-fed mice, sucralose supplementation improved glycemic homeostasis, hepatic steatosis, and increased energy expenditure.
Review
Food Science & Technology
Mingkai Zhang, Ling Zhu, Gangcheng Wu, Hui Zhang, Xingguo Wang, Xiguang Qi
Summary: Glucose and energy metabolism disorders are the main causes of type 2 diabetes and obesity. Dietary nutrients can regulate glucose homeostasis and food intake through intestinal nutrient sensing. Protein sensing in the intestines plays a crucial role in secreting hormones and regulating glucose homeostasis and food intake. Various research models, such as co-culture cell models, intestinal organoids, and gut-on-a-chips, have been used to study intestinal protein sensing.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Nutrition & Dietetics
Sarah Hubner, Julie Blaskewicz Boron, Karsten Koehler
Summary: This systematic review examined the impact of exercise on appetite in older adults, finding that exercise and physical activity may modulate resting hunger and satiety in this population. Decreases in fasting leptin and glucose hormones suggest that exercise promotes satiety sensitivity in adults aged 60+. The findings suggest that engaging in exercise programs may provide a meaningful avenue for improving chronic and functional disease burden in later life by promoting appetite control and balanced energy intake.
FRONTIERS IN NUTRITION
(2021)
Article
Endocrinology & Metabolism
Maria Andrikopoulou, Sunil K. Panigrahi, Giselle D. Jaconia, Cynthia Gyamfi-Bannerman, Richard M. Smiley, Gabrielle Page-Wilson
Summary: The study revealed that during early pregnancy, there are specific adaptations in the central regulation of energy balance, including reduced transport of leptin into the brain and decreased melanocortin tone favoring increased appetitive drive.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Biochemistry & Molecular Biology
Junewoo Na, Byong Seo Park, Doohyeong Jang, Donggue Kim, Thai Hien Tu, Youngjae Ryu, Chang Man Ha, Marco Koch, Sungchil Yang, Jae Geun Kim, Sunggu Yang
Summary: This study extensively characterizes the AgRP, POMC, and dopaminergic neurons in the hypothalamic arcuate nucleus (Arc). The distinct anatomical and physiological properties of these neurons in response to appetite-regulating hormones are identified. This research highlights the importance of hypothalamic Arc neurons in appetite control.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Tania Sanchez-Murguia, Nathaly Torres-Castillo, Lisset Magana-de la Vega, Sarai Citlalic Rodriguez-Reyes, Wendy Campos-Perez, Erika Martinez-Lopez
Summary: This study analyzed the relationship between polymorphisms in ghrelin and leptin receptor genes and dietary intake and appetite assessment. The results showed that these polymorphisms were associated with differential responses to a standardized meal, characterized by higher postprandial ghrelin levels and increased dietary sugar intake.
Review
Medicine, General & Internal
Gilmara Gomes de Assis, Eugenia Murawska-Cialowicz
Summary: A well-balanced metabolism lowers the risk of metabolism-related neuropsychiatric disorders. Leptin, a secretory adipokine involved in appetite control, plays a role in feeding-related disorders. Exercise influences feeding behaviors by modulating metabolite circulation and positively affects appetite through leptin signaling. Exercise at high intensity counteracts leptin resistance.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Wasan Naser, Saeed Maymand, Leni R. Rivera, Timothy Connor, Clifford Liongue, Craig M. Smith, Kathryn Aston-Mourney, Daniel R. McCulloch, Sean L. McGee, Alister C. Ward
Summary: CISH plays an important role in maintaining homeostasis by negatively regulating appetite control and glucose metabolism, in addition to its known function in immune cells.
Article
Nutrition & Dietetics
Giovanna M. F. Duarte, Ketolly de Freitas, Ana C. B. Marini, Bruna M. Giglio, Renata C. Fernandes, Patricia C. B. Lobo, Joao F. Mota, Gustavo D. Pimentel
Summary: This study compared the effects of acute supplementation of whey protein (WP) or hydrolysed collagen on appetite and energy consumption, finding no significant differences in hunger perception, desire to eat, full stomach feeling, or food consumption between the two groups. However, hydrolysed collagen supplementation led to higher leptin levels compared to WP, suggesting a potential role in regulating satiety.
BRITISH JOURNAL OF NUTRITION
(2022)
Article
Nutrition & Dietetics
Mohammed S. S. Albreiki, Ghalia H. H. Shamlan, Ahmed S. S. BaHammam, Nawaf W. W. Alruwaili, Benita Middleton, Shelagh M. M. Hampton
Summary: This study investigates the effect of exogenous melatonin on appetite control by examining plasma leptin and subjective appetite parameters. The results suggest a positive impact of exogenous melatonin on subjective appetite and plasma leptin.
FRONTIERS IN NUTRITION
(2022)
Article
Biochemistry & Molecular Biology
Wanxiu Cao, Fang Liu, Robert W. Li, Ruili Yang, Yuming Wang, Changhu Xue, Qingjuan Tang
Summary: The study found that triacylglycerol rich in DHA (DHA-TG) can reduce food intake in mice fed with a high-fat, high-sugar diet (HFHS), regulate neuropeptide expression, and modulate hormone secretion and digestive system processes. Additionally, DHA-TG improved leptin secretion, attenuated central leptin resistance, and protected intestinal epithelial barrier function in nutritive obese mice.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Article
Cell Biology
Ji Hyeon Kang, Hyung Sik Kim, Seon Hyang Park, Ye Seon Kim, Yoe-Sik Bae
Summary: Obesity is a metabolic disorder caused by an imbalance of energy intake and consumption, and its chronic inflammation can lead to various complications. This study investigates the effects of WKYMVm, an anti-inflammatory agent, against obesity. The results show that WKYMVm attenuates body weight gain, improves insulin sensitivity, ameliorates hepatic steatosis and adipose tissue hypertrophy induced by a high fat diet. WKYMVm also improves lipid metabolism and leptin signaling, suggesting its potential as an anti-obesity agent.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Yanni Zhang, Qiulei Xi, Ming Zhong, Yi Jiang, Qiulin Zhuang, Zuoyou Ding, Shanjun Tan, Junjie Wang, Hao Liu, Zhige Zhang, Ben Zhou, Guohao Wu
Summary: Cachexia is common in cancer patients and its molecular basis is still unclear. This study investigated the regulatory pathway of tumors on appetite-inhibiting neurons (POMC) in the hypothalamus. Results showed that the tumor-expressed SEMA3D is positively related to POMC expression. Knocking out SEMA3D in mice increased food intake and body weight, and reduced muscle and fat catabolism. SEMA3D enhances POMC neuron activity by activating NRP2 and PlxnD1 expression. This research reveals that SEMA3D may play a vital role in appetite suppression and catabolic metabolism.
Article
Physiology
Iain Templeman, Harry A. Smith, Jean-Philippe Walhin, Benita Middleton, Javier T. Gonzalez, Leonidas G. Karagounis, Jonathan D. Johnston, James A. Betts
Summary: In a controlled experimental setting, it was shown that healthy adults with normal weight exhibit diurnal rhythms in appetite regulation over a 24-hour period, including changes in plasma unacylated ghrelin and leptin, as well as subjective appetite components like hunger and prospective food consumption.
JOURNAL OF APPLIED PHYSIOLOGY
(2021)
Correction
Endocrinology & Metabolism
C. Tsuji, T. Tsuji, A. Allchorne, G. Leng, M. Ludwig
JOURNAL OF NEUROENDOCRINOLOGY
(2018)
Review
Biology
Gareth Leng, Duncan J. MacGregor
MATHEMATICAL BIOSCIENCES
(2018)
Review
Endocrinology & Metabolism
Gareth Leng, John A. Russell
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Review
Endocrinology & Metabolism
Gareth Leng
ENDOCRINE CONNECTIONS
(2018)
Review
Multidisciplinary Sciences
Gareth Leng, Rhodri Ivor Leng, Stewart Maclean
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
(2019)
Article
Neurosciences
Jorge Maicas Royo, Gareth Leng, Duncan J. MacGregor
JOURNAL OF PHYSIOLOGY-LONDON
(2019)
Article
Biochemical Research Methods
Duncan J. MacGregor, Gareth Leng
PLOS COMPUTATIONAL BIOLOGY
(2019)
Article
Chemistry, Multidisciplinary
Shumsuzzaman Khan, Xinjiang Lu, Qingyao Huang, Jiawei Tang, Jian Weng, Zhi Yang, Minchao Lv, Xiaokang Xu, Fangyuan Xia, Mengchen Zhang, Yi Li, Shuangshuang Liu, Gareth Leng, Nicholas Spitzer, Jizeng Du, Xuequn Chen
Article
Endocrinology & Metabolism
Catherine Hume, Andrew Allchorne, Valery Grinevich, Gareth Leng, Mike Ludwig
JOURNAL OF NEUROENDOCRINOLOGY
(2019)
Article
Endocrinology & Metabolism
Luis Paiva, Gareth Leng
JOURNAL OF NEUROENDOCRINOLOGY
(2020)
Article
Neurosciences
Yan Tang, Diego Benusiglio, Arthur Lefevre, Louis Hilfiger, Ferdinand Althammer, Anna Bludau, Daisuke Hagiwara, Angel Baudon, Pascal Darbon, Jonas Schimmer, Matthew K. Kirchner, Ranjan K. Roy, Shiyi Wang, Marina Eliava, Shlomo Wagner, Martina Oberhuber, Karl K. Conzelmann, Martin Schwarz, Javier E. Stern, Gareth Leng, Inga D. Neumann, Alexandre Charlet, Valery Grinevich
NATURE NEUROSCIENCE
(2020)
Article
Physiology
Takahiro Tsuji, Chiharu Tsuji, Maja Lozic, Mike Ludwig, Gareth Leng
PHYSIOLOGICAL REPORTS
(2019)
Review
Physiology
Catherine Hume, Gareth Leng
CURRENT OPINION IN PHYSIOLOGY
(2019)
Article
Endocrinology & Metabolism
Jorge Maicas-Royo, Gareth Leng, Duncan J. MacGregor
Meeting Abstract
Clinical Neurology
G. Leng
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2019)