Article
Biochemistry & Molecular Biology
Silja Skogstad Tuv, Marianne Skov-Skov Bergh, Jannike Morch Andersen, Synne Steinsland, Vigdis Vindenes, Michael H. Baumann, Marilyn A. Huestis, Inger Lise Bogen
Summary: In this study, it was found that Methiopropamine closely resembles methamphetamine with regard to its pharmacokinetics, pharmacodynamic effects and mechanism of action, but with a potency that is approximately five times lower than that of methamphetamine, which may heighten the risk of unintended overdose in NPS users.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Andrey Sequeira-Cordero, Juan C. Brenes
Summary: The study focused on the time-dependent neurochemical changes induced by amphetamine which revealed region and dose-dependent alterations in gene expression. Individual differences in neurotransmission and gene expression in brain pathways may influence behavioral sensitization to amphetamine.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Neurosciences
Michael Hrabak, Connor Moon, Carlos A. Bolanos-Guzman, Heinz Steiner
Summary: Selective serotonin reuptake inhibitors (SSRIs) such as fluoxetine have been found to potentiate the addiction liability of methylphenidate, a dopamine reuptake blocker. However, a novel SSRI called vilazodone does not enhance methylphenidate-induced addiction-related gene regulation, indicating its diminished addiction facilitating properties. The 5-HT1A receptor may serve as a potential therapeutic target for addiction treatment.
MOLECULAR NEUROBIOLOGY
(2023)
Editorial Material
Cell Biology
Elvira Brattico, Leonardo Bonetti, Gabriella Ferretti, Peter Vuust, Carmela Matrone
Summary: Physical exercise, such as sports or musical activities, can modulate brain functions and have positive effects on mood regulation, well-being, memory, and cognitive preservation. Exercise can increase BDNF levels, promoting the growth of neurons and synapses, benefiting memory, learning, and higher cognitive functions.
Article
Behavioral Sciences
Andrey Sequeira-Cordero, Juan C. Brenes
Summary: The study found that a single administration of amphetamine is enough to induce neuroplastic adaptations in the nucleus accumbens of vulnerable rats, affecting gene expression and neurotransmitter contents.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2022)
Article
Behavioral Sciences
Rabia Yilmaz, Didem Behice Oztop, Elif Funda Sener, Merve Cikili-Uytun, Fatma Dal, Emrah Yildiz, Musa Sahpolat, Gokmen Zararsiz
Summary: The study indicates that BDNF gene expression is more associated with psychiatric disorders rather than suicide attempt in children and adolescents. The suicide group showed significantly higher scores in problem-solving skills and childhood trauma experiences compared to the control group.
BEHAVIOURAL BRAIN RESEARCH
(2021)
Article
Multidisciplinary Sciences
Basma El-Helkan, Manal Emam, Marwa Mohanad, Shadia Fathy, Abdel Rahman Zekri, Ola S. Ahmed
Summary: This study evaluated a panel of long non-coding RNAs and two mRNAs as prognostic biomarkers for breast cancer. The results showed that the expression levels of some lncRNAs and mRNAs changed significantly in breast cancer patients, and they may serve as potential prognostic markers for breast cancer.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Siamak Sheikhi, Leila Derafshpour, Razieh Aghazadeh, Hojat Sayyadi, Ehsan Saboory, Morteza Bagheri
Summary: This study examined the effects of choline on hippocampal brain-derived neurotrophic factor (BDNF) gene expression in maternal hypothyroidism rats. The results showed that choline increased the ratio of BDNF gene expression in the hippocampus, leading to improved brain development and cognitive function in pre-pubertal offspring rats.
MOLECULAR BIOLOGY REPORTS
(2023)
Article
Nutrition & Dietetics
Shirelle X. Liu, Amanda K. Barks, Scott Lunos, Jonathan C. Gewirtz, Michael K. Georgieff, Phu Tran
Summary: Early-life iron deficiency leads to long-term gene dysregulation, including downregulation of JARID1B and BDNF genes in the rat hippocampus. Prenatal choline supplementation does not prevent the chromatin modifications induced by iron deficiency, but induces long-lasting repressive modifications in iron-sufficient rats, suggesting a separate mechanism for rescuing neural gene regulation. The negative epigenetic effects of choline supplementation in iron-sufficient rats warrant further investigation before considering it as an adjunctive therapeutic agent.
Article
Psychiatry
Kelly J. Heard, Maxim N. Shokhirev, Caroline Becronis, Callie Fredlender, Nadia Zahid, Amy T. Le, Yuan Ji, Michelle Skime, Timothy Nelson, Daniel Hall-Flavin, Richard Weinshilboum, Fred H. Gage, Krishna C. Vadodaria
Summary: The study explores the impact of chronic stress on cortisol-induced neuropathology, finding unique differences at the transcriptomic level between chronic and acute cortisol treatment, and investigates the stress response transcriptome of astrocytes from MDD patient iPSCs. These data emphasize the unique role of astrocytes in the central nervous system and present potential genes for further research on the relationship between chronic stress and MDD.
TRANSLATIONAL PSYCHIATRY
(2021)
Article
Genetics & Heredity
Buse Yuksel, Murat Dogan, Olcay Boyacioglu, Mustafa Sahin, Seda Orenay-Boyacioglu
Summary: Tinnitus is the perception of sound in the absence of external stimuli. The genes BDNF and BDNF-AS may play a role in the auditory pathway and affect hearing performance. This study suggests that certain polymorphisms in the BDNF-AS gene (rs925946, rs1488830, rs1519480, and rs10767658) may have an impact on the auditory pathway and affect hearing performance.
Article
Neurosciences
Jeanne P. Vu, Flannery McLamb, Zuying Feng, Lindsey Griffin, Sylvia Gong, Damian Shea, Mary A. Szuch, Savannah Scott, Richard M. Gersberg, Goran Bozinovic
Summary: The study found that the newer polymerization aid, HFPO-DA, does not accumulate in fruit flies and has sex-specific effects on lifespan, locomotion, and brain gene expression.
Article
Clinical Neurology
Felipe Balistieri Santinelli, Emerson Sebastiao, Lucas Simieli, Barbara Moura Antunes, Luiz Henrique Palucci Vieira, Alon Kalron, Fabio Augusto Barbieri
Summary: This study aimed to investigate the relationship between BDNF and gait spatial-temporal parameters and TUG in pwMS and HC. The results showed that BDNF was not related to clinical or gait parameters, suggesting that BDNF may not play a role in these parameters' performance.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2022)
Article
Biochemistry & Molecular Biology
Igor Sokolowski, Aleksandra Kucharska-Lusina, Elzbieta Miller, Ireneusz Majsterek, Bruno Bonetti
Summary: This study reveals strong correlations between gene expression and protein concentration in MS patients, emphasizing the relevance of these neuroprotective markers in the disease.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Connor Moon, Matt Marion, Panayotis K. Thanos, Heinz Steiner
Summary: Combining FLX with MP potentiates MP-induced gene regulation in the striatum. Chronic oral administration of MP alone may increase dynorphin and substance P expression, but not enkephalin expression. When given together, FLX greatly enhances MP-induced expression of dynorphin and substance P, predominantly in direct pathway neurons.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Clinical Neurology
D. Erskine, J. P. Taylor, M. J. Firbank, L. Patterson, M. Onofrj, J. T. O'Brien, I. G. McKeith, J. Attems, A. J. Thomas, C. M. Morris, A. A. Khundakar
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2016)
Article
Biochemistry & Molecular Biology
D. Erskine, A. A. Khundakar
JOURNAL OF CHEMICAL NEUROANATOMY
(2016)
Article
Neurosciences
Ahmad A. Khundakar, Peter S. Hanson, Daniel Erskine, Nichola Z. Lax, Joseph Roscamp, Evangelia Karyka, Eliona Tsefou, Preeti Singh, Simon J. Cockell, Andrew Gribben, Lynne Ramsay, Peter G. Blain, Urs P. Mosimann, Deborah J. Lett, Matthias Elstner, Douglass M. Turnbull, Charles C. Xiang, Michael J. Brownstein, John T. O'Brien, John-Paul Taylor, Johannes Attems, Alan J. Thomas, Ian G. McKeith, Christopher M. Morris
ACTA NEUROPATHOLOGICA COMMUNICATIONS
(2016)
Article
Clinical Neurology
Lauren Walker, Kirsty E. McAleese, Mary Johnson, Ahmad A. Khundakar, Daniel Erskine, Alan J. Thomas, Ian G. McKeith, Johannes Attems
JOURNAL OF NEURAL TRANSMISSION
(2017)
Article
Clinical Neurology
Daniel Erskine, Alan J. Thomas, Johannes Attems, John-Paul Taylor, Ian G. McKeith, Christopher M. Morris, Ahmad A. Khundakar
MOVEMENT DISORDERS
(2017)
Article
Clinical Neurology
Michael S. Unger, Julia Marschallinger, Julia Kaindl, Barbara Klein, Mary Johnson, Ahmad A. Khundakar, Steffen Rossner, Michael T. Heneka, Sebastien Couillard-Despres, Edward Rockenstein, Eliezer Masliah, Johannes Attems, Ludwig Aigner
ALZHEIMERS & DEMENTIA
(2018)
Article
Clinical Neurology
Daniel Erskine, Jinhui Ding, Alan J. Thomas, Alice Kaganovich, Ahmad A. Khundakar, Peter S. Hanson, John-Paul Taylor, Ian G. McKeith, Johannes Attems, Mark R. Cookson, Christopher M. Morris
MOVEMENT DISORDERS
(2018)
Article
Clinical Neurology
Elizabeth Gemmell, Edward Tam, Louise Allan, Roslyn Hall, Ahmad Khundakar, Arthur E. Oakley, Alan Thomas, Vincent Deramecourt, Raj N. Kalaria
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY
(2014)
Article
Neurosciences
Daniel Erskine, John-Paul Taylor, Alan Thomas, Daniel Collerton, Ian McKeith, Ahmad Khundakar, Johannes Attems, Christopher Morris
NEUROSCIENCE BULLETIN
(2019)
Article
Neurosciences
P. C. Keane, P. S. Hanson, L. Patterson, P. G. Blain, P. Hepplewhite, A. A. Khundakar, S. J. Judge, P. J. Kahle, F. E. N. LeBeau, C. M. Morris
NEUROSCIENCE LETTERS
(2019)
Article
Geriatrics & Gerontology
Yumi Yamamoto, Yoshiki Hase, Masafumi Ihara, Ahmad Khundakar, Sigrun. Roeber, Marco Duering, Raj N. Kalaria
Summary: CADASIL is the most common form of hereditary cerebral small vessel disease, with notable loss of subsets of projection neurons within the hippocampal formation found in patients, potentially contributing to memory deficits.
NEUROBIOLOGY OF AGING
(2021)
Article
Multidisciplinary Sciences
Agathe Quesnel, Nathan Coles, Tuomo M. Polvikoski, George S. Karagiannis, Claudio Angione, Meez Islam, Ahmad A. Khundakar, Panagiota S. Filippou
Summary: The study revealed that MUC4 and MMP9 are significantly upregulated during glioma progression, with MUC4 co-expressed with MMP9 and EGFR in the proliferative microvasculature of glioblastoma. The high expression of MUC4/MMP9 and MUC4/MMP9/EGFR was associated with poor overall survival.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Agathe Quesnel, Nathan Coles, Claudio Angione, Priyanka Dey, Tuomo M. Polvikoski, Tiago F. Outeiro, Meez Islam, Ahmad A. Khundakar, Panagiota S. Filippou
Summary: Raman spectroscopy combined with machine learning can discriminate different grades of gliomas and understand their molecular changes, particularly in glycosylation. This technique holds promise as a tool for assisting glioma diagnosis and evaluation.
Article
Geriatrics & Gerontology
Daniel Erskine, Alan J. Thomas, John-Paul Taylor, Michael A. Savage, Johannes Attems, Ian G. McKeith, Christopher M. Morris, Ahmad A. Khundakar
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY
(2017)
Review
Neurosciences
Ahmad A. Khundakar, Alan J. Thomas
JOURNAL OF ALZHEIMERS DISEASE
(2015)