Article
Behavioral Sciences
Olga Rodriguez-Borillo, Lorena Rosello-Jimenez, Julian Guarque-Chabrera, Maria Palau-Batet, Isis Gil-Miravet, Raul Pastor, Marta Miquel, Laura Font
Summary: After cocaine exposure, increased cFos activity was observed in the granular cell layer at the top of the posterior vermis (lobules VIII and IX) in mice, and this activity was positively correlated with cFos expression in the medial prefrontal cortex. These findings suggest that certain regions of the cerebellum may be involved in the regulation of cocaine-conditioned behavior.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2023)
Article
Neurosciences
Yang Chen, Libo Zhang, Zengbo Ding, Xianwen Wu, Guibin Wang, Jie Shi
Summary: 3-MMC, a synthetic cathinone, has addictive potential and affects anxiety-like behavior. The study revealed that 3-MMC can induce rewarding effect and exhibit anxiolytic-like effect, but long-term exposure increased anxiety-like behavior. Brain mapping showed increased c-Fos expression in anterior cingulate cortex, nucleus accumbens, and ventral tegmental area. Additionally, 3-MMC inhibited inhibitory synaptic transmission in nucleus accumbens.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Psychology, Biological
Chayaporn Reakkamnuan, Dania Cheaha, Nifareeda Samerphob, Nusaib Sa-ih, Ekkasit Kumarnsit
Summary: This study aimed to investigate the neural adaptive mechanisms associated with the formation of morphine conditioned place preference. The findings suggested that NAc LFP signaling and neural connectivities between the NAc and HC may play a role in morphine CPP.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Behavioral Sciences
Hayley N. Manke, Samuel S. Nunn, Robert A. Jones, Kenner C. Rice, Anthony L. Riley
Summary: This study examined the response of mice to synthetic cathinones, and found that mice displayed significant aversive and rewarding effects, similar to previous studies in rats. The results of this study are important for predicting abuse potential and understanding the impact of various factors on drug abuse.
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
(2023)
Article
Pharmacology & Pharmacy
Meng-Jing Zhao, Mi-Ya Wang, Le Ma, Khalil Ali Ahmad, Yong-Xiang Wang
Summary: The study showed that BAA attenuated morphine-induced withdrawal symptoms, CPP expression, and locomotor sensitization by stimulating microglial dynorphin A expression in the brain. This suggests that BAA may be a potential candidate for treating opioids-induced physical dependence and addiction.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Chen Yin Ou, Ying Hao Yu, Chi-Wen Wu, Anna Kozlowska, Bai-Chung Shyu, Andrew Chih Wei Huang
Summary: The study aimed to re-examine the paradoxical effect hypothesis of abused drugs by investigating the impact of different doses of morphine on neuronal activity and connectivity between subareas of the medial prefrontal cortex (mPFC), subregions of the nucleus accumbens (NAc), and the basolateral amygdala (BLA) after conditioned taste aversion (CTA) and conditioned place preference (CPP) tests. The results revealed differential effects of morphine doses on c-Fos expression in various brain regions. Furthermore, correlation analysis demonstrated distinct patterns of neural connectivity between different doses of morphine and the CTA and CPP tests. These findings expand our understanding of the paradoxical effects of abused drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Wenbin Jia, Ichiro Kawahata, An Cheng, Takuya Sasaki, Toshikuni Sasaoka, Kohji Fukunaga
Summary: We confirmed that the FABP3 inhibitor, MF1, successfully reduces nicotine-induced conditioned place preference in mice. MF1 treatment decreased CPP scores in a dose-dependent manner by inhibiting the activation of CaMKII and ERK in the nucleus accumbens and hippocampus.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Ellen R. Cullity, Alexandre A. Guerin, Christina J. Perry, Jee Hyun Kim
Summary: Adolescents may be more sensitive to the rewarding effects of methamphetamine, while females may be less likely to form an aversion compared to males. These results are in line with sex-specific findings in human research.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Neurosciences
Zahra Ebrahimi, Nazanin Kahvandi, Elahe Shahriari, Alireza Komaki, Seyed Asaad Karimi, Marzieh Naderishahab, Maryam Sharifi, Abdolrahman Sarihi
Summary: Nucleus accumbens (NAc) neurons play a critical role in reward circuitry, and new evidence suggests that mGlu4 receptors in NAc are involved in the regulation of morphine-induced conditioned place preference (CPP) through glutamate-mediated transmission.
BRAIN RESEARCH BULLETIN
(2023)
Article
Behavioral Sciences
Nazanin Kahvandi, Zahra Ebrahimi, Seyed Asaad Karimi, Siamak Shahidi, Iraj Salehi, Marzieh Naderishahab, Abdolrahman Sarihi
Summary: The study found that administration of the mGlu8 receptor agonist S-3,4-DCPG in the NAc dose-dependently reduced the acquisition phase of morphine-induced CPP, but had no effect on the expression phase.
BEHAVIORAL AND BRAIN FUNCTIONS
(2021)
Article
Neurosciences
Elizabeth A. Sneddon, Kristen M. Schuh, John W. Frankel, Anna K. Radke
Summary: The study found that inhibiting the NAc core can reduce compulsive ethanol intake in mice, but exciting the NAc core has no effect. Inhibiting neurons expressing D-1 or D-2 receptors does not alter compulsive ethanol intake.
Article
Clinical Neurology
Luisa Alessandra Atehortua Martinez, Emmanuel Curis, Nawel Mekdad, Claire Larrieu, Cindie Courtin, Laurent Jourdren, Corinne Blugeon, Jean-Louis Laplanche, Bruno Megarbane, Cynthia Marie-Claire, Nadia Benturquia
Summary: The study investigated the variability in the expression of the rewarding effects of cocaine in the conditioned place preference (CPP) paradigm and identified differentially expressed genes in the nucleus accumbens (NAc) between rats that did or did not express cocaine-induced place preference. The findings provide insights into the mechanisms underlying interindividual variability in response to cocaine's rewarding effects, with immediate early genes showing differential expression in CPPE rats.
JOURNAL OF PSYCHOPHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Zi-Xuan He, Ke Xi, Kai-Jie Liu, Mei-Hui Yue, Yao Wang, Yue-Yue Yin, Lin Liu, Xiao-Xiao He, Hua-Li Yu, Zhen-Kai Xing, Xiao-Juan Zhu
Summary: Neural circuits in the nucleus accumbens (NAc) play a crucial role in predicting and responding to aversive stimuli. This study identifies the Tac1 neurons in the NAc medial shell as regulators of avoidance responses. The NAcTac1 neurons project to the lateral hypothalamic area and mediate avoidance behaviors. Additionally, the medial prefrontal cortex is involved in regulating avoidance responses through excitatory inputs to the NAc. Overall, this study uncovers a specific NAc Tac1 circuit that detects aversive stimuli and drives avoidance behaviors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Yun Yao, Ge Gao, Kai Liu, Xin Shi, Mingxiu Cheng, Yan Xiong, Sen Song
Summary: The nucleus accumbens shell plays a crucial role in reward and aversion, with D2 neurons having varied effects on behavior based on their location within the NAcSh. Activation of D2 neurons in different regions of the NAcSh can induce different behaviors and affect movement speed. This study sheds light on the controversy surrounding the function of NAcSh D2 neurons and provides new insights into the heterogeneous nature of the NAcSh.
NEUROSCIENCE BULLETIN
(2021)
Article
Neurosciences
Jing Dai, Ran Xie, Zhou-Na Sun, Xiao-Lin Kou, Jia-Qi Zhang, Cui Qi, Rui Liu, Xiang Gao, Jing Wang, Jun Gao
Summary: Studies have shown that protein phosphorylation is important in morphine abuse, but the role of protein phosphatase 2A (PP2A) in the morphine-priming process is unclear. In this study, conditional knockout mice were used to investigate the role of hippocampal PP2A in morphine priming. The results suggest that hippocampal PP2A may be involved in morphine priming through the PP2A/HDAC4/Rack1 pathway.
Article
Neurosciences
Laura M. Best, Leah L. Zhao, Tina Scardochio, Paul B. S. Clarke
PSYCHOPHARMACOLOGY
(2017)
Article
Neurosciences
Annie Constantin, Paul B. S. Clarke
PSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Jennifer M. Wright, Suelynn Ren, Annie Constantin, Paul B. S. Clarke
PSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
YiQi C. Lin, Leah L. Zhao, Paul B. S. Clarke
PSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Maria Willadsen, Laura M. Best, Markus Woehr, Paul B. S. Clarke
PSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Yufei Wang, Benson Wan, Jodie Huang, Paul B. S. Clarke
PSYCHOPHARMACOLOGY
(2020)
Article
Multidisciplinary Sciences
Jace Jones-Tabah, Hanan Mohammad, Shadi Hadj-Youssef, Lucy E. H. Kim, Ryan D. Martin, Faiza Benaliouad, Jason C. Tanny, Paul B. S. Clarke, Terence E. Hebert
SCIENTIFIC REPORTS
(2020)
Article
Biochemical Research Methods
Jace Jones-Tabah, Hanan Mohammad, Paul B. S. Clarke, Terence E. Hebert
Summary: Genetically encoded fluorescent biosensors combined with fiber photometry allow real-time tracking of intracellular signaling dynamics and recording of drug responses, with wide applicability to various mammalian species and neuroscience research.
Article
Pharmacology & Pharmacy
Jace Jones-Tabah, Ryan D. Martin, Jason C. Tanny, Paul B. S. Clarke, Terence E. Hebert
Summary: Genetically encoded biosensors coupled with high-content microscopy revealed intercellular variations in signaling responses among neurons exposed to drug treatments, highlighting distinct cellular responses in subpopulations of neurons. Single-cell analysis demonstrated unexpected roles of PKA and ERK1/2 signaling in striatal neurons, suggesting a novel form of crosstalk between these pathways in the nucleus. High-content single-cell imaging provides a new perspective for studying cellular signaling beyond traditional population-level analyses.
MOLECULAR PHARMACOLOGY
(2021)
Article
Neurosciences
Cynthia Kwan, Catherine Levesque, Dominique Bedard, Imane Frouni, Jemal M. Yesuf, Adjia Hamadjida, Daniel Levesque, Paul Bs Clarke, Philippe Huot
Summary: Serotonin type 3 antagonists can alleviate dyskinesia induced by L-DOPA and enhance its anti-parkinsonian action. The results suggest that alterations in 5-HT3 mediated neurotransmission may contribute to the pathophysiology of L-DOPA induced dyskinesia.
NEUROSCIENCE RESEARCH
(2022)
Article
Neurosciences
Jace Jones-Tabah, Hanan Mohammad, Emma G. Paulus, Paul B. S. Clarke, Terence E. Hebert
Summary: This review summarizes the signaling of the dopamine D1 receptor in various neuronal populations and discusses its potential applications in the treatment of Parkinson's Disease and cognitive impairment.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2022)
Article
Cell Biology
Jace Jones-Tabah, Ryan D. Martin, Jennifer J. Chen, Jason C. Tanny, Paul B. S. Clarke, Terence E. Hebert
Summary: The activity of striatal medium-spiny projection neurons is regulated by D1 and D2 dopamine receptors. The BET protein family, specifically Brd4, has been identified as novel regulators of basal and D1R-dependent transcription in rat striatal neurons. The bromodomain inhibitor JQ1 suppresses the expression of D1R-upregulated genes and increases the expression of immediate-early genes. cAMP/PKA signaling promotes Brd4 recruitment to dopamine-induced genes, and knockdown of Brd4 attenuates D1R-induced gene expression. JQ1 treatment also downregulates expression of many GPCRs and impairs ERK1/2 signaling in striatal neurons.
CELLULAR SIGNALLING
(2022)
Article
Multidisciplinary Sciences
Adithi Sundarakrishnan, Paul B. S. Clarke
Summary: This study assessed the relationship between sucrose preference and ultrasonic vocalizations in adult rats without inducing depression. The results showed no correlation between sucrose preference and ultrasonic vocalizations, suggesting that these measures may capture different constructs relevant to animal models of depression.
Article
Biochemistry & Molecular Biology
Shahriar M. Khan, Ryan D. Martin, Andrew Bayne, Darlaine Petrin, Kyla Bourque, Jace Jones-Tabah, Celia Bouazza, Jacob Blaney, Jenny Lau, Kimberly Martins-Cannavino, Sarah Gora, Andy Zhang, Sarah MacKinnon, Phan Trieu, Paul B. S. Clarke, Jean-Francois Trempe, Jason C. Tanny, Terence E. Hebert
Summary: In this study, a negative regulatory role for the Gil1 gamma dimer in the fibrotic response was identified in primary rat neonatal cardiac fibroblasts. Gil1 was found to colocalize and interact with RNA polymerase II on fibrotic genes in an angiotensin II-dependent manner. This finding expands the role of Gil gamma signaling in cardiac fibrosis and suggests its importance in other cell types.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2023)
Article
Neurosciences
Doran J. Satanove, Simon Rahman, T. M. Vanessa Chan, Suelynn Ren, Paul B. S. Clarke
Summary: The study found that the reinforcement-enhancing effect of low-dose nicotine depends on nicotinic receptor stimulation and on neurotransmission via D1/D5 dopaminergic, opioid, alpha1-adrenergic, and CB1 cannabinoid receptors in adult male rats.
PSYCHOPHARMACOLOGY
(2021)