Article
Behavioral Sciences
Ngoc Chien Pham, Yong Gyu Kim, Sang Jeong Kim, Chang-Hee Kim
Summary: Using learning paradigms with the same total training time, this study demonstrated that the spacing effect is more robust in the adaptation of OKR than VOR, and the learning effect is also maintained longer in OKR than VOR.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Devonte Campbell, Bernadette Ann Murphy, James Burkitt, Nicholas La Delfa, Praveen Sanmugananthan, Ushani Ambalavanar, Paul Yielder
Summary: Alterations in neck sensory input from subclinical neck pain result in disordered sensorimotor integration. The study found that individuals with subclinical neck pain had a significantly larger COR gain and smaller VOR gain, suggesting an association between proprioceptive feedback and sensorimotor integration.
Article
Clinical Neurology
Priyani Patel, Patricia Castro, Nehzat Koohi, Qadeer Arshad, Lucia Gargallo, Sergio Carmona, Diego Kaski
Summary: This study explores whether the vestibulo-ocular reflex (VOR) gain changes in response to a clinical headshake maneuver in patients with vestibular migraine (VM). The study found that there was no significant change in VOR gain after headshaking in any group. Patients who reported nausea when reading in the passenger seat of a car were more likely to have VM.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Hyun Sung Kim, Eun Hye Oh, Jeong-Yeon Kim, Seo Young Choi, Kwang-Dong Choi, Jae-Hwan Choi
Summary: This study investigated the incidence, pattern, and etiology of dissociated vestibulo-ocular reflex (VOR) function in dizzy patients. It found that discordant VOR function according to the stimulus frequency was not uncommon and different etiologies showed specific patterns of VOR dissociation.
JOURNAL OF NEUROLOGY
(2022)
Article
Multidisciplinary Sciences
Fatma Kizilay, Deniz Ugur Cengiz
Summary: This study aimed to compare functional VOR and proprioception of athletes engaged in combat sports and ball sports. The results showed that athletes engaged in ball sports had better VOR and proprioception compared to those in combat sports. Participation in ball sports can improve proprioception and vestibular functioning, leading to enhanced performance.
Article
Computer Science, Software Engineering
Tsz Tai Chan, Yixuan Wang, Richard Hau Yue So, Jerry Jia
Summary: With advances in VR technology, the demand for a better user experience has increased. However, correcting lens distortion becomes more challenging when trying to achieve a wider field-of-view. Previous studies focused on motion sickness and discomfort caused by mismatches in accommodation and convergence, but little attention has been given to disorientation and discomfort caused by unintended optical flow resulting from lens distortion. This study examines the effects of these factors and provides insights for designing discomfort-free VR headset lenses.
IEEE TRANSACTIONS ON VISUALIZATION AND COMPUTER GRAPHICS
(2023)
Article
Clinical Neurology
Jacob M. Pogson, Rachael L. Taylor, Andrew P. Bradshaw, Leigh McGarvie, Mario D'Souza, Sean Flanagan, Jonathan Kong, Nigel Biggs, Brindha Shivalingam, Simon Greenberg, Glen Croxson, G. Michael Halmagyi, Miriam S. Welgampola
Summary: The vestibulo-ocular reflex (VOR) and compensatory-saccades undergo changes after surgical unilateral vestibular deafferentation (UVD). Compensatory-saccades adapt within one week post-surgery and remain stable over one year.
CLINICAL NEUROPHYSIOLOGY
(2022)
Article
Computer Science, Information Systems
Takuya Kono, Yuki Sato, Takahiro Wada, Daichi Tsunemichi, Naoyuki Fujiyama, Yoshiki Ono
Summary: This study investigates the association between heightened mental workload (MWL) during driving and variations in the vestibulo-ocular reflex (VOR) gain. The experiment reveals a significant decrease in VOR gain under high MWL, indicating the association between VOR suppression and increased MWL.
Article
Clinical Neurology
Akiyoshi Matsugi, Tomoyuki Shiozaki, Hiroaki Tanaka
Summary: The study investigated the effects of noisy galvanic vestibular stimulation (nGVS) on the vestibulo-ocular reflex (VOR) and body sway. Results showed that nGVS at 0.2 mA inhibited the VOR, while nGVS at 0.6 mA increased body sway during upright standing. However, there may not be a significant relationship between these effects in healthy individuals.
FRONTIERS IN NEUROLOGY
(2022)
Review
Neurosciences
Adrienne Crampton, A. Garat, H. A. Shepherd, M. Chevignard, K. J. Schneider, M. Katz-Leurer, I. J. Gagnon
Summary: The study found a rapid growth in the evaluation of VOR function after TBI in recent years, with a majority targeting mild TBI. However, moderate and severe TBIs continue to be under-represented. There is high variability in administration protocols when conducting tests, highlighting the need for further standardization.
Review
Medicine, Research & Experimental
Yufen Peng, Qi Tu, Yao Han, Chenyi Wan, Liang Gao
Summary: Spinocerebellar ataxias (SCAs) are a group of autosomal dominant neurodegenerative diseases that cause cerebellar ataxia. The most common types of SCAs are caused by polyglutamine (polyQ)-encoding cytosine-adenine-guanine repeat expansions. The present review discusses the visual oculomotor abnormalities and vestibulo-ocular reflex dynamics of polyQ-SCAs, as well as their genetic, clinical, and neuropathological features. Evaluating eye movement features can be helpful in the differential diagnosis of polyQ-SCAs.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2023)
Article
Neurosciences
Susan King, Kilian Dahlem, Faisal Karmali, Konstantina M. Stankovic, D. Bradley Welling, Richard F. Lewis
Summary: The severity of symptoms associated with vestibular schwannomas (VS) is poorly correlated with standard vestibulo-ocular reflex (VOR) metrics that are based on response amplitude. Imbalance in patients with VS scales with VOR precision and time constant, but not with VOR accuracy. Dizziness is related to the presence of a static central tone imbalance but not to any VOR metrics.
JOURNAL OF NEUROPHYSIOLOGY
(2022)
Article
Clinical Neurology
Adrienne Crampton, Kathryn J. Schneider, Lisa Grilli, Mathilde Chevignard, Michal Katz-Leurer, Miriam H. Beauchamp, Chantel Debert, Isabelle J. Gagnon
Summary: This study aimed to understand the changes in oculomotor and vestibulo-ocular reflex function in children and adolescents following mild traumatic brain injury. Results suggest impairments to the VOR pathway may be present and driving symptom provocation, highlighting the need to include tasks such as vertical smooth pursuit and saccades in assessments to comprehensively evaluate the integrity of the vestibular system post-mTBI.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Deniz Ugur Cengiz, Hatice Seyra Erbek, Sanem Can Colak, Buesra Kurtcu, Suemeyye Demirel Birisik, Ercan Karababa, Busra Kusman, Emre Akguen Ozdemir, Mehmet Isik, Ismail Demir
Summary: This study aimed to determine the normative values of the functional head impulse test (fHIT) in healthy young adults. The results showed differences in fHIT values between different semicircular canals and genders, providing important data for future studies.
FRONTIERS IN NEUROLOGY
(2023)
Article
Clinical Neurology
Dario Geisinger, Zohar Elyoseph, Roy Zaltzman, Matti Mintz, Carlos R. Gordon
Summary: The vestibular function in patients with Machado-Joseph Disease (MJD) was comprehensively evaluated, revealing significant impairments in horizontal and vertical VOR with preserved sacculo-collic function, suggesting a distinctive feature of MJD. The study supports the potential of horizontal VOR gain measured by vHIT as a neurophysiological biomarker for MJD.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Anesthesiology
Tatsuo Horiuchi, Tomonori Takazawa, Masaki Orihara, Shinya Sakamoto, Kazuhiro Nagumo, Shigeru Saito
Summary: Perioperative anaphylaxis is a sudden and life-threatening event that requires anesthesiologists to have sufficient knowledge and coping strategies. While studies on this condition are rare in Japan, a recent study analyzed data from 46 patients to identify common causative agents and their associated characteristics. The findings may provide valuable information for anesthesiologists in Japan dealing with perioperative anaphylaxis.
JOURNAL OF ANESTHESIA
(2021)
Article
Anesthesiology
Yusuke Matsui, Tomonori Takazawa, Akihito Takemae, Yukie Murooka, Masafumi Kanamoto, Shigeru Saito
Summary: The study found that placing a nasal cannula under a surgical mask is most beneficial for oxygenation in patients, followed by placing an oxygen mask under the surgical mask, with the least effective being placing an oxygen mask over the surgical mask.
JOURNAL OF ANESTHESIA
(2022)
Article
Anesthesiology
Kota Tsurumi, Shinji Takahashi, Yoshiyuki Hiramoto, Kazuhiro Nagumo, Tomonori Takazawa, Yoichiro Kamiyama
Summary: This case report details a 32-year-old man who experienced anaphylaxis during surgery induced by remimazolam. Despite normal levels of serum tryptase, intradermal allergy tests confirmed remimazolam as the causative agent for the allergic reaction.
JOURNAL OF ANESTHESIA
(2021)
Letter
Anesthesiology
Tatsuo Horiuchi, Tomonori Takazawa, Shigeru Saito
JOURNAL OF ANESTHESIA
(2021)
Article
Anesthesiology
Tomonori Takazawa, Yuki Sugiyama, Yasuhiro Amano, Tetsuhito Hara, Eiki Kanemaru, Takao Kato, Takashi Kawano, Tsukasa Kochiyama, Tatsuya Tsuji, Shigeru Saito
Summary: The COVID-19 pandemic has led to a decrease in the number of general anesthesia cases, particularly during the government's declaration of a state of emergency, and there were regional differences in the decline in cases.
ANESTHESIOLOGY RESEARCH AND PRACTICE
(2021)
Letter
Anesthesiology
Kazuhiro Nagumo, Tomonori Takazawa, Shigeru Saito
JA CLINICAL REPORTS
(2021)
Article
Cell Biology
Keiko Haraguchi-Suzuki, Reika Kawabata-Iwakawa, Toru Suzuki, Takashi Suto, Tomonori Takazawa, Shigeru Saito
Summary: Although surgery is a basic therapy for cancer, it often leads to inflammation and immunosuppression, causing recurrence and metastasis. This study demonstrates that lidocaine treatment can inhibit the growth of kidney and cervical cancer cells, and this inhibition is mediated through the regulation of Ki-67 expression and distribution.
Article
Multidisciplinary Sciences
Keiko Haraguchi-Suzuki, Reika Kawabata-Iwakawa, Toru Suzuki, Takashi Suto, Tomonori Takazawa, Shigeru Saito
Summary: Administration of lidocaine suppresses cancer cell growth and induces apoptosis through increasing the expression of GDF-15 and TRIB3. These findings suggest the potential application of lidocaine in cancer therapy.
SCIENTIFIC REPORTS
(2022)
Article
Anesthesiology
Tomonori Takazawa, Tatsuo Horiuchi, Masaki Orihara, Kazuhiro Nagumo, Akihiro Tomioka, Yuki Ideno, Kunihiko Hayashi, Hideaki Yashima, Takuya Araki, Kazuhisa Hatayama, Masanori Terauchi, Yoshio Ikeda, Shigeru Saito
Summary: This study investigated whether the antibiotic minocycline could prevent postoperative cognitive dysfunction, but the results suggest that minocycline is unlikely to have a preventive effect on this condition.
Article
Anesthesiology
Masaki Orihara, Tomonori Takazawa, Tatsuo Horiuchi, Kazuhiro Nagumo, Noboru Maruyama, Akihiro Tomioka, Shigeru Saito
Summary: This study used basophil activation tests and provided experimental evidence supporting an IgE-dependent mechanism for chlorhexidine-induced anaphylaxis.
JA CLINICAL REPORTS
(2022)
Article
Anesthesiology
Tatsuo Horiuchi, Tomonori Takazawa, Takashi Haraguchi, Masaki Orihara, Kazuhiro Nagumo, Shigeru Saito
Summary: Blood histamine concentrations are useful in diagnosing perioperative anaphylaxis (POA), with a threshold of 1.5 ng/ml at 30 minutes after surgery start and a threshold of 1.1 ng/ml at 2 hours after surgery start having good sensitivity and specificity. Collecting blood samples within two hours after symptom onset may aid in the diagnosis of POA.
JOURNAL OF ANESTHESIA
(2023)
Review
Anesthesiology
Yasuhiro Amano, Akari Matsuura, Takahiro Tamura, Yuki Kato, Natsumi Kameyama, Tomonori Takazawa, Kimitoshi Nishiwaki
Summary: Chlorhexidine is a common cause of perioperative anaphylaxis, and its use in skin preparation before central venous catheter (CVC) insertion can lead to life-threatening allergic reactions. Our case highlights the possibility of anaphylaxis even with chlorhexidine-free CVC insertion. Skin preparation before CVC insertion with chlorhexidine is often overlooked as a cause of chlorhexidine anaphylaxis, and its potential risk is underestimated. CVC insertion should be recognized as a potential cause of life-threatening chlorhexidine anaphylaxis.
JOURNAL OF ANESTHESIA
(2023)
Article
Anesthesiology
Yuki Suigiyama, Tomonori Takazawa, Natsuko Watanabe, Kiyoko Bito, Tetsuhiro Fujiyoshi, Shinsuke Hamaguchi, Takashi Haraguchi, Tatsuo Horiuchi, Yoshinori Kamiya, Noboru Maruyama, Hitoshi Masumo, Harumasa Nakazawa, Kazuhiro Nagumo, Masaki Orihara, Jun Sato, Kenichi Sekimoto, Kenichiro Takahashi, Mutsumi Uchiyama, Kazunobu Takahashi, Masao Yamaguchi, Mikito Kawamata
Summary: Diagnosis of perioperative anaphylaxis is challenging due to its non-specific and variable symptoms. The choice of therapeutic agents and anaesthesiologist responses can vary, potentially affecting outcomes. Limited research has focused on these factors.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Article
Anesthesiology
Tomonori Takazawa, Tatsuo Horiuchi, Kazuhiro Nagumo, Yuki Sugiyama, Tsubasa Akune, Yasuhiro Amano, Masataka Fukuda, Takashi Haraguchi, Chika Ishibashi, Eiki Kanemaru, Takao Kato, Keiichi Katoh, Takashi Kawano, Tsukasa Kochiyama, Michioki Kuri, Akihide Kurita, Yoshikazu Matsuoka, Takahiro Muramatsu, Masaki Orihara, Yutaka Saito, Nobukazu Sato, Toshie Shiraishi, Kaoru Suzuki, Miyuki Takahashi, Toshifumi Takahashi, Kumiko Tanabe, Akihiro Tomioka, Yukinari Tomita, Tatsuya Tsuji, Iwao Watanabe, Takashige Yamada, Nagahide Yoshida, Masao Yamaguchi, Shigeru Saito
Summary: This study describes the utility of a newly developed tool for identifying patients with a high possibility of anaphylaxis and investigates the frequency of anaphylaxis with each drug during the perioperative period in Japan. The developed composite score, which includes skin tests and basophil activation tests, improved the certainty of anaphylaxis diagnosis. The top causative agents were rocuronium, sugammadex, and cefazolin.
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Letter
Anesthesiology
Yusuke Matsui, Tomonori Takazawa, Akihito Takemae, Shigeru Saito
JA CLINICAL REPORTS
(2021)