Journal
EUROPEAN JOURNAL OF NEUROLOGY
Volume 22, Issue 1, Pages 207-210Publisher
WILEY-BLACKWELL
DOI: 10.1111/ene.12396
Keywords
deep brain stimulation; odor identification; Parkinson's disease
Categories
Funding
- EFNS fellowship
- Reta Lila Weston Trust for Medical Research
- Parkinson's UK
- Parkinson's Foundation
- Teva Lundbeck
- UCB
- Genus
- Abbott
- FAPESP
- UNICAMP
- GlaxoSmithKline
- Grunenthal
- Fundacao MSD (Portugal)
- TEVA
- European Huntington Disease Network
- Merck-Serono
- Lundbeck
- Novartis
- Merz
- Ipsen
- Solvay
- BIAL
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Background and purpose: Olfactory dysfunction is common in Parkinson's disease (PD) and it is one of the earliest non-motor symptoms. A few studies have suggested that deep brain stimulation of the subthalamic nucleus (STN-DBS) could improve olfactory function. Our aim was to evaluate the acute effect of bilateral STN-DBS on a commonly used smell test in PD patients. Methods: Fifteen PD patients who underwent bilateral STN-DBS and 15 controls were recruited. Patients and controls were tested for odor identification. Results: No statistical differences were documented between ON and OFF STN-DBS acute stimulation concerning olfaction. Controls presented a better performance for olfactory identification than patients. Conclusions: Our exploratory study did not support that bilateral STN-DBS could have an acute effect on olfactory function in PD patients.
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