Review
Clinical Neurology
Alireza Zali, Mahsa Motavaf, Saeid Safari, Narges Ebrahimi, Mahsa Ghajarzadeh, Reza Jalili Khoshnood, Omid Mirmosayyeb
Summary: This systematic review and meta-analysis found that the pooled prevalence of restless legs syndrome (RLS) in multiple sclerosis (MS) cases is 28%, with a higher prevalence in women (30%) compared to men (22%). The prevalence of RLS in the control group was 8%.
NEUROLOGICAL SCIENCES
(2023)
Review
Clinical Neurology
Felix Javier Jimenez-Jimenez, Hortensia Alonso-Navarro, Elena Garcia-Martin, Jose A. G. Agundez
Summary: The coexistence of peripheral neuropathy (PN) and restless legs syndrome (RLS) is relatively frequent, with RLS reported in 5.2%-53.7% of PN patients, and PN reported in 0%-87.5% of RLS patients, both significantly higher than controls. Variability across studies may be due to differences in diagnostic criteria. RLS is a common clinical complaint in patients with PN of different etiologies.
EUROPEAN JOURNAL OF NEUROLOGY
(2021)
Review
Clinical Neurology
Jing Guo, Lixia Pei, Lu Chen, Hao Chen, Dongmei Gu, Yongjun Peng, Jianhua Sun
Summary: This study found a significant bidirectional association between irritable bowel syndrome (IBS) and restless legs syndrome (RLS), with IBS patients having a higher risk of developing RLS and RLS patients having a higher risk of developing IBS. Further high-quality prospective population-based studies are needed in the future.
Article
Clinical Neurology
Davide Sparasci, Raffaele Ferri, Anna Castelnovo, Silvia Miano, Kosuke Tanioka, Naoko Tachibana, Chiara Carelli, Gianna Riccitelli, Giulio Disanto, Chiara Zecca, Claudio Gobbi, Mauro Manconi
Summary: Restless legs syndrome (RLS) is highly frequent in patients with multiple sclerosis (MS), with a comparable frequency of periodic limb movements during sleep (PLMS) to the general population. The low percentage of patients with RLS having a high PLMS index, together with the absence of correlation between RLS and clinical and polysomnography parameters, indicates the existence of a distinct symptomatic form of RLS in MS.
Article
Clinical Neurology
Kilian Froehlich, Michael Knott, Stefan Hock, Arnd Doerfler, Frank Seifert, Klemens Winder
Summary: Using voxel-wise lesion analysis, this study identified associations between restless legs syndrome (RLS) and multiple sclerosis (MS) lesions in the brain. The analysis revealed that cerebral lesions may contribute to the dysfunction of the efferent motor system, leading to the pathophysiology of RLS in MS.
NEUROLOGICAL SCIENCES
(2022)
Review
Clinical Neurology
Asiye Tuba Ozdogar, Alon Kalron
Summary: Restless legs syndrome (RLS) has a higher prevalence in patients with multiple sclerosis (MS) compared to healthy controls, with the risk of RLS significantly increased in people with MS. There is no significant relationship between the presence of RLS in PwMS and disability, disease duration, type of MS, age, or gender.
MULTIPLE SCLEROSIS AND RELATED DISORDERS
(2021)
Review
Clinical Neurology
Shichan Wang, Xiaoting Zheng, Jingxuan Huang, Junyu Lin, Tianmi Yang, Yi Xiao, Qirui Jiang, Chunyu Li, Huifang Shang
Summary: This meta-analysis investigated the relationship between restless legs syndrome (RLS) and cognitive function, including global cognition and various cognitive domains. The results showed negative associations between RLS and global cognition and attention, but no significant differences in memory, executive function, or spatial cognition. The findings suggest that RLS may have a negative impact on cognitive function, particularly global cognition and attention, but further research is needed to confirm the causal relationship.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Katie L. J. Cederberg, Brenda Jeng, Jeffer E. Sasaki, Morgan L. Schuetz, Brianna G. Mathison, Robert W. Motl
Summary: This study examined the associations between physical activity during different times of the day and weekdays with restless legs syndrome (RLS) severity and sleep quality in adults with multiple sclerosis. The results suggest that engaging in physical activity, particularly light physical activity (LPA) and steps, in the evenings may be important for managing RLS symptoms without worsening sleep quality.
Review
Clinical Neurology
Chaofan Geng, Zhenzhen Yang, Tingting Zhang, Pengfei Xu, Hongju Zhang
Summary: This study compared the differences in polysomnography between patients with RLS and healthy controls. The results showed that RLS patients had significant changes in sleep structure and continuity. Further research is needed to investigate the underlying pathophysiological mechanisms of RLS and its association with neurodegenerative diseases.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Ying-Sheng Li, Wei-Chih Yeh, Chung-Yao Hsu
Summary: This meta-analysis found an association between iron deficiency and augmentation of restless legs syndrome (RLS), suggesting that iron supplementation can not only relieve symptoms but also lower the risk of augmentation in iron-deficient RLS patients. Furthermore, non-dopaminergic agents should be considered as the first-line treatment for patients with persistent low serum ferritin levels or moderate to severe RLS to prevent augmentation.
Review
Clinical Neurology
Felix Javier Jimenez-Jimenez, Hortensia Alonso-Navarro, Elena Garcia-Martin, Jose A. G. Agundez
Summary: The role of inflammatory factors in the development of restless legs syndrome (RLS) is not well understood. This study conducted a systematic review and meta-analysis to investigate the association between serum/plasma levels of inflammatory markers and the risk of RLS. The results indicated a trend of higher levels of C reactive protein (CRP) and neutrophil-to-lymphocyte (NLR) ratio in RLS patients, although statistical significance disappeared after applying the random-effects model. Further studies are needed to confirm the potential role of inflammatory factors in RLS pathogenesis.
SLEEP MEDICINE REVIEWS
(2023)
Article
Clinical Neurology
Erik Tilch, Barbara Schormair, Chen Zhao, Birgit Hoegl, Ambra Stefani, Klaus Berger, Claudia Trenkwalder, Cornelius G. Bachmann, Magdolna Hornyak, Ingo Fietze, Martina Mueller-Nurasyid, Annette Peters, Stefan Herms, Markus M. Noethen, Bertram Mueller-Myhsok, Konrad Oexle, Juliane Winkelmann
Summary: Restless legs syndrome (RLS) is influenced by genetic factors, and the contribution of rare genetic variation to RLS has not been extensively studied. This study suggests that analyzing rare genetic variants through exome or whole genome sequencing is more effective in identifying risk variants for RLS.
Review
Clinical Neurology
Anders Brostrom, Zainab Alimoradi, Jonas Lind, Martin Ulander, Fredrik Lundin, Amir Pakpour
Summary: This study conducted a systematic review, meta-analysis, and meta-regression to assess the prevalence of restless legs syndrome (RLS) in the general adult population. A total of 97 studies from 33 countries were included, and the overall pooled prevalence of RLS was found to be 3%. The prevalence of RLS was influenced by factors such as methodological quality, gender (higher among women), and study design.
JOURNAL OF SLEEP RESEARCH
(2023)
Article
Clinical Neurology
Katie L. J. Cederberg, Arthur S. Walters, Amy W. Amara, Tiffany J. Braley, Morgan L. Schuetz, Brianna G. Mathison, Robert W. Motl
Summary: The study aimed to investigate the validity and reliability of SIT in assessing the severity of restless legs syndrome in adults with multiple sclerosis. Results showed that self-reported RLS severity during the SIT had excellent construct validity and convergent validity, but moderate test-retest reliability. Device-measured PLMs were significantly associated with PLMs during the night and had excellent test-retest reliability during the SIT in adults with MS.
Article
Clinical Neurology
Raffaele Ferri, Davide Sparasci, Anna Castelnovo, Silvia Miano, Kosuke Tanioka, Naoko Tachibana, Chiara Carelli, Gianna Carla Riccitelli, Giulio Disanto, Chiara Zecca, Claudio Gobbi, Mauro Manconi
Summary: This study compared leg movement activity during sleep among patients with multiple sclerosis, idiopathic restless legs syndrome, and healthy controls. The results showed that patients with multiple sclerosis had poorer sleep quality and less leg movement activity compared to those with idiopathic restless legs syndrome. These findings may have important implications for the treatment of restless legs syndrome secondary to multiple sclerosis.
JOURNAL OF CLINICAL SLEEP MEDICINE
(2022)