Article
Medicine, General & Internal
Haremaru Kubo, Yuya Tsurutani, Takashi Sunouchi, Yoshitomo Hoshino, Rei Hirose, Sho Katsuragawa, Noriko Kimura, Jun Saito, Tetsuo Nishikawa
Summary: RET gene mutation may be associated with PCC cases that exhibit negative accumulation on MIBG scintigraphy.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Neurosciences
Martin Iniguez, Antonio Jimenez-Marin, Asier Erramuzpe, Marian Acera, Beatriz Tijero, Ane Murueta-Goyena, Rocio Del Pino, Tamara Fernandez, Mar Carmona-Abellan, Alberto Cabrera-Zubizarreta, Juan Carlos Gomez-Esteban, Jesus M. Cortes, Inigo Gabilondo
Summary: Heart rate variability (HRV) abnormalities are potential early biomarkers in Parkinson's disease (PD), and this study analyzed the synchronization between HRV and brain activity in PD patients using resting-state functional brain MRI. The findings suggest a desynchronization between heart and brain in PD, which has an impact on clinically relevant autonomic outcomes.
NPJ PARKINSONS DISEASE
(2022)
Article
Peripheral Vascular Disease
Jin-woo Park, Luis E. Okamoto, Sung-hwan Kim, Seol-hee Baek, Joo Hye Sung, Namjoon Jeon, Alfredo Gamboa, Cyndya A. Shibao, Andre Diedrich, Byung-jo Kim, Italo Biaggioni
Summary: This study found that Valsalva maneuver responses can help identify patients who require prolonged head-up tilt table test to diagnose late-onset orthostatic hypotension (dOH). Patients with late-onset dOH had lower baseline systolic blood pressure changes at late phase 2, lower heart rate difference between baseline and phase 3, lower Valsalva ratio, and longer pressure recovery time (PRT) at phase 4 compared to controls. Long PRT and short increment HRVM3 can assist in identifying patients with late-onset dOH.
Article
Multidisciplinary Sciences
Yuiko Inaba, Masaaki Yamamoto, Shin Urai, Masaki Suzuki, Seiji Nishikage, Maki Kanzawa, Yayoi Aoyama, Tomonori Kanda, Katsumi Shigemura, Hironori Bando, Genzo Iguchi, Yasuhiro Nakamura, Masato Fujisawa, Akihisa Imagawa, Hidenori Fukuoka, Wataru Ogawa
Summary: This study investigates the presence of bilateral uptake in adrenal incidentalomas and its association with adrenal medullary hyperplasia. The clinical features of these cases mainly include symptoms related to catecholamine excess and hypertension. Half of the cases have unilateral adrenal tumors. Adrenocortical adenomas may be associated with adrenal medullary hyperplasia.
SCIENTIFIC REPORTS
(2022)
Review
Cell Biology
Aziz Debain, Fien Ann Loosveldt, Veerle Knoop, Axelle Costenoble, Siddhartha Lieten, Mirko Petrovic, Ivan Bautmans, Gerontopole Brussels Study Grp
Summary: Autonomic dysfunction and frailty are common geriatric syndromes that increase with age and have similar negative health outcomes. Frailty is associated with an increased risk of orthostatic hypotension (OH) in older adults, particularly initial OH (IOH). Frail older adults also exhibit other autonomic function alterations such as reduced orthostatic heart rate increase, systolic blood pressure recovery, and heart rate variability.
AGEING RESEARCH REVIEWS
(2023)
Article
Clinical Neurology
Katherine Longardner, Aristide Merola, Irene Litvan, Alberto Maria De Stefano, Simona Maule, Fabrizio Vallelonga, Leonardo Lopiano, Alberto Romagnolo
Summary: Cardiovascular dysautonomia was associated with a sevenfold higher risk of developing dementia and a fivefold higher risk of falls in PD patients, as well as significantly higher impairment in ADLs and HRQoL. No relevant associations were found between the other autonomic domains and these outcomes.
JOURNAL OF NEUROLOGY
(2022)
Article
Clinical Neurology
Ahmet Turan Isik, Neziha Erken, Idil Yavuz, Derya Kaya, Mehmet Selman Ontan, Esra Ates Bulut, Fatma Sena Dost
Summary: The meta-analysis reveals a higher prevalence of orthostatic hypotension in Alzheimer's disease patients, with a risk approximately 2.5 times higher compared to healthy controls. Therefore, evaluating postural blood pressure changes should be a crucial follow-up and treatment goal for individuals with AD.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Mauro Catalan, Franca Dore, Paola Polverino, Claudio Bertolotti, Arianna Sartori, Lucia Antonutti, Alberto Cucca, Giovanni Furlanis, Selene Capitanio, Paolo Manganotti
Summary: The study found suboptimal diagnostic accuracy of myocardial scintigraphy in distinguishing PD from atypical parkinsonism. However, it confirmed the relevance of I-123-MIBG myocardial scintigraphy for the discrimination of PD from atypical parkinsonism, especially when dysautonomic symptoms are present.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2021)
Review
Chemistry, Medicinal
Derk O. Verschure, Kenichi Nakajima, Hein J. Verberne
Summary: Cardiac sympathetic upregulation plays an important role in chronic heart failure. Cardiac I-123-mIBG scintigraphy is a feasible technique for evaluating cardiac sympathetic innervation and has been extensively studied in ischemic and non-ischemic CHF. It has the potential to evaluate prognosis and optimize patient selection for implantable devices such as ICD and CRT.
Article
Cardiac & Cardiovascular Systems
Keisuke Fukuda, Seiji Hasegawa, Tomonori Kawamura, Naoto Waratani, Kumiko Hirata, Akihiro Higashimori, Yoshiaki Yokoi
Summary: This study evaluated the impact of MitraClip therapy on cardiac sympathetic nerve activity in patients with mitral regurgitation. Results showed that MitraClip therapy improved CSN activity, particularly in terms of washout rate, in patients with 3+ or 4+ MR after 6 months.
Article
Clinical Neurology
Junya Ebina, Sunao Mizumura, Nobutomo Ishii, Yukio Kobayashi, Mari Shibukawa, Harumi Morioka, Junpei Nagasawa, Masaru Yanagihashi, Takehisa Hirayama, Kiyokazu Kawabe, Satoshi Orimo, Osamu Kano
Summary: This study aimed to analyze the uptake of I-123-MIBG in the parotid and submandibular glands of Parkinson's disease (PD) patients compared to controls, and to compare this uptake with that in the myocardium. The study also aimed to identify any relationships between clinical features and MIBG uptake. The results showed that PD patients had significantly reduced uptake ratios in the parotid glands/mediastinum, submandibular glands/mediastinum, and heart/mediastinum compared to controls. The parotid glands/submandibular glands ratio correlated with the parotid glands/mediastinum ratio, while neither ratio correlated with the heart/mediastinum ratio. This study provides a new perspective on the pathological distribution of PD.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Brent P. Goodman, Julie A. Khoury, Janis E. Blair, Marie F. Grill
Summary: This study reported a case series of dysautonomia associated with COVID-19 infection in 6 patients. While all patients presented typical symptoms like fatigue and activity intolerance, autonomic testing results varied, with postural tachycardia, orthostatic hypotension, and postural hypertension observed in different patients.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Don Gueu Park, Jae Whan Kim, Young-Sil An, Jaerak Chang, Jung Han Yoon
Summary: This study investigated the impact of non-motor markers on neuronal injury in early-stage Parkinson's disease, finding a correlation between OH, age, and disease duration with plasma NFL levels. It provides biomarker evidence for the association between OH and poor clinical outcomes in patients with PD.
JOURNAL OF NEURAL TRANSMISSION
(2021)
Article
Cardiac & Cardiovascular Systems
Roberta Assante, Elena Salvatore, Carmela Nappi, Silvio Peluso, Giovanni De Simini, Luigi Di Maio, Gianluigi Rosario Palmieri, Isabella Pia Ferrara, Alessandro Roca, Giuseppe De Michele, Alberto Cuocolo, Sabina Pappata, Anna De Rosa
Summary: This study found that cardiac autonomic innervation is essentially preserved or only minimally involved in Huntington's disease patients. This suggests that cardiovascular dysfunction in HD may be mainly due to brain area impairments associated with heart function regulation and modulation.
JOURNAL OF NUCLEAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Masahiro Seo, Takahisa Yamada, Shunsuke Tamaki, Tetsuya Watanabe, Takashi Morita, Yoshio Furukawa, Masato Kawasaki, Atsushi Kikuchi, Tsutomu Kawai, Jun Nakamura, Kiyomi Kayama, Masatsugu Kawahira, Takanari Kimura, Kunpei Ueda, Daisuke Sakamoto, Yasushi Sakata, Masatake Fukunami
Summary: This study aimed to investigate the prognostic value of cardiac sympathetic nerve dysfunction assessed by I-123-MIBG SPECT imaging in patients with HFpEF. The study found that cardiac I-123-MIBG SPECT imaging provided useful prognostic information in nonischemic ADHF patients, and there was a significant association between TDS and cardiac events.
JACC-CARDIOVASCULAR IMAGING
(2022)