UK research expenditure on dementia, heart disease, stroke and cancer: are levels of spending related to disease burden?

Background and purpose: A UK government review recommended that the impact of disease on the population and economy should be assessed to inform health research priorities. This study aims to quantify UK governmental and charity research funding for dementia, cancer, coronary heart disease (CHD) and stroke in 2007/08 and assess whether the levels of research expenditure are aligned with disease and economic burden. Methods: We identified UK governmental agencies and charities providing health research funding and determined their levels of funding for dementia, cancer, CHD and stroke. Research funding levels were compared to the number of cases, disabilityadjusted life years (DALYs) and economic burden. Economic costs were estimated using data on morbidity, mortality, health and social care use, private costs and other related indicators. Results: Research funding to the four diseases was pound 833 million, of which pound 590 million (71%) was devoted to cancer, pound 169 million (20%) to CHD, pound 50 million (6%) to dementia and pound 23 million (4%) to stroke. Cancer received pound 482 in research funding per 1000 DALYs lost, CHD received pound 266, dementia received pound 166, with stroke receiving pound 71. In terms of economic burden, for every pound 1 million of health and social care costs attributable to each disease, cancer received pound 129 269 in research funding, CHD received pound 73 153, stroke received pound 8745 and dementia received pound 4882. Conclusions: Most health research funding in the UK is currently directed towards cancer. When compared to their burden, our analysis suggests that research spending on dementia and stroke is severely underfunded in comparison with cancer and CHD.