Journal
EUROPEAN JOURNAL OF NEUROLOGY
Volume 18, Issue 10, Pages 1272-1274Publisher
WILEY-BLACKWELL
DOI: 10.1111/j.1468-1331.2011.03377.x
Keywords
complement; functional outcome; genetics; ischaemic stroke; single nucleotide polymorphism; TOAST
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Funding
- Swedish Research Council [14605, 20116]
- Swedish state [ALFBGB-148861, ALFBGB-11267]
- Swedish Heart and Lung Foundation [20100256]
- Yngve Land Foundation for Neurological Research
- Goteborg Foundation for Neurological Research
- Lars Hierta Memorial Foundation
- Torsten and Ragnar Soderberg, Wilhelm and Martina Lundgren, Tore Nilsson, Emelle, Rune and Ulla Amlov, Edit Jacobson, John and Brit Wennerstrom, and O.E. and Edla Johanssons Foundations
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Background and purpose: The aim of this study was to investigate whether genetic variation at the third complement component (C3) locus is associated with ischaemic stroke (IS). Methods: The Sahlgrenska Academy Study on Ischaemic Stroke comprises 844 patients with IS, and 668 healthy controls. Sixteen SNPs were analyzed. Results: Two SNPs, rs2277984 and rs3745565, showed a significant association with overall IS. The SNP rs2277984 also showed association with the IS subtype cryptogenic stroke. These associations were independent of hypertension, diabetes, and smoking. The independent association between rs3745565 and overall IS withstands correction for multiple testing. Conclusion: In this sample of patients with IS, genetic variation in C3 is associated with IS.
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