Review
Medicine, General & Internal
Paloma Moreta-de-Esteban, Patricia Martin-Casas, Rosa Maria Ortiz-Gutierrez, Sofia Straudi, Roberto Cano-de-la-Cuerda
Summary: Resting tremor is a common motor manifestation in Parkinson's disease (PD) patients. Mobile applications using the measurement components of smartphones show potential for objectively assessing resting tremor in PD, but validation studies are lacking. This systematic review identified 13 apps in mobile markets for assessing resting tremor in PD, meeting an average of 85.09% of the recommendations for medical mobile app development.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Engineering, Biomedical
Luciano Brinck Peres, Bruno Coelho Calil, Ana Paula Sousa Paixao Barroso da Silva, Valdeci Carlos Dionisio, Marcus Fraga Vieira, Adriano de Oliveira Andrade, Adriano Alves Pereira
Summary: Parkinson's disease is a neurological disorder that affects the motor system and has a significant impact on the individual's quality of life. This study proposed a method based on inertial sensor recordings to differentiate individuals with PD from healthy groups, showing promising results for the accurate diagnosis and classification of PD patients.
BIOMEDICAL ENGINEERING ONLINE
(2021)
Article
Chemistry, Analytical
Christina van der Linden, Thea Berger, Gregor A. Brandt, Joshua N. Strelow, Hannah Jergas, Juan Carlos Baldermann, Veerle Visser-Vandewalle, Gereon R. Fink, Michael T. Barbe, Jan Niklas Petry-Schmelzer, Till A. Dembek
Summary: Clinical rating scales for tremor have limitations, and reliable quantitative approaches are needed. This study investigated the use of accelerometry metrics to objectively classify tremor amplitude and compared them to clinical ratings. The results showed that accelerometry can reliably quantify tremor amplitude, with finger-worn accelerometry performing slightly better.
Article
Neurosciences
Asma Channa, Oana Cramariuc, Madeha Memon, Nirvana Popescu, Nadia Mammone, Giuseppe Ruggeri
Summary: Resting tremor refers to a complete repose of a body part that often dampens or subsides entirely with action. The most common cause of resting tremors is idiopathic Parkinson's disease (PD). This study analyzed the severity of an imbalanced dataset of PD patients and found that the oversampling method performed better than undersampling and hybrid sampling techniques.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Yuke Zhong, Hang Liu, Guohui Liu, Yi Liang, Chengcheng Dai, Lili Zhao, Hongyu Lai, Lijuan Mo, Changhong Tan, Fen Deng, Xi Liu, Lifen Chen
Summary: This study used diffusion tensor imaging (DTI) to investigate white matter alterations in the cerebrum and cerebellum in Parkinson's disease patients with resting tremor. The results showed better white matter integrity in the cerebrum and cerebellum, suggesting a potential association between white matter and resting tremor in this disease.
Review
Clinical Neurology
Atul Goel, Ramkumar Sugumaran, Sunil K. Narayan
Summary: Parkinson's disease is a progressive neurodegenerative disease caused by a depletion of dopamine, with limited available therapies. Zonisamide may be a potential candidate to alleviate symptoms of PD, with evidence supporting its efficacy in motor symptoms as an adjunctive therapy but lacking for non-motor symptoms, requiring further investigation.
NEUROLOGICAL SCIENCES
(2021)
Article
Chemistry, Analytical
Luis Sigcha, Ignacio Pavon, Nelson Costa, Susana Costa, Miguel Gago, Pedro Arezes, Juan Manuel Lopez, Guillermo De Arcas
Summary: A novel approach using smartwatches and multitask classification models can accurately assess resting tremor in Parkinson's disease patients without interfering with their daily lives. Results show high agreement with clinical assessments, indicating the potential for early-stage disease monitoring and improvement of Parkinson's disease clinical evaluation.
Article
Neurosciences
Satoshi Tada, Mohammed E. Choudhury, Madoka Kubo, Rina Ando, Junya Tanaka, Masahiro Nagai
Summary: This study demonstrates the potential ameliorative effects of zonisamide on microglial mitochondrial dysfunction in Parkinson's disease, providing novel evidence for its clinical use as an antiparkinsonian drug.
Article
Medicine, General & Internal
Basilio Vescio, Rita Nistico, Antonio Augimeri, Andrea Quattrone, Marianna Crasa, Aldo Quattrone
Summary: This study developed a new low-cost, wearable mobile device called mu EMG for the automated and quantitative characterization of resting tremor patterns in ambulatory clinical settings. The results showed good agreement with standard EMG and demonstrated that tremor analysis using mu EMG is easy to perform and operator-independent for routine clinical practice.
Article
Clinical Neurology
Kanchana Soman Pillai, Priyanka Bhat, Achal Kumar Srivastava, Roopa Rajan, Divya M. Radhakrishnan, Arunmozhimaran Elavarasi, M. V. Padma Srivastava, Mamta Bhushan Singh, V. Y. Vishnu, Kameshwar Prasad, Awadh Kishor Pandit, Vinay Goyal
Summary: This study aimed to assess the effect of Zonisamide 25 mg on tremor in tremor-dominant PD patients. The results showed that a dose of 25 mg Zonisamide per day did not improve tremor in tremor-dominant PD patients, but a positive trend was observed compared to placebo in the UPDRS tremor score. Larger studies are required to confirm this finding.
PARKINSONISM & RELATED DISORDERS
(2022)
Review
Clinical Neurology
Michiel F. Dirkx, Matteo Bologna
Summary: This article reviews the dysfunctional network underlying tremor in PD, discusses the oscillations and synchronization changes in two central motor circuits, and emphasizes the pathophysiological consequences of the abnormal interaction between the two systems.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Tatsuhiko Naito, Wataru Satake, Pei-Chieng Cha, Kazuhiro Kobayashi, Miho Murata, Tatsushi Toda
Summary: This study found that the efficacy of zonisamide in Parkinson's disease patients is associated with glutamate-related synaptic modulation and p53-mediated dopaminergic neural loss. Transcriptional differences can be used to predict patient response to zonisamide before treatment.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yina Lan, Xinyun Liu, ChunYu Yin, Jinhao Lyu, Xiaoxaio Ma, Zhiqiang Cui, Xuemei Li, Xin Lou
Summary: This study examined spontaneous brain activity patterns in different subtypes of Parkinson's disease (tremor dominant and postural instability gait difficulty). The results showed that patients with postural instability gait difficulty had increased activity in certain regions of the brain, suggesting a compensatory mechanism for altered motor function. In contrast, patients with tremor dominant had lower activity levels in certain regions. These findings provide insights into the neural mechanisms underlying different subtypes of Parkinson's disease.
Article
Engineering, Biomedical
Junjie Li, Huaiyu Zhu, Jiaxiang Li, Haotian Wang, Bo Wang, Wei Luo, Yun Pan
Summary: This study proposes a wearable system for assessing upper limb tremor and differentiating between Parkinson's disease and essential tremor. The system collects tremor data from the wrist and fingers simultaneously and extracts multi-segment features to perform the differential diagnosis using support vector machine classifiers. The system demonstrated high accuracy in diagnosing Parkinson's disease versus essential tremor in real-world settings.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Clinical Neurology
Mario Stanziano, Nico Golfre Andreasi, Giuseppe Messina, Sara Rinaldo, Sara Palermo, Mattia Verri, Greta Demichelis, Jean Paul Medina, Francesco Ghielmetti, Salvatore Bonvegna, Anna Nigri, Giulia Frazzetta, Ludovico D'Incerti, Giovanni Tringali, Francesco DiMeco, Roberto Eleopra, Maria Grazia Bruzzone
Summary: Magnetic resonance-guided high-intensity focused ultrasound is a non-invasive alternative treatment for tremor. This study found that the treatment modulated resting state functional connectivity within the tremor network and these changes were associated with clinical outcomes.
FRONTIERS IN NEUROLOGY
(2022)
