Article
Clinical Neurology
Yun Jung Bae, Byung Se Choi, Jong-Min Kim, Ji-Hyun Choi, Se Jin Cho, Jae Hyoung Kim
Summary: The study assessed glymphatic activity in patients with idiopathic normal pressure hydrocephalus using DTI-ALPS method, which proved to be a useful tool for identifying glymphatic dysfunction and quantifying activity in individual patients.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Multidisciplinary Sciences
Laura Hiraldo-Gonzalez, Jose Luis Trillo-Contreras, Pablo Garcia-Miranda, Rocio Pineda-Sanchez, Reposo Ramirez-Lorca, Silvia Rodrigo-Herrero, Magdalena Olivares Blanco, Maria Oliver, Maria Bernal, Emilio Franco-Macias, Javier Villadiego, Miriam Echevarria
Summary: The study aimed to investigate the potential of AQP1 and AQP4 proteins in CSF as biomarkers for iNPH, but ELISA analysis showed insufficient sensitivity to detect their presence. The study also revealed differences in vascular risk factors between patients with iNPH and AD.
Article
Multidisciplinary Sciences
Laura Hiraldo-Gonzalez, Jose Luis Trillo-Contreras, Pablo Garcia-Miranda, Rocio Pineda-Sanchez, Reposo Ramirez-Lorca, Silvia Rodrigo-Herrero, Magdalena Olivares Blanco, Maria Oliver, Maria Bernal, Emilio Franco-Macias, Javier Villadiego, Miriam Echevarria
Summary: The study aimed to analyze the presence of AQP1 and AQP4 in the CSF of iNPH and AD patients as potential biomarkers. However, ELISA analysis showed insufficient sensitivity to detect these proteins, ruling out their use as biomarkers for diagnosing iNPH.
Article
Health Care Sciences & Services
Salvatore Mazzeo, Filippo Emiliani, Silvia Bagnoli, Sonia Padiglioni, Lorenzo Maria Del Re, Giulia Giacomucci, Juri Balestrini, Assunta Ingannato, Valentina Moschini, Carmen Morinelli, Giulia Galdo, Cristina Polito, Camilla Ferrari, Gastone Pansini, Alessandro Della Puppa, Sandro Sorbi, Benedetta Nacmias, Valentina Bessi
Summary: Patients with idiopathic normal pressure hydrocephalus (iNPH) and Alzheimer's Disease (AD) show similar levels of CSF A beta(42), but the levels of A beta(42)/A beta(40), p-tau, and t-tau are significantly different and can accurately distinguish iNPH from AD. A beta(42)/A beta(40) is the most important variable for differentiation. Positive A beta(42)/A beta(40) in iNPH, especially when associated with positive p-tau, may indicate the presence of coexistent AD pathology.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Clinical Neurology
Giovanni Mostile, Alfonso Fasano, Mario Zappia
Summary: This study reviewed the potential issues in the core clinical definition of iNPH and proposed reconsidering the diagnostic definition of the iNPH triad to possibly include parkinsonism.
NEUROLOGICAL SCIENCES
(2022)
Article
Clinical Neurology
Anna Jeppsson, Maria Bjerke, Per Hellstroem, Kaj Blennow, Henrik Zetterberg, Petronella Kettunen, Carsten Wikkelso, Anders Wallin, Mats Tullberg
Summary: The study compares similarities and differences in brain biomarkers between patients with iNPH and SSVD, finding common features of subcortical neuronal degeneration, demyelination, and astroglial response in both groups. The reduction in all APP-derived proteins characterizing iNPH patients is also present in SSVD, indicating similar pathophysiological phenomena between the two conditions.
FRONTIERS IN NEUROLOGY
(2022)
Article
Neurosciences
Aleksi Vanninen, Heikki Lukkarinen, Tarja Kokkola, Anne M. Koivisto, Merja Kokki, Tadeusz Musialowicz, Mikko Hiltunen, Henrik Zetterberg, Ville Leinonen, Sanna-Kaisa Herukka, Tuomas Rauramaa
Summary: Alzheimer's disease (AD) is a common cause of dementia, particularly in patients with idiopathic normal pressure hydrocephalus (iNPH). The presence of AD pathology in iNPH is associated with worse outcomes after a shunt procedure. Preoperative diagnosis of AD in iNPH patients is challenging due to reduced cerebrospinal fluid (CSF) AD biomarker concentrations. Our study aimed to determine the effect of iNPH on CSF levels of AD biomarkers and investigate the potential for correction to improve diagnostic value. Results showed significant differences in biomarker levels between groups, and correction for iNPH did not improve diagnostic effectiveness. However, the P-Tau(181)/A beta(1-42) ratio showed some utility in diagnosing AD in iNPH patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Liu Chunyan, Hua Rongrong, Wei Youping, Li Hongliang, Yang Qiong, Liu Xing, Xing Yan
Summary: The study found that many parameters in the Boon gait test were responsive to the CSF TT, and combining the 10-MWT and 3-mTUG gait assessments may help objectively assess the response to the CSF TT.
CLINICAL NEUROLOGY AND NEUROSURGERY
(2021)
Article
Clinical Neurology
Yasutaka Nikaido, Hideyuki Urakami, Yohei Okada, Toshihiro Akisue, Yuki Kawami, Naoya Ishida, Yoshinaga Kajimoto, Ryuichi Saura
Summary: This study evaluated the rehabilitation effects of dynamic equilibrium gait training (DEGT) for patients with idiopathic normal pressure hydrocephalus (iNPH) who underwent cerebrospinal fluid (CSF) shunting, compared to standard exercise (SE) and no further treatment. The results showed that DEGT can improve gait-balance functions and reduce the fall incidence of iNPH patients after CSF shunting.
JOURNAL OF NEUROLOGY
(2023)
Review
Neurosciences
Haoyun Xiao, Fan Hu, Jing Ding, Zheng Ye
Summary: This review summarizes recent advances in understanding the neurobiological mechanisms of cognitive impairment in iNPH. It suggests that cognitive symptoms in iNPH can be partially alleviated through interventions targeting abnormal CSF dynamics, dysfunctional neural circuits, abnormal neuromodulation, and the presence of amyloid-beta and tau pathologies.
NEUROSCIENCE BULLETIN
(2022)
Article
Neurosciences
Fuxia Yang, Lu Yang, Xuhao Fang, Yao Deng, Renling Mao, Aijuan Yan, Wenshi Wei
Summary: The study found that CSF sTREM2 levels were higher in iNPH patients, indicating the involvement of neuroinflammation in the pathogenesis of iNPH. Furthermore, the levels of sTREM2 were positively correlated with YKL-40, suggesting the importance of glial cell interactions in iNPH.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Geriatrics & Gerontology
Rongrong Hua, Chunyan Liu, Xing Liu, Jinwu Zhu, Jie Zhang, Lidong Wang, Zhe Shi, Jian Li, Shuangyan Kong, Chenhui Yang, Nan Liu, Lijuan Liu, Jie Sun, Qiong Yang, Yubing Wu, Ying Zhou, Yanfeng Li, Yan Xing
Summary: The analysis of CSF biomarkers showed decreased levels of tau and its phosphorylated form, especially in the tap test (+) group. The responsiveness of the tap test was related to the number of combined symptoms, and a correlation was found between the end pressure or pressure difference in CSF and tap test responsiveness.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Surgery
Xinxia Guo, Abdul Malik Popal, Zhoule Zhu, Chengwei Cai, Jingquan Lin, Hongjie Jiang, Zhe Zheng, Jianmin Zhang, Anwen Shao, Junming Zhu
Summary: This case demonstrates that ventriculosternal shunting is a feasible and effective alternative for managing hydrocephalus.
FRONTIERS IN SURGERY
(2021)
Article
Clinical Neurology
Gabriel Andre da Silva Mendes, Cintya Yukie Hayashi, Gustavo Henrique Frigieri Vilela, Lissa Kido, Manoel Jacobsen Teixeira, Fernando Campos Gomes Pinto
Summary: This study compares the results of a tap test with parameters obtained from a non-invasive sensor for monitoring intracranial compliance in patients suspected of having normal pressure hydrocephalus (NPH). The results suggest that a higher P2/P1 ratio in patients with a positive tap test result indicates a change in intracranial compliance. There was also a significant difference between patients with positive, negative, and inconclusive tap test results, particularly in the lying position. The non-invasive intracranial compliance device showed correspondence with the tap test result when used with the patient lying down and standing up.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2023)
Article
Multidisciplinary Sciences
Antonio Scollato, Saverio Caini, Lucia Angelini, Giancarlo Lastrucci, Nicola Di Lorenzo, Berardino Porfirio, Pasquale Gallina
Summary: This study reviewed the records of 69 patients and found that maintaining stroke volume values within a definite range could maximize clinical benefit and avoid the risk of CSF overdrainage. The odds of negative outcome between two consecutive checks increased significantly with certain stroke volume differences.
SCIENTIFIC REPORTS
(2021)
Article
Anesthesiology
Lisa Hentsch, Patrick Stancu, Gilles Allali, Karl-Olof Lovblad, Johannes A. Lobrinus, Sara Cocetta, Sophie Pautex, Marjolaine Uginet, Jacques Serratrice, Matteo Coen
Summary: The article reports three cases of chronic cancer pain patients experiencing a significant reduction or disappearance of pain when infected with COVID-19, with pain reappearing after recovery. Neurological imaging and pathological findings did not provide conclusive results. The authors believe further investigation is essential for shedding new light on pain perception and modulation mechanisms.
Article
Geriatrics & Gerontology
Olivier Beauchet, Marc Afilalo, Gilles Allali, Joshua Lubov, Kevin Galery, Cyrille P. Launay
Summary: This study examined the impact of ER2 recommendations on incident hospital admissions and length of stay in the emergency department (ED) for older people with major neurocognitive disorders (MNCD) visiting the ED. The results showed that ER2 recommendations were associated with reduced hospital admissions and increased length of stay in the ED, suggesting additional benefits beyond usual ED care.
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
(2022)
Article
Neurosciences
Giulia Bommarito, Valentina Garibotto, Giovanni B. Frisoni, Federica Ribaldi, Sara Stampacchia, Frederic Assal, Stephane Armand, Gilles Allali, Alessandra Griffa
Summary: This pilot study used a multimodal imaging approach to explore the biological substrate of the Motoric Cognitive Risk (MCR) syndrome in a Memory Clinic cohort. The results showed that MCR+ patients had increased ventricular volume and altered diffusion parameters, suggesting that ventricular enlargement and microstructural damage of the surrounding white matter tracts could contribute to MCR pathophysiology.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Alice Bruel, Salim Ben Ghorbel, Andrea Di Russo, Dimitar Stanev, Stephane Armand, Gregoire Courtine, Auke Ijspeert
Summary: This study investigates pathological toe and heel gaits in human locomotion and explores the potential cause-effect relationships between biomechanical or neural impairments and these gaits. The study suggests that toe walking may be generated by hyperreflexia, while muscle and neural weaknesses partially induce heel gait.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Article
Rehabilitation
Fabienne Keller, Lara Allet, Andre Meichtry, Luca Scascighini, Mandy Scheermesser, Markus Wirz, Irina Nast
Summary: This study investigated the ability of Swiss physiotherapists to diagnose and triage patients in a direct access setting and found that their characteristics were associated with correct diagnoses and decision-making. The results showed that improving physiotherapists' screening abilities is important and further research is needed to develop innovative educational concepts and improve training.
PHYSIOTHERAPY THEORY AND PRACTICE
(2023)
Article
Neurosciences
Mickael Fonseca, Raphael Dumas, Stephane Armand
Summary: This study proposes a new auto-selection approach to improve the accuracy of gait event detection. By retrospectively analyzing pathological gait data from 272 patients with cerebral palsy and idiopathic toe walking, the results show that this approach outperforms other implemented methods in terms of accuracy.
Article
Neurosciences
Annie Pouliot-Laforte, Marys Franco Carvalho, Alice Bonnefoy-Mazure, Stephane Armand
Summary: The study aims to determine the number of observations needed in the reference dataset to compute consistent and reliable Gait Deviation Index (GDI) and Gait Profile Score (GPS). The results indicate that a minimum of 90 observations is required for consistent GDI computation, while a minimum of 20 observations is required for consistent GPS computation. In the case of a small reference dataset, GPS should be preferred.
Article
Neurosciences
Anais Gouteron, Anne Tabard-Fougere, Florent Moissenet, Abderrahmane Bourredjem, Kevin Rose-Dulcina, Stephane Genevay, Davy Laroche, Stephane Armand
Summary: This study investigates the sensitivity and specificity of different methods used to calculate flexion relaxation ratio (FRR) and extension relaxation ratio (ERR) in identifying an altered flexion relaxation phenomenon in nonspecific chronic low back pain patients. The results show that all methods used for calculating these ratios are highly sensitive and specific.
JOURNAL OF ELECTROMYOGRAPHY AND KINESIOLOGY
(2023)
Article
Clinical Neurology
Giulia Bommarito, Valentina Garibotto, Giovanni B. Frisoni, Frederic Assal, Patrice H. Lalive, Gilles Allali
Summary: Delirium disorder is a frequent neurological complication of SARS-CoV-2 infection and is associated with increased disease severity and mortality. Cognitive impairment is a major risk factor for developing delirium disorder during Covid-19, which then increases the risk of subsequent neurological complications and cognitive decline.
NEURODEGENERATIVE DISEASES
(2023)
Article
Multidisciplinary Sciences
Gautier Grouvel, Lena Carcreff, Florent Moissenet, Stephane Armand
Summary: Human motion capture and analysis can be simplified through the use of wearable devices such as inertial sensors and pressure insoles. This dataset has been established on 10 asymptomatic adults to enable comparisons between different motion capture systems and stimulate the development of new methods for gait analysis. It includes three-dimensional trajectories of reflective markers, signals from inertial sensors and pressure insoles, ground reaction forces, and moments obtained from force plates.
Letter
Rehabilitation
Anais Gouteron, Davy Laroche, Jacques Beaurain, Elea Ksiazek, Isabelle Fournel, Amelie Bohm, Paul Ornetti, Jean-Marie Casillas, Stephane Armand, Mathieu Gueugnon
ANNALS OF PHYSICAL AND REHABILITATION MEDICINE
(2023)
Article
Clinical Neurology
Marine Thomasson, Philippe Voruz, Alexandre Cionca, Isabele Jacot de Alcantara, Anthony Nuber-Champier, Gilles Allali, Lamyae Benzakour, Patrice H. Lalive, Karl-Olof Loevblad, Olivia Braillard, Mayssam Nehme, Matteo Coen, Jacques Serratrice, Jean-Luc Reny, Jerome Pugin, Idris Guessous, Basile N. Landis, Alessandra Griffa, Dimitri Van de Ville, Frederic Assal, Julie A. Peron
Summary: A study on 105 patients with SARS-CoV-2 infection found that 6 to 9 months after infection, patients with severe respiratory symptoms had poorer recognition abilities for fear expressions, while patients with mild symptoms had poorer recognition abilities for disgust and irritation expressions. These findings suggest long-term consequences of SARS-Cov-2 infection on the limbic system.
BRAIN COMMUNICATIONS
(2023)
Article
Engineering, Biomedical
Andrea Di Russo, Dimitar Stanev, Anushree Sabnis, Simon M. Danner, Jessica Ausborn, Stephane Armand, Auke Ijspeert
Summary: This study presents a physiologically plausible model to investigate spinal control and modulation of human locomotion. The model consists of two coupled central pattern generators (CPGs) and a reflex-based network simulating low-level reflex pathways and Renshaw cells. By optimizing the open parameters, the controller can naturally generate human kinematics and muscle activation.
JOURNAL OF NEURAL ENGINEERING
(2023)
Article
Orthopedics
T. Vendeuvre, A. Tabard-Fougere, S. Armand, R. Dayer
Summary: This study evaluated the use of rasterstereography of the spine as a diagnostic test for adolescent idiopathic scoliosis and compared it with the scoliometer. The results showed that the rasterstereographic scoliosis angle had better diagnostic characteristics, with higher sensitivity, compared to the angle of trunk rotation evaluated with a scoliometer.
BONE & JOINT JOURNAL
(2023)
Article
Multidisciplinary Sciences
Xavier Gasparutto, Pauline Besonhe, Peter Luca DiGiovanni, Stephane Armand, Didier Hannouche
Summary: This paper introduces a measurement method of 3D acetabular offset with bi-plane X-rays, which is important for the functional outcome of total hip arthroplasty. The study found that using appropriate technical and anatomical coordinate systems can yield reliable results, indicating the suitability of this measurement method for clinical use.
SCIENTIFIC REPORTS
(2023)
