Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 68, Issue -, Pages 244-252Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2013.07.051
Keywords
Antiproliferative activity; Copper (II) complexes; Cytotoxicity; DNA binding
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Funding
- CSIR-India
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Mononuclear complexes [Cu(Itpy)X(H2O)]X (Itpy - imidazole terpyridine, X - NO3 1 and X - ClO4 2) have been synthesized and characterized. Single crystal X-ray diffraction of complex 1 shows distorted octahedral geometry around the copper (II) ion. Presence of multiple hydrogen bonding network in the molecule results in anti-parallel stacking of the molecule. Both the complexes show dual mode of binding to DNA. Both the complexes have been found to bring about DNA cleavage in the presence of H2O2 and show potent cytotoxicity towards lung carcinoma cell line. The ability of the two complexes to induce apoptosis has been investigated by using combination of nuclear stains. FACS analysis shows that both the complexes bring about cell cycle arrest at 2.5 mu M concentration. (C) 2013 Elsevier Masson SAS. All rights reserved.
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