Article
Biochemistry & Molecular Biology
Shuo Miao, Chaoqiong Liang, Jianqiang Li, Barbara Baker, Laixin Luo
Summary: CGMMV, a seed-borne virus causing costly diseases in the vegetable trade worldwide, has limited genetic sources for resistance in cucurbits. RNA interference-based technologies, such as amiRNA and syn-tasiRNA, effectively prevented the occurrence and accumulation of CGMMV in cucumber plants, providing a basis for preventing and treating seed-based viral infections.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Agriculture, Multidisciplinary
Chen Wang, Yunlong Yan, Min Huang, Guangming Ma, Li Wang, Xin Xie, Wei Xue, Xiangyang Li
Summary: This study identifies the CMV 2b protein as a potential molecular target for antiviral agents. LP11, among other compounds, shows strong affinity and inhibitory effects against CMV infection in tobacco. These findings provide a theoretical basis for the development of anti-CMV agents.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Agriculture, Multidisciplinary
Qing Zhou, Yuanxiang Zhou, Yunying Zhu, Chenyu Gong, Yongjun Wu, Wei Xue
Summary: Novel 1,4-pentadien-3-one derivatives containing a sulfonamide moiety were synthesized and found to exhibit strong antifungal, antibacterial, and antiviral activities. These compounds showed superior activity against bacteria and fungi compared to commercial agents. The results suggest that active splicing can enhance the biological activity of natural compounds and contribute to the development of novel pesticides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Xiaoxiao Han, Yahong Zhang, Zhiyun Zhang, Hua Xiao, Liping Wu, Lan Wu
Summary: The TEER-decreasing protein from Flammulina velutipes showed antiviral effects against tobacco mosaic virus, activating various signaling pathways in plants to enhance defense mechanisms and protect tobacco from virus infection.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Agronomy
Fangzhou Xu, Shengxin Guo, Wei Zhang, Yanyan Wang, Panpan Wei, Shunhong Chen, Jian Wu
Summary: Novel phthalamide-like thiourea derivatives, especially compound 7b containing trifluoromethylpyridine, showed good antiviral activity against tobacco mosaic virus (TMV) by inhibiting the self-assembly of TMV particles. Compound 7b exhibited even better inactivation activity against TMV than commercial ningnanmycin.
PEST MANAGEMENT SCIENCE
(2022)
Article
Agronomy
Yanfang Li, Yubing Jiao, Jia Shi, Jingjing Xie, Jing Yin, Xiuxiang Zhao, Huamin Chen
Summary: The antiviral protein BLB8 from Brevibacillus laterosporus B8 effectively inhibits TMV infection through triggering plant immunity, showing protective, inactive and curative effects. This provides a new antiviral agent for prevention and control of viral disease.
PEST MANAGEMENT SCIENCE
(2021)
Article
Plant Sciences
Reenu Kumari, Surender Kumar, Diana Leibman, Bekele Abebie, Yulia Shnaider, Shou-Wei Ding, Amit Gal-On
Summary: RDRs play important roles in plant development and resistance to pathogens through mechanisms such as siRNA signal amplification and viral genome methylation. In cucumber, various CsRDR1 genes are induced during virus infection with complex mechanisms involved in antiviral responses.
MOLECULAR PLANT PATHOLOGY
(2021)
Article
Multidisciplinary Sciences
Peipei Cui, Mingjiang Cai, Yanan Meng, Yan Yang, Hongjian Song, Yuxiu Liu, Qingmin Wang
Summary: In this study, a series of echinopsine derivatives containing acylhydrazone moieties were designed, synthesized, and evaluated for their biological activities. The compounds showed good antiviral activity against tobacco mosaic virus, as well as insecticidal and fungicidal activities.
SCIENTIFIC REPORTS
(2022)
Article
Plant Sciences
Elzbieta Paduch-Cichal, Ewa Mirzwa-Mroz, Patrycja Wojciechowska, Katarzyna Baczek, Olga Kosakowska, Zenon Weglarz, Marek Stefan Szyndel
Summary: The study aimed to evaluate the antiviral activity of selected essential oils against Cucumber mosaic virus (CMV) in vitro and in vivo. Greek oregano, thyme, and costmary were used to obtain the essential oils. The dominant compounds in the oils were carvacrol, thymol, and beta-thujone, respectively. Thyme essential oil showed the most promising effects against CMV, but its activity was influenced by the time of application. In vivo, thyme essential oil exhibited protective activity rather than curative activity.
Article
Plant Sciences
Byung-Kook Ham, Xiaohua Wang, Roberto Toscano-Morales, Jinxing Lin, William J. Lucas
Summary: This study characterized the function of ER luminal proteins AtBiP1/2 and ER integral membrane proteins AtERdj2A/B in regulating the movement of non-cell-autonomous proteins within plasmodesmata. The interaction between these proteins and cucumber mosaic virus (CMV) movement protein (MP) was confirmed, and the role of the AtBiP1/2-AtERdj2A-CMV MP complex in CMV infection was established.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Review
Biochemistry & Molecular Biology
F. Murilo Zerbini, Elliot W. Kitajima
Summary: This article discusses the discovery of viruses as agents of diseases and their classification efforts throughout history. It highlights the creation of the International Committee on Nomenclature of Viruses in 1966, which led to the establishment of an official taxonomy for viruses based on evolutionary relationships.
Article
Agronomy
Ting Yuan, Zhengxing Wang, Dan Liu, Huanan Zeng, Juncheng Liang, Deyu Hu, Xiuhai Gan
Summary: By synthesizing and screening, novel ferulic acid derivatives were discovered to have excellent antiviral activity, among which compound E2 exhibited remarkable curative activities against tobacco mosaic virus and cucumber mosaic virus. The outstanding antiviral activity of compound E2 was achieved by increasing host photosynthesis, making it a potential lead structure for the development of new antiviral agents.
PEST MANAGEMENT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jianting Zhang, Ranjith Kumar Kankala, Jingyao Ma, Yihao Zhou, Shi-Bin Wang, Ai-Zheng Chen
Summary: Utilizing the hollow tobacco mosaic virus coat protein as a restrictive template, well-organized one-dimensional inorganic nanostructures were successfully fabricated with high yields, including gold nanoparticles and silver sulfide quantum dots. Different types of functional nanoparticles were encapsulated and assembled into ordered 1D nanochains through TMV-assisted self-assembly approach, showing potential for the fabrication of highly complex hybrid-metal nanostructures.
Article
Horticulture
Roshan Shaalan, Ludmilla Ibrahim, Falah As-sadi, Walid El Kayal
Summary: Plant-endophyte interactions play a crucial role in protecting plants from stresses and pests. Entomopathogenic fungi (EPF) are effective biological control agents. Metabolomics analysis reveals the mechanisms involved in defense against CMV in EPF-treated cucumber plants.
Article
Microbiology
Sruthy Maria Augustine, Stavros Tzigos, Rod Snowdon
Summary: Since the discovery of the tobacco mosaic virus in the 1890s, there has been an increasing awareness of the impact of viruses on the environment. Not only do viral infections cause disease, but some viruses can also have a beneficial effect on plants. This study shows that heat-killed tobacco mosaic virus can enhance abiotic stress tolerance in plants, which has not been reported before.
Article
Biochemistry & Molecular Biology
Puying Qi, Na Wang, Taihong Zhang, Yumei Feng, Xiang Zhou, Dan Zeng, Jiao Meng, Liwei Liu, Linhong Jin, Song Yang
Summary: Anti-virulence strategies are effective for controlling bacterial diseases by targeting virulence factors. In this study, a series of dehydroabietic acid derivatives were synthesized and evaluated for their antibacterial activity. Compound 2b showed promising antibacterial activity against Xanthomonas oryzae pv. oryzae and effective control of bacterial leaf blight in rice. It also suppressed various virulence factors. These compounds can serve as lead compounds for developing novel bactericides.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Agriculture, Multidisciplinary
Dan Zeng, Shuai-Shuai Liu, Wu-Bin Shao, Tai-Hong Zhang, Pu-Ying Qi, Hong-Wu Liu, Xiang Zhou, Li-Wei Liu, Heng Zhang, Song Yang
Summary: This study synthesized 35 new 1,3,4-oxadiazole derivatives and evaluated their anti-phytopathogenic activities. Compound C-7 showed excellent antibacterial activity in vitro and acceptable activity in vivo against rice bacterial leaf blight. Moreover, C-7 could indirectly reduce the inducible expression of host SWEET genes, alleviating nutrient supply in the infection process of phytopathogenic bacteria. The study highlights the potential of 1,3,4-oxadiazole-based agrochemicals in controlling plant bacterial diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Lihui Shao, Su Zhao, Song Yang, Xiang Zhou, Yan Li, Chengpeng Li, Danping Chen, Zhuirui Li, Guiping Ouyang, Zhenchao Wang
Summary: To discover novel antibacterial agents, two series of quinazolinone derivatives with novel structures were synthesized and their bioactivity against plant bacteria was tested. Compound D32 was identified as a potent antibacterial inhibitor against Xanthomonas oryzae pv. Oryzae (Xoo), with better inhibitory capacity compared to the commercial drugs. Further investigation revealed the mechanism of action of D32, which provides clues for the development of new therapeutic strategies.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agronomy
Wu-Bin Shao, Yan-Mei Liao, Rong-Shuang Luo, Jin Ji, Wan-Lin Xiao, Xiang Zhou, Li-Wei Liu, Song Yang
Summary: In this study, new phenothiazine derivatives were synthesized and evaluated for their inhibitory activity against tobacco mosaic virus (TMV). Compound A(8) exhibited the highest protective activity against TMV, with an EC50 of 115.67 μg/mL, which was significantly superior to the positive controls ningnanmycin and ribavirin. Biochemical assays demonstrated that compound A(8) could inhibit TMV replication by disrupting its self-assembly and also enhance the defense responses of tobacco plants. This research provides valuable insights for the discovery of new agrochemicals to control plant viral diseases.
PEST MANAGEMENT SCIENCE
(2023)
Article
Agronomy
Jiao-Jiao Zhang, Yu-Mei Feng, Jun-Rong Zhang, Wan-Lin Xiao, Shuai-Shuai Liu, Xiang Zhou, Heng Zhang, Pei-Yi Wang, Li-Wei Liu, Song Yang
Summary: A series of simple triclosan derivatives containing isopropanolamine moiety were designed and assessed for their antibacterial behavior. Some compounds showed excellent bioactivity against three destructive bacteria. Compound C-8 displayed high bioactivities towards Xoo and Xac.
PEST MANAGEMENT SCIENCE
(2023)
Article
Agronomy
Zhenxing Li, Binxin Yang, Yue Ding, Xiang Zhou, Zimian Fang, ShuaiShuai Liu, Jie Yang, Song Yang
Summary: A series of phosphonate derivatives containing a 1,2,3-triazole motif were developed and evaluated for their antiviral activity against tobacco mosaic virus (TMV) helicase. The optimized B-17 showed stronger curative activity against TMV compared to the commercial drug Ribavirin. Additionally, B-17 exhibited potential antiviral activity against other viruses and pathogens.
PEST MANAGEMENT SCIENCE
(2023)
Article
Agronomy
Bin-Xin Yang, Zhen-Xing Li, Shuai-Shuai Liu, Jie Yang, Pei-Yi Wang, Hong-Wu Liu, Xiang Zhou, Li-Wei Liu, Zhi-Bing Wu, Song Yang
Summary: Two series of novel cinnamic acid derivatives were designed and synthesized to explore alternative agrochemicals for controlling plant virus and bacterial diseases. The bioassay results showed that these derivatives exhibited excellent antiviral competence, with compound A(5) demonstrating remarkable protective effects against tobacco mosaic virus. This research provides a foundation for the practical application of cinnamic acid derivatives in pesticide exploration.
PEST MANAGEMENT SCIENCE
(2023)
Article
Agriculture, Multidisciplinary
Wu-Bin Shao, Rong-Shuang Luo, Jiao Meng, Xiao-Kang Lv, Hong-Mei Xiang, Wan-Lin Xiao, Xiang Zhou, Li-Wei Liu, Zhi-Bing Wu, Song Yang
Summary: Phenothiazine derivatives showed excellent bioactivity against different bacteria and demonstrated potential as pesticide candidates for plant diseases. Compound C-2 had high effectiveness against rice leaf blight, outperforming commonly used pesticides.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Agronomy
Zhen-Xing Li, Jin-Hong Hu, Rong-Shuang Luo, Tai-Hong Zhang, Yue Ding, Xiang Zhou, Li-Wei Liu, Zhi-Bing Wu, Song Yang
Summary: This study established an efficient screening platform based on natural alkaloids to discover novel compounds targeting TMV helicase. Rutaecarpine from Evodia rutaecarpa (Juss.) Benth showed excellent TMV helicase inhibitory properties (Kd = 1.1 μm, IC50 = 227.24 μm) and demonstrated strong anti-TMV activity. Molecular docking and dynamic simulations revealed that Rutaecarpine could stably bind to the active pockets of the helicase through hydrogen bonding and hydrophobic interactions with low binding energy (ΔG(bind) = -17.8 kcal/mol).
PEST MANAGEMENT SCIENCE
(2023)
Review
Chemistry, Physical
Wenfeng Zhao, Hu Li, Heng Zhang, Song Yang, Anders Riisager
Summary: Ammonia borane (AB) is a promising material for hydrogen storage and has attracted much attention in reductive organic transformations. This review summarizes the recent progress of AB-mediated transfer hydrogenation reactions of various substrates and discusses the synthesis protocols, reaction parameters, product distribution, and reactivity. The mechanism involving the action mode of AB and structure-activity relationships are also discussed, and the challenges and opportunities for AB-enabled transfer hydrogenation reactions are highlighted.
GREEN ENERGY & ENVIRONMENT
(2023)
Article
Chemistry, Multidisciplinary
Ye Meng, Jinshu Huang, Jie Li, Yumei Jian, Song Yang, Hu Li
Summary: By mimicking the key active species of hemoglobin p450 heme monooxygenase, a Fe-N-4 single atom-doped sulfur-containing carbon nitride photocatalyst was prepared and demonstrated to efficiently convert bio-based alcohols and NH2OH dot HCl to nitriles. The Fe-N-4 sites in the catalyst directly capture photogenerated electrons and molecular oxygen to generate superoxide radicals, while the surrounding S atoms confine photogenerated holes. This strategy of constructing atomic sites enhances the photocatalytic activity and selectivity for biomass valorization.
Article
Chemistry, Multidisciplinary
Feng Xu, Zao Li, Li-Long Zhang, Shengqi Liu, Hu Li, Yuhe Liao, Song Yang
Summary: Upgrading biomass-derived platforms to functionalized aromatics by a tandem Diels-Alder (DA) cycloaddition-aromatization strategy has attracted attention. Three challenges exist: improving the equilibrium of DA cycloaddition, controlling the regioselectivity of DA adducts, and increasing the stability of the cycloadduct. In this study, an intramolecular cycloaromatization strategy was developed using a defective Zn-BTC-SA catalyst and an acidic ionic liquid to achieve efficient and selective conversion of bio-furfurals to isoindolinones under liquid phase conditions. The protocol showed high yields and scalability.
Article
Chemistry, Multidisciplinary
Long Chen, Yixuan Liu, Heng Zhang, Yuncong Li, Songdang Zhang, Yulin Hu, Hu Li, Song Yang
Summary: Utilization of renewable biomass resources to produce value-added platform molecules, such as anethole, has attracted significant attention. In this study, a green and effective method for the stereoselective conversion of biomass-derived 4'-methoxyphenylacetone into trans-anethole was developed using a bifunctional acid catalyst. The catalyst exhibited a favorable structure with specific surface area, abundant mesopores, acidic sites, hydrophobicity, and stability. The optimized reaction conditions resulted in a high yield and excellent reusability. This catalytic strategy shows promise for the synthesis of anethole and other high-value molecules.
REACTION CHEMISTRY & ENGINEERING
(2023)
Article
Chemistry, Inorganic & Nuclear
Li-Long Zhang, Yaqiong Su, Dandan Chen, Hongguo Wu, Feng Xu, Hu Li, Song Yang
Summary: NOx is used as an oxidant for direct selective conversion of methane into methanol, but the interconversion of NOx compounds and the easy formation of O-2 have posed challenges in determining its effectiveness. This study proposes a new cooperative multi-functional mechanism strategy using dual oxidants (NO and N2O) to enhance catalytic performance. Compared with normal mechanisms, this strategy shows stronger CH4 adsorption and thermodynamic favorability. It is expected to inspire further research in DSCMM and other catalytic systems.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Physical
Li-Long Zhang, Ji Zheng, Jinxing Gu, Zhuochun Huang, Linguo Lu, Hu Li, Zhongfang Chen, Song Yang
Summary: This study investigated 11 phosphotungstic acid-supported single-atom catalysts (SACs) and found that Os-1/PTA SACs exhibited superior catalytic activity for the purification of methane and hydrogen, with the ease of oxidation following the CO > H-2 > CH4 order. It selectively removed CO in water and MeOH without consuming H-2, due to strong Os-PTA interactions and charge transfer mechanism.
JOURNAL OF MATERIALS CHEMISTRY A
(2023)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
