Article
Medicine, Research & Experimental
Franz Steppeler, Dominika Iwan, Radoslaw Gaida, Marta Denel-Bobrowska, Agnieszka B. Olejniczak, Elzbieta Wojaczy
Summary: 2-Azabicycloalkanes were used as a chiral platform to synthesize a set of 1,2,3-triazole, thiourea, and ebselen derivatives. The selected thioureas showed the most promising cytotoxicity and antiviral activity.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Huan Li, Shuang Fu, Yudan Wang, Xuan Yuan, Lijia Liu, Hongxing Dong, Qiang Wang, Zhijia Zhang
Summary: Thirteen cationic peptidomimetics derived from amino acids were designed and synthesized to mimic the structure of cationic antibacterial peptides. Most of them showed significant broad-spectrum antibacterial activity against various bacteria, with some exhibiting low cytotoxicity. These peptidomimetics may have potential for the treatment of bacterial infections.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Ping Yang, Jia-Bao Luo, Zi-Zhou Wang, Li-Lei Zhang, Jin Feng, Xiao-Bao Xie, Qing-Shan Shi, Xin-Guo Zhang
Summary: A series of 1,2,4-triazole-norfloxacin hybrids were designed, synthesized, and evaluated for their in vitro antibacterial activity against common pathogens. The newly synthesized compounds showed superior antibacterial activity to norfloxacin, with high toxicity towards bacterial cells but good biocompatibility. Molecular docking analysis suggested strong affinity of the compounds for bacterial topoisomerase IV.
BIOORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Reem I. Al-Wabli, Mona A. Alsulami, Sarah I. Bukhari, Nadine M. S. Moubayed, Maha S. Al-Mutairi, Mohamed I. Attia
Summary: A series of new indole-triazole conjugates were designed and synthesized for evaluation as new antimicrobial candidates, showing good to moderate activity against most tested Gram-negative strains and potent activity against Candida tropicalis, with one compound exhibiting the strongest activity against Candida albicans.
Article
Chemistry, Physical
Sana Saffour, Amal A. AL-Sharabi, Asaf Evrim Evren, Meral Yilmaz Cankilic, Leyla Yurttas
Summary: In this study, thirteen new compounds were synthesized and evaluated for their antifungal and antimicrobial activities. One compound exhibited the best activity and selectivity against Yersinia enterocolitica. Additionally, all compounds showed good activity against filamentous fungi.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Biochemistry & Molecular Biology
Urszula Kosikowska, Monika Wujec, Nazar Trotsko, Wojciech Plonka, Piotr Paneth, Agata Paneth
Summary: In this study, a library of fluorobenzoylthiosemicarbazides and their cyclic analogues was created and tested for antibacterial activity. The trifluoromethyl derivatives showed optimum activity against Gram-positive bacteria strains, suggesting their potential as allosteric d-alanyl-d-alanine ligase inhibitors.
Review
Chemistry, Medicinal
Xuemei Ge, Zhi Xu
Summary: MRSA, a significant pathogen in hospitals and communities, requires urgent development of novel antimicrobial agents. 1,2,4-triazole hybrids, with diverse mechanisms of antibacterial activity, exhibit broad-spectrum antibacterial activity against clinically important drug-resistant pathogens, including MRSA.
ARCHIV DER PHARMAZIE
(2021)
Article
Chemistry, Multidisciplinary
Li Zhu, Si-Yu Tang, Dan-Ping Chen, Cheng-Peng Li, Li-Hui Shao, Gui-Ping Ouyang, Zhen-Chao Wang, Zhu-Rui Li
Summary: In this study, a series of novel indole 3-substituted-[1,2,4]triazole derivatives were designed and synthesized. The antibacterial activities of these compounds were evaluated and showed excellent bioactivity against Xanthomonas oryzae pv. oryzae (Xoo).
Article
Agriculture, Multidisciplinary
Muhan Ding, Suran Wan, Nan Wu, Ya Yan, Junhong Li, Xiaoping Bao
Summary: In this study, 52 novel compounds were designed, synthesized, and evaluated for their antimicrobial activities against Xanthomonas oryzae pv. oryzae (Xoo) and Rhizoctonia solani. Some of these compounds showed excellent antibacterial activities and good pesticide-likeness, making them potential candidates for agricultural antimicrobial agents.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Review
Chemistry, Medicinal
Jie Li, Junwei Zhang
Summary: This review provides an update on the latest developments of 1,2,3-triazole and 1,2,4-triazole-containing hybrids with anti-S. aureus activity.
CURRENT TOPICS IN MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Tamer El Malah, Hanan A. Soliman, Bahaa A. Hemdan, Randa E. Abdel Mageid, Hany F. Nour
Summary: A series of new compounds with antibacterial properties were synthesized by the research team, and their inhibitory and antibiofilm activities against methicillin-resistant Staphylococcus aureus (MRSA) were evaluated. The results showed that some compounds exhibited significant growth inhibition activity against MRSA cells, with antibiofilm effects superior to Vancomycin.
NEW JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Applied
Manoj Kumar Bharty, Aarti Singh, Pooja Bharati, Shivendra Kumar Pandey, Devesh Kumar Singh, Vellaichamy Ganesan, Praveen Kumar Verma, Arvind Acharya, Akhilesh Bharti, Ray J. Butcher
Summary: This study focuses on the electrocatalytic water oxidation by cobalt(III) complexes and their cytotoxicity against Dalton's lymphoma cells. Complex 2 showed significant cytotoxicity against DL cells with an IC50 value of 5 μM, indicating its potential as an anticancer agent.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Mukhlif Mohsin Slaihim, Fouad Saleih R. Al-Suede, Melati Khairuddean, Siti Balkees S. T. N. Hameed Sultan, V Mansoureh Nazari, Mohamed B. Khadeer Ahamed, Amin Malik Shah Abdul Majid
Summary: This study synthesized and characterized a new ring system based on 1,2,4-triazole compounds, and explored their anti-tumor properties against breast cancer (MCF-7) and colorectal cancer (HCT-116) cells. The results showed that compounds 6A and 7B exhibited significant cytotoxic efficacy against MCF-7 cells, with an IC50 of 38 and 53 μM, respectively, while other compounds demonstrated moderate cytotoxicity.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Inorganic & Nuclear
Tianyun Pei, Xuanhe Zhang, Zhenzhen Yang, Zhonglu Ke, Qingsong Shi, Qingqing Mao, Shunze Gong, Hanwei Zeng, Feng Xu, Defeng Xu
Summary: A series of triazole-tetrazine derivatives were synthesized and screened for their anticancer activity, with compound 4g exhibiting good activity against human colon carcinoma.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2022)
Article
Biochemistry & Molecular Biology
Mohamed T-E Maghraby, Tahani Mazyad Almutairi, Stefan Brase, Ola I. A. Salem, Bahaa G. M. Youssif, Mahmoud M. Sheha
Summary: A novel series of 1,2,3-triazole/1,2,4-triazole hybrids were designed and synthesized as antiproliferative agents targeting aromatase enzymes. Compounds 6a and 6b demonstrated the highest antiproliferative activity and aromatase inhibitory action, indicating their potential as anticancer candidates. Molecular docking investigations further supported these findings.
Article
Chemistry, Physical
Vali Alizadeh, Ghodrat Mahmoudi, Marina A. Vinokurova, Kuzma M. Pokazeev, Kseniia A. Alekseeva, Barbara Miroslaw, Ali Akbar Khandar, Antonio Frontera, Damir A. Safin
Summary: In this work, the crystal structures of three heteroleptic coordination compounds were reported, showing specific coordination characteristics of the ligand molecule HL. The interactions between metal and halogen play a crucial role in the formation of multi-dimensional structures.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Chemistry, Physical
Mirjana Antonijevic Nikolic, Branka Drazic, Beata Cristovao, Agata Bartyzel, Barbara Miroslaw, Sladana Tanaskovic
Summary: New cationic complexes of Cu(II) with bridged aminocarboxylates were synthesized and characterized, showing to exist as hydrates. The complexes exhibited anti-proliferative effects on leukemia cell lines with IC50 values ranging from 37.9 to 63.05 µM.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Green & Sustainable Science & Technology
Przemystaw Wolinski, Agnieszka Kacka-Zych, Barbara Mirostaw, Ewelina Wielgus, Aleksandra Olszewska, Radomir Jasinski
Summary: In this study, a new green procedure for the synthesis of a series of 1,2-oxazine N oxide moieties via Hetero Diels-Alder (HDA) reaction was described, using (2E)-3-aryl-2-nitroprop-2-enenitriles. Unlike most known HDA reactions, this process does not require a Lewis acid-type catalyst, operates under mild conditions, and exhibits full atomic economy and selectivity. Additionally, the reaction process was characterized using Molecular Electron Density Theory (MEDT).
JOURNAL OF CLEANER PRODUCTION
(2022)
Article
Chemistry, Multidisciplinary
Danuta Branowska, Waldemar Wysocki, Ewa Wolinska, Karolina Koc, Katarzyna Stanska, Barbara Miroslaw, Zbigniew Karczmarzyk
Summary: In this study, two new 1,2,4-triazine-containing sulfonamide derivatives were synthesized and characterized. The experiment and theoretical calculations showed that these two tautomeric forms can coexist in solvents, with the sulfonamide form being more predominant in polar solvents.
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Alicja Chrzanowska, Dagmara Kurpios-Piec, Barbara Zyzynska-Granica, Ewelina Kiernozek-Kalinska, Wen Xin Lay, Andrzej K. Ciechanowicz, Marta Struga
Summary: The positive trend in cancer treatment management is to explore the antineoplastic potential of widely used and safe drugs with different clinical purposes. Moxifloxacin, a fourth-generation fluoroquinolone with broad-spectrum antibacterial activity, has shown promising cytotoxic potential as moxifloxacin conjugates with fatty acids. These conjugates exhibited stronger cytotoxic activity than free moxifloxacin, especially with oleic and stearic acid, without toxicity to normal cells. The conjugates activated caspases 3/7 and induced late apoptosis in cancer cells, and also showed potential anti-inflammatory effects.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Drzewiecka-Antonik, Marta Struga, Agnieszka Glogowska, Ewa Augustynowicz-Kopec, Katarzyna Dobrzynska, Alicja Chrzanowska, Anna Wolska, Pawel Rejmak, Marcin T. Klepka, Malgorzata Wrzosek, Anna Bielenica
Summary: Copper complexes with 1,3-disubstituted thiourea derivatives were synthesized and their structures and properties were investigated. The complexes exhibited antimicrobial, antituberculosis, and antitumor activities.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Physical
Barbara Miroslaw, Oleg M. Demchuk, Roman Luboradzki, Katarzyna Tyszczuk-Rotko
Summary: The study synthesized low-molecular-weight organogelators (LMOGs) derived from two endogenous (L)-alanine, (L)-leucine, and three exogenous (L)-valine, (L)-phenylalanine, and (L)-proline amino acids using lauric acid. Crystallographic diffraction and energy frameworks analysis were used to investigate the organization and gelling properties of these compounds. The findings provide valuable insights for designing new low-molecular-weight organic gelators.
Article
Chemistry, Physical
Katarzyna Kaplon, Slawomir Frynas, Barbara Miroslaw, Janusz Lipkowski, Oleg M. Demchuk
Summary: The enantiomerically pure ligand BisNap-Phos was obtained from inexpensive starting materials in high overall yield using a straightforward sequence of reactions. The asymmetric BisNap-Phos-palladium complex-catalyzed Suzuki-Miyaura coupling led to the synthesis of axially chiral biaryl compounds. The reactions were carried out under mild conditions, resulting in the synthesis of atropisomeric biaryls with excellent yields and high enantioselectivities (up to 86% ee). This methodology provides an efficient and practical strategy for the synthesis of novel multifunctionalized axially chiral biaryl compounds under mild environmentally friendly and easily affordable conditions.
Article
Pharmacology & Pharmacy
Anna Basile, Carla Zannella, Margot De Marco, Giuseppina Sanna, Gianluigi Franci, Massimiliano Galdiero, Aldo Manzin, Vincenzo De Laurenzi, Massimiliano Chetta, Alessandra Rosati, Maria Caterina Turco, Liberato Marzullo
Summary: Researchers have developed a specific antibody against IFITM2 that can interfere with the invasion of SARS-CoV-2 and reduce its damage to host cells. This antibody also reduces the damage caused by other viruses such as HSV and RSV, suggesting that IFITM2 may have a similar mechanism of invasion to other viruses. These results demonstrate the specific role of IFITM2 in viral entry and its potential as a cell target for antiviral therapies.
ANTIVIRAL RESEARCH
(2023)
Article
Thermodynamics
Monika Pitucha, Pawel Ramos, Karolina Wojtunik-Kulesza, Agnieszka Glogowska, Joanna Stefanska, Dorota Kowalczuk, Drozd Monika, Ewa Augustynowicz-Kopec
Summary: The aim of this research was to evaluate the antimicrobial, anti-tuberculosis, and antioxidant activity of thiosemicarbazone derivatives. The results showed that selected compounds have potential against Staphylococcus aureus, Staphylococcus epidermidis, and Mycobacterium tuberculosis. Some compounds also exhibited free radical scavenging and Fe3+ reducing properties. Thermal analysis revealed variations in the thermal stability of thiosemicarbazone derivatives, with T2 derivative being the most stable and T11 derivative being the least stable. Most derivatives underwent two-stage thermal decomposition.
JOURNAL OF THERMAL ANALYSIS AND CALORIMETRY
(2023)
Article
Biochemistry & Molecular Biology
Sara Janowska, Dmytro Khylyuk, Michal Janowski, Urszula Kosikowska, Paulina Strzyga-Lach, Marta Struga, Monika Wujec
Summary: The treatment of infectious diseases poses a challenge to the medical community due to the emergence of drug-resistant strains. Schiff bases, a promising class of compounds, were synthesized and tested for their antibacterial and antifungal activities. Compound RO4 exhibited the highest antifungal activity against Candida spp., with an MIC value of 62.5 μg/mL. The synthesized compounds were also evaluated for their toxicity on cell lines and their mechanism of action through molecular docking studies.
Article
Chemistry, Medicinal
Roberta Ibba, Paola Corona, Francesca Nonne, Paola Caria, Gabriele Serreli, Vanessa Palmas, Federico Riu, Simona Sestito, Maria Nieddu, Roberta Loddo, Giuseppina Sanna, Sandra Piras, Antonio Carta
Summary: Researchers designed and synthesized a series of novel benzo[d][1,2,3]triazol-1(2)-yl derivatives, which were evaluated for their cytotoxicity and antiviral activity against Coxsackievirus B5. Compound 18e showed cell protective effects against CVB5 infection by interfering with the viral attachment process.
Article
Biochemistry & Molecular Biology
Annalisa Chianese, Carla Zannella, Alessandra Monti, Nunzianna Doti, Giuseppina Sanna, Aldo Manzin, Anna De Filippis, Massimiliano Galdiero
Summary: Pandemic and epidemic outbreaks of respiratory viruses pose significant challenges to public health. This study identifies a potent antimicrobial peptide with broad-spectrum antiviral activity against several respiratory viruses.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Daniel Szulczyk, Mateusz Wozinski, Michal Kolinski, Sebastian Kmiecik, Agnieszka Glogowska, Ewa Augustynowicz-Kopec, Michal A. Dobrowolski, Piotr Roszkowski, Marta Struga, Krzesimir Ciura
Summary: This study investigated the antitubercular properties of Ciprofloxacin derivatives conjugated with menthol and thymol moieties. The results showed that these compounds have antitubercular activity and exhibit similar or better activity against drug-resistant strains. Additionally, the increased lipophilicity and affinity to phospholipids of the new derivatives offer advantages for new drug candidates. Further studies are needed to understand their safety, efficacy, and mechanism of action.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Inorganic & Nuclear
Barbara Miroslaw, Izabela Dybala, Radomir Jasinski, Oleg M. Demchuk
Summary: In this study, the X-ray single crystal structures of palladium(II) complexes of a family of biaryl monophosphine ligands were analyzed, and the crystallographic structure of a related phosphine sulfide was reported for the first time. Despite the similar basic structure, these ligands exhibited diverse coordination modes. These findings shed light on the multiverse of coordination modes in biaryl monophosphine ligands.
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)