Article
Biochemistry & Molecular Biology
Ganesh Kumar Raut, Genji Sukumar, Moumita Chakrabarti, Jolly Janette Mendonza, Srihari Pabbaraja, B. Jagan Mohan Reddy, Ramakrishna Sistla, Sai Balaji Andugulapati, Manika Pal Bhadra
Summary: Polyphenols are natural compounds with anti-tumorigenic effects. This study designed and synthesized a compound that interferes with the cell cycle progression in aggressive prostate cancer. Further experiments showed that the compound inhibits the viability of prostate cancer cells and induces apoptosis through oxidative stress. In a mouse model, the compound showed no toxicity and reduced the tumor burden.
Article
Medicine, Research & Experimental
Shabeeba M. Ashraf, Susobhan Mahanty, Krishnan Rathinasamy
Summary: Securinine effectively inhibits the proliferation of cervical, breast, and lung cancer cells while inducing minimal toxicity in non-malignant HEK cells. It disrupts microtubule organization in both interphase and mitotic phases, as well as inhibits tubulin assembly. Additionally, securinine induces a mitochondrial-dependent ROS response in cancer cells and leads to apoptosis through a p53-dependent pathway in MCF-7 cells.
Article
Biochemistry & Molecular Biology
Irina Tolmacheva, Yulia Beloglazova, Mikhail Nazarov, Olga Gagarskikh, Victoria Grishko
Summary: Multidrug resistance (MDR) is a common occurrence in cancer treatment, where cancer cells become resistant to chemotherapy drugs due to overexpression of ATP-binding cassette efflux transporters, including P-glycoprotein (P-gp). A new semi-synthetic derivative, MK, was found to have the highest cytotoxicity against cancer cells, but it was not identified as a P-gp inhibitor or substrate. Further studies suggest that the cytotoxic effect of MK on cancer cells may be induced through the ROS-mediated mitochondrial pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Nkafu Bechem Ndemazie, Andriana Inkoom, Dexter Ebesoh, Raviteja Bulusu, Esther Frimpong, Jose Trevino, Bo Han, Xue Zhu, Edward Agyare
Summary: In this study, MFU was synthesized and characterized, showing potential anticancer activity against pancreatic cancer (PCa). The inhibitory concentration of MFU was significantly lower than that of Gemcitabine hydrochloride (GemHCl) in both cell lines, indicating its potential as a new therapeutic option for PCa.
Review
Veterinary Sciences
Mingbang Wei, Yourong Ye, Muhammad Muddassir Ali, Yangzom Chamba, Jia Tang, Peng Shang
Summary: Fluoride, commonly found in the environment, can have harmful effects on the ecological environment and human health. Mitochondrial dysfunction, which has been observed in various model systems, is a shared feature of fluorosis. Fluoride damages mitochondria and leads to decreased enzyme activity, weakened protein expression, respiratory chain damage, excessive fission, disturbance of fusion, disorder of calcium regulation, and the accumulation of Reactive oxygen species. This results in decreased intracellular ATP and the release of Cyt c, causing apoptosis. This article reviews the mechanism of cytotoxicity related to mitochondrial dysfunction after fluorosis, emphasizing on various aspects of mitochondrial dysfunction caused by fluorosis, such as mitochondrial dynamics, mitochondrial Reactive oxygen species, mitochondrial fission, mitochondrial respiratory chain, mitochondrial autophagy apoptosis, mitochondrial fusion disturbance, and mitochondrial calcium regulation.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Article
Chemistry, Applied
Elumalai Kowsalya, Kithiyon MosaChristas, Chinna Rani Inbaraj Jaquline, Pannerselvam Balashanmugam, Thiyagarajan Devasena
Summary: Green synthesis of functionalized gold nanoparticles using leaf aqueous extracts from 10 different plants was successful, with Pterygota alata showing enhanced antioxidant activity and potent anticancer efficacy against MCF-7 breast cancer cells. The phytosynthesized AuNPs may be a promising anti-cancer strategy for breast cancer without toxicity to normal cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Chemistry, Organic
Mahshid Yaghoubi, Ryan D. D. Baxter
Summary: New methods for the synthesis of 1,3-diaryltriazenes and azo dyes from aryl amines are presented. These methods involve the formation of aryl diazonium intermediates through the transnitrosation of aryl amines with N-nitrososulfonamides. The reactions can be conducted in one vessel at room temperature without any precautionary measures to exclude air or moisture. The reported novel structures of triazenes and azo dyes demonstrate the effectiveness of the mild conditions for the two-step reaction sequence.
Article
Immunology
Shan Sasidharan, Kumar S. S. Nishanth, Hareendran J. J. Nair
Summary: Candida albicans infection is a significant public health problem, and the extract from Caesalpinia bonduc seeds, EECS, has shown potential as an anticandidal agent. The study found that EECS triggered mitochondrial dysfunction and apoptosis in C. albicans through the elevation of ROS, release of cytochrome c, and increased Ca(2+) levels. In vivo experiments also demonstrated the efficacy of EECS in treating C. albicans infection.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Maria Schroder, Maria Petrova, Zlatina Vlahova, Georgi M. Dobrikov, Ivaylo Slavchev, Evdokia Pasheva, Iva Ugrinova
Summary: The successful design of antitumour drugs often involves combining different biologically active subunits to affect multiple cellular regulatory pathways, leading to higher efficacy. In this study, two ferrocene derivatives, DK-164 and CC-78, were tested for their cytotoxic potential on lung cancer cell lines. DK-164 showed selective cytotoxicity towards cancer cells, while CC-78 exhibited higher cytotoxicity without selectivity. The different cellular mechanisms induced by these compounds in lung cancer cells provide insights into the specific functions of functional groups in ferrocene compounds and can guide the design of new antitumour drugs.
Article
Pharmacology & Pharmacy
Nida Nayyar Farshori, Mai Mohammad Al-Oqail, Ebtesam Saad Al-Sheddi, Shaza Mohamed Al-Massarani, Quaiser Saquib, Maqsood Ahmed Siddiqui, Rizwan Wahab, Abdulaziz Ali Al-Khedhairy
Summary: In this study, silver nanoparticles were successfully synthesized using a green method and their anticancer effects in human lung adenocarcinoma cells were investigated. The results showed that the synthesized silver nanoparticles can inhibit the growth of cancer cells by inducing apoptosis.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jing Hao, Huiwen Zhang, Li Tian, Linlin Yang, Yi Zhou, Yuanyuan Zhang, Yunjun Liu, Degang Xing
Summary: The synthesized iridium(III) complexes exhibited potent cytotoxicity against various cancer cell lines, inhibited cell colony formation and migration, and induced apoptosis through the mitochondrial death pathway.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Food Science & Technology
Yu Peng, Tongxi Zhou, Sisi Wang, Yerlan Bahetjan, Xiaojun Li, Xinzhou Yang
Summary: This study found that dehydrocostus lactone (DHL) can inhibit the proliferation and migration of esophageal cancer cells and inhibit tumor growth in vivo. This anti-cancer effect is achieved through ROS-mediated apoptosis and autophagy. Therefore, DHL may be a potential therapeutic drug for esophageal cancer.
FOOD AND CHEMICAL TOXICOLOGY
(2022)
Article
Chemistry, Applied
Larica Pathaw, Themmila Khamrang, Balasubramaniam Selvakumaran, Mariappan Murali, Pitchan Arul Prakash, Mohamed Sultan Mohamed Jaabir, Marappan Velusamy
Summary: The synthesis and characterization of copper(I) complexes show potential antitumor activity, moderate cytotoxicity against A549 cancer cells, relative inactivity against normal cells, and induction of apoptosis in cancer cells.
APPLIED ORGANOMETALLIC CHEMISTRY
(2021)
Article
Nanoscience & Nanotechnology
S. Buvana, Julie Charles, R. Subashini
Summary: This study reports a method for producing iron oxide nanoparticles using triphala extract and evaluates their anticancer effectiveness against breast cancer cells. The results indicate low toxicity and strong antibacterial efficacy, making these nanoparticles a promising material for biomedical applications.
Article
Chemistry, Inorganic & Nuclear
Chinmoy Biswas, Arnab Chatterjee, Vinu Vijayan, Chandra Shekhar Purohit, Manikantan Syamala Kiran, Rajarshi Ghosh
Summary: This article reports the synthesis and structural characterization of a dinuclear silver(I) complex 1, which exhibits selective anticancer activity against liver cancer cells. The anticancer activity of 1 is achieved through induction of mitochondrial death via Reactive Oxygen Species (ROS).
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Oncology
Juran Kralj, Margareta Pernar Kovac, Sanja Dabelic, Darija Stupin Polancec, Thorsten Wachtmeister, Karl Koehrer, Anamaria Brozovic
Summary: A novel OC cell model was established, and two transcriptome analysis approaches identified TMEM200A and PRKAR1B as important genes in carboplatin resistance and metastasis, with high predictive and prognostic values for OC patients. Compared to parental cells, carboplatin-resistant cells showed increased sensitivity to PI3K/Akt/mTOR pathway inhibitors and enhanced sensitivity to carboplatin when treated with a transcription inhibitor.
BRITISH JOURNAL OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Ivana Fabijanic, Atanas Kurutos, Ana Tomasic Paic, Vanja Tadic, Fadhil S. Kamounah, Lucija Horvat, Anamaria Brozovic, Ivo Crnolatac, Marijana Radic Stojkovic
Summary: The binding interactions of six ligands with various nucleic acid structures were evaluated using fluorescence, UV/Vis, and circular dichroism spectroscopy. The results showed that the cyanine dyes bind with G-quadruplex structures through end pi-pi stacking interactions and possible additional interactions with the nucleobases/phosphate backbone. The ability of cyanines to distinguish different nucleic acid structures was demonstrated by their varying ICD signals. Additionally, the cyanines exhibited inhibitory effects on cell viability and showed potential as theranostic agents.
Article
Biochemistry & Molecular Biology
Daniela Jaksic, Maja Segvic Klaric, Hrvoje Rimac, Robert Kerep, Ivo Piantanida
Summary: This study shows that sterigmatocystin (STC) can interact with cyclodextrins (CDs), with the highest affinity observed for sugammadex and gamma-CD. Molecular modelling and fluorescence spectroscopy revealed that STC inserts better into larger CDs. In addition, the study found that STC has a much lower affinity for human serum albumin (HSA) compared to sugammadex and gamma-CD, indicating that CDs can effectively displace STC from the STC-HSA complex.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Milena Mlakic, Ivona Cipor, Petra Kovacec, Goran Kragol, Ana Ratkovic, Tatjana Kovacevic, Rahela Zadravec, Valentina Milasinovic, Kresimir Molcanov, Ivo Piantanida, Irena Skoric
Summary: A new series of 4H-1,3-benzothiazine dyes were synthesized and characterized. Two synthetic pathways, Buchwald-Hartwig amination and electrochemical synthesis, were used to prepare benzothiazine salts. Electrochemical intramolecular dehydrogenative cyclization was employed to form 4H-1,3-benzothiazines. The binding of these compounds to polynucleotides was examined, and compounds 1 and 2 showed potential as DNA/RNA groove binders.
Article
Biochemistry & Molecular Biology
Lidija-Marija Tumir, Dijana Pavlovic Saftic, Ivo Crnolatac, Zeljka Ban, Matea Maslac, Stefanie Griesbeck, Todd B. Marder, Ivo Piantanida
Summary: A series of tetracationic bis-triarylborane dyes with different aromatic linkers showed high affinities towards ds-DNA and ds-RNA. The linker influenced the emissive properties of triarylborane cations and controlled the fluorimetric response of dyes. The different dye analogs exhibited selective or non-selective fluorescence responses and induced circular dichroism signals depending on the DNA/RNA sequences.
Article
Medicine, Research & Experimental
Margareta Pernar Kovac, Vanja Tadic, Juran Kralj, Marija Milkovic Perisa, Slavko Oreskovic, Ivan Babic, Vladimir Banovic, Wei Zhang, Zoran Culig, Anamaria Brozovic
Summary: Through high-throughput miRNA and cDNA profiling, pathway analysis, and data mining, epigenetically regulated miRNAs were identified in drug-resistant, mesenchymal-like ovarian cancer cells, which may serve as markers to combat therapy-induced short-term survival and tumor metastatic potential.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Margareta Pernar Kovac, Vanja Tadic, Juran Kralj, George E. Duran, Alessia Stefanelli, Darija Stupin Polancec, Sanja Dabelic, Niko Bacic, Maja T. Tomicic, Petra Heffeter, Branimir I. Sikic, Anamaria Brozovic
Summary: This study investigated resistance to platinum and taxane-based chemotherapy in ovarian cancer cells and the role of TUBB3 in therapy response prediction.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Zeljka Ban, Antun Baris, Ivo Crnolatac, Sasa Kazazic, Sanja Skulj, Filippo Savini, Branimir Bertos, Ivan Barisic, Ivo Piantanida
Summary: The field of bio-nanoengineering has made significant progress in the past decade, allowing the generation of nanoscaled molecular machineries with arbitrary shapes. Functionalising complex molecules and nanostructures precisely is important to fully utilize novel methods like DNA origami technology. This study presents a method for selectively attaching oligonucleotides to glycosylated horseradish peroxidase protein (HRP) with high N-terminus selectivity and yield, while preserving enzymatic activity. The resulting protein-oligonucleotide conjugates were characterized using electrophoresis and mass spectrometry.
ENZYME AND MICROBIAL TECHNOLOGY
(2023)
Article
Pharmacology & Pharmacy
Marta Jurkovic, Marijana Radic Stojkovic, Ksenija Bozinovic, Davor Nestic, Dragomira Majhen, Estefania Delgado-Pinar, Mario Inclan, Enrique Garcia-Espana, Ivo Piantanida
Summary: This article introduces a novel polyamine compound that exhibits strong intramolecular interactions and has strong binding and antiproliferative activity, making it applicable in cancer and gene therapy.
Article
Chemistry, Medicinal
Marta Jurkovic, Matthias Ferger, Isabela Draskovic, Todd B. Marder, Ivo Piantanida
Summary: This study presents a novel triarylborane (TB)-dye that serves as both an NMe2 pi-donor and an inductive NMe2-alkyl cationic acceptor. The TB-dye is highly sensitive to a click reaction with an azide-substituted lysine side chain, resulting in a significant red shift of emission. Furthermore, the TB-dye exhibits high affinities towards both DNA and proteins, making it an ideal fluorimetric probe for detecting the progress of click reactions and sensing the binding site composition.
Article
Chemistry, Inorganic & Nuclear
Jorge Gonzalez-Garcia, Carolina Galiana, M. Auxiliadora Dea-Ayuela, Marijana Radic Stojkovic, Sonia Lopez-Molina, Cristina Galiana-Rosello, Salvador Blasco, Ivo Piantanida, Enrique Garcia-Espana
Summary: Metal complexes have become a focus of biomedical research due to their ability to explore unexplored chemical space and provide additional functionalities for diagnosis and therapy. This study evaluated the interaction between two polytopic polyaza ligands, their zinc complexes, and DNA/RNA using various spectroscopic assays. The results showed selective binding of zinc-PHENPOD complexes to GC-containing DNA and stabilization of AT-based DNA by PYPOD metal complexes. Additionally, the ligands and their trinuclear zinc complexes exhibited high antimicrobial activity. This research provides valuable insights into the nucle-arity of polytopic polyaza ligands in DNA/RNA binding and antimicrobial effects.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Silvio Jakopec, Lisa Gourdon-Grunewaldt, Ivona Cipor, Andrijana Mescic Macan, Berislav Peric, Ivo Piantanida, Kevin Cariou, Gilles Gasser, Srecko I. Kirin, Silvana Raic-Malic
Summary: Bioorganometallic complexes have shown promise for potential application in cancer treatment and diagnosis, as well as in bioimaging agents, with some acting as theranostic agents. A series of novel complexes with bidentate pyridyl-1,2,3-triazole and 2,2'-dipyridylamine ligands were prepared and characterized. The complexes exhibited interactions with biomacromolecules and showed significant antiproliferative activity on colon cancer cells.
DALTON TRANSACTIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Sasa Opacak, Margareta Pernar Kovac, Anamaria Brozovic, Ivo Piantanida, Srecko I. Kirin
Summary: Two novel pyrene triphenylphosphine ruthenium conjugates function as fluorescent turn-on beacons for serum albumin, exhibiting strong emission upon binding to BSA while being non-fluorescent in aqueous media. The compounds' selective cytotoxicity against tumour cells is enhanced under UV-light irradiation, suggesting potential application in two-photon excited photodynamic therapy.
DALTON TRANSACTIONS
(2023)
Article
Urology & Nephrology
Beate Koeberle, Svetlana Usanova, Andrea Piee-Staffa, Ulrike Heinicke, Philipp Clauss, Anamaria Brozovic, Bernd Kaina
Summary: Metastatic testicular germ cell tumors (TGCT) are sensitive to cisplatin-based combination therapy due to activation of apoptotic pathways and limited DNA repair, while other solid metastatic cancers are resistant to chemotherapy.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)