Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 46, Issue 5, Pages 1638-1647Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2011.02.012
Keywords
Transition metal complexes; Bovine serum albumin binding; DNA interaction; Cleavage
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Funding
- Foundation of Key Laboratory of Nonferrous Metals Chemistry and Resources Utilization of Gansu Province
- State Key Laboratory of Applied Organic Chemistry
- NSFC [20171019]
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A symmetric ligand 2, 6-di ((phenazonyl-4-imino)methyl)-4-methylphenol (Dpmp) and its cobalt dinuclear complex (Co-2(Dpmp)(2)(NO3)(2)(H2O)(2)center dot NO3 center dot EtOH, (1) and zinc mononuclear complex Zn(Dpmp) (NO3)(2), (2) have been prepared. The crystal structures were determined by single-crystal X-ray diffraction. The biological activity has been evaluated by examining their anti-oxidative activity and ability to bind to bovine serum albumin (BSA) and calf-thymus DNA (CT DNA) with UV-vis absorption, fluorescence, viscosity measurements and circular dichroism (CD) spectroscopies. The complexes exhibit good binding propensity to BSA and CT DNA. Both 1 and 2 have been found to promote cleavage of pUC19 DNA in the absence of any reducing agent. Antioxidant tests in vitro show the compounds possess significant antioxidant activity against superoxide and hydroxyl radicals. (C) 2011 Elsevier Masson SAS. All rights reserved.
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