Article
Biochemistry & Molecular Biology
A. Sakthivel, B. Thangagiri, N. Raman, J. Joseph, Ramu Guda, Mamatha Kasula, L. Mitu
Summary: Novel macrocyclic Schiff base complexes with different metal ions have been synthesized and characterized, showing promising antioxidant, antimicrobial, and anticancer activities. The interaction of the complexes with DNA through the macrocyclic ligand and the inhibitory effects on target proteins such as EGFR and HER2 have been investigated and demonstrated.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2021)
Review
Chemistry, Multidisciplinary
Anmol Singh, Pranjit Barman
Summary: Ruthenium Schiff bases can be easily modified by selecting appropriate aldehydes or ketones and amines, and their metal complexes have diverse applications in areas such as biology, catalysis, materials, sensors, and pigments. The octahedral bonding structure of ruthenium complexes allows for a broad range of activities, with a high degree of site selectivity for binding to biological targets.
TOPICS IN CURRENT CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Aili Wang, Mengying Zhou, Qian Chen, Hui Jin, Gaochi Xu, Ruiyin Guo, Jianmin Wang, Ren Lai
Summary: With the increase in drug-resistant bacteria, the study and development of new antibacterial drugs have become important. This study found that three antimicrobial peptides derived from goat submandibular glands have potent antibacterial activity and low cytotoxicity against mammalian cells, making them potential candidates for the development of novel antibacterial agents.
Article
Engineering, Chemical
Serpil Gonca, Sadin ozdemir, Atakan Tekgul, Cumhur Gokhan Unlu, Kasim Ocakoglu, Nadir Dizge
Summary: The enhanced biological activity of perovskite type La1-xBaxMnO3 (x = 0.2, 0.3, 0.4) nanoparticles was investigated in terms of antioxidant, antimicrobial, anti-biofilm, bacterial viability inhibition, and DNA cleavage studies. The nanoparticles showed favorable biological activities, making them promising for various applications.
ADVANCED POWDER TECHNOLOGY
(2022)
Article
Chemistry, Inorganic & Nuclear
S. Sukkur Saleem, M. Sankarganesh, P. Adwin Jose, J. Dhaveethu Raja
Summary: This study synthesized and characterized a morpholine-based Schiff base ligand and its metal(II) complexes. They exhibited good free radical scavenging and antimicrobial activities, with the metal complexes showing stronger antimicrobial effects. In addition, L and its complexes may interact with DNA through an intercalative mode.
INORGANIC CHEMISTRY COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Nagaraj Revathi, Murugesan Sankarganesh, Jeyaraj Dhaveethu Raja, Samuelraj Johnson Raja, Shunmugasundaram Gurusamy, Radhakrishnan Nandini Asha, Thayalraj Christopher Jeyakumar
Summary: In this study, a new pyrimidine derivative Schiff base (HL) was synthesized and transition metal complexes of Cu(II) and Zn(II) were prepared. The geometries of the complexes 1 and 2 were confirmed to be square planar. The complexes showed good antimicrobial, antioxidant, and intercalation properties with CT-DNA and BSA.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Temesgen Achamo, Enyew Amare Zereffa, H. C. Ananda Murthy, Venkatesha Perumal Ramachandran, Ruthramurthy Balachandran
Summary: Copper oxide nanoparticles (CONPs) with desirable properties, including semiconductor nature, antimicrobial and antioxidant potential, as well as DNA binding activity, were successfully synthesized using ethanolic leaf extract of the indigenous plant Artemisia abyssinica.
GREEN CHEMISTRY LETTERS AND REVIEWS
(2022)
Article
Chemistry, Physical
Shunmugasundaram Gurusamy, Kumar Krishnaveni, Murugesan Sankarganesh, Veerasamy Sathish, Pounraj Thanasekaran, Alagarsamy Mathavan
Summary: A novel naphthalene-based Schiff-base ligand (NNP) was synthesized and characterized, showing selective colorimetric response towards Co2+ and Cu2+ cations, high antioxidant effect, and strong binding affinity with DNA and BSA. The results suggest NNP's potential for biological and environmental monitoring studies as well as the design of new multiple target detection and binding sensors.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Chemistry, Applied
Laila H. Abdel-Rahman, Maram T. Basha, Badriah Saad Al-Farhan, Mohamed R. Shehata, Ehab M. Abdalla
Summary: In this study, five novel metal ion complexes were synthesized and characterized, showing anticancer potential with antiproliferative effects on cancer cell lines, as well as antioxidant and antibacterial activities. The binding nature of the complexes with CT-DNA was investigated to determine intercalation or replacement mode.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Environmental Sciences
Eman Saad, Mohamed Hamed, Abdelnaby M. Elshahawy, Mohamed Abd El-Aal, Alaa El-Din H. Sayed
Summary: This study provides an intensive investigation on the influence of alkaline rocks on Nile Tilapia. The results show that exposure to bulk alkaline rocks leads to decreased blood profiles, liver and kidney dysfunction, increased antioxidant enzyme activities, DNA mutation, and erythrocyte distortion. This highlights the importance of climate changes, rock erosion, and their impact on water quality.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Francesco Bellia, Valeria Lanza, Irina Naletova, Barbara Tomasello, Valeria Ciaffaglione, Valentina Greco, Sebastiano Sciuto, Pietro Amico, Rosanna Inturri, Susanna Vaccaro, Tiziana Campagna, Francesco Attanasio, Giovanni Tabbi, Enrico Rizzarelli
Summary: A series of copper(II) complexes varying the molecular weight of Hyaluronic acid (Hy, x = 200 or 700 kDa) conjugated with carnosine (Car) were synthesized and characterized. The metal complexes showed excellent Cu, Zn-superoxide dismutase (SOD1) mimicking activity. The presence of non-functionalized Hyaluronic acid OH groups enhanced the scavenger activity of the copper(II) complexes.
Article
Chemistry, Physical
Aysel Aydin Kocaeren, Dilek Senol Bahceci, Neslihan Demir, Busra Dalgic, Elifnur Karatag
Summary: New Schiff bases, ligand (L), poly-ligand (PL) and metal complexes [M(PL)2], were synthesized and characterized. The metal complexes showed better biological properties than PL, including DNA binding-cleavage, antioxidant and antibacterial activities. The [Cu(PL)2] complex exhibited excellent oxidative cleavage activity and denaturing ability, while [Hg(PL)2] complex showed high antioxidant and antibacterial activities. The UV-Vis spectra confirmed the electrostatic mode of DNA binding for the poly-ligand and its metal complexes. Rating: 8 points
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Biochemistry & Molecular Biology
Adesola Abimbola Adeleke, Md Shahidul Islam, Olakunle Sanni, Chunderika Mocktar, Sizwe J. Zamisa, Bernard Omondi
Summary: The study synthesized five ligands and their silver(I) complexes, which were characterized spectroscopically. Some of the silver complexes showed better antibacterial and antioxidant activities compared to standard drugs.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Laila H. Abdel-Rahman, Maram T. Basha, Badriah Saad Al-Farhan, Walaa Alharbi, Mohamed R. Shehata, Noura O. Al Zamil, Doaa Abou El-ezz
Summary: A new chlorobenzylidene imine ligand and its five metal complexes were synthesized and characterized. The complexes were found to have octahedral geometrical structures and good thermal stability. They exhibited excellent antibacterial, DNA binding, antioxidant, and anti-inflammatory activities. Molecular docking studies revealed their good binding affinity with the receptor of Candida albicans oxidoreductase/oxidoreductase INHIBITOR. Overall, these compounds show potential as effective fungicidal and anti-inflammatory agents.
Article
Nutrition & Dietetics
Natnicha Promyos, Pornpimol Panprathip Phienluphon, Naruemon Wechjakwen, Jirayu Lainampetch, Pattaneeya Prangthip, Karunee Kwanbunjan
Summary: Oxidative stress and defective antioxidant defenses, specifically lower concentrations of superoxide dismutase (SOD) and catalase (CAT) activities, may contribute to the risk of type 2 diabetes (T2D). This study found that individuals with lower SOD and CAT activities had a higher risk of T2D, while the relationship between vitamin A and vitamin E concentrations and T2D risk was not significant. Factors like physical activity, total cholesterol, and triglyceride levels might mediate the association between SOD/CAT and T2D risk.
Article
Chemistry, Organic
Yildiz Uygun Cebeci, Sule Ceylan, Neslihan Demirbas, Sengul Alpay Karaoglu
Summary: A study was conducted on synthesizing new compounds from triazoles, where a series of new triazole derivatives were obtained through transformation steps, and their antibacterial activity was evaluated.
LETTERS IN ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Yildiz Uygun Cebeci, Sule Ceylan, Neslihan Demirbas, Sengul Alpay Karaoglu
Summary: In this study, new Mannich bases and conazol derivatives with biological activity were synthesized using the microwave-assisted method. Green chemistry techniques were applied during the reactions. The synthesized compounds showed excellent antimicrobial activity against various microorganisms, with some demonstrating particularly strong effects on M. smegmatis and good antituberculosis activity.
LETTERS IN DRUG DESIGN & DISCOVERY
(2021)
Article
Biochemical Research Methods
Tugba Serin Kalay, Yakup Kara, Sengul Alpay Karaoglu, Sevgi Kolayli
Summary: This study compared the antimicrobial activity and effect on dentin bond strength of four cavity disinfectants. The results showed that 0.3% stabilized ClO2 exhibited the highest antimicrobial activity and had no adverse effects on bond strength.
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING
(2022)
Article
Chemistry, Medicinal
Cihan Kantar, Nimet Baltas, Sengul Alpay Karaoglu, Selami Sasmaz
Summary: The newly synthesized pyridinazo compounds showed antioxidant capacity, urease enzyme inhibition, and anti-Helicobacter pylori activity. The monotherapeutic approach indicates that a single drug with both strong urease enzyme inhibitory and antibiotic properties can be used to treat Helicobacter pylori infection. All newly obtained compounds demonstrated urease enzyme inhibitory properties and anti-Helicobacter pylori activity as expected.
PHARMACEUTICAL CHEMISTRY JOURNAL
(2021)
Article
Plant Sciences
Ishak Erik, Nurettin Yayli, Kamil Coskuncelebi, Serdar Makbul, Sengul Alpay Karaogul
Summary: Three new dihydroisocoumarin glycosides and five known compounds were isolated from Scorzonera aucheriana in Turkey, with iso-scorzopygmaecoside, scorzoaucherioside I, and 3,4-dihydroxyphenyl caffeate showing notable antimicrobial activity. Iso-scorzopygmaecoside and scorzoaucherioside II exhibited strong activity against Mycobacterium smegmatis.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Plant Sciences
Gozde Kilic, Gonca Tosun, Arif Bozdeveci, Ishak Erik, Elif Ozturk, Rengin Reis, Hande Sipahi, Merve Cora, Sengul Alpay Karaoglu, Nurettin Yayli
Summary: The study aimed to identify bioactive pharmaceutical metabolites produced by the Fusarium oxysporum YP9B isolate, resulting in the isolation and characterization of ten new natural compounds. These compounds exhibited antimicrobial, cytotoxic, and antiviral activities.
RECORDS OF NATURAL PRODUCTS
(2021)
Article
Dentistry, Oral Surgery & Medicine
Zeynep Demirez Bircan, Sema Aydinoglu, Ipek Arslan, Sengul Alpay Karaoglu, Emine Yurteri, Arif Bozdeveci
Summary: The study evaluated the antimicrobial activities of HA, AT, and SR against S. mutans and S. wiggsiae in biofilms formed on primary teeth. Results showed that HA, AT, and SR are effective natural alternatives to CHX against cariogenic bacteria, with lower colony counts and potential inhibitory effects.
INTERNATIONAL JOURNAL OF PAEDIATRIC DENTISTRY
(2022)
Article
Chemistry, Organic
Necla Kulabas, Asli Ture, Arif Bozdeveci, Vagolu Siva Krishna, Sengul Alpay Karaoglu, Dharmarajan Sriram, Ilkay Kucukguzel
Summary: Novel substituted fluoroquinolone derivatives were synthesized and evaluated for their antituberculosis and antibacterial activity. Compound 14 exhibited the most potent antimicrobial activity against all tested bacteria. Most of the compounds showed antimycobacterial effects, with compounds 14 and 18 displaying the highest activity. In addition, these compounds demonstrated a similar binding mode to DNA gyrase enzymes as known fluoroquinolone drugs.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Physical
Yildiz Uygun Cebeci, Sule Ceylan, Sengul Alpay Karaoglu
Summary: In this study, a series of new indole-3-carbaldehyde embedded triazole derivatives were synthesized and tested for their antibacterial properties. The fluoroquinolone derivative compounds showed high activity.
JOURNAL OF MOLECULAR STRUCTURE
(2022)
Article
Virology
Arif Bozdeveci, Merve Karali, Rahsan Akpinar, Sengul Alpay Karaoglu
Summary: A novel lysogenic bacteriophage, phage Pd22F, was isolated from Paenibacillus dendritiformis, with an 86,388-bp linear dsDNA genome. Genome sequencing revealed 124 coding sequences, including 57% encoding unknown proteins, placing Pd22F as a new phage belonging to the family Myoviridae, order Caudovirales.
ARCHIVES OF VIROLOGY
(2022)
Article
Chemistry, Organic
Yildiz Uygun Cebeci, Sule Ceylan, Sengul Alpay Karaoglu, Muhammed Altun
Summary: This study synthesizes and analyzes a series of novel 1,2,4-triazole compounds for their antibacterial and anticancer activities. These compounds show enhanced antibacterial activity against both Gram-positive and Gram-negative bacteria, as well as inhibitory effects on the proliferation of HeLa cervical cancer cells.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Emine Sonmez, Meral Kekecoglu, Arif Bozdeveci, Sengul Alpay Karaoglu
Summary: This study explored the antimicrobial and antifungal activity of Anatolian honey bee venom (HBV) against bacteria and yeast-like fungi. The results showed that Anatolian HBV exhibited significant inhibitory effects on various Gram-positive, Gram-negative, and antibiotic-resistant bacteria, as well as yeast-like fungi.
Article
Biotechnology & Applied Microbiology
Seyma Suyabatmaz, Sengul Alpay Karaoglu, Arif Bozdeveci, Rahsan Akpinar
Summary: This study identified lactic acid bacteria (LAB) from honeybees and investigated their probiotic properties. The LAB strains exhibited antimicrobial activity, tolerance to digestive conditions, and aggregation ability. They also showed antagonistic effects against human pathogens and positive probiotic characteristics under in vitro gastrointestinal tract conditions. Therefore, LAB symbionts in honeybees may be potential probiotics for human use.
WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY
(2023)
Article
Biology
Ali Sevim, Rahsan Akpinar, Sengul Alpay Karaoglu, Arif Bozdeveci, Elif Sevim
Summary: This study aimed to identify and determine the distribution of chalkbrood disease agents in honeybee colonies, particularly in beekeeping areas in Turkey. Morphological and molecular methods, including ITS gene sequencing, were used to isolate and identify the causative agents. Out of the 1,193 randomly selected hives from 400 apiaries in 40 provinces in Turkey, 2.18% were found to be infected with A. apis. These findings are important for understanding the spread rate and prevalence of chalkbrood disease in Turkey.
Article
Chemistry, Multidisciplinary
Nurettin Yayli, Gozde Kilic, Gonca Celik, Nuran Kahriman, Seyda Kanbolat, Arif Bozdeveci, Sengul Alpay Karaoglu, Rezzan Aliyazicioglu, Hasan Erdinc Sellitepe, Inci Selin Dogan, Ali Aydin
Summary: In this study, various organic compounds were synthesized and their biological activities were evaluated, including antioxidant, antimicrobial, and enzyme inhibition. Some compounds showed anti-cancer activity against human cervical cancer cell lines. The synthesized compounds were characterized using spectroscopic methods.
TURKISH JOURNAL OF CHEMISTRY
(2021)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
