Article
Multidisciplinary Sciences
Daratu Eviana Kusuma Putri, Harno Dwi Pranowo, Anugrah Ricky Wijaya, Novia Suryani, Maisari Utami, Artania Adnin Tri Suma, Woo Jin Chung, Saeedah Musaed Almutairi, Dina S. Hussein, Rabab Ahmed Rasheed, Venkatalakshmi Ranganathan
Summary: This study aimed to predict the anti-colon and anti-hepatoma cancer activity of newly designed substituted 4-anilino coumarin derivatives using quantitative structure-activity relationship (QSAR). QSAR models were generated by optimizing the molecular and electronic properties data through H-GGA DFT/BPV86 method calculation. Two validated QSAR models were obtained, which successfully predicted the anticancer activity of 17 newly designed derivatives.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Chemistry, Multidisciplinary
Mouad Lahyaoui, Hafsa El-Idrissi, Taoufiq Saffaj, Bouchaib Ihssane, Nabil Saffaj, Rachid Mamouni, Youssef Kandri Rodi
Summary: In this study, 28 compounds derived from phosphorus-substituted quinoline were investigated for their anti-proliferative activity and binding affinity with proteins related to lung, ovarian, and kidney malignancies. The results suggest that these compounds could be valuable models for the development of more effective anticancer prospects.
ARABIAN JOURNAL OF CHEMISTRY
(2023)
Article
Agriculture, Multidisciplinary
Pedro Alves Bezerra Morais, Karolinni B. Britto, Evandro Messias, Peterson de Andrade, Elias Werner, Adilson Vidal Costa, Valdemar Lacerda Jr, Christiano Jorge Gomes Pinheiro, Heberth de Paula, Warley de Souza Borges
Summary: To address the issues of weed infestation and herbicide resistance, the authors synthesized eight isatin derivatives using Click Chemistry. These derivatives were evaluated for their phytotoxic activity against two model plants, Lactuca sativa and Allium cepa. Six derivatives showed similar activity to the positive control trifluralin, with compound 8 being more active than trifluralin in L. sativa. ALS crystallographic structure analysis revealed the inhibitory activity of compounds 11 and 17 against A. cepa.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Wanting Xie, Sopon Wiriyarattanakul, Thanyada Rungrotmongkol, Liyi Shi, Amphawan Wiriyarattanakul, Phornphimon Maitarad
Summary: A series of pyrrole derivatives were studied using QSAR in order to investigate their antioxidant scavenging activities. The GA-MLR and QSAR-ANN models were used to establish relationships between the molecular descriptors and the scavenging activities. Both models showed good predictive abilities, with high R-2 values and low RMSE values in the test set. The key molecular descriptors for the antioxidant activities were bond length, HOMO energy, polarizability, and AlogP.
Article
Multidisciplinary Sciences
Fatima Ezzahra Bennani, Latifa Doudach, Khalid Karrouchi, Youssef El Rhayam, Christopher E. Rudd, M'hammed Ansar, My El Abbes Faouzi
Summary: Despite decades of scientific studies, cancer remains a leading cause of illness and death globally. This study developed six 2D-QSAR models and used them to predict the anti-cancer activity of pyrazole derivatives.
Article
Environmental Sciences
Imad Hammoudan, Mohammed Chafi
Summary: In this study, the efficacy of 34 pyrazoline derivatives as carbonic anhydrase inhibitors was investigated using computational methods. Quantum descriptors were calculated, and four models were created to predict the pIC50 values of six chemicals in a test set. Each model was validated internally and externally, and Model 3 was chosen based on its higher R-2, R-test(2), and Q(cv)(2) values (R-2 = 0.79, R-test(2) = 0.95, Q(cv)(2) = 0.64). New molecules with significant inhibitory activity could be proposed based on the descriptors of the model.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Cell Biology
Atamjit Singh, Karanvir Singh, Aman Sharma, Sambhav Sharma, Kevin Batra, Kaustubh Joshi, Brahmjeet Singh, Kirandeep Kaur, Renu Chadha, Preet Mohinder Singh Bedi
Summary: Breast cancer is a common and difficult-to-manage disease with high mortality and morbidity rates, posing a significant threat to mankind and healthcare systems. In 2020, there were 2.3 million diagnosed cases of breast cancer and it caused 685,000 deaths globally, highlighting the severity of the disease. The relapse of cases, drug resistance, and associated side effects further worsen the situation. Therefore, there is an urgent need to develop potent and safer antibreast cancer agents.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Alejandro Cenalmor, Elena Pascual, Sergio Gil-Manso, Rafael Correa-Rocha, Jose Ramon Suarez, Isabel Garcia-Alvarez
Summary: Neuroinflammation is a critical factor in the progression of Alzheimer's disease and other neurodegenerative disorders. In this study, a series of isatin derivatives were synthesized and evaluated for their anti-neuroinflammatory potential using lipopolysaccharide activated microglia as a cell model. Compound 10 with N-1 alkylation and compound 20 with chlorination showed the best results in reducing nitric oxide, pro-inflammatory interleukin 6, and tumour necrosis factor alpha release by microglial cells, indicating their potential as lead compounds for developing new neuroprotective agents.
Article
Chemistry, Physical
Khaoula Kouchkar, Youcef Boumedjane, Dalal Harkati, Muneerah Mogren Al-Mogren, Majdi Hochlaf
Summary: This theoretical work examines the structural properties and anti-proliferative activity of a series of 2-iminothiazolidin-4-one derivatives against A549 and H460 human lung carcinoma cells. First, benchmarks were performed to validate the use of the B3LYP/6-311++G(d,p) method in determining the structures and properties of these derivatives. The method was then applied to investigate the derivatives and establish quantitative structure activity relationships models, which were evaluated for predictivity using the leave-one-out method.
COMPUTATIONAL AND THEORETICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Philipe de Oliveira Fernandes, Joao Paulo A. Martins, Eduardo B. de Melo, Renata Barbosa de Oliveira, Thales Kronenberger, Vinicius Goncalves Maltarollo
Summary: The study suggests that aliphatic substituents at the hydrazone moiety are crucial for the antifungal activity of thiazolylhydrazones. Modern techniques were used to create QSAR models with high predictive power, supporting the design of new antifungal compounds.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Environmental Sciences
Ali Shahi, Hamed Vafaei Molamahmood, Naser Faraji, Mingce Long
Summary: In this study, quantitative structure-activity relationship (QSAR) models were developed to predict the second-order rate constant (k(app)) for the reaction of peracetic acid (PAA) with various organic contaminants. The models, based on different molecular descriptors, were proven to be accurate and reliable in predicting the removal efficiency of organic contaminants in wastewater treatment.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Chemistry, Multidisciplinary
Davood Gheidari, Morteza Mehrdad, Mahboubeh Ghahremani
Summary: The study focused on the quantitative structure-activity relationship (QSAR) modeling and prediction of Candida albicans inhibitors, utilizing a dataset of 60 derivatives and highlighting the superiority of the SPA-MLR model in predicting the anti-fungus activity. RDF090u was identified as the most crucial parameter influencing the behavior of the inhibitors.
FRONTIERS IN CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Wagdy M. Eldehna, Mahmoud F. Abo-Ashour, Tarfah Al-Warhi, Sara T. Al-Rashood, Amal Alharbi, Rezk R. Ayyad, Khayal Al-Khayal, Maha Abdulla, Hatem A. Abdel-Aziz, Rehan Ahmad, Radwan El-Haggar
Summary: The study developed novel isatin-indole conjugates as potential anticancer Bcl2 and BclxL inhibitors, which showed significant inhibition of colorectal cancer cell lines with selective cytotoxicity. Compounds 7c and 7g exhibited dose-dependent apoptosis induction and inhibition of Bcl2 and BclxL expression, suggesting them as a starting point for further optimization towards developing novel anti-tumor agents.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Snehal A. Arvindekar, Suraj Mohole, Aishwarya Patil, Pradnya Mane, Aditya Arvindekar, Suraj N. Mali, Bapu Thorat, Ravi Rawat, Shilpa Sharma
Summary: This study aimed to design and synthesize a series of benzopyran-chalcones as potential anti-breast cancer agents. The synthesized compounds showed activity against ER+MCF-7 cells and in-silico analysis suggested their affinity towards hormone-dependent breast cancer. Compounds 4A1 to 4A3 exhibited the highest cytotoxicity against MCF-7 cells.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Lian Bai, Chunle Wei, Jian Zhang, Runjiang Song
Summary: In this study, a lead optimization was carried out using a commercial agent with antivirus activity and moroxydine hydrochloride. Several 1,3,5-triazine derivatives with piperazine structures were synthesized and evaluated for their anti-potato virus Y (PVY) activity. Compound C35 showed comparable or superior antiviral activity to the positive control and moroxydine hydrochloride, and molecular docking provided a theoretical basis for its activity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Organic
Masoumeh Divar, Kamiar Zomorodian, Razieh Sabet, Maryam Moeini, Soghra Khabnadideh
Summary: Oxindoles and spirooxindoles are important synthetic targets due to their biological activity and pharmaceutical applications. In this study, 18 new derivatives of spirooxindoles were synthesized efficiently using a multicomponent reaction method. The chemical structures were confirmed and reaction conditions were optimized for catalysts, temperature, and solvents.
POLYCYCLIC AROMATIC COMPOUNDS
(2021)
Meeting Abstract
Ophthalmology
Amir Sadeghi, Elisa Toropainen, Annika Valtari, Jooseppi Puranen, Marika Ruponen, Veli-Pekka Ranta, Arto Urtti
ACTA OPHTHALMOLOGICA
(2019)
Article
Pharmacology & Pharmacy
Amir Sadeghi, Jooseppi Puranen, Marika Ruponen, Annika Valtari, Astrid Subrizi, Veli-Pekka Ranta, Elisa Toropainen, Arto Urtti
Summary: Rats and rabbits were used to study intravitreal pharmacokinetics with non-invasive ocular fluorophotometry, showing differences in pharmacokinetic parameters between the two species which need to be considered in dose scaling and translation for drug development.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Pharmacology & Pharmacy
Vijayabhaskarreddy Junnuthula, Amir Sadeghi Boroujeni, Shoupeng Cao, Shirin Tavakoli, Roxane Ridolfo, Elisa Toropainen, Marika Ruponen, Jan C. M. van Hest, Arto Urtti
Summary: This study synthesized and characterized block copolymers that self-assembled into polymersomes and polymeric micelles, which showed stability and diffusibility in the vitreous and no cellular toxicity. Pharmacokinetic evaluation in rabbits showed prolonged half-lives and retention of these nanocarriers in the vitreous, making them promising for controlled and site-specific drug delivery in the posterior eye segment.
Article
Pharmacology & Pharmacy
Eva M. del Amo, Anam Hammid, Melanie Tausch, Elisa Toropainen, Amir Sadeghi, Annika Valtari, Jooseppi Puranen, Mika Reinisalo, Marika Ruponen, Arto Urtti, Achim Sauer, Paavo Honkakoski
Summary: The study investigated the pharmacokinetics of four drugs in albino rabbit eyes, revealing that metabolite levels were lower than parent drugs, with cefuroxime axetil being an exception. Enzyme activity in the eye was low, suggesting that metabolism may not play a major role in ocular pharmacokinetics.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Merve Sen, Md Al-Amin, Eva Kickova, Amir Sadeghi, Jooseppi Puranen, Arto Urtti, Paolo Caliceti, Stefano Salmaso, Blanca Arango-Gonzalez, Marius Ueffing
Summary: Mutations in rhodopsin can cause autosomal dominant retinitis pigmentosa (adRP), and pharmacological inhibition of the ATP-driven chaperone valosin-containing protein (VCP) has shown potential for treating retinal degeneration. This study developed nanoformulations of the VCP inhibitor ML240 using amphiphilic polymers to increase water-solubility and prolong drug release. Encapsulation of ML240 in mPEG(5kDa)-cholane demonstrated superior photoreceptor protection at lower drug concentrations and potential for treating adRP.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Pharmacology & Pharmacy
Marco Bassetto, Daniel Ajoy, Florent Poulhes, Cathy Obringer, Aurelie Walter, Nadia Messadeq, Amir Sadeghi, Jooseppi Puranen, Marika Ruponen, Mikko Kettunen, Elisa Toropainen, Arto Urtti, Helene Dollfus, Olivier Zelphati, Vincent Marion
Summary: The study presents the development of a non-invasive, magnetic nanoparticle-based drug delivery system for the treatment of retinal degeneration in BBS, demonstrating successful targeting of photoreceptors in vivo after topical administration. The magnetic drug targeting approach showed beneficial biological effects by maintaining light detection in Bbs(-/-) mice (KO), offering potential for expanding treatment options for various retinal degenerations and other ocular diseases.
Article
Pharmacology & Pharmacy
Eva Kickova, Amir Sadeghi, Jooseppi Puranen, Shirin Tavakoli, Merve Sen, Veli-Pekka Ranta, Blanca Arango-Gonzalez, Sylvia Bolz, Marius Ueffing, Stefano Salmaso, Paolo Caliceti, Elisa Toropainen, Marika Ruponen, Arto Urtti
Summary: This study focuses on pullulan-dexamethasone conjugates as therapeutic systems for intravitreal administration. The conjugates can self-assemble into negatively charged nanoparticles and have a prolonged retention time in the vitreous, allowing for drug delivery to the retina via Muller glial cells.
Article
Pharmacology & Pharmacy
Amir Sadeghi, Marika Ruponen, Jooseppi Puranen, Shoupeng Cao, Roxane Ridolfo, Shirin Tavakoli, Elisa Toropainen, Tatu Lajunen, Veli-Pekka Ranta, Jan van Hest, Arto Urtti
Summary: This study investigates the pharmacokinetics of nanomaterials in the eyes of rats and rabbits. The impact of particle size and shape on ocular distribution and elimination was examined using various imaging techniques. The results show that differently sized particles have different retention times and elimination rates, suggesting that factors other than size also play a role in their kinetics. The study also demonstrates the importance of synchronized particle retention and drug release rate for efficient drug delivery.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Chemistry, Multidisciplinary
Farnaz Salehi, Leila Emami, Zahra Rezaei, Soghra Khabnadideh, Behnaz Tajik, Razieh Sabet
Summary: In this study, quantitative structure-activity relationship analysis was used to investigate the structure requirements for a series of fluconazole analogues. New potent antifungal compounds were identified through in silico screening and molecular docking simulation. Compound F13 showed promising antifungal activity and is a suitable candidate for further development.
JOURNAL OF CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Razieh Fazel, Bahareh Hassani, Fateme Zare, Habibollah Jokar Darzi, Mehdi Khoshneviszadeh, Alireza Poustforoosh, Marzieh Behrouz, Razieh Sabet, Hossein Sadeghpour
Summary: In this study, hybrids of 3-hydroxypyridine-4-one and acylhydrazones were synthesized and evaluated for their anti-tyrosinase and antioxidant activities. The results showed that compound 5h exhibited potent inhibitory effects on tyrosinase and strong antioxidant activity. Molecular docking and dynamics simulation confirmed the binding site of compound 5h with tyrosinase. Furthermore, reactivity descriptors and molecular orbitals of 5g and 5h were investigated using DFT calculations and compared with experimental data.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Chemistry, Multidisciplinary
Bahareh Hassani, Fateme Zare, Leila Emami, Mehdi Khoshneviszadeh, Razieh Fazel, Negin Kave, Razieh Sabet, Hossein Sadeghpour
Summary: This study focused on the design and synthesis of new compounds that exhibited antioxidant and anti-tyrosinase activities. The most potent compound, 6i, showed strong inhibition of the tyrosinase enzyme and formed a stable complex with the target protein at the active site. The tested compounds also demonstrated drug-like and bioavailability properties.
Article
Chemistry, Multidisciplinary
Madhushree Bhattacharya, Amir Sadeghi, Sanjay Sarkhel, Marja Hagstrom, Sina Bahrpeyma, Elisa Toropainen, Seppo Auriola, Arto Urtti
JOURNAL OF CONTROLLED RELEASE
(2020)
Article
Chemistry, Multidisciplinary
Julia R. Shakirova, Amir Sadeghi, Alla A. Koblova, Pavel S. Chelushkin, Elisa Toropainen, Shirin Tavakoli, Leena-Stiina Kontturi, Tatu Lajunen, Sergey P. Tunik, Arto Urtti
Article
Pharmacology & Pharmacy
Soghra Khabnadideh, Razieh Sabet, Hasti Pour Naghz, Masoumeh Divar
JOURNAL OF PHARMACEUTICAL RESEARCH INTERNATIONAL
(2019)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
