Review
Chemistry, Inorganic & Nuclear
Gabrieli L. Parrilha, Raquel G. dos Santos, Heloisa Beraldo
Summary: Metallic radionuclides have diverse applications as diagnostic and therapeutic agents. This study reports the behavior of different radiometal complexes with mono(thiosemicarbazones) and bis(thiosemicarbazones) as potential radiopharmaceuticals. The application of bis(thiosemicarbazonato)copper(II) complexes as diagnostic radiopharmaceuticals has been successful, while other radioisotopes such as Ga-67/68, (111/114)mIn, and Tc-99m have also been used to obtain mono- and bis(thiosemicarbazone) complexes for potential diagnosis and therapy.
COORDINATION CHEMISTRY REVIEWS
(2022)
Article
Chemistry, Medicinal
Wenjuan Li, Shanhe Li, Zhenlei Zhang, Gang Xu, Xueyu Man, Feng Yang, Hong Liang
Summary: This study proposed a multitargeted palladium agent based on the specific residue(s) of human serum albumin for treating cancer. The Pd agent showed significant capacity in inhibiting tumor growth through multiple actions on different components of the tumor microenvironment.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Spectroscopy
Jebiti Haribabu, Othman I. Alajrawy, Kumaramangalam Jeyalakshmi, Chandrasekar Balachandran, Dhanabalan Anantha Krishnan, Nattamai Bhuvanesh, Shin Aoki, Karuppannan Natarajan, Ramasamy Karvembu
Summary: Copper(II) complexes containing N-substituted isatin thiosemicarbazone(s) were synthesized and characterized using analytical and spectroscopic techniques. The bimetallic nature of one of the complexes was confirmed by X-ray crystallography. Molecular docking studies revealed interactions with tyrosinase kinase receptors. The cytotoxic activity of the complexes against leukemia and cervical cancer cell lines was found to be promising with better efficacy than cisplatin.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2021)
Article
Chemistry, Multidisciplinary
Periyanayagam Arockia Doss, Jebiti Haribabu, Nithya Balakrishnan, Srividya Swaminathan, Jose A. Pino, Nattamai Bhuvanesh, Ramasamy Karvembu
Summary: The research and development department is actively seeking effective anticancer medications. They have created four new copper(I) complexes using thiosemicarbazone ligands with an indole fragment. Multiple examinations confirmed the formation of the complexes, and XRD revealed the expected tetrahedral structure of complex 4. The complexes were assessed for cytotoxicity on different cell lines, and complex 3 showed superior cytotoxic effects towards EAhy.926 and HepG-2 cells.
Article
Biochemistry & Molecular Biology
Avinash Kotian, Vinayak Kamat, Krishna Naik, Dhoolesh G. Kokare, Karthik Kumara, Krishnappagowda Lokanath Neratur, Vijay Kumbar, Kishore Bhat, Vidyanand K. Revankar
Summary: This paper investigates the p-halo N4-phenyl substituted thiosemicarbazones derived from 8-hydroxyquinoline, their crystal structures, spectral characterization, and in vitro cytotoxic studies of Co(III), Ni(II) and Cu(II) complexes. The complexes show enhanced antiproliferative activity against MCF-7 breast cancer cell lines, especially the Co(III) complexes displaying a roughly two fold increase in activity compared to the standard drug, Paclitaxel. Additionally, fluorescence microscopy images suggest an apoptotic mode of cell death.
BIOORGANIC CHEMISTRY
(2021)
Article
Crystallography
Luis Alonso, Rodrigo Buron, Elena Lopez-Torres, Maria Antonia Mendiola
Summary: The new ligand HMeATSM derived from 2-3-butanedione with 4-methyl-3-thiosemicarbazide and 2,4-dimethyl-3-thiosemicarbazide has been synthesized and its reactivity with nickel(II) and zinc(II) nitrates has been explored. The structures of the resulting complexes were thoroughly characterized and it was found that nickel(II) prefers a square-planar environment while zinc(II) prefers a distorted square-base pyramid or trigonal bipyramid arrangement.
Article
Chemistry, Multidisciplinary
Esteban Rodriguez-Arce, Eric Gavrilov, Ximena Alvite, Nazia Nayeem, Ignacio E. Leon, Michelle C. Neary, Lucia Otero, Dinorah Gambino, Claudio Olea Azar, Maria Contel
Summary: This work reports the synthesis and stability study of four gold(I) [AuClL] compounds containing chloro and biologically active protonated thiosemicarbazones based on 5-nitrofuryl (L=HSTC). The cytotoxicity of these compounds was evaluated against cancer cell lines, and one compound showed significant antimigratory and anti-angiogenic properties on a renal cancer cell line (Caki-1), along with preferential accumulation in the cell nuclei. Its mode of action seems to involve interaction with DNA and induction of apoptosis.
Article
Chemistry, Physical
Pratidnya Shendge, Shailza Sharma, Minati Baral, B. K. Kanungo
Summary: The study focused on a catechol-thiosemicarbazone based tridentate NOS chelator and its octahedral pincer complexes with trivalent aluminum, chromium, iron and gallium. The coordination of metal-ligands in the complexes resulted in two planar pincer type arrangements with meridional configuration, maintaining a perpendicular profile. Quantum mechanical studies at DFT level were conducted to explore the structure, reactivity and spectroscopic properties of the compounds. The fluorescence behavior of the chelator was found to exhibit a significant alteration in the emission spectrum in the presence of zinc ion, indicating a ten-fold enhancement.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Applied
Vishnunarayanan Namboothiri Vadakkedathu Palakkeezhillam, Jebiti Haribabu, Vaishnu Suresh Kumar, Vipin Manakkadan, Puthiyavalappil Rasin, Nattamai Bhuvanesh, Cesar Echeverria, Juan F. Santibanez, Anandaram Sreekanth
Summary: A series of thiosemicarbazones were synthesized and evaluated for their anticancer activity. One compound (CFM) showed potent inhibitory effects against breast adenocarcinoma and urinary bladder cancer cells, while exhibiting negligible cytotoxicity against normal cells. Molecular docking studies suggested effective binding of these compounds with cancer proteins and serum proteins. These findings provide insights into the bioactivities of thiosemicarbazones.
APPLIED ORGANOMETALLIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Dennis Groedler, Alexander Haseloer, Christian Tobeck, Yusuf Bulut, Jorg M. Neudoerfl, Sanjay Mathur, Uwe Ruschewitz, Axel Klein, Mathias S. Wickleder, Markus Zegke
Summary: The first homoleptic thiosemicarbazone complexes of uranium exhibit high stability and strong oxidation resistance, with the ability to control coordination environments by simple methylation of the ligand's terminal amino group. These complexes also demonstrate good thermal stability, being stable up to 155 degrees C.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Pharmacology & Pharmacy
Patricia Fernandez de Larrinoa, Jordan Parmentier, Antoine Kichler, Thierry Achard, Monique Dontenwill, Christel Herold-Mende, Sylvie Fournel, Benoit Frisch, Beatrice Heurtault, Stephane Bellemin-Laponnaz
Summary: A novel series of platinum(II) complexes modified with the mitochondria targeting group triphenylphosphonium were synthesized, which showed significantly higher anticancer activity on cancer stem cell line compared to oxaliplatin. Mechanistic studies revealed that these complexes altered mitochondrial function and induced atypical cell death.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Multidisciplinary Sciences
Kyle B. Lupo, Sandra Torregrosa-Allen, Bennett D. Elzey, Sagar Utturkar, Nadia A. Lanman, Aaron A. Cohen-Gadol, Veronika Slivova, Mackenzie Mcintosh, Karen E. Pollok, Sandro Matosevic
Summary: TIGIT functions as a regulator in glioblastoma (GBM) by controlling the expression of NK activating ligands and receptors, and interacting with shared TIGIT ligands rather than inhibiting NK cells directly. Moreover, TIGIT+ NK cells exhibit hyperfunction in GBM. The correlation between 4-1BB and TIGIT expression contributes to TIGIT immunotherapy in GBM.
Article
Chemistry, Physical
Avinash Kotian, Vinayak Kamat, Krishna Naik, Dhoolesh G. Kokare, Karthik Kumara, Neratur Krishnappagowda Lokanath, Vidyanand K. Revankar
Summary: This study synthesized later first-row transition metal complexes of hydroxyacetone derived N4-methyl substituted thiosemicarbazone, and determined their crystal structures and spectroscopic characterization. The complexes showed different molecular structures and crystalline structures. The synthesized compounds exhibited high activity in in vitro antitubercular tests.
JOURNAL OF MOLECULAR STRUCTURE
(2021)
Article
Chemistry, Inorganic & Nuclear
Kelsey R. Cairns, William Levason, Gillian Reid, Wenjian Zhang
Summary: The study found that metal complexes formed in the experiment exhibited different coordination states and varied ligand substitution patterns.
Article
Chemistry, Inorganic & Nuclear
Ming Jiang, Tongfu Yang, Yong Chu, Zhenlei Zhang, Hongbin Sun, Hong Liang, Feng Yang
Summary: By synthesising a series of novel platinum complexes, we discovered that C6 exhibits strong cytotoxicity against resistant lung cancer cells, inducing apoptosis and autophagy, and can reverse cisplatin-induced resistance.
DALTON TRANSACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Ludmila Leroy, Joao Alexandre Ribeiro Goncalves Barbosa, Gonzalo de Prat-Gay, Igor Polikarpov, Carlos Basilio Pinheiro
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS
(2020)
Article
Chemistry, Multidisciplinary
Ana P. A. Oliveira, Jennifer T. J. Freitas, Renata Diniz, Claudia Pessoa, Sarah S. Maranhao, Juliana M. Ribeiro, Elaine Maria Souza-Fagundes, Heloisa Beraldo
Article
Chemistry, Physical
Ana P. A. Oliveira, Micael Ferencs, Vivianne O. Azevedo, Renata Diniz, Sonia R. W. Louro, Odivaldo C. Alves, Heloisa Beraldo
JOURNAL OF MOLECULAR STRUCTURE
(2020)
Article
Chemistry, Medicinal
Eclair Venturini Filho, Jorge W. S. Pina, Mariana K. Antoniazi, Laiza B. Loureiro, Marcos A. Ribeiro, Carlos B. Pinheiro, Celina J. Guimaraes, Fatima C. E. de Oliveira, Claudia Pessoa, Alex G. Taranto, Sandro J. Greco
Summary: A simple and fast methodology using microwave irradiation was reported for the synthesis of 2-aminopyrimidine and pyrazole derivatives via the Atwal reaction. Eight 2-aminopyrimidines and three ferrocene pyrazoles were synthesized in good yields, with some compounds exhibiting promising anti-proliferative activity. Docking simulation and machine learning methods were employed to explain the biological activity of the synthesized compounds.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2021)
Article
Chemistry, Inorganic & Nuclear
Ludmila Leroy, Thiago M. Francisco, Helena J. Shepherd, Mark R. Warren, Lucy K. Saunders, David A. Shultz, Paul R. Raithby, Carlos B. Pinheiro
Summary: In this study, single crystal X-ray diffraction was used to observe light-induced VT in the solid state, and controlled use of hard X-rays via attenuation was demonstrated to avoid X-ray-induced VT interconversion. High-yield light-induced VT in Co(diox)(2)(4-CN-py)(2) crystals illuminated with 450 nm light at 30 K was achieved, showing evidence of ls-CoIII to hsCoII interconversion. Such high-yield light-induced VT had never been experimentally observed in molecular crystals of cobalt tautomers before.
INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Maximiliano Jesus Moreno Zapata, Willian Xerxes Coelho Oliveira, Carlos Basilio Pinheiro
Summary: The cocrystal hexamethylenetetramine-tridecanedioic acid was studied using single-crystal X-ray diffraction techniques at various temperatures during cooling and heating processes. Two crystalline phases were observed, separated by a temperature range of 290-340 K where phase co-existence occurred. Phase I was stable above 341 K and had an orthorhombic structure, while Phase II was stable below 290 K and had a monoclinic symmetry. The coexistence of phases was observed during both cooling and heating processes and appeared to be related to complex domain-growth dynamics within the crystal.
ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Ana P. Araujo de Oliveira, Victoria C. Romero Colmenares, Renata Diniz, Jennifer T. J. Freitas, Clara M. da Cruz, Eduardo B. Lages, Lucas A. M. Ferreira, Rafael P. Vieira, Heloisa Beraldo
Summary: In this study, novel memantine-derived Schiff bases were synthesized through condensation reactions of salicylaldehyde, 2-pyridinecarboxaldehyde, and pyridoxaldehyde with memantine. The results showed that these Schiff bases exhibited increased lipophilicity and hydrophobicity in all conditions and pH values. Compound (3) had the highest solubility and also demonstrated the release of pyridoxal through hydrolysis, indicating potential pharmacological effects. Therefore, this study suggests that synthesizing Schiff bases could be an effective strategy to enhance the lipophilicity of drugs.
Article
Archaeology
Monica Groppo Parma, Heloisa Beraldo, Isolda de Castro Mendes
Summary: This paragraph describes the statute of the first black's brotherhood in Ouro Preto, Brazil. Through X-ray fluorescence and Raman spectroscopy analysis, the materials used for the book decoration were identified, including gold, silver, brass gilding, and various colors. The study also revealed the painting techniques widely used in Brazil during the 18th century, including the use of Prussian Blue.
JOURNAL OF CULTURAL HERITAGE
(2023)
Article
Chemistry, Inorganic & Nuclear
Bruna Paes, Andrea R. Aguirre, Bernardo L. Rodrigues, Isolda C. Mendes, Joao Paulo Ataide Martins, Rafael P. Vieira, Heloisa Beraldo
Summary: Attempts to obtain Schiff bases from the reactions of pyridoxal with L-histidine and L-tryptophan resulted in Pictet-Spengler cyclization, leading to the formation of specific cyclic compounds. The diastereoselectivity of the reactions was investigated and the cis isomer was found to be present in both cases. The theoretical calculations of the reactions' free energies and the formation of complexes with zinc indicated the thermodynamic preferences and the prevention of cyclization.
Meeting Abstract
Chemistry, Multidisciplinary
Ludmila Leroy, Lucas G. Pimenta, Leonardo F. Calazans, Marcos Antonio Ribeiro, Frederico A. Lima, Simone Alexandre, David A. Shultz, Majed Chergui, Carlos B. Pinheiro
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES
(2021)
Meeting Abstract
Chemistry, Multidisciplinary
Juliana Assuncao Pereira de Figueiredo, Gabriel Galvani, Joao Alves, Laise Amorim, Maximiliano Zapata, Carlos Pinheiro
ACTA CRYSTALLOGRAPHICA A-FOUNDATION AND ADVANCES
(2021)
Article
Materials Science, Multidisciplinary
C. W. Galdino, D. C. Freitas, C. P. C. Medrano, D. R. Sanchez, R. Tartaglia, L. P. Rabello, A. A. Mendonca, L. Ghivelder, M. A. Continentino, M. J. M. Zapata, C. B. Pinheiro, G. M. Azevedo, J. A. Rodriguez-Velamazan, G. Garbarino, M. Nunez-Regueiro, E. Granado
Summary: This study investigates the charge ordering phenomenon in a homometallic Co ludwigite, confirming the mixed-valent character of Co ions and observing smaller Co ions at the M4 site at low temperatures. As temperature increases, the size difference between Co ions at M4 and M2 sites decreases, indicating gradual charge redistribution within the structure. Structural disorder and broadened vibrational modes are observed at medium to high temperatures, along with consistent local Co-O distance distribution.
Article
Chemistry, Inorganic & Nuclear
Walace D. do Pim, Ingrid F. Silva, Eufranio N. da Silva Junior, Humberto O. Stumpf, Willian X. C. Oliveira, Emerson F. Pedroso, Carlos B. Pinheiro, Yves Journaux, Felipe Fantuzzi, Ivo Krummenacher, Holger Braunschweig, Bernd Engels, Joan Cano, Miguel Julve, Cynthia L. M. Pereira
Summary: In this study, a unique heterobimetallic dodecanuclear oxamate-based {CoII6CuII6} nanowheel was successfully obtained using an environmentally friendly synthetic protocol. The effective Hamiltonian methodology employed allowed for the rationalisation of magnetic isotropic or anisotropic metal clusters, marking a significant advance for future studies of properties observed at low and ultralow temperatures.
DALTON TRANSACTIONS
(2021)
Article
Information Science & Library Science
Antonio Gomes Souza Filho, Carlos Basilio Pinheiro, Marcus Vinicius Domingues, Vivian Duarte Couto Fernandes, Yuri Luiz Reis Leite
Summary: Defining quality in higher education is complex and university rankings, despite their flaws, are an unavoidable reality. The establishment of a unified data management system among IFES is crucial for institutional self-awareness and fostering communication both within and outside the walls. Governance and operational aspects are key to building this system.
PERSPECTIVAS EM CIENCIA DA INFORMACAO
(2021)
Article
Chemistry, Multidisciplinary
Tatiana R. G. Simoes, Walace D. do Pim, Karina C. Metz, Marcos A. Ribeiro, Daniel C. A. Valente, Thiago M. Cardozo, Carlos B. Pinheiro, Emerson F. Pedroso, Bruno A. C. Horta, Cynthia L. M. Pereira, Gilmar P. de Souza, Humberto O. Stumpf
NEW JOURNAL OF CHEMISTRY
(2020)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
