Article
Chemistry, Multidisciplinary
Polina O. Serebrennikova, Julia A. Paznikova, Eva A. Kirnos, Irina A. Utepova, Elizaveta D. Kazakova, Vladimir F. Lazarev, Liubov S. Kuznetcova, Boris A. Margulis, Irina V. Guzhova, Oleg N. Chupakhin, Alexey P. Sarapultsev
Summary: The present study synthesized new derivatives of mono- and bis-1,2,4-triazoloazines and evaluated their cytotoxic activity against cancer cells. These compounds exhibited significant toxicity towards tumor cells while having minimal effects on normal cells, suggesting their potential as effective and selective anticancer agents.
NEW JOURNAL OF CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Mounir A. A. Mohamed, Adnan A. Bekhit, Omyma A. Abd Allah, Asmaa M. Kadry, Tamer M. Ibrahim, Salma A. Bekhit, Kikuko Amagase, Ahmed M. M. El-Saghier
Summary: A series of novel [1,2,4]-triazole derivatives bearing amino acids were synthesized using lemon juice as an acidic catalyst under green chemistry conditions. These compounds showed promising antibacterial activity against standard bacteria and multidrug resistant strains, with better MIC values compared to reference drugs. Some compounds exhibited bacteriostatic activity and high selectivity towards antimicrobial activity against specific bacteria, indicating a good safety profile.
Article
Chemistry, Multidisciplinary
Egor K. Voinkov, Roman A. Drokin, Victor V. Fedotov, Ilya I. Butorin, Konstantin Savateev, Daniil N. Lyapustin, Denis A. Gazizov, Evgeny B. Gorbunov, Pavel A. Slepukhin, Natalya A. Gerasimova, Natalya P. Evstigneeva, Natalya Zilberberg, Nikolay Kungurov, Evgeny N. Ulomsky, Vladimir L. Rusinov
Summary: This study reports the synthesis of a series of compounds and their antibacterial and antifungal activities. Several compounds showed strong antibacterial activity, but weak antifungal activity. Through pharmacophore search and homologous modeling, a potential biological target was identified and confirmed by molecular docking.
Article
Chemistry, Organic
Xin Yuan, Xuan Ke, Jiaxi Xu
Summary: In this study, various delta-phosphinolactones (delta-phostines) were efficiently and diastereospecifically synthesized through a series of chemical reactions. The synthesis features good to excellent yields, diastereospecificity, wide substrate scope, and other characteristics.
Review
Biochemistry & Molecular Biology
Shima Nasri, Mohammad Bayat, Khudaidad Kochia
Summary: Compounds containing 1,2,4-triazole scaffolds play a crucial role in drug discovery, this review article summarizes their pharmacological significance and synthesis strategies, encouraging further research to discover new drug candidates.
MOLECULAR DIVERSITY
(2022)
Article
Chemistry, Organic
Sierra C. Nguyen, Allen Y. Hong
Summary: A new two-step method for the preparation of annulated 1,2,4-triazoles has been developed, showing the incorporation of various annulated ring sizes into the resulting polycyclic triazoles.
TETRAHEDRON LETTERS
(2021)
Article
Pharmacology & Pharmacy
Bassam Abu Thaher, Ihab Al-Masri, Kanan Wahedy, Rami Morjan, Saeb Aliwaini, Iman Mahmoud Al Atter, Aayat Ahmed Elmabhouh, Areej Khaled Al Ibwaini, Saba Luay Alkhaldi, Basem Qeshta, Claus Jacob, Hans-Peter Deigner
Summary: Four novel 3-Aryl-1-(pyridin-4-yl)benzo[4,5]imidazo[1,2-d][1,2,4]-triazin-4(3H)-ones derivatives were designed, synthesized, and evaluated for their anticancer activity. The structures of the compounds were characterized and their binding to EGFR was determined. One compound, C3, exhibited the highest cytotoxicity against breast cancer cells and also inhibited cell migration. Western blotting results indicated that C3 treatment inhibited EGFR signaling, induced cell cycle arrest and apoptosis. This study provides a promising starting point for the development of new compounds targeting cancer cells.
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
(2023)
Article
Chemistry, Organic
Pondpavee Taweesak, Phanida Thongaram, Panitan Kraikruan, Adisak Thanetchaiyakup, Nutthawat Chuanopparat, Hsing-Pang Hsieh, Biing-Jiun Uang, Paiboon Ngernmeesri
Summary: This work describes a novel and simple one-pot synthesis of substituted dibenzo[b,f]oxepines under transition-metal-free conditions, which was achieved through a cascade process involving nucleophilic aromatic substitution followed by Knoevanagel condensation. The synthesis of anticancer bauhinoxepin C was also successfully achieved in 7 steps with 5.1% overall yield using this synthetic approach.
JOURNAL OF ORGANIC CHEMISTRY
(2021)
Article
Chemistry, Applied
Rene Hommelsheim, Robin van Nahl, Lena M. Hanek, Jas S. Ward, Kari Rissanen, Carsten Bolm
Summary: This study reports a palladium-catalyzed domino reaction that enables the synthesis of 3-amino-substituted 1,2,4-benzothiadiazine 1,1-dioxides at room temperature. The method demonstrates good substrate compatibility and mild reaction conditions.
ADVANCED SYNTHESIS & CATALYSIS
(2023)
Article
Chemistry, Organic
Fenghai Zhao, Thishana Singh, Yumei Xiao, Wangcang Su, Dongyan Yang, Changqing Jia, Jia-Qi Li, Zhaohai Qin
Summary: An efficient assembly of disubstituted 1,2,4-triazoles was achieved by cyclization of readily accessible N'-nitro-2-hydrocarbylidene-hydrazinecarboximidamides with moderate to excellent yields under mild reaction conditions. This divergent synthetic strategy allows for the formation of amino-1,2,4-triazoles under acidic conditions and nitroimino-1,2,4-triazoles under neutral conditions with water as the solvent.
SYNTHESIS-STUTTGART
(2021)
Article
Biochemistry & Molecular Biology
Dmytro S. Radchenko, Vasyl S. Naumchyk, Igor Dziuba, Andrii A. Kyrylchuk, Kateryna E. Gubina, Yurii S. Moroz, Oleksandr O. Grygorenko
Summary: The three-component one-pot approach described in this study successfully synthesized unsymmetrical 1,3,5-trisubstituted-1,2,4-triazoles, with a high success rate of 81%. The methodology shows great potential for generating a large number of REAL compounds, some of which meet lead-likeness criteria and can be valuable in medicinal chemistry.
MOLECULAR DIVERSITY
(2022)
Article
Chemistry, Organic
Karen R. Winters, Jean-Luc Montchamp
Summary: A series of P-stereogenic chiral phosphorus acids (CPAs) were synthesized to determine the requirements for efficient asymmetric organocatalysis. Although the efficacy of these compounds was disappointing for the specific reaction, the study is valuable for developing structural design elements.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Eman A. Ghareeb, Naglaa F. H. Mahmoud, Eman A. El-Bordany, Eman A. E. El-Helw
Summary: A series of nitrogen heterocycles were successfully synthesized using a readily obtainable building block synthon, and a fused heterocycle was also synthesized by different reaction routes. The synthesized compounds showed potent insecticidal activity against two insect species, prompting further study. DFT analysis was performed on the most potent compounds.
BIOORGANIC CHEMISTRY
(2021)
Article
Chemistry, Physical
Samet Poyraz, H. Ali Dondas, Jose M. Sansano, Samet Belveren, Cem Yamali, Mahmut Ulger, Naciye Yaktubay Dondas, Begum Nurpelin Saglik, Christopher M. Pask
Summary: A series of novel N-benzoylthiourea-pyrrolidine carboxylic acid derivatives with an imidazole moiety were synthesized and their various biological activities were evaluated. The molecules' ability to form intermolecular hydrogen bonds was studied to find the best antimicrobial activity. The compounds were tested for their enzyme inhibitory potency against AChE and BChE, which are the main targets for Alzheimer's disease. Additionally, the compounds were screened for antituberculosis and antibacterial activities, as well as antifungal activities against various strains of Candida.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Elzbieta Regulska, Philip Hindenberg, Adrian Espineira-Gutierrez, Carlos Romero-Nieto
Summary: Linearly-fused diphosphaarenes are a novel family of molecules with striking optoelectronic properties and outstanding stability, which hold great importance in materials science.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Chemistry, Organic
Tarik E. Ali, Mohammed A. Assiri
Summary: A series of novel compounds were synthesized using a facile green one-pot and three-component synthesis. The method demonstrated simple procedure, high yields, short rection time and environmentally benign characteristics.
POLYCYCLIC AROMATIC COMPOUNDS
(2023)
Article
Chemistry, Organic
Tarik E. Ali, Mohammed A. Assiri, Noha M. Hassanin
Summary: Some novel phosphorus compounds including 1,2-benzoxaphosphinines, phospholo-[3,4-b][1]benzofuran, and chromonyl/coumarinyl/indenonyl phosphonates were successfully synthesized. These compounds exhibit excellent antimicrobial properties.
SYNTHETIC COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Asif Rasool, Zahra Batool, Majid Khan, Sobia Ahsan Halim, Zahid Shafiq, Ahmed Temirak, Mohamed A. Salem, Tarik E. Ali, Ajmal Khan, Ahmed Al-Harrasi
Summary: The synthesis and carbonic anhydrase-II (CA-II) inhibition of cinnamaldehyde-clubbed thiosemicarbazones derivatives were reported. Compound 3n showed the highest inhibitory activity by specifically interacting with the Zn ion in the active site of CA-II. The molecular docking results correlated well with the in vitro activity.
SCIENTIFIC REPORTS
(2022)
Article
Infectious Diseases
Chanat Chokejaroenrat, Chainarong Sakulthaew, Khomson Satchasataporn, Daniel D. Snow, Tarik E. Ali, Mohammed A. Assiri, Apichon Watcharenwong, Saksit Imman, Nopparat Suriyachai, Torpong Kreetachat
Summary: This study investigated the adsorption capabilities of carbonized leonardite (cLND) for removing antibiotics from water, showing potential for efficient removal. The results demonstrated that cLND samples prepared at 450°C and 550°C effectively adsorbed sulfamethoxazole and enrofloxacin, retaining the antibiotics and serving as a low-cost adsorbent.
Article
Environmental Sciences
Jianfeng Hou, Zhangfeng Shen, Xihan Tan, Tarik E. Ali, Mohammed A. Assiri, Saira Asif, Ning Han
Summary: This article provides a detailed review of the progress in the development of RP perovskite oxide membranes for oxygen transport, including separation mechanisms, material types, synthesis methods, and performance evaluation.
Article
Chemistry, Inorganic & Nuclear
Tarik E. E. Ali, Mohammed A. A. Assiri, Mai S. A. Hussien, Noha M. M. Hassanin
Summary: An efficient method was developed for the synthesis of novel fused phosphorus heterocycles using a one-pot reaction in the presence of Fe3O4 nanoparticles as a reusable catalyst. The reaction involved the four-component reaction of ortho-substituted anilines with salicylaldehyde, diethyl phosphite, and hexaethylphosphorus triamide, yielding the desired products in good yields. Substitution of salicylaldehyde with benzaldehyde resulted in the formation of different phosphorus heterocycles.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2023)
Article
Chemistry, Applied
Mohamed R. Elmorsy, Safa A. Badawy, Ehab Abdel-Latif, Mohammed A. Assiri, Tarik E. Ali
Summary: A series of new metal-free D-D-pi-A dyes (TMS-1-4) based on triphenylamine (TPA) and carbazole (Cz) have been designed and used in dye-sensitized solar cells (DSSCs) as strong donor species. These dyes exhibit strong absorption ability, which shows promise in improving the performance of DSSCs.
Article
Engineering, Electrical & Electronic
Shimaa Abdel Halim, Hesham Hamad, Tarik E. Ali
Summary: This article discusses in detail the structure-activity relationship of compounds 1-4 studied by DFT calculations and its association with practical antimicrobial results. The compounds 1-4 were studied using DFT/B3LYB/6-311++G(d,p) at the theory level, and the geometric parameters, bond lengths, and bond angles were discussed. Quantum mechanical calculations revealed that the presence of phosphorus and sulfur atoms altered the planarity of the parent compound 1 within a range of -11 to 125 degrees. Various spectroscopic and quantum chemical parameters were evaluated through frontier molecular orbital analysis. The electronic absorption spectra of 1,3,2-diazaphosphinines 1-4 molecules were theoretically studied using TD-DFT/CAM-B3LYP/6-311++G(d,p) computations and showed good agreement with the observed spectra in methanol and cyclohexane.
OPTICAL AND QUANTUM ELECTRONICS
(2023)
Article
Chemistry, Inorganic & Nuclear
Mohamed Hussien, Tarik E. Ali, Ibrahim El-Tantawy El Sayed, Abdelaleem Hassan Abdelaleem, H. M. Torkey
Summary: In this study, a series of novel diethyl {(4-oxo-1,4-dihydroquinolin-3-yl)(aryl/heteroaryl-amino)methyl}phosphonates were successfully synthesized. The methodology involved a one-pot three-component reaction of 4-oxo-1,4-dihydroquinoline-3-carboxaldehyde (1), amine, and diethyl phosphite using CdI2 nanoparticles as an efficient catalyst under conventional heating or ultrasound irradiation. The mild reaction conditions, operational simplicity, and excellent yields are the key advantages of this protocol. Most of the products exhibited inhibitory effects on plant pathogenic fungi similar to the standard control. The hybridization of diethyl α-aminophosphonate with quinolin-4-one moieties combined with sulfonamide, antipyrine, or 1,2,4-triazine in a single molecular frame showed good antifungal activities.
PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS
(2023)
Article
Chemistry, Organic
M. A. Assiri, T. E. Ali, A. Y. Alzahrani, M. A. Salem
Summary: A simple one-pot synthesis of novel 5-pyrazolyl-1,4,2-diazaphosphole derivatives was developed via a three-component reaction. The reaction involved dimethyl (formamide/acetamide) dimethyl acetal or carbon disulfide, triethyl phosphite, and 1H-pyrazole-1-carboximidamides in dioxane. Spectral methods and elemental analysis confirmed the structure of the synthesized compounds.
RUSSIAN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Organic
Mohammed A. Assiri, Tarik E. Ali, Maha N. Alqahtani, Ali. A. Shati, Mohammed. Y. Alfaifi, Serag. E. I. Elbehairi
Summary: A series of new 5-(arylidene/heteroarylidene)-2-(morpholinoimino)-3-phenylthiazolidin-4-ones (3-30) were synthesized and tested for their cytotoxic effectiveness against three cancerous cell lines. Compounds 5, 7, 11, 12, 17, and 18 showed the most active inhibitory effect on all tested cancer cells, similar to doxorubicin. Flow cytometry and cell cycle analysis confirmed the apoptosis-inducing effect of compounds 5, 7, and 12 on tumor cells, while compounds 5, 7, 11, and 12 significantly arrested cancer cells at the S and G2 phases. Molecular docking was performed to understand the binding mode of compounds 5 and 7 with the VEGFR-2-KDR receptor.
SYNTHETIC COMMUNICATIONS
(2023)
Review
Chemistry, Organic
Tarik E. Ali, Mohammed A. Assiri, Mohamed Hussien, Ibrahim El Tantawy El Sayed
Summary: This review discusses recent advancements in the synthesis of dialkyl (aryl) alpha-aminophosphonates containing heterocyclic compounds. The target structures are categorized into three groups and various synthetic protocols, including the Kabachnik-Fields and Pudovik reactions, are presented. This review serves as a valuable resource for researchers working in this emerging field.
CURRENT ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Applied
Safa A. Badawy, Ehab Abdel-Latif, Mohammed A. Assiri, Tarik E. Ali, Mohamed R. Elmorsy
Summary: Dye-sensitized solar cells (DSSCs) using hydrazonothiazole dyes (MHS-1-4) have shown promising potential for greenhouse applications. These dyes absorb light in the green region and transmit light in the red and blue regions, making them suitable for plant growth. The MHS-4 DSSCs achieved a high power conversion efficiency of 8.85%, a short-circuit photocurrent density of 17.90 mA cm-2, and a maximum incident monochromatic photonto-electron conversion efficiency (IPCE) of 80%. Additionally, the DSSCs based on MHS-4 demonstrated excellent long-term stability, maintaining constant power conversion efficiency after 1000 hours of exposure to sunlight.
Article
Chemistry, Multidisciplinary
Tarik E. Ali, Mohammed A. Assiri, Maha N. Alqahtani, Ali. A. Shati, Mohammad. Y. Alfaifi, Serag. E. I. Elbehairi
Summary: A convenient synthetic approach involving ring-opening and ring-closure reactions was successfully utilized to construct a series of novel substituted azoles, azines, azepines, and pyrans with a morpholinothiazolidinone hybrid. The cytotoxic effects of the synthesized compounds were evaluated against three cancer cell lines, and eight compounds (7, 11, 12, 15, 19, 22, 26, and 28) were found to exhibit strong cytotoxic activity comparable to doxorubicin. These compounds induced significant early and late apoptosis in tumor cells and arrested cell cycle progression in the G1 and G2 phases. Additionally, molecular docking studies provided insights into the binding mode of compounds 12 and 22 with the p53-MDM2 protein receptor.
Review
Chemistry, Organic
Tarik E. Ali, Noha M. Hassanin, Mohammed A. Assiri, Somaia M. Abdel-Kariem
Summary: This review summarizes the progress made in the synthesis and chemistry of 1,2,4,3-triazaphospholes over the past fifty years. These compounds have attracted significant attention in homogeneous catalysis and molecular materials science due to their highly aromatic conjugated p systems and diverse reactivity.
CURRENT ORGANIC CHEMISTRY
(2023)
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
