Review
Chemistry, Inorganic & Nuclear
Archana Rajmane, Sanjay Jadhav, Arjun Kumbhar
Summary: Pd-catalyzed cross-coupling reactions are crucial in achieving valuable organic transformations, and recent developments have focused on phosphine-free ligands such as N-heterocyclic carbenes and amines, which offer broad scope and environmental friendliness.
JOURNAL OF ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Dmitry I. Pavlov, Denis G. Samsonenko, Laura Bonfili, Massimiliano Cuccioloni, Enrico Benassi, Riccardo Pettinari, Andrei S. Potapov, Vladislava V. Matveevskaya
Summary: Six new arene-ruthenium(II) complexes with different arene and oxime ligands were synthesized and characterized. The complexes exhibited a half-sandwich piano-stool geometry and showed promising anti-proliferative activity.
INORGANICA CHIMICA ACTA
(2022)
Article
Chemistry, Inorganic & Nuclear
Tasha R. Steel, Kelvin K. H. Tong, Tilo Sohnel, Stephen M. F. Jamieson, L. James Wright, James D. Crowley, Muhammad Hanif, Christian G. Hartinger
Summary: Multimetallic complexes have been synthesized and characterized, with studies conducted on their binding properties with DNA and protein models. The anticancer activity of the complexes was evaluated against cancer cell lines, showing moderate antiproliferative effects.
INORGANICA CHIMICA ACTA
(2021)
Article
Chemistry, Inorganic & Nuclear
Nikolai F. Romashev, Pavel A. Abramov, Ivan Bakaev, Iakov S. Fomenko, Denis G. Samsonenko, Alexander S. Novikov, Kelvin K. H. Tong, Dohyun Ahn, Pavel Dorovatovskii, Yan Zubavichus, Aleksey A. Ryadun, Olga A. Patutina, Maxim N. Sokolov, Maria Babak, Artem L. Gushchin
Summary: A series of Pt and Pd complexes with dpp-Bian and different ligands were synthesized and characterized. The Pt(dpp-Bian) complexes showed high anticancer activity at low concentrations and exhibited selectivity towards cancer cells. These complexes induced the generation of reactive oxygen species in cancer cells and were able to intercalate into DNA.
INORGANIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Jia Nuo Leung, Han Vinh Huynh
Summary: A library of 12 palladium(II) complexes, consisting of 10 dithiocarbamato and two xanthato ligands, were synthesized and characterized. The electronic and steric properties of the ligands were evaluated using HEP2 and %Vbur methodologies. The construction of a stereoelectronic map for dithiocarbamates allowed for the identification of optimal ligand parameters for enhanced cytotoxic activities of gold(III) complexes, showcasing the map's usefulness in rational ligand design.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Ming Li, Sandeep K. Gupta, Sebastian Dechert, Serhiy Demeshko, Franc Meyer
Summary: Synthetic routes have been developed for a dicobalt(I) complex using a unique pyrazolate-bridged dinucleating ligand, showing efficient catalytic activity in the reductive silylation of nitrogen. Protonation leads to the formation of a tetracobalt(I) complex, demonstrating potential in the field of molecular nitrogen fixation catalysts.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Chemistry, Applied
Andrea Longhi, Marco Baron, Marzio Rancan, Gregorio Bottaro, Laura Orian, Claudia Graiff, Marco Roverso, Ileana Menegazzo, Lidia Armelao, Sara Bogialli, Cristina Tubaro
Summary: This study explored the coordinating properties of the bis(1,4-dimethyl-1,2,4-triazol-5-ylidene) ligand (bitz) towards silver(I) and gold(I) centers. Results showed that bitz behaves as a bridging ligand, forming both dinuclear and trinuclear complexes, which were supported by X-ray diffraction analysis, NMR spectroscopy, and mass spectrometry evidence.
APPLIED ORGANOMETALLIC CHEMISTRY
(2022)
Article
Chemistry, Inorganic & Nuclear
Ariadna Lazaro, Ramon Bosque, Jas S. Ward, Kari Rissanen, Margarita Crespo, Laura Rodriguez
Summary: Two series of Pt(II)-cyclometallated compounds with different (NCN)-C-boolean AND-N-boolean AND ligands and alkynyl-chromophore ligands were synthesized and characterized. The presence of weak intermolecular contacts leading to dimerization or aggregation was observed in the crystal structures of some compounds. The photophysical characterization showed two emission bands in solution, originating from the N<^>C<^>N ligands and (MLCT)-M-3/(ILCT)-I-3 transitions, and the formation of excimers with near-infrared (NIR) emission was identified in compounds with phenanthrene chromophores. Aggregates emitting at around 650 nm were also detected in acetonitrile/water mixtures.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Aoi Hori, Yuna Kim, Keishiro Tahara, Tomofumi Kadoya, Jun-ichi Yamada, Kazuya Kubo
Summary: Two unsymmetrical metal dithiolene complexes, labeled as 1 and 2, were synthesized and studied. The absorption bands of the HOMO-LUMO transitions for 1 and 2 shift in opposite directions with increasing solvent polarity, resulting in red and blue shifts, respectively.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2021)
Article
Chemistry, Inorganic & Nuclear
Aisling L. Ryan, Joshua Northcote-Smith, Aoife McKeon, Andrew Roe, Paul O'Dowd, Brendan Twamley, Triona Ni Chonghaile, Kogularamanan Suntharalingam, Darren M. Griffith
Summary: The first example of a Pt complex of GANT61, a hedgehog (Hh) pathway inhibitor, is reported. The complex showed potent inhibition activity against breast CSC cells and triple negative breast cancer cells, as well as significant inhibition effect on the CSC-enriched mammosphere model.
DALTON TRANSACTIONS
(2022)
Review
Chemistry, Physical
Csilla Eniko Czegeni, Ferenc Joo, Agnes Katho, Gabor Papp
Summary: This review summarizes the recent advances in the synthesis and catalytic applications of heterobimetallic carbene complexes. New synthetic methods and catalytic activity studies are presented. It is found that certain heterobimetallic complexes exhibit significantly higher catalytic activity compared to their homobimetallic analogs or mixtures, highlighting the importance of metal cooperation in catalysis.
Article
Biochemistry & Molecular Biology
Aleksandra M. Bondzic, Jelena J. Zakula, Lela B. Koricanac, Otilija D. Keta, Goran Janjic, Ivana S. Dordevic, Snezana U. Rajkovic
Summary: The stability, lipophilicity, in vitro cytotoxicity, and influence on acetylcholinesterase of five dinuclear platinum(II) complexes were evaluated. Some of the complexes showed promising anticancer activity and selectivity, with minimal effects on normal cells. Docking studies provided insights into the binding modes with acetylcholinesterase.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Chemistry, Multidisciplinary
Pascal Jurt, Anne Sofie Abels, Juan Jose Gamboa-Carballo, Israel Fernandez, Gregoire Le Corre, Marcel Aebli, Matthew G. Baker, Frederik Eiler, Fabian Mueller, Michael Worle, Rene Verel, Sebastien Gauthier, Monica Trincado, Thomas L. Gianetti, Hansjorg Grutzmacher
Summary: A bimetallic Rh-I-Pt-II complex with a specially designed multidentate phosphine olefin ligand can catalytically detoxify nitrogen oxides, forming water and N-2 as benign products at room temperature. Investigation into the conversion process revealed the generation of a hyponitrite (N2O22-) complex as an intermediate, shedding light on a possible reaction mechanism.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2021)
Article
Polymer Science
Micheal K. Farh, Franka V. Gruschwitz, Nicole Ziegenbalg, Hassan Abul-Futouh, Helmar Goerls, Wolfgang Weigand, Johannes C. Brendel
Summary: This article introduces β-hydroxy dithiocinnamic esters as a new class of materials for reversible CTAs in the polymerization of acrylates, acrylamides, or styrene. Kinetic studies show that these materials provide reasonable control over the polymerization process, and the resulting polymer chains exhibit good structural integrity.
MACROMOLECULAR RAPID COMMUNICATIONS
(2022)
Article
Pharmacology & Pharmacy
Leide Laura Figueiredo Maciel, Marina Barreto Silva, Rafaela Oliveira Moreira, Ana Paula Cardoso, Christiane Fernandes, Adolfo Horn Jr, Joao Carlos de Aquino Almeida, Milton Masahiko Kanashiro
Summary: This study investigated the antineoplastic activity of two platinum complexes containing alpha- and beta-naphthyl groups. The results showed that one of the platinum complexes exhibited higher cytotoxicity against all cancer cell lines tested and lower cytotoxicity against normal peripheral blood mononuclear cells. Further investigations revealed that this complex induced cell death by apoptosis and was associated with mitochondrial membrane depolarization, elevated levels of reactive oxygen species (ROS), and caspase activation.
Article
Chemistry, Multidisciplinary
Salvatore Cataldo, Gabriele Lando, Demetrio Milea, Santino Orecchio, Alberto Pettignano, Silvio Sammartano
NEW JOURNAL OF CHEMISTRY
(2018)
Article
Chemistry, Inorganic & Nuclear
Simona Rubino, Ivana Pibiri, Chiara Minacori, Rosa Alduina, Vita Di Stefano, Santino Orecchio, Silvestre Buscemi, Maria Assunta Girasolo, Luisa Tesoriere, Alessandro Attanzio
INORGANICA CHIMICA ACTA
(2018)
Article
Chemistry, Inorganic & Nuclear
Piera Sabatino, Simone D'Agostino, Jacopo Isopi, Simona Rubino, Massimo Marcaccio, Maria Assunta Girasolo
Article
Biochemistry & Molecular Biology
Alessandro Attanzio, Simone D'Agostino, Rosalia Busa, Anna Frazzitta, Simona Rubino, Maria Assunta Girasolo, Piera Sabatino, Luisa Tesoriere
Article
Biochemistry & Molecular Biology
Simona Rubino, Rosa Alduina, Patrizia Cancemi, Maria Assunta Girasolo, Vita Di Stefano, Santino Orecchio, Silvestre Buscemi, Ivana Pibiri
Article
Chemistry, Multidisciplinary
Diana Amorello, Roberta Indelicato, Salvatore Barreca, Santino Orecchio, Silvia Orecchio
Summary: This study presents a simple method to quantify phthalate esters in coffee brew. The results show that the content of single phthalate esters in the analyzed coffee samples falls within a certain range. Considering the daily coffee consumption, the intake of phthalates is relatively high.
Review
Chemistry, Multidisciplinary
Diana Amorello, Santino Orecchio, Salvatore Barreca, Silvia Orecchio
Summary: The interest in quantifying Pt, Pd, and Rh in environmental and food matrices arises from the production of catalytic converters for car engines. While high concentrations of these elements have shown sensitization, mutagenic effects, and increased tumor incidence, their effects at low environmental concentrations are unknown. Voltammetric techniques offer advantages in quantifying PGEs in these matrices due to their sensitivity and ability to distinguish between different redox species and metal complexes. Spectrophotometric methods face practical challenges in PGE analysis. This article reviews research on environmental and food matrices from 1996 to 2022.
Article
Chemistry, Multidisciplinary
Francesca Di Gaudio, Diana Amorello, Marzia Ferrara, Santino Orecchio, Silvia Orecchio
Summary: The aim of this study was to develop an analytical method to quantitatively determine the concentration of 18 elements in tattoo inks using Inductively Coupled Plasma Mass Spectrometry. The results showed that the total concentrations of metals in the 16 analyzed tattoo ink samples ranged from 0.060 to 16.9 g kg(-1). Zinc was the most abundant metal, with concentrations ranging from 3.4 to 13882 mg kg(-1). The concentrations of zinc in three samples exceeded the legal limit (2000 μg g(-1)), and the concentration of chromium in all cases was higher than allowed (0.5 μg g(-1)). Four of the analyzed samples should not be used by tattoo artists according to the limit values.
Article
Chemistry, Analytical
Francesca Di Gaudio, Salvatore Barreca, Santino Orecchio
Summary: In this study, an analytical method based on reversed-phase ion-pair chromatography coupled with mass spectrometry was optimized for the quantification of ultra-trace levels of DADMAC in drinking water. The method was validated and showed good accuracy, precision, linearity range, and limits of quantification and detection. DADMAC was detected in all analyzed samples, with concentrations ranging from 1.2 to 3.8 μg/L and a mean value of 1.7 μg/L. This is the first study on DADMAC concentration in water samples collected in Italy, and it is of significant interest for future comparison of DADMAC monitoring data in water. Moreover, this study highlights one of the few cases where DADMAC has been found in drinking water.
Review
Environmental Sciences
Dario Savoca, Salvatore Barreca, Riccardo Lo Coco, Diletta Punginelli, Santino Orecchio, Antonella Maccotta
Summary: This review provides a survey of recent progress in the study of the impact of phthalic acid esters on aquatic organisms. It introduces the classification, properties, sources, fate, and toxic effects related to phthalates, and provides an overview of the techniques of extracting and analyzing these substances. Environmental bioindicators, biomonitoring systems, and other concepts related to phthalate contamination in the aquatic environment are presented. Bioaccumulation data of different phthalates are summarized and organized according to organism type, tissue, and geographical area. Representative bioindicator organisms and relevant variables in assessing environmental pollution are discussed. The final part suggests new research objectives and directions for the future.
Article
Chemistry, Applied
Salvatore Barreca, Santino Orecchio, Silvia Orecchio, Irene Abbate, Claudia Pellerito
Summary: The aim of this study was to estimate the dietary exposure of macro and micro elements in meals consumed by the Mediterranean population, particularly Sicilian. Various elements were analyzed in typical Mediterranean meal samples, and it was found that the consumption of these foods did not pose significant health risks in terms of heavy metal intake.
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
(2023)
Article
Food Science & Technology
Santino Orecchio, Diana Amorello
Article
Food Science & Technology
Antonella Maggio, Santino Orecchio
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)