Article
Plant Sciences
Santiago Michavila Puente-Villegas, Luis Apaza Ticona, Angel Rumbero Sanchez, Jose-Luis Acebes
Summary: This study identified six diterpenes from the resin of P. pinaster for the first time, which showed anti-inflammatory, analgesic, and antibacterial activities. Compound 9 demonstrated the highest activity and was considered a promising candidate for analgesic and antibacterial agents.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Adnan A. Bekhit, Sherry N. Nasralla, Eman J. El-Agroudy, Nahla Hamouda, Ahmed Abd El-Fattah, Salma A. Bekhit, Kikuko Amagase, Tamer M. Ibrahim
Summary: This study evaluates the therapeutic activity and adverse drug reactions of a newly synthesized pyrazole derivative, compound AD732, and compares it to standard agents. The results show that AD732 has higher anti-inflammatory and analgesic effects compared to standard agents, without ulcerogenic effects and minimal detrimental effects on renal function. AD732 may be a safer and more effective molecule with promising potential for pain and inflammation management.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Chemistry, Inorganic & Nuclear
Jinling Sui, Mingxin Jin, Hassan Morovvati, Samaneh Goorani
Summary: In this study, gold nanoparticles were synthesized using plant leaf extract and characterized using various chemical tests. The nanoparticles showed local anesthetic, anti-inflammatory, and analgesic activities in cell and animal experiments, suggesting their potential as a novel therapeutic drug.
INORGANIC CHEMISTRY COMMUNICATIONS
(2022)
Article
Food Science & Technology
Zefeng Chen, Shupeng Cheng, Huiqiong Lin, Wenjing Wu, Liyi Liang, Xicai Chen, Xi Zheng, Yan He, Kun Zhang
Summary: The study investigated the active ingredients of different extracts of Acanthopanax trifoliatus, revealing their antibacterial, anti-inflammatory, analgesic, and hemostatic effects. The ethyl acetate layer extract contained the highest levels of active substances, exhibiting strong hemostatic and analgesic activities, while the chloroform layer extract showed the strongest anti-inflammatory effect. High levels of polyphenols and flavonoids in the ethyl acetate layer extract contribute to its nutritional activities.
FOOD SCIENCE & NUTRITION
(2021)
Article
Plant Sciences
Thaise Gabriele da Silva Brito, Ana Paula Sant'Anna da Silva, Rebeca Xavier da Cunha, Caique Silveira Martins da Fonseca, Tiago Ferreira da Silva Araujo, Janaina Karin de Lima Campos, Weber Melo Nascimento, Hallysson Douglas Andrade de Araujo, Joanda Paolla Raimundo e Silva, Josean Fechine Tavares, Bianka Santana dos Santos, Vera Lucia de Menezes Lima
Summary: Plinia cauliflora fruits are rich sources of secondary metabolites, mainly tannins and phenolic acids with high biological potential, which can effectively contribute to the approach of preventing and controlling chronic non-communicable diseases.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Plant Sciences
Xinduo Wu, Jizhao Xie, Li Qiu, Luhui Zou, Yunfeng Huang, Yunfeng Xie, Huanji Xu, Shineng He, Qing Zhang
Summary: Viburnum taitoense has been used as a folk medicine by minority groups in Southwestern China for treating fractures and rheumatism. Ethyl acetate extract of V. taitoense (EEVt) has been found to have definite anti-inflammatory and analgesic effects, rich in triterpenoids. This warrants further investigation.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Article
Pharmacology & Pharmacy
Lili Cui, Chaorui Peng, Jun Li, Xin Cheng, Xiao Fan, Jingyu Li, Zixian Yang, Yuancui Zhao, Yunshu Ma
Summary: This study investigated the anti-inflammatory and analgesic effects of 2Br-Cre and Step, and explored the specific biological mechanisms involved. The results showed that 2Br-Cre and Step exhibited remarkable anti-inflammatory and analgesic effects, with better efficacy, suggesting their potential value as analgesic agents.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Hai Ye, Tian Lv, Tao Min, Di Mao, Xingran Chen, Boxiang Ding, Can Zhang
Summary: The combinational use of intravenous NSAIDs with opium analgesic is effective for pain control after surgery, reducing the risk of addiction. However, current intravenous NSAIDs have solubility issues. Researchers developed a new intravenous NSAID, HR1405-01, using the bioactive metabolite of loxoprofen. HR1405-01 demonstrated stronger anti-inflammatory and analgesic activities with better solubility, leading to fewer side effects.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Pharmacology & Pharmacy
Yan-Qing Xie, Jing-Yao Huang, Yun-Xiu Chen, Qian Zhou, Qi-Xiu Zhou, Zhu-Ya Yang, Shi-Kui Xu, Wen-Hong Tan, Lu Liu
Summary: This study investigates the metabolites in the bark and leaves of Streblus indicus for their anti-inflammatory and analgesic effects. The results provide scientific evidence for the traditional use of S. indicus and offer a theoretical foundation for the development of new anti-inflammatory and analgesic drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Mona F. Said, Hanan H. Georgey, Eman R. Mohammed
Summary: The newly synthesized oxadiazolo and thiadiazolo fused pyrimidinones demonstrate promising analgesic properties and excellent pharmacokinetic properties. Among them, the methoxyphenyl piperazinyl derivative 3d shows outstanding analgesic and anti-inflammatory activity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Plant Sciences
Eziuche Amadike Ugbogu, Happiness Okoro, Okezie Emmanuel, Ositadinma Chinyere Ugbogu, Celestine Nwabu Ekweogu, Miracle Uche, Emmanuel Dike Dike, Solomon Nnah Ijioma
Summary: This study investigated the anti-diarrhoeal, anti-inflammatory, and analgesic effects of Ananas comosus leaf extract (AACLE) in rats. The results showed that AACLE is non-toxic and contains bioactive compounds with various pharmacological activities. The extract also exhibited antimicrobial and hepatoprotective properties. Therefore, the traditional medicinal use of Ananas comosus leaves is justified.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Plant Sciences
Gourav Chandan, Chetan Kumar, Pankaj Chibber, Ashwani Kumar, Gurdarshan Singh, Naresh K. Satti, Henok Gulilat, Adesh K. Saini, Anupam Bishayee, Reena Saini
Summary: This study isolated and identified three steroidal lactones from Datura stramonium leaves, which showed anti-inflammatory properties in in vitro and in vivo experiments. Docking analysis confirmed their binding efficiency with key inflammation-related targets, suggesting the potential of these lactones as anti-inflammatory agents for chronic inflammatory ailments.
Article
Pharmacology & Pharmacy
Doudou Huang, Shenggui Jiang, Zenan Du, Yanhong Chen, Dan Xue, Xiujuan Wang, Mengshuang Li, Feng Zhang, Wansheng Chen, Lianna Sun
Summary: Polysaccharides in Chaenomeles speciosa (CSP) have significant analgesic and anti-inflammatory effects on pain and arthritis symptoms, mainly by inhibiting the production of pro-inflammatory cytokines and activation of the MAPK pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Veterinary Sciences
Dongyang Ye, Jing Sun, Yinqian Li
Summary: This study demonstrated that HHPJE is a safe and effective traditional Chinese veterinary medicine for treating bovine mastitis, with significant bacteriostatic, analgesic, anti-inflammatory, and antipyretic potential. The extract showed dose-dependent antibacterial effects on various bacteria strains and was safe for acute oral toxicity, indicating potential value for future clinical applications with no drug resistance or side effects.
VETERINARY SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Bilal Aslam, Asif Hussain, Muhammad Usman Bari, Muhammad Naeem Faisal, Zia ud Din Sindhu, Rasha Alonaizan, Rasha K. Al-Akeel, Shabana Naz, Rifat Ullah Khan
Summary: This study evaluated the in vivo effects of meloxicam and curcumin co-encapsulated PLGA nanoparticles in acute models of pyrexia, nociception, and inflammation. The results showed that PLGA encapsulation significantly improved the in vivo activities of both compounds, and co-encapsulation of meloxicam and curcumin enhanced their anti-pyretic, anti-nociceptive, and anti-inflammatory effects in a dose-dependent manner. Therefore, the combination of meloxicam and curcumin in a biodegradable nanocarrier system could provide a promising therapeutic approach for acute conditions.
Article
Chemistry, Multidisciplinary
Yasser Attia Attia, Shams H. Abdel-Hafez
RESEARCH ON CHEMICAL INTERMEDIATES
(2020)
Article
Biochemistry & Molecular Biology
Mosselhi A. M. Mohamed, Shams H. Abdel-Hafez, Adil A. Gobouri
Summary: Two new compounds were synthesized by reacting 6-amino-2-methylthio-3-methyluracil with different substrates, leading to the formation of novel pyrido[2,3-d]pyrimidines after cyclization and ribosylation. Further synthesis of novel pyrido[2,3-d]pyrimidine nucleosides was achieved by debenzoylation. The structural assignments were confirmed based on elemental analysis and spectroscopic data.
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS
(2021)
Article
Chemistry, Multidisciplinary
Yasser Attia Attia, Shams H. Abdel-Hafez
Summary: The efficient synthesis of transition-metal cobalt oxide nanoparticles (Co3O4 NPs) was achieved using the co-precipitation method without the use of costly and toxic solvents or complicated equipment. These reusable nanoparticles demonstrated high catalytic activity under microwave irradiation for the synthesis of organoselenium compounds with higher yields and milder reaction conditions.
RESEARCH ON CHEMICAL INTERMEDIATES
(2021)
Article
Materials Science, Multidisciplinary
Saleem Mumtaz, Muhammad Naeem Ashiq, Bashir Ahmad, Muhammad Faheem Ashiq, Ruqiya Sehrish Gohar, Nosheen Nazar, Shams H. Abdel-Hafez, Wael A. El-Sayed, Hafiz Muhammad Tahir Farid
Summary: The effects of Si doping on the dielectric and electrical properties of disordered pyrochlores Ce2Zr2-xSixO7 were observed. Various techniques revealed that doping of Si contents enhanced the dielectric and electrical measurements, making the prepared material suitable for frequency filters, oscillators, and resonators.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2021)
Article
Materials Science, Multidisciplinary
Y. S. Rammah, H. O. Tekin, Shams A. M. Issa, F. I. El-Agawany, K. A. Mahmoud, Shams H. Abdel-Hafez, A. S. Abouhaswa
Summary: The influence of Gd2O3 on the structure, physical properties, and radiation shielding capabilities of newly prepared glasses was investigated. The addition of Gd2O3 led to changes in density, mass attenuation coefficient, atomic cross section, and effective atomic number of the glass samples. The radiation shielding capacity was found to be the highest in Gd4 glass, while the fast neutron removal cross section was the lowest in Gd0 glass.
APPLIED PHYSICS A-MATERIALS SCIENCE & PROCESSING
(2021)
Article
Materials Science, Ceramics
Adel M. Binyaseen, Abrar Bayazeed, Samar Y. Al-nami, Khulood Abu Al-Ola, Sara A. Alqarni, Shams H. Abdel-Hafez, Nashwa M. El-Metwaly
Summary: Novel epoxy resin/CNW nanocomposite coatings with rare-earth doped aluminate nanoparticles were developed. The coatings exhibited excellent optical properties and corrosion resistance, making them suitable for industrial production of anti-corrosive, superhydrophobic, and long-persistent phosphorescent materials.
CERAMICS INTERNATIONAL
(2022)
Article
Chemistry, Organic
Ahmed F. M. EL-Mahdy, Etify A. Bakhite, Shams H. Abdel-Hafez, Omaima F. Ibrahim, Hajjaj H. M. Abdu-Allah, Islam S. Marae
Summary: This study focused on the synthesis and photophysical properties of a series of pyrrolylthienopyyridine compounds, showing aggregation-induced emission behavior with high absolute quantum yields.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Chemistry, Organic
Islam S. Marae, Omaima F. Ibrahim, Shams H. Abdel-Hafez, Shaaban K. Mohamed, Joel T. Mague, Etify A-G Bakhite
Summary: In this study, a new 7,8-dihydroisoquinoline scaffold was synthesized via ketonic hydrolysis using potassium hydroxide. Two possible mechanistic approaches for this synthesis were proposed. Various related compounds were also successfully synthesized, and their crystal structures were determined using X-ray diffraction analysis.
JOURNAL OF HETEROCYCLIC CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Salwinder Singh Dhaliwal, Vivek Sharma, Arvind Kumar Shukla, Janpriya Kaur, Vibha Verma, Prabhjot Singh, Harkirat Singh, Shams H. Abdel-Hafez, Samy Sayed, Ahmed Gaber, Reham Ali, Akbar Hossain
Summary: The foliar application of ZnSO4 center dot 7H(2)O (0.5%) + FeSO4 center dot 7H(2)O (0.5%) at pre-flowering and pod formation stages significantly enhanced grain and straw yield, as well as Zn and Fe concentration and uptake in lentil cultivation. This treatment also showed the highest benefit:cost ratio among all the tested combinations, indicating its potential economic returns.
Article
Biochemistry & Molecular Biology
Hemmat M. Abd-Elhady, Mona A. Ashor, Abdelkader Hazem, Fayez M. Saleh, Samy Selim, Nihal El Nahhas, Shams H. Abdel-Hafez, Samy Sayed, Enas A. Hassan
Summary: The study synthesized spherical silver nanoparticles through a biological approach, which had small size and high antimicrobial activity. The nanoparticles did not affect the development and phenotype of Drosophila melanogaster and exhibited significant inhibition on the viability of human lung carcinoma and normal cells.
Article
Chemistry, Physical
Muhammad Adnan, Taj Ur Rahman, Ali Bahadur, Muhammad Aurang Zeb, Wajiha Liaqat, Takashiro Akitsu, Shams H. Abdel-Hafez, Wael A. El-Sayed
Summary: The thermal degradation of polymethylmethacrylate (PMMA) was studied using aluminum triiodide (AlI3) as an inorganic salt additive. The addition of AlI3 was found to enhance the stability and flame retardancy properties of PMMA, with chemical association and molecular mixing confirmed through FTIR and SEM analysis.
Article
Green & Sustainable Science & Technology
Salwinder Singh Dhaliwal, Vivek Sharma, Janpriya Kaur, Arvind Kumar Shukla, Akbar Hossain, Shams H. Abdel-Hafez, Ahmed Gaber, Samy Sayed, Vijay Kant Singh
Summary: This study investigated the variations of DTPA-extractable micronutrients in three different soil types in Punjab. The results showed that the content of micronutrients declined with increasing soil depth in all soil types. pH and electrical conductivity (EC) were significantly negatively correlated with micronutrient content, while organic carbon (OC) had no significant correlation with it.
Article
Materials Science, Multidisciplinary
M. U. Sohaib, Kamran Abid, N. A. Noor, M. Aslam Khan, R. Neffati, Shams H. Abdel-Hafez, Enas E. Hussein
Summary: This study utilizing density functional theory calculations found that Cd-based spinel chalcogenides CdCr2X4 possess stable ferromagnetic phase, making them potential candidates for ferromagnetic systems. Additionally, these materials exhibit unique optical and thermoelectric properties, showing promise for opto-electronic applications and thermoelectric power generators.
JOURNAL OF MATERIALS RESEARCH AND TECHNOLOGY-JMR&T
(2021)
Article
Agronomy
Salwinder Singh Dhaliwal, Vivek Sharma, Arvind Kumar Shukla, Vibha Verma, Prabhjodh Singh Sandhu, Sanjib K. Behera, Prabhjot Singh, Janpriya Kaur, Harkirat Singh, Shams H. Abdel-Hafez, Ahmed Gaber, Samy Sayed, Akbar Hossain
Summary: Indian mustard is an important winter oilseed crop in India with high demand for zinc and iron, and foliar application of micronutrients along with urea can significantly increase yield and nutrient uptake, especially the treatment FZU showing the greatest improvement in grain and stover yield and nutrient efficiency.
Article
Agronomy
Salwa M. El-Sayed, Nevin Ahmed, Samy Selim, Areej A. Al-Khalaf, Nihal El Nahhas, Shams H. Abdel-Hafez, Samy Sayed, Heba M. Emam, Mervat A. R. Ibrahim
Summary: The essential oil of anise seeds showed significant acaricidal activity against T. urticae, which was highly correlated with the inhibition of acetylcholinesterase and protease activities in the mites.
Article
Chemistry, Medicinal
Shuang Mei, Su Jiang, Yuting Wang, Han Jing, Peng Yang, Miao-Miao Niu, Jindong Li, Kai Yuan, Yan Zhang
Summary: This study identifies a dual-targeting peptide, AP-1, that effectively inhibits variants of concern (VOCs) of SARS-CoV-2 without impairing host cell viability. The findings suggest that AP-1 could be a promising broad-spectrum agent for treating emerging VOCs of SARS-CoV-2.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Hyeonjun Lee, Ju Yeon Lee, Hyunsoo Jang, Hye Young Cho, Minhee Kang, Sang Hyun Bae, Suin Kim, Eunji Kim, Jaebong Jang, Jin Young Kim, Young Ho Jeon
Summary: By using liquid chromatography-tandem mass spectrometry and nuclear magnetic resonance experiments, we identified new chemical moieties that bind to the target sites of the protein of interest, allowing for reversible binding and protein degradation. This method has the potential to expand the application of PROTAC technology.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Yingying Li, Xiyou Du, Xinru Kong, Yuelin Fang, Zhijing He, Dongzhu Liu, Hang Wu, Jianbo Ji, Xiaoye Yang, Lei Ye, Guangxi Zhai
Summary: This study proposes a novel nanoplatform based on the autophagy cascade to overcome the obstacles in chemo-immunotherapy. The platform combines chemotherapy and starvation therapy to initiate pro-death autophagy and enhance antigen presentation, while also remodeling the immunosuppressive tumor microenvironment. Furthermore, the study discovers a new therapeutic direction for the respiration inhibitor 3-bromopyruvic acid (3BP) in cancer treatment. Overall, this study offers an opportunity to improve antitumor efficacy and boost immune responses.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Bingsi Wang, Mingxu Ma, Yusen Dai, Pengfei Yu, Liang Ye, Wenyan Wang, Chunjie Sha, Huijie Yang, Yingjie Yang, Yunjing Zhu, Lin Dong, Shujuan Wei, Linlin Wang, Jingwei Tian, Hongbo Wang
Summary: Breast cancer is a common malignant tumor in women, and drug resistance remains a clinical challenge. In this study, a novel compound, G-5b, was developed with potent antagonistic and degradation activities comparable to the current drug fulvestrant. G-5b also showed improved stability and solubility. Mechanistically, G-5b engages the proteasome pathway to degrade ER, inhibiting the ER signaling pathway and inducing apoptosis and cell cycle arrest. In animal models, G-5b exhibited superior pharmacokinetics and pharmacodynamics properties. Overall, G-5b is a promising long-acting SERD worthy of further investigation and optimization.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Karoline B. Waitman, Larissa C. de Almeida, Marina C. Primi, Jorge A. E. G. Carlos, Claudia Ruiz, Thales Kronenberger, Stefan Laufer, Marcia Ines Goettert, Antti Poso, Sandra V. Vassiliades, Vinicius A. M. de Souza, Monica F. Z. J. Toledo, Neuza M. A. Hassimotto, Michael D. Cameron, Thomas D. Bannister, Leticia Costa-Lotufo, Joa o A. Machado-Neto, Mauricio T. Tavares, Roberto Parise-Filho
Summary: A series of hybrid inhibitors combining pharmacophores of known kinase inhibitors and benzohydroxamate HDAC inhibitors were synthesized and evaluated for their anticancer activity and pharmacokinetic properties. Compounds 4d-f exhibited promising cytotoxicity against hematological cells and moderate activity against solid tumor models. Compound 4d showed potent inhibition of multiple kinase targets and had stable interactions with HDAC and members of the JAK family. These compounds showed selective cytotoxicity with minimal effects on non-tumorigenic cells and favorable pharmacokinetic profiles.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Michal Sulik, Diana Fontinha, Dietmar Steverding, Szymon Sobczak, Michal Antoszczak, Miguel Prudencio, Adam Huczynski
Summary: This study describes the synthesis of the first-in-class ivermectin derivatives obtained through derivatization of the C13 position, along with the unexpected rearrangement of the macrolide ring. These derivatives show potential for antiparasitic activity and are important for the development of new antiparasitic agents.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Jun Liu, Qiu-Xian Chen, Wen-Fu Wu, Dong Wang, Si -Yu Zhao, Jia-Hao Li, Yi-Qun Chang, Shao-Gao Zeng, Jia-Yi Hu, Yu-Jie Li, Jia-Xin Du, Shu-Meng Jiao, Hai-Chuan Xiao, Qiang Zhang, Jun Xu, Jian-Fu Zhao, Hai -Bo Zhou, Yong-Heng Wang, Jian Zou, Ping-Hua Sun
Summary: A new anti-infective drug strategy has been discovered to attenuate virulence and modulate inflammation caused by drug-resistant Pseudomonas aeruginosa infections. Compound 5f inhibits biofilm formation, macrophage migration, and inflammatory response induced by P. aeruginosa, showing potential as a novel candidate against drug-resistant infections.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Liuzeng Chen, Ke Wang, Lingyun Wang, Wei Wang, Lifan Wang, Jia Li, Xiaohan Liu, Mengya Wang, Banfeng Ruan
Summary: In this study, a series of novel anti-inflammatory compounds were designed and synthesized based on the natural product pterostilbene skeleton. Among them, compound 8 showed the highest activity and exhibited its effects through inhibition of pro-inflammatory cytokines by blocking the NF-KB/MAPK signaling pathway. Compound 8 also demonstrated a good relieving effect on acute colitis in mice and showed good safety in acute toxicity experiments.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
Article
Chemistry, Medicinal
Si-Min Liang, Gui-Bin Liang, Hui-Ling Wang, Hong Jiang, Xian-Li Ma, Jian-Hua Wei, Ri-Zhen Huang, Ye Zhang
Summary: A series of novel multi-target antitumor agents were designed, synthesized, and evaluated. Some compounds exhibited significant antitumor activity and one compound showed excellent efficacy, limited toxicity, and low resistance. Further mechanism studies revealed that the compound exerted antitumor effects through multiple pathways.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2024)
