Journal
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
Volume 43, Issue 12, Pages 2891-2900Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.ejmech.2008.02.009
Keywords
4-Amino-3,4-dihydro-2H-naphthalen-1-one; Mast cell stabilising; Anti-inflammatory
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Funding
- Enterprise Ireland [IF/2001/014]
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A novel series of amine and amide derivatives of 4-amino-3,4-dihydro-2H-naphthalen-1-one were synthesised. The amine derivatives were evaluated for mast cell stabilising activity in rodent mast cell preparations against the reference compound disodium cromoglycate and found to possess significant activity in vitro. The amide compounds were evaluated in an in vivo murine model for anti-inflammatory activity. (C) 2008 Elsevier Masson SAS. All rights reserved.
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