Article
Nursing
Chestharid Borriboon, Jindarat Chaiard, Chiraporn Tachaudomdach, Sue Turale
Summary: This study aimed to investigate the relationship between health belief model factors and CPAP adherence in Thai individuals with obstructive sleep apnoea. Results showed a low rate of CPAP adherence, with perceived seriousness of the conditions being the only significant factor associated with adherence. Healthcare professionals, especially nurses, should provide support and education to encourage regular CPAP use and be aware of psychological factors affecting patients' perception of sleep apnoea and CPAP treatment. Intervention strategies targeting these factors should be developed and implemented in clinical practice.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Ophthalmology
Meltem Guzin Altinel, Hasim Uslu, Ayse Yagmur Kanra, Orhan Dalkilic
Summary: The study evaluated the effect of OSAS and CPAP therapy on choroidal structural changes and CVI in patients with OSAS. OSAS was associated with stromal edema in the choroid, which improved after 12 months of CPAP therapy. CVI can be an important parameter for monitoring patients with OSAS.
Review
Clinical Neurology
Marcello Bosi, Serena Incerti Parenti, Antonio Sanna, Giuseppe Plazzi, Andrea De Vito, Giulio Alessandri-Bonetti
Summary: The phenotyping of obstructive sleep apnoea (OSA) is crucial for tailored treatments and poses a major challenge in clinical practice. Advanced techniques have provided insights into the variability of endotypic traits in OSA patients, impacting the success of treatment options.
SLEEP MEDICINE REVIEWS
(2021)
Article
Respiratory System
Macy Mei-Sze Lui, Hung-Fat Tse, David Chi-Leung Lam, Kui-Kai Lau, Carmen Wing-Sze Chan, Mary Sau-Man Ip
Summary: In subjects with OSA and difficult-to-control hypertension, short-term CPAP treatment improved ambulatory blood pressure, alleviated subclinical myocardial injury and strain. This study suggests potential benefits of CPAP therapy in reducing cardiovascular risk in this high-risk population.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Biology
Konstantinos Chaidas, Kallirroi Lamprou, Amberley Munnings, John R. Stradling, Annabel H. Nickol
Summary: This study aimed to investigate the association between CPAP usage and nasal symptoms in patients with obstructive sleep apnoea. The findings suggested that runny nose was a predictive factor for poorer CPAP adherence and worsened after three months of high-CPAP usage.
Article
Medicine, General & Internal
Subash S. Heraganahally, Kyi K. Zaw, Sai Tip, Xinlin Jing, Joy J. Mingi, Timothy Howarth, Anil Roy, Henrik Falhammar, Dimitar Sajkov
Summary: This retrospective study explored the clinical characteristics, polysomnographic features, and adherence to continuous positive airway pressure (CPAP) therapy among Australian women with obstructive sleep apnoea (OSA). The results showed that age, BMI, and hypertension were predictors of OSA presence and severity. Adherence to CPAP therapy was associated with symptomatic OSA and severe oxygen desaturation.
INTERNAL MEDICINE JOURNAL
(2022)
Article
Clinical Neurology
Mariana Fernandes, Luisa Mari, Agostino Chiaravalloti, Barbara Paoli, Marzia Nuccetelli, Francesca Izzi, Maria Pia Giambrone, Riccardo Camedda, Sergio Bernardini, Orazio Schillaci, Nicola Biagio Mercuri, Fabio Placidi, Claudio Liguori
Summary: The study found cognitive impairment, reduced cerebral glucose consumption, and alterations in CSF biomarkers in OSA patients, which may reinforce the hypothesis of AD neurodegenerative processes triggered by OSA. Notably, cognition and brain glucose consumption improved after beneficial CPAP treatment. Further studies are needed to evaluate the long-term effects of CPAP treatment on these AD biomarkers.
JOURNAL OF NEUROLOGY
(2022)
Article
Health Care Sciences & Services
Manuel Fernandes, Catarina Antunes, Cristina Martinho, Joao Carvalho, Tiago Abreu, Ana Oliveira, Paula Pinto, Cristina Barbara
Summary: This study found that, with a comprehensive educational programme during positive airway pressure adaptation, telemonitoring did not show significant benefits in terms of compliance and efficacy compared to usual care or phone-call care. Further long-term follow-up is needed to evaluate the outcomes of telemonitoring programmes.
JOURNAL OF TELEMEDICINE AND TELECARE
(2021)
Article
Biochemistry & Molecular Biology
Monika Michalek-Zrabkowska, Rafal Poreba, Pawel Gac, Weronika Frosztega, Anna Wojakowska, Mieszko Wieckiewicz, Justyna Kanclerska, Piotr Macek, Wlodzimierz Wieckiewicz, Grzegorz Mazur, Helena Martynowicz
Summary: This study examined the effectiveness and adherence to CPAP therapy in 149 adults with obstructive sleep apnea during the COVID-19 pandemic. The results showed that the pandemic had no significant impact on CPAP therapy overall, but certain demographic and clinical features influenced its effectiveness.
Article
Multidisciplinary Sciences
Michael S. H. Chou, Natasha C. H. Ting, Nicole El-Turk, Zinta Harrington, Claudia C. Dobler
Summary: This study found that patients using CPAP for OSA experience significant treatment burden, including healthcare tasks, consequences of healthcare tasks, exacerbating and alleviating factors of treatment burden. Patients commonly reported burden from attending healthcare appointments, treatment cost, lifestyle changes, treatment side effects and general discomfort.
Article
Obstetrics & Gynecology
Peter G. Middleton
Summary: This review provides a summary of the interactions between pregnancy and breathing during sleep, and highlights the changes in respiratory function that can increase the incidence and severity of sleep-disordered breathing. The increased risk of snoring and obstructive sleep apnea hypopnea syndrome during pregnancy is discussed, and the potential impact of increasing obesity rates on sleep-disordered breathing in pregnant women is considered.
BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY
(2022)
Review
Medicine, General & Internal
Frederico T. Barbosa, Michele P. Silva, Luis Eduardo S. Fontes, Daniela Pachito, Tamara Melnik, Rachel Riera
Summary: The study evaluated the effectiveness and acceptability of CPAP therapy for improving erectile dysfunction in OSAS patients. Uncertainty was found in the comparison of CPAP with no CPAP, while sildenafil may slightly improve erectile function at 12 weeks compared to CPAP.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Clinical Neurology
Ai Sugiyama, Satomi Shiota, Mariko Yanagihara, Hideaki Nakayama, Satoru Tsuiki, Kenichi Hayashida, Yuichi Inoue, Kazuhisa Takahashi
Summary: Research suggests that reducing body mass index and maintaining good treatment adherence are significant predictors of favorable progression in obstructive sleep apnea (OSA). Among patients with unchanged BMI and good treatment adherence, improvement in apnea-hypopnea index (AHI) was significantly associated with decreases in certain index indicators, which are known to relate to ventilator instability. This highlights the importance of weight and treatment adherence in the natural progression of OSA severity.
JOURNAL OF SLEEP RESEARCH
(2021)
Article
Multidisciplinary Sciences
Narongkorn Saiphoklang, Kanyada Leelasittikul, Apiwat Pugongchai
Summary: Continuous positive airway pressure (CPAP) is an effective treatment for obstructive sleep apnea patients, and a predictive equation for CPAP in Thai patients was developed in this study, with neck circumference, body mass index, respiratory disturbance index, and lowest pulse oxygen saturation being significant factors in predicting the optimal pressure. The equation accounted for 50% of the variance in optimal pressure, providing insight into tailored CPAP therapy for Thai patients with OSA.
SCIENTIFIC REPORTS
(2021)
Article
Medicine, General & Internal
Laetitia S. Gaspar, Janina Hesse, Muge Yalcin, Barbara Santos, Catarina Carvalhas-Almeida, Mafalda Ferreira, Joaquim Moita, Angela Relogio, Claudia Cavadas, Ana Rita Alvaro
Summary: The study revealed that obstructive sleep apnea (OSA) affects the biological clock, and long-term continuous positive airway pressure (CPAP) treatment can partially restore normal clock function. However, the treatment does not fully reverse the impact on clock gene expression levels.
Article
Biochemical Research Methods
Maximilian Boesch, Martina Sykora, Silvia Gasteiger, Florent Baty, Martin H. Brutsche, Sieghart Sopper
Summary: This optimized multicolor immunofluorescence panel is designed to efficiently identify and quantify various leukocyte populations in human blood with minimal markers. It offers high performance, is suitable for whole blood, and widely applicable for immune cell identification, quantification, and characterization.
Article
Infectious Diseases
Severin Studer, Frank Rassouli, Frederike Waldeck, Martin H. Brutsche, Florent Baty, Werner C. Albrich
Article
Respiratory System
Simona Tabea Huebner, Simona Henny, Stephanie Giezendanner, Thomas Brack, Martin Brutsche, Prashant Chhajed, Christian Clarenbach, Thomas Dieterle, Adrian Egli, Martin Frey, Ingmar Heijnen, Sarosh Irani, Noriane Andrina Sievi, Robert Thurnheer, Marten Trendelenburg, Malcolm Kohler, Anne Barbara Leuppi-Taegtmeyer, Joerg Daniel Leuppi
Summary: This study found that using immunological biomarkers and clinical characteristics can predict the frequency and severity of acute exacerbations in stable COPD patients. However, clinical parameters had better discriminatory power in identifying patients likely to experience frequent AECOPD.
Article
Mathematical & Computational Biology
Florent Baty, Jemima Hegermann, Tiziana Locatelli, Claudio Rueegg, Christian Gysin, Frank Rassouli, Martin Brutsche
Summary: This study used text mining methodology to analyze polysomnographic medical reports and quantify sources of variation in the work-up of sleep-disordered breathing. The results showed that the inter-rater variability was twice as high as the variation introduced by effective diagnostic information. A simple text block standardization was found to significantly reduce the inter-rater variability and improve the diagnostic accuracy of polysomnography reports.
JOURNAL OF BIOMEDICAL SEMANTICS
(2022)
Article
Critical Care Medicine
Andrei M. Darie, Nina Khanna, Kathleen Jahn, Michael Osthoff, Stefano Bassetti, Mirjam Osthoff, Desiree M. Schumann, Werner C. Albrich, Hans Hirsch, Martin Brutsche, Leticia Grize, Michael Tamm, Daiana Stolz
Summary: Multiplex bacterial PCR examination of bronchoalveolar lavage decreases the duration of inappropriate antibiotic therapy in patients with pneumonia.
LANCET RESPIRATORY MEDICINE
(2022)
Article
Respiratory System
Ilena Mueller, Marco Mancinetti, Anja Renner, Pierre-Olivier Bridevaux, Martin H. Brutsche, Christian Clarenbach, Christian Garzoni, Alexandra Lenoir, Bruno Naccini, Sebastian Ott, Lise Piquilloud, Maura Prella, Yok-Ai Que, Paola Marina Soccal, Christophe von Garnier, Thomas K. Geiser, Manuela Funke-Chambour, Sabina Guler
Summary: The CFS score significantly increases post-COVID-19, and dyspnea is identified as an important risk factor for frailty after COVID-19, emphasizing the importance of comprehensive management for respiratory symptoms in survivors.
BMJ OPEN RESPIRATORY RESEARCH
(2022)
Article
Critical Care Medicine
Tobias Sinnberg, Christa Lichtensteiger, Omar Hasan Ali, Oltin T. Pop, Ann-Kristin Jochum, Lorenz Risch, Silvio D. Brugger, Ana Velic, David Bomze, Philipp Kohler, Pietro Vernazza, Werner C. Albrich, Christian R. Kahlert, Marie-Therese Abdou, Nina Wyss, Kathrin Hofmeister, Heike Niessner, Carl Zinner, Mara Gilardi, Alexandar Tzankov, Martin Rocken, Alex Dulovic, Srikanth Mairpady Shambat, Natalia Ruetalo, Philipp K. Buehler, Thomas C. Scheier, Wolfram Jochum, Lukas Kern, Samuel Henz, Tino Schneider, Gabriela M. Kuster, Maurin Lampart, Martin Siegemund, Roland Bingisser, Michael Schindler, Nicole Schneiderhan-Marra, Hubert Kalbacher, Kathy D. McCoy, Werner Spengler, Martin H. Brutsche, Boris Macek, Raphael Twerenbold, Josef M. Penninger, Matthias S. Matter, Lukas Flatz
Summary: COVID-19 can cause severe respiratory distress syndrome, and dysregulated immune responses, including autoimmunity, play a key role. This study investigated the presence of IgA autoantibodies targeting lung-specific proteins and their effects on pulmonary surfactant in severe COVID-19 cases.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2023)
Article
Multidisciplinary Sciences
Maurice Moser, Florent Baty, Martin H. Brutsche, Otto D. Schoch
Summary: Sleep apnea (SA) is a prevalent disorder that can disrupt normal sleep and have an impact on the cardio- and cerebrovascular system. Hospitalized patients with SA typically have a greater burden of comorbidity and a longer length of hospital stay, but may show an improvement in in-hospital mortality compared to patients without SA.
Article
Computer Science, Information Systems
Stefan Jokic, David Cleres, Frank Rassouli, Claudia Steurer-Stey, Milo A. Puhan, Martin Brutsche, Elgar Fleisch, Filipe Barata
Summary: Cough monitoring and automatic detection algorithms have been studied for the development of consumer-centric devices. This study proposes a weakly supervised metric learning approach for cougher recognition based on smartphone audio recordings. Using a triplet network architecture with convolutional neural networks, the approach maps cough recordings to an embedding space for better distinguishability. The approach outperforms human raters in verification tests.
IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
(2022)
Article
Respiratory System
Alexandra Lenoir, Andreas Christe, Lukas Ebner, Catherine Beigelman-Aubry, Pierre-Olivier Bridevaux, Martin Brutsche, Christian Clarenbach, Berra Erkosar, Christian Garzoni, Thomas Geiser, Sabina A. Guler, Dik Heg, Frederic Lador, Marco Mancinetti, Sebastian R. Ott, Lise Piquilloud, Maura Prella, Yok-Ai Que, Christophe von Garnier, Manuela Funke-Chambour
Summary: This study aimed to investigate lung function and radiological abnormalities over 12 months in patients after severe and non-severe COVID-19. The study found that patients with severe COVID-19 had lower lung function after one year compared to non-severe patients, although the severe disease group had a greater extent of recovery.
Article
Medicine, General & Internal
Noriane A. Sievi, Jerome Sepin, Maurice Roeder, Thomas Brack, Martin H. Brutsche, Martin Frey, Sarosh Irani, Jorg D. Leuppi, Robert Thurnheer, Christian F. Clarenbach, Malcolm Kohler
Summary: This study evaluated whether longitudinal assessment of predictors provides additional information on the mortality risk in COPD compared to cross-sectional analysis. The results showed that predictors of mortality in COPD are not time dependent, and cross-sectional measured predictors still have stable effect estimates over time.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Health Care Sciences & Services
Filipe Barata, David Cleres, Peter Tinschert, Chen-Hsuan Iris Shih, Frank Rassouli, Maximilian Boesch, Martin Brutsche, Elgar Fleisch
Summary: This study validated an automated smartphone-based cough counting system for continuous monitoring of coughs in hospital wards. The system showed high sensitivity and specificity in detecting coughs compared to manual counting. Therefore, it can be used for continuous hourly assessment of cough frequency in the ward.
JMIR FORMATIVE RESEARCH
(2023)
Review
Medicine, General & Internal
Lisa Jungblut, Christophe von Garnier, Milo Puhan, Yuki Tomonaga, Cornel Kaufmann, Andrea Azzola, Urs Burgi, Jens Bremerich, Martin Brutsche, Andreas Christe, Lukas Ebner, Johannes T. Heverhagen, Christine Eich, Daniel Franzen, Isabelle Schmitt-Opitz, Didier Schneiter, Jorg Spieldenner, Nigel Horwarth, Malcolm Kohler, Walter Weder, Alban Lovis, Reto Meuli, Matthias Menig, Catherine Beigelmann-Aubry, Tilo Niemann, Susanna Stohr, Peter Vock, Oliver Senn, Stefan Neuner-Jehle, Kevin Selby, Simin Laures, Sebastian Ott, Thomas Frauenfelder
Summary: This article outlines a potential lung cancer screening program in Switzerland, based on an exhaustive literature review, interviews with international experts, and workshops with national experts and stakeholders. The suggested screening approach includes involvement of general practitioners, pulmonologists, and the media, decentralized screening to improve adherence, integration of screening with lung health checks, and the use of risk calculation and nodule classification models.
SWISS MEDICAL WEEKLY
(2022)
Review
Medicine, General & Internal
Daniel P. Franzen, Martin Brutsche, Jakob Nilsson, Christian Boeni, Cecile Daccord, Oliver Distler, Dieter Elsener, Manuela Funke-Chambour, Christiane Gruner, Helen Hayward-Koennecke, Katrin E. Hostettler, Thomas Kuendig, Camillo Ribi, Joerg D. Seebach, Harald Seeger, Bart Vrugt, Antonios G. A. Kolios
Summary: Sarcoidosis is a systemic inflammatory disease characterized by diverse clinical manifestations, primarily affecting the lungs, lymph nodes, skin, and eyes. Severe cases require long-term immunosuppressive treatment, while mild symptoms can be managed with topical therapy. Treatment decisions should be based on individual factors and treatment tolerability.
SWISS MEDICAL WEEKLY
(2022)
