Article
Medicine, General & Internal
Jae Hyun Yoon, Chung Hwan Jun, Jeong Han Kim, Eileen L. Yoon, Byung Seok Kim, Jeong Eun Song, Ki Tae Suk, Moon Young Kim, Seong Hee Kang
Summary: A study in South Korea found a decreasing trend in chronic hepatitis B cases and an increasing trend in alcoholic liver disease cases among cirrhotic patients. While the etiology of liver cirrhosis shifted, the severity of cirrhosis remained stable over a 10-year period. Additionally, the incidence of complications such as variceal bleeding, severe ascites, hepatic encephalopathy, and spontaneous bacterial peritonitis decreased significantly.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Gastroenterology & Hepatology
Carla Osiowy, Ken Swidinsky, Sarah Haylock-Jacobs, Matthew D. Sadler, Scott Fung, David Wong, Gerald Y. Minuk, Karen E. Doucette, Philip Wong, Edward Tam, Curtis Cooper, Alnoor Ramji, Mang Ma, Carmine Nudo, Keith Tsoi, Carla S. Coffin
Summary: Approximately 5% of the Canadian HBV referral population is seropositive for HDV. HDV infection is closely associated with risk behaviors and both domestic and foreign-born patients with CHB. Those infected with HDV are more likely to suffer from severe liver diseases, including liver cancer, compared to HBV mono-infected patients.
Article
Virology
Maisuri T. Chalid, Turyadi, Susan I. Ie, Rizalinda Sjahril, Ridha Wahyuni, M. Nasrum Massi, David H. Muljono
Summary: This study examines the HBV characteristics and potential risk of mother-to-child transmission among HBeAg-negative/HBsAg-positive expectant mothers in an area with a high prevalence of e-CHB. It highlights the importance of considering antiviral prophylaxis eligibility in situations with limited resources and in regions where e-CHB is prevalent, as some HBeAg-negative mothers may still pose a high transmission risk.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Virology
Kaouther Ayouni, Ghassen Kharroubi, Rym Mallekh, Walid Hammami, Ridha Marouani, Moncef Mhamdi, Afif Ben Salah, Henda Triki, Jihene Bettaieb
Summary: Hepatitis A infection remains a significant global health concern, and a transition in the epidemiology of the virus has been observed in Tunisia. A study in Central-West Tunisia found a high seroprevalence of hepatitis A virus infection, with higher rates in certain age groups and rural areas. The study highlights the need for continued monitoring and potential vaccination strategies in regions with lower socioeconomic levels.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Article
Immunology
Jie Li, Hwai- Yang, Ming-Lun Yeh, Michael H. Le, An K. Le, Yee Hui Yeo, Chia-Yen Dai, Scott Barnett, Jian Q. Zhang, Jee-Fu Huang, Huy N. Trinh, Christopher Wong, Clifford Wong, Joseph K. Hoang, Ramsey Cheung, Ming-Lung Yu, Mindie H. Nguyen
Summary: This study found that concurrent FL in patients with CHB significantly reduces the risk of cirrhosis and HCC, as well as increases the rate of HBsAg seroclearance. Further research is needed to confirm these findings and investigate the underlying mechanisms of FL on CHB.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Multidisciplinary Sciences
Adedotun Ogunbajo, Mitchell Brooks, Temitope A. Oke, Omar Martinez, Carl Latkin, Kirk Myers, DeMarc Hickson
Summary: This study describes a prospective epidemiological research on HIV-negative Black and Latino SMM to quantify the prevalence and incidence of HCV infection and investigate the predictors of HCV infection. The results will have important implications for HCV screening, intervention development, and patient assistance programs for uninsured individuals.
Article
Biochemistry & Molecular Biology
Cih-En Huang, Jung-Jung Chang, Yu-Ying Wu, Shih-Hao Huang, Wei-Ming Chen, Chia-Chen Hsu, Chang-Hsien Lu, Chao-Hung Hung, Chung-Sheng Shi, Kuan-Der Lee, Chih-Cheng Chen, Min-Chi Chen
Summary: This study compared the different risk factors and impacts of hepatitis C virus-associated thrombocytopenia (HCV-TP) and hepatitis B virus-associated thrombocytopenia (HBV-TP). The findings showed that the incidence of thrombocytopenia was higher in HCV patients compared to HBV patients. Additionally, the risk factors for thrombocytopenia varied with the severity and virus type, suggesting the need for different management approaches for HCV-TP and HBV-TP.
BIOMEDICAL JOURNAL
(2022)
Article
Oncology
Shih-Han Hung, Tzong-Hann Yang, Yen-Fu Cheng, Chin-Shyan Chen, Herng-Ching Lin
Summary: This case-control study investigates the associations between head and neck cancer (HNC), hepatitis B virus (HBV), and hepatitis C virus (HCV) infection, and suggests a potential association between HBV and HCV infections and the risk of HNC.
Article
Medicine, General & Internal
Heiner Wedemeyer, Soo Aleman, Maurizia Rossana Brunetto, Antje Blank, Pietro Andreone, Pavel Bogomolov, Vladimir Chulanov, Nina Mamonova, Natalia Geyvandova, Viacheslav Morozov, Olga Sagalova, Tatyana Stepanova, Annemarie Berger, Dmitry Manuilov, Vithika Suri, Qi An, Ben Da, John Flaherty, Anu Osinusi, Yang Liu, Uta Merle, Julian Schulze zur Wiesch, Stefan Zeuzem, Sandra Ciesek, Markus Cornberg, Pietro Lampertico
Summary: Bulevirtide treatment reduces HDV RNA and ALT levels in patients with chronic hepatitis D, with a dose-dependent effect.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Article
Medicine, General & Internal
Heiner Wedemeyer, Soo Aleman, Maurizia Rossana Brunetto, Antje Blank, Pietro Andreone, Pavel Bogomolov, Vladimir Chulanov, Nina Mamonova, Natalia Geyvandova, Viacheslav Morozov, Olga Sagalova, Tatyana Stepanova, Annemarie Berger, Dmitry Manuilov, Vithika Suri, Qi An, Ben Da, John Flaherty, Anu Osinusi, Yang Liu, Uta Merle, Julian Schulzezur Wiesch, Stefan Zeuzem, Sandra Ciesek, Markus Cornberg, Pietro Lampertico
Summary: In this study, it was found that bulevirtide is effective in inhibiting the entry of hepatitis D virus and reducing the progression of liver disease in patients with chronic hepatitis B. The recommended dosage of bulevirtide is 2 mg or 10 mg per day.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Gastroenterology & Hepatology
Norah A. Terrault, Miriam T. Levy, Ka Wang Cheung, Gonzague Jourdain
Summary: The management of viral hepatitis in pregnancy requires special consideration due to the unique characteristics of each hepatitis virus and their impact on maternal and infant outcomes. Preventing mother-to-child transmission is crucial in reducing the global burden of chronic viral hepatitis.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2021)
Article
Chemistry, Analytical
Youngung Seok, Qingtian Yin, Huiwen Bai, Haim H. Bau
Summary: Untreated HBV and HCV infections can lead to severe illnesses. To address the challenge of convenience and patient follow-up, a sensitive two-stage molecular test called Penn-RAMP was developed for test and treat strategy.
ANALYTICAL CHEMISTRY
(2022)
Review
Medicine, General & Internal
Zhijiang Miao, Zhenrong Xie, Li Ren, Qiuwei Pan
Summary: HDV infection can cause severe hepatitis leading to cirrhosis and hepatocellular carcinoma, requiring advanced scientific knowledge and joint efforts from multi-stakeholders to combat effectively.
CHINESE MEDICAL JOURNAL
(2022)
Article
Gastroenterology & Hepatology
Paul Henriot, Mathieu Castry, Liem Binh Luong Nguyen, Yusuke Shimakawa, Kevin Jean, Laura Temime
Summary: Hospital-based invasive procedures play an important role in the transmission of hepatitis C virus (HCV). Different invasive procedures are significantly associated with HCV infection. These results can be used to prioritize infection control interventions, especially in settings with high HCV prevalence.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Gastroenterology & Hepatology
Jun Zi, Yu-Huan Li, Xiao-Mei Wang, Hong-Qin Xu, Wen-Hui Liu, Jia-Yue Cui, Jun-Qi Niu, Xiu-Mei Chi
Summary: The screening practices for hepatitis D virus (HDV) are diverse and non-standardized worldwide, leading to uncertainty in the exact prevalence of HDV. This study aimed to estimate the prevalence of HDV and investigate the trends in viral marker quantity in patients with hepatitis D in Jilin Province, China. The results showed a correlation between HDV infection and HBsAg level, anti-HDAg level, and HBV DNA level.
WORLD JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Peripheral Vascular Disease
Ariadni Menti, Natasa Kalpourtzi, Magda Gavana, Apostolos Vantarakis, Paraskevi V. Voulgari, Christos Hadjichristodoulou, Eugenia Gkaliagkousi, Michael Doumas, Rigas G. Kalaitzidis, Manolis S. Kallistratos, Argiro Karakosta, Vasiliki Katsi, Xenophon Krokidis, Efstathios Manios, Maria Marketou, Angeliki Ntineri, John A. Papadakis, Dimitrios Papadopoulos, Pantelis Sarafidis, Grigoris Trypsianis, Michail Chatzopoulos, Grigoris Chlouverakis, Yannis Alamanos, Pantelis Zebekakis, Giota Touloumi, George S. Stergiou
Summary: The study found that opportunistic screening and random sampling methods have similar reliability in estimating the prevalence of hypertension, but opportunistic screening underestimates undiagnosed hypertension and overestimates hypertension treatment and control rates.
JOURNAL OF HUMAN HYPERTENSION
(2022)
Editorial Material
Allergy
M. Speletas, S. Raftopoulou, E. Farmaki, N. Gatselis, G. Germanidis, V. A. Mouchtouri, S. Hatzianastasiou, S. Georgiadou, G. Tsinti, O. Tsachouridou, M. Tseroni, S. Metallidis, G. Dalekos, H. Eibel, C. Hadjichristodoulou
JOURNAL OF INVESTIGATIONAL ALLERGOLOGY AND CLINICAL IMMUNOLOGY
(2022)
Article
Virology
Nikolaos K. Gatselis, Vasiliki Lygoura, Aggeliki Lyberopoulou, George Giannoulis, Anna Samakidou, Antonia Vaiou, George Vatidis, Katerina Antoniou, Aggelos Stefos, Sarah Georgiadou, Dimitrios Sagris, Dafni Sveroni, Despoina Stergioula, Stella Gabeta, George Ntaios, George N. Dalekos
Summary: This study found that soluble interleukin-2 receptor (sIL-2R) is a strong laboratory marker for predicting the development of severe COVID-19 outcomes. sIL-2R levels were significantly higher in patients with severe disease compared to those with moderate disease, and the dynamic changes of sIL-2R can reflect disease severity and predict the occurrence of severe respiratory failure and mortality.
Article
Neurosciences
Katerina Dadouli, Michel B. Janho, Apostolia Hatziefthimiou, Ioanna Voulgaridi, Konstantina Piaha, Lemonia Anagnostopoulos, Panagiotis Ntellas, Varvara A. Mouchtouri, Konstantinos Bonotis, Nikolaos Christodoulou, Matthaios Speletas, Christos Hadjichristodoulou
Summary: The study found that patients with BD had higher NLR, MLR, and SII index compared to healthy controls during manic and depressive episodes, indicating a higher level of inflammation in BD patients.
Article
Environmental Sciences
Taxiarchis Chassalevris, Serafeim C. Chaintoutis, Michalis Koureas, Maria Petala, Evangelia Moutou, Christina Beta, Maria Kyritsi, Christos Hadjichristodoulou, Margaritis Kostoglou, Thodoris Karapantsios, Agis Papadopoulos, Nikolaos Papaioannou, Chrysostomos I. Dovas
Summary: Wastewater-based variant surveillance provides valuable supplementary practice to conventional SARS-CoV-2 surveillance, offering timely and cost-effective information on virus prevalence.
SCIENCE OF THE TOTAL ENVIRONMENT
(2022)
Article
Biology
Georgios K. Georgakilas, Achilleas P. Galanopoulos, Zafeiris Tsinaris, Maria Kyritsi, Varvara A. Mouchtouri, Matthaios Speletas, Christos Hadjichristodoulou
Summary: T cell receptor profiling has emerged as an important method to study COVID-19. This study proposes a novel Machine Learning approach to analyze T cell receptor repertoires, which not only explores the properties and characteristics of T cell receptors, but also identifies the preferential recognition of viral antigens by T-cell-mediated immune response. The study reveals a group of T cell receptors capable of recognizing SARS-CoV-2 antigens, which were already established in samples from the healthy cohort, suggesting a cross-reactivity phenomenon. Additionally, the study provides evidence of putative cross-reactivity between SARS-CoV-2 and a wide spectrum of pathogens and diseases.
Article
Biochemistry & Molecular Biology
Matthaios Speletas, Evangelos Bakaros, Athanasia-Marina Peristeri, Ioanna Voulgaridi, Styliani Sarrou, Vassiliki Paliatsa, Asimina Nasika, Maria Tseroni, Lemonia Anagnostopoulos, Kalliopi Theodoridou, Fani Kalala, Aikaterini Theodoridou, Barbara A. Mouchtouri, Sotirios Tsiodras, Hermann Eibel, Christos Hadjichristodoulou
Summary: This study evaluated the impact of the rs1883832 polymorphism on humoral immune responses following COVID-19 vaccination. The T allele of rs1883832 was associated with lower antibody levels and can serve as a predictor of antibody response intensity after vaccination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Panagiotis Prezerakos, Katerina Dadouli, Eirini Agapidaki, Christina-Maria Kravvari, Ioanna Avakian, Athanasia-Marina Peristeri, Lemonia Anagnostopoulos, Varvara A. A. Mouchtouri, Konstantinos N. N. Fountoulakis, Sotirios Koupidis, Christos Hadjichristodoulou
Summary: Monitoring behavioral and cultural insights during the pandemic is important for understanding COVID-19 vaccine acceptance. Data collected through surveys showed an increase in vaccination acceptance, decrease in undecided individuals, and relatively stable vaccine resistance. Factors associated with vaccination included age, gender, following recommendations, and access to information sources. The study also identified pandemic fatigue and its impact on preventive measures. It highlighted the need for tailored approaches to hesitant populations.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2023)
Article
Genetics & Heredity
Antonis Giakountis, Zoe Stylianidou, Anxhela Zaka, Styliani Pappa, Anna Papa, Christos Hadjichristodoulou, Kostas D. Mathiopoulos
Summary: West Nile virus (WNV) is an emerging neurotropic RNA virus that primarily circulates between mosquitoes and birds. In humans, most infections are asymptomatic, while a small percentage develop mild febrile infection and an even smaller percentage develop severe neuroinvasive disease. Current diagnostic tools for WNV are either serological methods with cross-reactivity or expensive molecular approaches. However, a low-cost and non-invasive synthetic biology-based method using riboswitches has been developed, which allows for sensitive detection of WNV in humans, birds, and mosquitoes.
Article
Microbiology
Dimitrios A. Anagnostopoulos, Foteini F. Parlapani, Stamatia Natoudi, Faidra Syropoulou, Maria Kyritsi, Ioannis Vergos, Christos Hadjichristodoulou, Ifigenia Kagalou, Ioannis S. Boziaris
Summary: This study investigated the bacterial communities, microbial populations, and antibiotic resistance in water and fish from different areas of Lake Karla in Greece. The results showed that Serratia fonticola and several species of Aeromonas were the dominant bacteria, with S. fonticola exhibiting resistance to multiple antibiotics. The findings suggest that Lake Karla's water can be used for irrigation and recreation, but quality management is necessary to ensure environmental hygiene and prevent zoonotic diseases.
Article
Parasitology
Stavroula Beleri, Georgios Balatsos, Nikolaos Tegos, Dimitrios Papachristos, Varvara Mouchtouri, Christos Hadjichristodoulou, Antonios Michaelakis, Nikos T. Papadopoulos, Eleni Patsoula
Summary: The Asian tiger mosquito has the ability to overwinter and survive in temperate regions, which can contribute to the spread of diseases. A study in Greece shows evidence of winter survival in two different populations of the mosquito, but there are variations in lifespan between the populations. Further research is needed to understand the impact of local and climatic conditions on the survival of this mosquito species.
Article
Virology
Danai Pervanidou, Chrysovaladou Niki Kefaloudi, Anna Vakali, Ourania Tsakalidou, Myrsini Karatheodorou, Katerina Tsioka, Maria Evangelidou, Kassiani Mellou, Styliani Pappa, Konstantina Stoikou, Vasiliki Bakaloudi, George Koliopoulos, Kostas Stamoulis, Eleni Patsoula, Constantina Politis, Christos Hadjichristodoulou, Anna Papa
Summary: Since 2010, the West Nile virus (WNV) has been established in Greece. In 2022, there were 286 diagnosed cases of WNV infection in Greece, with 184 cases of neuroinvasive disease (WNND) and 33 deaths. The virus strain belonged to the Central European subclade of WNV lineage 2. Prompt diagnosis and investigation of cases are important for a timely response, and whole genome sequences enable studies on the molecular epidemiology of the disease.
Article
Virology
Evangelos Bakaros, Ioanna Voulgaridi, Vassiliki Paliatsa, Nikolaos Gatselis, Georgios Germanidis, Evangelia Asvestopoulou, Stamatia Alexiou, Elli Botsfari, Vasiliki Lygoura, Olga Tsachouridou, Iordanis Mimtsoudis, Maria Tseroni, Styliani Sarrou, Varvara A. Mouchtouri, Katerina Dadouli, Fani Kalala, Simeon Metallidis, George Dalekos, Christos Hadjichristodoulou, Matthaios Speletas
Summary: COVID-19 exhibits heterogeneous clinical presentation and prognosis. In addition to old age and comorbidities, the genetic background of the host plays a crucial role in disease severity and prognosis. This study analyzes the contribution of innate immune gene polymorphisms to COVID-19 severity and identifies several polymorphisms as potential molecular predictors of clinical phenotype.
Article
Immunology
Asimina Nasika, Zacharoula Bogogiannidou, Varvara A. Mouchtouri, Katerina Dadouli, Maria A. Kyritsi, Alexandros Vontas, Ioanna Voulgaridi, Zafeiris Tsinaris, Konstantina Kola, Alexia Matziri, Athanasios G. Lianos, Fani Kalala, Efthimia Petinaki, Matthaios Speletas, Christos Hadjichristodoulou
Summary: There is a lack of accurate data on susceptibility rates against measles in the general population of Greece. The purpose of the study was to determine the measles immunity status, especially after the latest outbreak in 2017-2018. The overall seroprevalence was 89.8%, with higher immunity rates in older age groups.
Article
Pediatrics
Dimitra Dimopoulou, Maria Kyritsi, Katerina Dadouli, Eleni Vergadi, Ekaterini Tsiligianni, Eleni Papadimitriou, Artemis Mavridi, Spyridon Giannakopoulos, Georgia Tsiourvopoulou, Maria Palyvou, Evangelia Angeli, Nikitas Brikos, Irini Eleftheriou, Vassiliki Spoulou, Athanasios Michos, Despoina Gkentzi, Ekaterini Siomou, Vassiliki Papaevangelou, Ioanna Grivea, George Syrogiannopoulos, Emmanouil Galanakis, Christos Hadjichristodoulou, Maria Tsolia
Summary: A study conducted in Greece during the COVID-19 lockdown found that the prevalence of SARS-CoV-2 transmission among children was low, similar to adults, most likely due to intrafamilial transmission. Therefore, it is unlikely that children play a significant role in virus transmission.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
