Review
Infectious Diseases
Ashar Dhana, Yohhei Hamada, Andre P. Kengne, Andrew D. Kerkhoff, Tobias Broger, Claudia M. Denkinger, Molebogeng X. Rangaka, Ankur Gupta-Wright, Katherine Fielding, Robin Wood, Helena Huerga, Sekai Chenai Mathabire Ruecker, Stephanie Bjerrum, Isik S. Johansen, Swe Swe Thit, Mar Mar Kyi, Josh Hanson, David A. Barr, Graeme Meintjes, Gary Maartens
Summary: This study assessed the performance of WHO screening criteria and alternative screening tests/strategies to guide LF-LAM testing in HIV-positive inpatients. The results showed limited utility of WHO criteria and alternative screening tests/strategies, suggesting the implementation of AlereLAM testing in all HIV-positive inpatients and the potential improvement in tuberculosis diagnosis through routine FujiLAM testing.
JOURNAL OF INFECTION
(2022)
Article
Microbiology
Mohammad Khaja Mafij Uddin, Md. Fahim Ather, Senjuti Kabir, Arfatur Rahman, Sabrina Choudhury, Rumana Nasrin, Tanjina Rahman, S. M. Mazidur Rahman, Shahriar Ahmed, Sayera Banu
Summary: Accurate and appropriate diagnosis of extrapulmonary tuberculosis (EPTB) remains challenging. This study investigated the diagnostic performance of different methods for EPTB diagnosis and found that the Xpert MTB/RIF assay showed the highest sensitivity. Considering its short turnaround time and promising findings, the Xpert MTB/RIF assay should be integrated into national TB guidelines as a routine diagnostic test.
Review
Medicine, General & Internal
Shahad Saif Khandker, Nik Haszroel Hysham Nik Hashim, Zakuan Zainy Deris, Rafidah Hanim Shueb, Md Asiful Islam
Summary: The study evaluated the overall performance of rapid antigen tests (RAT) in the diagnosis of SARS-CoV-2, finding a specificity and sensitivity of 99.4% and 68.4% respectively. Nasopharyngeal specimens and symptomatic patient's samples were found to be more sensitive in RAT, while the cycle threshold (Ct) values had an inverse relationship with sensitivity. RAT showed better performance in European and American populations, indicating it could be used as an alternative diagnostic tool.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Veterinary Sciences
Tarun Kumar, Mahavir Singh, Babu Lal Jangir, Devan Arora, Sreenidhi Srinivasan, Devender Bidhan, Dipin Chander Yadav, Maroudam Veerasami, Douwe Bakker, Vivek Kapur, Naresh Jindal
Summary: The study evaluated a defined-antigen skin test for diagnosing bTB in water buffaloes, showing that the 20 μg DST cocktail had the same diagnostic sensitivity as the SIT, indicating potential utility in routine surveillance programs for BCG vaccination of water buffaloes.
FRONTIERS IN VETERINARY SCIENCE
(2021)
Article
Veterinary Sciences
Fernanda Larenas-Munoz, Jose M. Sanchez-Carvajal, Angela Galan-Relano, Ines Ruedas-Torres, Eduardo Vera-Salmoral, Lidia Gomez-Gascon, Alfonso Maldonado, Librado Carrasco, Carmen Tarradas, Inmaculada Luque, Irene M. Rodriguez-Gomez, Jaime Gomez-Laguna
Summary: This study emphasizes the role of histopathology in the systematic diagnosis of bovine tuberculosis (bTB), showing that it can rapidly confirm the results of real-time PCR and bacteriology. Histopathology plays a significant role in the control and monitoring of bTB.
FRONTIERS IN VETERINARY SCIENCE
(2022)
Review
Medicine, General & Internal
Maniya Arshadi, Fatemeh Fardsanei, Behnaz Deihim, Zahra Farshadzadeh, Farhad Nikkhahi, Farima Khalili, Giovanni Sotgiu, Amir Hashem Shahidi Bonjar, Rosella Centis, Giovanni Battista Migliori, Mohammad Javad Nasiri, Mehdi Mirsaeidi
Summary: This study evaluated the accuracy of rapid antigen tests (RATs) in diagnosing COVID-19. The results showed that RATs had high sensitivity and specificity compared to the reference test (real-time PCR), making them suitable for early detection and resource-limited countries.
FRONTIERS IN MEDICINE
(2022)
Article
Medical Laboratory Technology
Xin Yin, Qi-Qing Ye, Ke-Fan Wu, Ji-Yuan Zeng, Nan-Xi Li, Jun-Jian Mo, Pei-Ying Huang, Li-Min Xie, Li-Ying Xie, Xu-Guang Guo
Summary: Urine LAM is a promising diagnostic test for tuberculosis, particularly suitable for HIV-infected adults with a CD4+ cell count of <= 100 per mu l.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2022)
Article
Virology
Verena Haage, Edmilson Ferreira de Oliveira-Filho, Andres Moreira-Soto, Arne Kuhne, Carlo Fischer, Jilian A. Sacks, Victor Max Corman, Marcel A. Muller, Christian Drosten, Jan Felix Drexler
Summary: This study assessed the analytical sensitivity and specificity of eleven commercially-available SARS-CoV-2 Ag-RDTs under different storage and operational temperatures, finding that elevated temperatures impair sensitivity while low temperatures impair specificity. Recommended storage and operation conditions are essential for successful usage of SARS-CoV-2 Ag-RDTs during the pandemic.
JOURNAL OF CLINICAL VIROLOGY
(2021)
Article
Mathematics
Jose Antonio Roldan-Nofuentes
Summary: Adjusting for covariates is important in the study of diagnostic test performance. Four methods were presented to simultaneously compare the sensitivities and specificities of two binary diagnostic tests. Simulation experiments were conducted to study the asymptotic behaviors of these methods when the covariate is binary.
Editorial Material
Microbiology
Yong Qi, Kun Li, Yuxi Li, Donglin Guo, Jing Xu, Yuexi Li, Wenping Gong
Summary: Tuberculosis is a global infectious disease, and rapid diagnosis of drug-resistant tuberculosis and latent tuberculosis infection has become a challenge. CRISPR-based diagnostics show advantages in tuberculosis diagnosis compared to traditional methods, but further development and optimization are needed.
Article
Microbiology
Michael Woelfl-Duchek, Felix Bergmann, Anselm Jorda, Maria Weber, Matthias Mueller, Tamara Seitz, Alexander Zoufaly, Robert Strassl, Markus Zeitlinger, Harald Herkner, Harald Schnidar, Karolina Anderle, Ulla Derhaschnig
Summary: This study evaluated the sensitivity and specificity of rapid antigen detection tests versus reverse transcriptase PCR (RT-PCR) using different swab samples. The results showed that self-collected anterior nasal swabs were as sensitive and more tolerable than professionally collected nasopharyngeal swabs when the C-T value was less than 30. Rapid antigen detection tests provide immediate results, while PCR should be preferred in crucial settings whenever possible.
MICROBIOLOGY SPECTRUM
(2022)
Article
Virology
Maria C. Montalvo Villalba, Elena Sosa Glaria, Licel de los A. Rodriguez Lay, Odalys Valdes Ramirez, Dayana Vallina Garcia, Amely Arencibia Garcia, Javier Martinez Alfonso, Dunia M. Menes Llerena, Loida Torres Perez, Sonia R. Resik Aguirre, Maria G. Guzman Tirado
Summary: The Elecsys SARS-CoV-2 Antigen immunoassay has shown high sensitivity and specificity in diagnosing SARS-CoV-2 infections, with no cross-reactivity to other respiratory viruses. This test could be used as an alternative or complementary method to RT-PCR testing for identifying infectious individuals and reducing transmission of the virus.
JOURNAL OF MEDICAL VIROLOGY
(2022)
Review
Public, Environmental & Occupational Health
Pei-Jung Hung, Cheng-Chieh Chen
Summary: This meta-analysis aimed to evaluate the diagnostic accuracy of immunochromatographic rotavirus antigen tests in children. The results showed that these tests have high sensitivity for diagnosing rotavirus infection in children, which can help with clinical management and disease prevention.
TROPICAL MEDICINE & INTERNATIONAL HEALTH
(2023)
Article
Veterinary Sciences
Paulo Alex Machado Carneiro, Eliomar de Moura Sousa, Rinaldo Batista Viana, Bruno Moura Monteiro, Aline do Socorro Lima Kzam, Damazio Campos de Souza, Anderson Silva Coelho, Jose Dantas Ribeiro Filho, Ricardo Spacagna Jordao, Maria Regina Madruga Tavares, John B. Kaneene
Summary: The study found that the ELISA IDEXX TM may serve as a supplemental test for detecting Mycobacterium bovis infection in regions without routine testing and slaughter, where the disease tends to progress to more advanced stages and antibody responses are likely to be more prevalent. Evidence supported the validation of the ELISA IDEXX (TM) as a supplemental test for bTB eradication programs.
BMC VETERINARY RESEARCH
(2021)
Article
Respiratory System
Zhifeng Liu, Yang Yang, Qingfeng Wang, Lei Wang, Wenjuan Nie, Naihui Chu
Summary: The study shows that nanopore sequencing-based testing of BALF or sputum samples provides higher diagnostic accuracy for suspected pulmonary tuberculosis (PTB) patients compared to Xpert and MGIT culture-based assays. The sensitivity and specificity of nanopore sequencing were 75.86% and 80.77% respectively.
BMC PULMONARY MEDICINE
(2023)
Article
Nutrition & Dietetics
Mark Hvistendahl, Christopher Filtenborg Brandt, Siri Tribler, Rahim Mohammad Naimi, Bolette Hartmann, Jens Juul Holst, Jens Frederik Rehfeld, Mads Hornum, Jens Rikardt Andersen, Birthe Merete Henriksen, Per Brobech Mortensen, Palle Bekker Jeppesen
JOURNAL OF PARENTERAL AND ENTERAL NUTRITION
(2018)
Review
Infectious Diseases
Anne Line Engsbro, Karen Leth Nielsen, Mads Hornum, Leif Percival Andersen
INFECTIOUS DISEASES
(2018)
Article
Infectious Diseases
K. R. Lausch, M. Sogaard, F. S. Rosenvinge, H. K. Johansen, T. Boysen, B. Roder, K. L. Mortensen, L. Nielsen, L. Lemming, B. Olesen, C. Leitz, L. Kristensen, E. Dzajic, L. Ostergaard, H. C. Schonheyder, M. C. Arendrup
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2018)
Article
Infectious Diseases
M. Murra, K. L. Mortensen, M. Wang
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2019)
Article
Transplantation
Mads Hornum, Luit Penninga, Andreas A. Rostved, Karl B. Christensen, Peter Oturai, Ulla Plagborg, Bo Feldt-Rasmussen, Jens G. Hillingso, Allan Rasmussen
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)
Article
Infectious Diseases
Karen Rokkedal Lausch, Mette Sogaard, Flemming Schonning Rosenvinge, Helle Krogh Johansen, Trine Boysen, Bent Lowe Roder, Klaus Leth Mortensen, Lene Nielsen, Lars Lemming, Bente Olesen, Christine Leitz, Lise Kristensen, Esad Dzajic, Lars Jorgen Ostergaard, Henrik Carl Schonheyder, Maiken Cavling Arendrup
INFECTION AND DRUG RESISTANCE
(2018)
Article
Transplantation
Pantelis Sarafidis, Charles J. Ferro, Enrique Morales, Alberto Ortiz, Jolanta Malyszko, Radovan Hojs, Khaled Khazim, Robert Ekart, Jose Valdivielso, Denis Fouque, Gerard M. London, Ziad Massy, Petro Ruggenenti, Esteban Porrini, Andrej Wiecek, Carmine Zoccali, Francesca Mallamaci, Mads Hornum
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2019)
Correction
Transplantation
Pantelis Sarafidis, Charles J. Ferro, Enrique Morales, Alberto Ortiz, Jolanta Malyszko, Radovan Hojs, Khaled Khazim, Robert Ekart, Jose Valdivielso, Denis Fouque, Gerard M. London, Ziad Massy, Petro Ruggenenti, Esteban Porrini, Andrzej Wiecek, Carmine Zoccali, Francesca Mallamaci, Mads Hornum
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)
Article
Gastroenterology & Hepatology
Bo Broberg, Jan L. Madsen, Stefan Fuglsang, Jens J. Holst, Karl Bang Christensen, Casper Rydahl, Thomas Idorn, Bo Feldt-Rasmussen, Mads Hornum
NEUROGASTROENTEROLOGY AND MOTILITY
(2019)
Article
Immunology
Karen Rokkedal Lausch, Kia Hee Schultz Dungu, Michael Thude Callesen, Henrik Schroder, Steen Rosthoj, Anja Poulsen, Lars Ostergaard, Klaus Leth Mortensen, Merete Storgaard, Henrik Carl Schonheyder, Mette Sogaard, Maiken Cavling Arendrup
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2019)
Article
Cardiac & Cardiovascular Systems
Caroline Back, Mads Hornum, Peter Skov Olsen, Christian H. Moller
SCANDINAVIAN CARDIOVASCULAR JOURNAL
(2019)
Correction
Transplantation
Pantelis Sarafidis, Charles J. Ferro, Enrique Morales, Alberto Ortiz, Jolanta Malyszko, Radovan Hojs, Khaled Khazim, Robert Ekart, Jose Valdivielso, Denis Fouque, Gerard M. London, Ziad Massy, Petro Ruggenenti, Esteban Porrini, Andrzej Wiecek, Carmine Zoccali, Francesca Mallamaci, Mads Hornum
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2020)
Article
Medicine, General & Internal
Mads Hornum, Morten Baltzer Houlind, Esben Iversen, Esteban Porrini, Sergio Luis-Lima, Peter Oturai, Martin Iversen, Pia Bredahl, Jorn Carlsen, Christian Holdflood Moller, Mads Jonsson Andersen, Bo Feldt-Rasmussen, Michael Perch
Summary: Patients undergoing lung transplantation (LTx) experience a rapid decline in glomerular filtration rate (GFR) in the acute postoperative period. This study compared different equations for estimating GFR in LTx patients and found that equations based on plasma creatinine underestimated GFR decline, while equations based on plasma cystatin C overestimated GFR decline after LTx. The 2021 CKD-EPI combination equation had the most accurate estimation of GFR in both pre-LTx and post-LTx periods. Therefore, caution should be exercised when interpreting renal function based on GFR estimation equations in the acute postoperative period following LTx.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Marie Elise Wistrup Torm, Birgit Sander, Mads Hornum, Paul Krohn, Henrik Birn, Michael Larsen
Summary: This study analyzed the characteristics and perfusion status of hyperreflective dots using OCT scans and developed a method to differentiate between perfused and occluded capillaries. It has the potential to non-invasively identify capillary non-perfusion.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Nadja Sparding, Federica Genovese, Daniel Guldager Kring Rasmussen, Morten A. Karsdal, Nicoline V. Krogstrup, Marie Bodilsen Nielsen, Mads Hornum, Subagini Nagarajah, Henrik Birn, Bente Jespersen, Martin Tepel, Rikke Norregaard
Summary: This study evaluated endotrophin (ETP) as a prognostic marker in kidney transplant recipients. It found that ETP levels in the blood on the first day after transplantation were strongly associated with delayed graft function, while ETP levels in the urine at the third month after transplantation were significantly correlated with kidney graft function at twelve months. The measurement of collagen type VI formation could aid in predicting graft function in kidney transplant recipients.
