Review
Biochemistry & Molecular Biology
HyunTaek Jung, Jae Seok Kim, Keum Hwa Lee, Kalthoum Tizaoui, Salvatore Terrazzino, Sarah Cargnin, Lee Smith, Ai Koyanagi, Louis Jacob, Han Li, Sung Hwi Hong, Dong Keon Yon, Seung Won Lee, Min Seo Kim, Paul Wasuwanich, Wikrom Karnsakul, Jae Il Shin, Andreas Kronbichler
Summary: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract that mainly affects young people. Recent studies have shown that microRNAs (miRNAs) play an important role in the pathogenesis, diagnosis, and treatment of IBD.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Srikruthi S. Krishnachaitanya, Max Liu, Ken Fujise, Qingjie Li
Summary: Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, is a group of chronic gastrointestinal inflammatory conditions that cause multiple complications. MicroRNA (miRNA) plays a significant role in the pathogenesis and complications of IBD, particularly in chronic inflammatory pathways. In addition to its involvement in the progression of colorectal cancer, miRNA is also associated with various extraintestinal complications in IBD, such as cardiovascular diseases, neuropsychiatric conditions, and musculoskeletal, dermatologic, ocular, and hepatobiliary complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Ioanna Aggeletopoulou, Efthymios P. P. Tsounis, Christos Triantos
Summary: Interleukin-33 (IL-33) is a pleiotropic cytokine with both extracellular and nuclear functions, and its receptor ST2 plays a critical role in regulating inflammatory disorders. The IL-33/ST2 axis is involved in maintaining intestinal homeostasis and mucosal defenses. This review focuses on the pro- and anti-inflammatory effects of the IL-33/ST2 axis in ulcerative colitis and Crohn's disease, as well as the molecular mechanisms underlying its association with IBD pathogenesis. Understanding the IL-33/ST2-mediated mechanisms in IBD has potential for clinical applications as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Orthopedics
K. M. Scott, D. J. Cohen, M. Hays, D. W. Nielson, M. W. Grinstaff, T. B. Lawson, B. D. Snyder, B. D. Boyan, Z. Schwartz
Summary: Both miR-122 and miR-451 were upregulated in OA in a rat bilateral anterior cruciate ligament transection (ACLT) model. miR-122 prevented the effects of IL-1 beta on rArCs, while miR-451 exacerbated them.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Review
Gastroenterology & Hepatology
Bram Verstockt, Azucena Salas, Bruce E. Sands, Clara Abraham, Haim Leibovitzh, Markus Neurath, Niels Vande Casteele
Summary: IL-12 and IL-23 play a crucial role in intestinal homeostasis and inflammation, and are implicated in the pathogenesis of inflammatory bowel disease. Monoclonal antibodies targeting IL-12 and/or IL-23 have been developed for the treatment of Crohn's disease and ulcerative colitis. This Review summarizes the biological characteristics of IL-12 and IL-23, discusses their role in intestinal homeostasis and inflammation, and highlights the development of drugs targeting IL-12 and/or IL-23.
NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Letizia Masi, Ivan Capobianco, Carlotta Magri, Irene Marafini, Valentina Petito, Franco Scaldaferri
Summary: Inflammatory bowel disease (IBD) is a chronic relapsing autoimmune disease, and miRNAs have the potential to serve as important biomarkers in diagnosis and treatment, as well as for developing a new screening model for colorectal cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Aleksandra Korta, Julia Kula, Krzysztof Gomulka
Summary: Interleukin-23 (IL-23) is a proinflammatory cytokine that plays a role in tissue damage. It interacts with both the innate and adaptive immune systems, and the IL-23/Th17 axis appears to be involved in the development of chronic intestinal inflammation. Despite the incomplete understanding of the etiology and pathophysiology of inflammatory bowel disease (IBD), research on IL-23 shows potential for clinical applications as therapeutic targets in IBD treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Shih-Chun Yang, Ahmed Alalaiwe, Zih-Chan Lin, Yu-Chih Lin, Ibrahim A. Aljuffali, Jia-You Fang
Summary: miRNA plays a critical role in regulating skin inflammation and has anti-inflammatory features. miRNA-based therapies could be potential candidates for treating skin inflammation.
Review
Gastroenterology & Hepatology
Akira Andoh, Atsushi Nishida
Summary: IL-33, IL-36, and IL-38 are members of the IL-1 cytokine family and their expression is increased in the inflamed mucosa of patients with inflammatory bowel disease (IBD). IL-33 and IL-36 have pro- and anti-inflammatory functions, while IL-38 acts as an anti-inflammatory cytokine by antagonizing the IL-36 receptor. IL-33 and IL-36 also play a crucial role in intestinal fibrosis, a characteristic manifestation of IBD.
JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Jaber Alfaifi, Adeline Germain, Anne-Charlotte Heba, Djesia Arnone, Laura Gailly, Ndeye Coumba Ndiaye, Emilie Viennois, Benedicte Caron, Laurent Peyrin-Biroulet, Natacha Dreumont
Summary: This article reviews the published studies on microRNA (miRNA) expression in inflammatory bowel disease (IBD), including miRNAs extracted from blood, tissue, and stool samples. The main mechanisms of miRNA involvement in IBD and their potential use as biomarkers are discussed.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Pharmacology & Pharmacy
Zhenzhen Deng, Shengfeng Wang, Cuifang Wu, Chunjiang Wang
Summary: This study investigated the association between IL-17 inhibitors and the onset of inflammatory bowel disease (IBD). The results showed that IL-17 inhibitor treatment is associated with exacerbation and new onset of IBD and colitis. Obtaining a detailed patient history before treatment and monitoring gastrointestinal symptoms and intestinal inflammatory biomarkers is important for safe use of these drugs.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Miruna Nemecz, Diana Simona Stefan, Ioana Karla Comarita, Alina Constantin, Gabriela Tanko, Cristian Guja, Adriana Georgescu
Summary: In this study, miR-218, miR-132, and miR-143 were identified as significantly up-regulated miRNAs in both circulating MVs and plasma from diabetic patients with dyslipidemia. These miRNAs showed significant correlations with important plasma markers representative of this pathology.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Dentistry, Oral Surgery & Medicine
Aysegul Sari, Serdar Dogan, Luigi Nibali, Serhat Koseoglu
Summary: This study evaluated the levels of IL-39 in gingival crevicular fluid (GCF) in patients with periodontal diseases and health, and correlated them with levels of IL-1 beta and periostin in GCF. The results showed that IL-39 levels were elevated in the presence of periodontal disease, paralleling the increase in IL-1 beta and periostin levels, suggesting that IL-39 may have a role in the periodontal inflammation process.
CLINICAL ORAL INVESTIGATIONS
(2022)
Article
Chemistry, Multidisciplinary
Min Nie, Danqing Huang, Guopu Chen, Yuanjin Zhao, Lingyun Sun
Summary: A bioadhesive microparticle carrying IL-27 MSC-derived extracellular vesicles (MSCIL-27 EVs) was developed using microfluidic technology. The microcarriers exhibited sustained release effect and effective wet adhesion, and demonstrated potential therapeutic efficacy in treating IBD.
Review
Pharmacology & Pharmacy
Rocio Rivera Rodriguez, Jeremy James Johnson
Summary: Inflammatory Bowel Disease (IBD) is a chronic autoimmune disease characterized by intestinal inflammation. The incidence of IBD is rapidly increasing in newly developed countries, making it a global concern. Two major types of IBD, ulcerative colitis (UC) and Crohn's disease (CD), have different manifestations and locations of inflammation in the digestive tract. Current FDA-approved treatments for IBD are only effective for 50% of patients and come with serious side effects, highlighting the need for safer and more effective therapies. Plant-based diets, such as the Mediterranean diet rich in anti-inflammatory phytochemicals, have shown benefits in preventing and improving symptoms of IBD. Terpenes, a class of phytochemicals abundant in Mediterranean herbs and citrus fruits, have been studied for their potential to modulate inflammatory signaling in IBD. However, there is still conflicting and inconclusive evidence regarding their effectiveness. This review evaluates preclinical studies on terpenes and their impact on basic inflammatory signaling in IBD.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Endocrinology & Metabolism
Tong-Lie Huang, Nan Mu, Jin-Tao Gu, Zhen Shu, Kuo Zhang, Jin-Kang Zhao, Cun Zhang, Qiang Hao, Wei-Na Li, Wang-Qian Zhang, Nan-Nan Liu, Yong Zhang, Wei Zhang, Xiao-Chang Xue, Ying-Qi Zhang
JOURNAL OF BONE AND MINERAL RESEARCH
(2017)
Article
Chemistry, Multidisciplinary
Jintao Gu, Shuo Liu, Nan Mu, Tonglie Huang, Wangqian Zhang, Huadong Zhao, Zhen Shu, Cun Zhang, Qiang Hao, Weina Li, Xiaochang Xue, Wei Zhang, Yingqi Zhang
JOURNAL OF CONTROLLED RELEASE
(2017)
Article
Biochemistry & Molecular Biology
Wangqian Zhang, Shuning Wang, Jintao Gu, Yuan Gao, Zhaowei Wang, Kuo Zhang, Nan Mu, Tonglie Huang, Weina Li, Qiang Hao, Xiaochang Xue, Wei Zhang, Yingqi Zhang, Cun Zhang
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2018)
Article
Medicine, Research & Experimental
Xiaowen Ma, Zhijun Pang, Jiming Zhou, Lei He, Qjang Hao, Weina Li, Kuo Zhang, Shuning Wang, Wangqi Zhang, Xiaochang Xue, Wei Zhang, Yingqi Zhang, Cun Zhang, Meng Li
MOLECULAR PHARMACEUTICS
(2018)
Article
Cell Biology
Yuan Gao, Xiaoju Li, Zhen Shu, Kuo Zhang, Xiaochang Xue, Weina Li, Qiang Hao, Zhaowei Wang, Wangqian Zhang, Shuning Wang, Cheng Zeng, Dong Fan, Wei Zhang, Yingqi Zhang, Huadong Zhao, Meng Li, Cun Zhang
CELL DEATH & DISEASE
(2018)
Article
Medicine, Research & Experimental
Nan Mu, Jintao Gu, Nannan Liu, Xiaochang Xue, Zhen Shu, Kuo Zhang, Tonglie Huang, Chu Chu, Wangqian Zhang, Li Gong, Huadong Zhao, Bo Jia, Dakuan Gao, Lei Shang, Wei Zhang, Qingdong Guo
Article
Biotechnology & Applied Microbiology
Chu Chu, Wangqian Zhang, Jialin Li, Yi Wan, Zenglu Wang, Ruyi Duan, Pei Yu, Ning Zhao, Kuo Zhang, Shuning Wang, Qiang Hao, Weina Li, Cun Zhang, Wei Zhang, Yingqi Zhang, Meng Li, Xiaochang Xue
BIOMED RESEARCH INTERNATIONAL
(2018)
Article
Pharmacology & Pharmacy
Jintao Gu, Jun Liu, Tonglie Huang, Wangqian Zhang, Bo Jia, Nan Mu, Kuo Zhang, Qiang Hao, Weina Li, Wei Liu, Wei Zhang, Yingqi Zhang, Xiaochang Xue, Cun Zhang, Meng Li
BIOCHEMICAL PHARMACOLOGY
(2018)
Article
Cell Biology
Tianhong Su, Pi Liu, Xinyu Ti, Shouzhen Wu, Xiaochang Xue, Zenglu Wang, Elhardji Dioum, Qiuyang Zhang
CELL COMMUNICATION AND SIGNALING
(2019)
Article
Rheumatology
Mu Nan, Gu Jin-Tao, Huang Tong-Lie, Liu Nan-Nan, Chen Hui, Bu Xin, Zheng Zhao-Hui, Jia Bo, Liu Jun, Wang Bao-Long, Wang Ying-Mei, Zhu Zhen-Feng, Zhang Yong, Zhang Ying-Qi, Xue Xiao-Chang, Li Meng, Zhang Wei
ARTHRITIS & RHEUMATOLOGY
(2020)
Article
Biotechnology & Applied Microbiology
Dou Niu, Xue Chen, Ting Wang, Fuxing Wang, Qiusheng Zhang, Xiaochang Xue, Jiefang Kang
Summary: The study showed that iridoid glycosides extracted from Corni Fructus have significant therapeutic effects on a mouse model of T2DM with NAFLD, alleviating hyperglycemia, insulin resistance, inflammation, oxidative stress, and liver fat accumulation. This is achieved through the inhibition of NF-kappa B and enhancement of the PI3K-AKT signaling pathway.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Food Science & Technology
Shujing An, Dou Niu, Ting Wang, Binkai Han, Changfen He, Xiaolin Yang, Haoqiang Sun, Ke Zhao, Jiefang Kang, Xiaochang Xue
Summary: Corni Fructus saponins extracted from Corni Fructus could potentially be a promising functional food ingredient for improving diabetes by regulating insulin-related signaling pathways and ameliorating glucose and lipid metabolism, inflammation, oxidative stress, and organ damages in diabetic mice.
Article
Oncology
Jintao Gu, Nan Mu, Bo Jia, Qingdong Guo, Luxiang Pan, Maorong Zhu, Wangqian Zhang, Kuo Zhang, Weina Li, Meng Li, Lichun Wei, Xiaochang Xue, Yingqi Zhang, Wei Zhang
Summary: This study presents a novel preclinical model for radiobiological studies and identifies a radiation-tolerant persister subpopulation that drives radioresistance by activating DNA damage repair and promoting stemness. The NF-kappa B-YY1-miR-103a regulatory axis is essential for the function of the radiation-tolerant persister cells. Furthermore, transferrin-functionalized nanoparticles improve radiosensitivity and provide a significant survival benefit.
Article
Biochemistry & Molecular Biology
Binkai Han, Haoqiang Sun, Xiaolin Yang, Ting Wang, Changfen He, Ke Zhao, Shujing An, Chen Guo, Dou Niu, Xiaochang Xue, Jiefang Kang
Summary: The study demonstrates that GIs extracted from CF by UAEE are effective for diabetes treatment, with a yield of 70.44 mg g-1 and an activity of 91.99%, showing significant improvement in glucose metabolism in an insulin-resistant cell model.
Article
Biochemistry & Molecular Biology
Binkai Han, Dou Niu, Ting Wang, Shujing An, Yanzhen Wang, Xue Chen, Huailong Bi, Xiaochang Xue, Jiefang Kang